In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophores

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4567-4575

  Brahmachari, Goutam ^a   Choo, Cheeyan ^b   Ambure, Pravin ^c   Roy, Kunal ^c,d  

^a VISVA BHARATI UNIVERSITY   (India)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^c JADAVPUR UNIVERSITY   (India)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Acetylcholinesterase (AChE) inhibition; Docking; Functionalized piperidines; Green synthesis; In silico; Pharmacophore

Indexed keywords

1,2,5,6 TETRAHYDROPYRIDINE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; FUNCTIONALIZED PIPERIDINE; GALANTAMINE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHOLINESTERASE INHIBITION; COMPUTER MODEL; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; GREEN CHEMISTRY; HALOGENATION; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR INTERACTION; NITRATION; ONE POT SYNTHESIS; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; CHEMISTRY; COMPUTER SIMULATION;

CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; IN VITRO TECHNIQUES; PIPERIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937811625     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.06.005     Document Type: Article

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