MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation

Blood

Volumn 126, Issue 1, 2015, Pages 103-112

  Chen, Sophia ^a   Smith, Benjamin A H ^a   Iype, Joseena ^a   Prestipino, Alessandro ^a   Pfeifer, Dietmar ^a   Grundmann, Sebastian ^b   Schmitt Graeff, Annette ^b   Idzko, Marco ^a   Beck, Yvonne ^a   Prinz, Gabriele ^a   Finke, Jürgen ^a   Duyster, Justus ^a   Zeiser, Robert ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTAGOMIR; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 23; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MICRORNA 155; MITOGEN ACTIVATED PROTEIN KINASE; PURINERGIC RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; MICRORNA; MIRN155 MICRORNA, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC SYSTEM; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RECIPIENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL; WESTERN BLOTTING; ADVERSE EFFECTS; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CELL MOTION; FEMALE; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; KNOCKOUT MOUSE; MALE; METABOLISM; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INFLAMMASOMES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; SEVERITY OF ILLNESS INDEX; TRANSPLANTATION, HOMOLOGOUS;

EID: 84937808970     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-12-617258     Document Type: Article

References (45)

1. Passweg JR, Baldomero H, Gratwohl A, et al European Group for Blood and Marrow Transplantation (EBMT). The EBMT activity survey: 1990-2010. Bone Marrow Transplant. 2012;47(7):906-923.
2. Wolff D, Ayuk F, Elmaagacli A, et al. Current practice in diagnosis and treatment of acute graftversus-host disease: results from a survey among German-Austrian-Swiss hematopoietic stem cell transplant centers. Biol Blood Marrow Transplant. 2013;19(5):767-776.
3. Liu J. Control of protein synthesis and mRNA degradation by microRNAs. Curr Opin Cell Biol. 2008;20(2):214-221.
4. Jankovic D, Ganesan J, Bscheider M, et al. The Nlrp3 inflammasome regulates acute graft-versushost disease. JExpMed.2013;210(10):1899-1910.
5. Hill GR, Teshima T, Gerbitz A, et al. Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. J Clin Invest. 1999;104(4):459-467.
6. Ceppi M, Pereira PM, Dunand-Sauthier I, et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocytederived dendritic cells. Proc Natl Acad Sci USA. 2009;106(8):2735-2740.
7. Ranganathan P, Heaphy CE, Costinean S, et al. Regulation of acute graft-versus-host disease by microRNA-155. Blood. 2012;119(20):4786-4797.
8. Murugaiyan G, Beynon V, Mittal A, Joller N, Weiner HL. Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2011;187(5):2213-2221.
9. O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D. MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci USA. 2007;104(5):1604-1609.
10. Wilhelm K, Ganesan J, Müller T, et al. Graftversus-host disease enhanced by extracellular adenosine triphosphate activating P2X7R. Nat Med. 2010;16(12):1434-1438.
11. Schwab L, Goroncy L, Palaniyandi S, et al. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance GvHD via tissue damage. Nat Med. 2014;20(6):648-654.
12. Zeiser R, Nguyen VH, Beilhack A, et al. Inhibition of CD41CD251 regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood. 2006;108(1):390-399.
13. Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD. Target antigens determine graft-versus-host disease phenotype. J Immunol. 2004;173(9):5467-5475.
14. Zeiser R, Youssef S, Baker J, Kambhan N, Steinman L, Negrin RS. HMG-CoA reductase inhibitors (statins) provide acute-graft-versus-host disease protection by Th-2 cytokine induction while sparing graft-versus-leukemia activity. Blood. 2007;110(13):4588-4598.
15. Dudda JC, Lembo A, Bachtanian E, et al. Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol. 2005;35(4): 1056-1065.
16. Leonhardt F, Zirlik K, Buchner M, et al. Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels. Leukemia. 2012;26(7):1617-1629.
17. Ayata CK, Ganal SC, Hockenjos B, et al. Purinergic P2Y2 receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. Gastroenterology. 2012;143(6): 1620-1629, e4.
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-D DC(T)) Method. Methods. 2001;25(4):402-408.
19. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4(2):249-264.
20. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57:289.
21. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545-15550.
22. Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000; 28(1):27-30.
23. Cooke KR, Gerbitz A, Crawford JM, et al. LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation. J Clin Invest. 2001;107(12):1581-1589.
24. Leonhardt F, Grundmann S, Behe M, et al. Inflammatory neovascularization during graft-versus-host disease is regulated by av integrin and miR-100. Blood. 2013;121(17): 3307-3318.
25. Babelova A, Moreth K, Tsalastra-Greul W, et al. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem. 2009;284(36): 24035-24048.
26. Pizzirani C, Ferrari D, Chiozzi P, et al. Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood. 2007;109(9):3856-3864.
27. Abele S, Spriewald BM, Ramsperger-Gleixner M, et al. Attenuation of transplant arteriosclerosis with clopidogrel is associated with a reduction of infiltrating dendritic cells and macrophages in murine aortic allografts. Transplantation. 2009; 87(2):207-216.
28. Ben Addi A, Cammarata D, Conley PB, Boeynaems JM, Robaye B. Role of the P2Y12 receptor in the modulation of murine dendritic cell function by ADP. JImmunol.2010;185(10): 5900-5906.
29. Müller T, Robaye B, Vieira RP, et al. The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation. Allergy. 2010;65(12): 1545-1553.
30. Idzko M, Ferrari D, Eltzschig HK. Nucleotide signalling during inflammation. Nature. 2014; 509(7500):310-317.
31. Ma HH, Ziegler J, Li C, et al. Sequential activation of inflammatory signaling pathways during graftversus-host disease (GVHD): early role for STAT1 and STAT3. Cell Immunol. 2011;268(1):37-46.
32. Sagar D, Lamontagne A, Foss CA, Khan ZK, Pomper MG, Jain P. Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation. J Neuroinflammation. 2012;9:245.
33. Ghonime MG, Shamaa OR, Das S, et al. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol. 2014;192(8):3881-3888.
34. Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol. 2009;27:229-265.
35. Masters SL, Gerlic M, Metcalf D, et al. NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity. 2012; 37(6):1009-1023.
36. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10(2): 417-426.
37. Dunand-Sauthier I, Santiago-Raber ML, Capponi L, et al. Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function. Blood. 2011;117(17): 4490-4500.
38. Suto A, Nakajima H, Tokumasa N, et al. Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation. J Immunol. 2005;175(9): 5681-5689.
39. Koyama M, Hashimoto D, Aoyama K, et al. Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells. Blood. 2009;113(9): 2088-2095.
40. McDonald B, Pittman K, Menezes GB, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science. 2010; 330(6002):362-366.
41. Yanagawa Y, Iijima N, Iwabuchi K, Onoé K. Activation of extracellular signal-related kinase by TNF-alpha controls the maturation and function of murine dendritic cells. J Leukoc Biol. 2002;71(1): 125-132.
42. Kahlenberg JM, Lundberg KC, Kertesy SB, Qu Y, Dubyak GR. Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol. 2005;175(11):7611-7622.
43. Mariathasan S, Weiss DS, Newton K, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006; 440(7081):228-232.
44. Li X, Tian F, Wang F. Rheumatoid arthritisassociated microRNA-155 targets SOCS1 and upregulates TNF-a and IL-1b in PBMCs. Int J Mol Sci. 2013;14(12):23910-23921.
45. Xie LN, Zhou F, Liu XM, et al. Serum microRNA155 is increased in patients with acute graft-versus-host disease. Clin Transplant. 2014; 28(3):314-323.