-
3
-
-
84895761597
-
In vitro pan-genotypic and combination activity of sofosbuvir (GS-7977) in stable replicon cell lines [abstract no. 1875]
-
Hebner C, Lee Y-J, Han B, et al. In vitro pan-genotypic and combination activity of sofosbuvir (GS-7977) in stable replicon cell lines [abstract no. 1875]. Hepatology. 2012;56(4 Suppl):1066A.
-
(2012)
Hepatology.
, vol.56
, Issue.4
, pp. 1066A
-
-
Hebner, C.1
Lee, Y.-J.2
Han, B.3
-
4
-
-
84900339263
-
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
-
24725239
-
Afdhal N, Zeuzem S, Kwo P, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370(20):1889-98.
-
(2014)
N Engl J Med.
, vol.370
, Issue.20
, pp. 1889-1898
-
-
Afdhal, N.1
Zeuzem, S.2
Kwo, P.3
-
5
-
-
84898669547
-
Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
-
1:CAS:528:DC%2BC2cXmvFShtLk%3D 24725238
-
Afdhal N, Reddy KR, Nelson DR, et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014;370(16):1483-93.
-
(2014)
N Engl J Med.
, vol.370
, Issue.16
, pp. 1483-1493
-
-
Afdhal, N.1
Reddy, K.R.2
Nelson, D.R.3
-
6
-
-
84900326091
-
Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis
-
24720702
-
Kowdley KV, Gordon SC, Reddy KR, et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370(20):1879-88.
-
(2014)
N Engl J Med.
, vol.370
, Issue.20
, pp. 1879-1888
-
-
Kowdley, K.V.1
Gordon, S.C.2
Reddy, K.R.3
-
7
-
-
84923842585
-
Baseline and post-baseline resistance analyses of phase 2/3 studies of ledipasvir/sofosbuvir ± RBV [abstract no. 1926 plus poster]
-
Sarrazin C, Dvory-Sobol H, Svarovskaia ES, et al. Baseline and post-baseline resistance analyses of phase 2/3 studies of ledipasvir/sofosbuvir ± RBV [abstract no. 1926 plus poster]. Hepatology. 2014;60(4 Suppl):1128A.
-
(2014)
Hepatology.
, vol.60
, Issue.4
, pp. 1128A
-
-
Sarrazin, C.1
Dvory-Sobol, H.2
Svarovskaia, E.S.3
-
8
-
-
84973272829
-
100 % SVR12 in Japanese patients with chronic genotype 1 hepatitis C virus infection receiving ledipasvir/sofosbuvir fixed dose combination for 12 weeks: Results from a multicenter phase 3 study [abstract no. 1929 plus poster]
-
Mizokami M, Takehara T, Yokosuka O, et al. 100 % SVR12 in Japanese patients with chronic genotype 1 hepatitis C virus infection receiving ledipasvir/sofosbuvir fixed dose combination for 12 weeks: results from a multicenter phase 3 study [abstract no. 1929 plus poster]. Hepatology. 2014;60(4 Suppl):1130A.
-
(2014)
Hepatology.
, vol.60
, Issue.4
, pp. 1130A
-
-
Mizokami, M.1
Takehara, T.2
Yokosuka, O.3
-
9
-
-
84896125632
-
The pharmacokinetics of ledipasvir, an HCV specific NS5A inhibitor in HCV-uninfected subjects with moderate and severe hepatic impairment [abstract no. 467 plus poster]
-
(4 Suppl 1):432A
-
German P, Mathias A, Yang JC, et al. The pharmacokinetics of ledipasvir, an HCV specific NS5A inhibitor in HCV-uninfected subjects with moderate and severe hepatic impairment [abstract no. 467 plus poster]. Hepatology. 2013;58(4 Suppl 1):432A.
-
(2013)
Hepatology
, vol.58
-
-
German, P.1
Mathias, A.2
Yang, J.C.3
-
10
-
-
84937765915
-
The pharmacokinetics of ledipasvir, an HCV specific NS5A inhibitor
-
[abstract no. 1952]. Hepatology. 2014;60(4 Suppl):1145A-6A
-
Mogalian E, Mathias A, Yang JC, et al. The pharmacokinetics of ledipasvir, an HCV specific NS5A inhibitor, in HCV-uninfected subjects with severe renal impairment [abstract no. 1952]. Hepatology. 2014;60(4 Suppl):1145A-6A.
-
HCV-uninfected Subjects with Severe Renal Impairment
-
-
Mogalian, E.1
Mathias, A.2
Yang, J.C.3
-
11
-
-
85027431501
-
No differences in the pharmacokinetics of sofosbuvir (GS-7977) and sofosbuvir/ledipasvir (GS-7977/GS-5885) fixed dose combination between Japanese and Caucasians [abstract no. 954]
-
(Suppl 1):S375-6
-
Kirby B, German P, Shen G, et al. No differences in the pharmacokinetics of sofosbuvir (GS-7977) and sofosbuvir/ledipasvir (GS-7977/GS-5885) fixed dose combination between Japanese and Caucasians [abstract no. 954]. Hepatol Int. 2013;7(Suppl 1):S375-6.
-
(2013)
Hepatol Int
, vol.7
-
-
Kirby, B.1
German, P.2
Shen, G.3
-
12
-
-
84923835679
-
Drug-drug interaction profile of the fixed-dose combination tablet ledipasvir/sofosbuvir [abstract no. 1976 plus poster]
-
German P, Pang PS, Fang L, et al. Drug-drug interaction profile of the fixed-dose combination tablet ledipasvir/sofosbuvir [abstract no. 1976 plus poster]. Hepatology. 2014;60(4 Suppl):1162A.
-
(2014)
Hepatology.
, vol.60
, Issue.4
, pp. 1162A
-
-
German, P.1
Pang, P.S.2
Fang, L.3
-
14
-
-
85027949450
-
Lack of a clinically important pharmacokinetic interaction between sofosbuvir or ledipasvir and hormonal oral contraceptives norgestimate/ethinyl estradiol in HCV-uninfected female subjects
-
1:CAS:528:DC%2BC2cXhvVSjs7jE 24925712
-
German P, Moorehead L, Pang P, et al. Lack of a clinically important pharmacokinetic interaction between sofosbuvir or ledipasvir and hormonal oral contraceptives norgestimate/ethinyl estradiol in HCV-uninfected female subjects. J Clin Pharmacol. 2014;54(11):1290-8.
-
(2014)
J Clin Pharmacol.
, vol.54
, Issue.11
, pp. 1290-1298
-
-
German, P.1
Moorehead, L.2
Pang, P.3
-
15
-
-
84885319302
-
No clinically significant pharmacokinetic drug-drug interactions between sofosbuvir (GS-7977) and the immunosuppressants
-
cyclosporine A or tacrolimus in healthy volunteers [abstract no. 1869 plus poster] (4 Suppl):1063A-4A
-
Mathias A, Cornpropst M, Clemons D, et al. No clinically significant pharmacokinetic drug-drug interactions between sofosbuvir (GS-7977) and the immunosuppressants, cyclosporine A or tacrolimus in healthy volunteers [abstract no. 1869 plus poster]. Hepatology. 2012;56(4 Suppl):1063A-4A.
-
(2012)
Hepatology
, vol.56
-
-
Mathias, A.1
Cornpropst, M.2
Clemons, D.3
-
16
-
-
84920990853
-
Ledipasvir/sofosbuvir with ribavirin for the treatment of HCV in patients with decompensated cirrhosis: Preliminary results of a prospective multicenter study [abstract no. 239 plus slide presentation]
-
2014 (4 Suppl):320A-1A
-
Flamm SL, Everson GT, Charlton M, et al. Ledipasvir/sofosbuvir with ribavirin for the treatment of HCV in patients with decompensated cirrhosis: preliminary results of a prospective multicenter study [abstract no. 239 plus slide presentation]. Hepatology. 2014;60(4 Suppl):320A-1A.
-
Hepatology
, vol.60
-
-
Flamm, S.L.1
Everson, G.T.2
Charlton, M.3
-
17
-
-
84920936858
-
Ledipasvir/sofosbuvir with ribavirin for the treatment of HCV in patients with post-transplant recurrence: Preliminary results of a prospective
-
multicenter study [abstract no. 8 plus slide presentation] (4 Suppl):200A-1A
-
Reddy KR, Everson GT, Flamm SL, et al. Ledipasvir/sofosbuvir with ribavirin for the treatment of HCV in patients with post-transplant recurrence: preliminary results of a prospective, multicenter study [abstract no. 8 plus slide presentation]. Hepatology. 2014;60(4 Suppl):200A-1A.
-
(2014)
Hepatology
, vol.60
-
-
Reddy, K.R.1
Everson, G.T.2
Flamm, S.L.3
-
18
-
-
84894297488
-
Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 infection
-
1:CAS:528:DC%2BC2cXislKitb8%3D 24262278
-
Gane EJ, Stedman CA, Hyland RH, et al. Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 infection. Gastroenterology. 2014;146(3):736-43.
-
(2014)
Gastroenterology.
, vol.146
, Issue.3
, pp. 736-743
-
-
Gane, E.J.1
Stedman, C.A.2
Hyland, R.H.3
-
19
-
-
84894621765
-
Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): An open-label, randomised, phase 2 trial
-
1:CAS:528:DC%2BC3sXhslehsr%2FN 24209977
-
Lawitz E, Poordad FF, Pang PS, et al. Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial. Lancet. 2014;383(9916):515-23.
-
(2014)
Lancet.
, vol.383
, Issue.9916
, pp. 515-523
-
-
Lawitz, E.1
Poordad, F.F.2
Pang, P.S.3
-
21
-
-
84937761387
-
Concordance between SVR4, SVR12 and SVR24 in genotype 1 HCV-infected patients who received all oral fixed-dose combination ledipasvir/sofosbuvir with or without ribavirin in phase 3 clinical trials
-
[abstract no. 1947 plus slide presentation] (4 Suppl):1142A-3A
-
Bernstein DE, Mangia A, Brau N, et al. Concordance between SVR4, SVR12 and SVR24 in genotype 1 HCV-infected patients who received all oral fixed-dose combination ledipasvir/sofosbuvir with or without ribavirin in phase 3 clinical trials [abstract no. 1947 plus slide presentation]. Hepatology. 2014;60(4 Suppl):1142A-3A.
-
(2014)
Hepatology
, vol.60
-
-
De, B.1
Mangia, A.2
Brau, N.3
-
22
-
-
84923838305
-
Virologic response rates to all oral fixed-dose combination ledipasvir/sofosbuvir regimens are similar in patients with and without traditional negative predictive factors in phase 3 clinical trials
-
[abstract no. 1945 plus poster] (4 Suppl):1141A-2A
-
Jacobson IM, Kwo PY, Kowdley KV, et al. Virologic response rates to all oral fixed-dose combination ledipasvir/sofosbuvir regimens are similar in patients with and without traditional negative predictive factors in phase 3 clinical trials [abstract no. 1945 plus poster]. Hepatology. 2014;60 (4 Suppl):1141A-2A.
-
(2014)
Hepatology
, vol.60
-
-
Jacobson, I.M.1
Kwo, P.Y.2
Kowdley, K.V.3
-
23
-
-
84924428592
-
No differences in the efficacy of fixed-dose combination ledipasvir/sofosbuvir in patients according to fibrosis stage determined by liver biopsy or laboratory biomarker in phase 3 clinical trials
-
[abstract no. 1958 plus poster] (4 Suppl):1149A-50A
-
Gordon SC, Fried MW, Kwo PY, et al. No differences in the efficacy of fixed-dose combination ledipasvir/sofosbuvir in patients according to fibrosis stage determined by liver biopsy or laboratory biomarker in phase 3 clinical trials [abstract no. 1958 plus poster]. Hepatology. 2014;60(4 Suppl):1149A-50A.
-
(2014)
Hepatology
, vol.60
-
-
Gordon, S.C.1
Fried, M.W.2
Kwo, P.Y.3
-
24
-
-
84937764102
-
Sustained virologic response with ledipasvir (LDV) and sofosbuvir (SOF) regimens lead to substantial improvement in patient-reported outcomes (PROs) among chronic hepatitis C (CHC) patients with early hepatic fibrosis as well as those with advanced hepatic fibrosis
-
[abstract no. 1445 plus poster] (4 Suppl):892A-3A
-
Younossi Z, Stepanova M, Marcellin P, et al. Sustained virologic response with ledipasvir (LDV) and sofosbuvir (SOF) regimens lead to substantial improvement in patient-reported outcomes (PROs) among chronic hepatitis C (CHC) patients with early hepatic fibrosis as well as those with advanced hepatic fibrosis [abstract no. 1445 plus poster]. Hepatology. 2014;60(4 Suppl):892A-3A.
-
(2014)
Hepatology
, vol.60
-
-
Younossi, Z.1
Stepanova, M.2
Marcellin, P.3
-
25
-
-
84929607189
-
Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, 2 and 3 clinical trials
-
doi: 10.1002/hep.27724
-
Younossi ZM, Stepanova M, Marcellin P, et al. Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: results from the ION-1, 2 and 3 clinical trials. Hepatology. 2015. doi: 10.1002/hep.27724.
-
(2015)
Hepatology
-
-
Younossi, Z.M.1
Stepanova, M.2
Marcellin, P.3
-
26
-
-
84925436650
-
Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection
-
doi: 10.1001/jama.2015.1373
-
Osinusi A, Townsend K, Kohli A, et al. Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection. JAMA. 2015. doi: 10.1001/jama.2015.1373.
-
(2015)
JAMA
-
-
Osinusi, A.1
Townsend, K.2
Kohli, A.3
-
27
-
-
84937765919
-
Sofosbuvir/ledipasvir fixed dose combination is safe and effective in HCV infected populations including decompensated patients and patients with prior sofosbuvir treatment experience
-
[abstract no. 238 plus slide presentation] (5 Suppl 1):S904-S5
-
Gane E, Hyland RH, Pang P, et al. Sofosbuvir/ledipasvir fixed dose combination is safe and effective in HCV infected populations including decompensated patients and patients with prior sofosbuvir treatment experience [abstract no. 238 plus slide presentation]. Gastroenterology. 2014;146(5 Suppl 1):S904-S5.
-
(2014)
Gastroenterology
, vol.146
-
-
Gane, E.1
Hyland, R.H.2
Pang, P.3
-
28
-
-
84922477979
-
All oral treatment for genotype 4 chronic hepatitis C infection with sofosbuvir and ledipasvir: Interim results from the NIAID SYNERGY trial [abstract no. 240 plus slide presentation]
-
Kapoor R, Kohil A, Sidharthan S, et al. All oral treatment for genotype 4 chronic hepatitis C infection with sofosbuvir and ledipasvir: interim results from the NIAID SYNERGY trial [abstract no. 240 plus slide presentation]. Hepatology. 2014;60(4 Suppl):321A.
-
(2014)
Hepatology.
, vol.60
, Issue.4
, pp. 321A
-
-
Kapoor, R.1
Kohil, A.2
Sidharthan, S.3
-
29
-
-
84937765920
-
Infection 6 or 3 Genotype Hcv with Patients for Weeks 12 for Regimens Ldv/sof of Efficacy High E.
-
[abstract no. LB-11 plus poster] (1 Suppl)
-
Gane EJ, Hyland RH, An D, et al. High efficacy of LDV/SOF regimens for 12 weeks for patients with HCV genotype 3 or 6 infection [abstract no. LB-11 plus poster]. Hepatology. 2014;60(1 Suppl).
-
(2014)
Hepatology
, vol.60
-
-
Gane, E.J.1
Hyland, R.H.2
An, D.3
-
30
-
-
84937765921
-
Safety of ledipasvir/sofosbuvir with and without ribavirin for the treatment of patients with chronic HCV genotype 1 infection: An analysis of the phase 3 ION trials
-
[abstract no. 1944 plus poster] (4 Suppl):1140A-1A
-
Alqahtani S, Afdhal NH, Zeuzem S, et al. Safety of ledipasvir/sofosbuvir with and without ribavirin for the treatment of patients with chronic HCV genotype 1 infection: an analysis of the phase 3 ION trials [abstract no. 1944 plus poster]. Hepatology. 2014;60 (4 Suppl):1140A-1A.
-
(2014)
Hepatology
, vol.60
-
-
Alqahtani, S.1
Afdhal, N.H.2
Zeuzem, S.3
-
31
-
-
84922479159
-
An integrated safety and efficacy analysis of >500 patients with compensated cirrhosis treated with ledipasvir/sofosbuvir with or without ribavirin [abstract no. 82 plus slide presentation]
-
Bourlière M, Sulkowski MS, Omata M, et al. An integrated safety and efficacy analysis of >500 patients with compensated cirrhosis treated with ledipasvir/sofosbuvir with or without ribavirin [abstract no. 82 plus slide presentation]. Hepatology. 2014;60(4 Suppl):239A.
-
(2014)
Hepatology.
, vol.60
, Issue.4
, pp. 239A
-
-
Bourlière, M.1
Sulkowski, M.S.2
Omata, M.3
-
32
-
-
84898470261
-
-
Association For The Study Of Liver Diseases And Infectious Diseases Society Of America A. (December 19)
-
American Association for the Study of Liver Diseases and Infectious Diseases Society of America. Recommendations for testing, managing, and treating hepatitis C (December 19). 2014. http://www.hcvguidelines.org/full-report-view. Accessed 2 Mar 2015.
-
(2014)
Recommendations for Testing, Managing, and Treating Hepatitis C
-
-
-
33
-
-
84937765922
-
Pill burden and treatment length reduce adherence to IFN-free hepatitis C therapy in an urban cohort
-
[abstract no. 667] (e-1):331-2
-
Petersen T, Gordon LA, Townsend K, et al. Pill burden and treatment length reduce adherence to IFN-free hepatitis C therapy in an urban cohort [abstract no. 667]. Top Antivir Med. 2014;22(e-1):331-2.
-
(2014)
Top Antivir Med
, vol.22
-
-
Petersen, T.1
Gordon, L.A.2
Townsend, K.3
-
34
-
-
84925607745
-
Virological response after 6 week triple-drug regimens for hepatitis C: A proof-of-concept phase 2A cohort study
-
doi: 10.1016/S0140-6736(14)61228-9
-
Kohli A, Osinusi A, Sims Z, et al. Virological response after 6 week triple-drug regimens for hepatitis C: a proof-of-concept phase 2A cohort study. Lancet. 2015. doi: 10.1016/S0140-6736(14)61228-9.
-
(2015)
Lancet
-
-
Kohli, A.1
Osinusi, A.2
Sims, Z.3
-
35
-
-
84973259574
-
High rates of SVR in patients with genotype 1 HCV infection and cirrhosis after treatment with ledipasvir/sofosbuvir + ribavirin or ledipasvir/sofosbuvir + GS-9669 for 8 weeks [abstract no. 1948]
-
Lawitz E, Poordad F, Hyland RH, et al. High rates of SVR in patients with genotype 1 HCV infection and cirrhosis after treatment with ledipasvir/sofosbuvir + ribavirin or ledipasvir/sofosbuvir + GS-9669 for 8 weeks [abstract no. 1948]. Hepatology. 2014;60(4 Suppl):1143A.
-
(2014)
Hepatology.
, vol.60
, Issue.4
, pp. 1143A
-
-
Lawitz, E.1
Poordad, F.2
Hyland, R.H.3
-
36
-
-
84919342996
-
Re-treatment of chronic hepatitis C virus genotype 1 infection after relapse: An open-label pilot study
-
25364884
-
Osinusi A, Kohli A, Marti MM, et al. Re-treatment of chronic hepatitis C virus genotype 1 infection after relapse: an open-label pilot study. Ann Intern Med. 2014;161(9):634-8.
-
(2014)
Ann Intern Med.
, vol.161
, Issue.9
, pp. 634-638
-
-
Osinusi, A.1
Kohli, A.2
Marti, M.M.3
-
37
-
-
84923852032
-
Retreatment of patients who failed prior sofosbuvir-based regimens with all oral fixed-dose combination ledipasvir/sofosbuvir plus ribavirin for 12 weeks
-
[abstract no. 235 plus slide presentation] (4 Suppl):317A-8A
-
Wyles DL, Pockros PJ, Yang JC, et al. Retreatment of patients who failed prior sofosbuvir-based regimens with all oral fixed-dose combination ledipasvir/sofosbuvir plus ribavirin for 12 weeks [abstract no. 235 plus slide presentation]. Hepatology. 2014;60(4 Suppl):317A-8A.
-
(2014)
Hepatology
, vol.60
-
-
Wyles, D.L.1
Pockros, P.J.2
Yang, J.C.3
-
38
-
-
84883089005
-
Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: A randomized clinical trial
-
4254410 1:CAS:528:DC%2BC2cXisVShsLg%3D 23982366
-
Osinusi A, Meissner EG, Lee YJ, et al. Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial. JAMA. 2013;310(8):804-11.
-
(2013)
JAMA.
, vol.310
, Issue.8
, pp. 804-811
-
-
Osinusi, A.1
Meissner, E.G.2
Lee, Y.J.3
-
39
-
-
84898634396
-
Therapy for hepatitis C: The costs of success
-
1:CAS:528:DC%2BC2cXmvFShtbo%3D 24725236
-
Hoofnagle JH, Sherker AH. Therapy for hepatitis C: the costs of success. N Engl J Med. 2014;370(16):1552-3.
-
(2014)
N Engl J Med.
, vol.370
, Issue.16
, pp. 1552-1553
-
-
Hoofnagle, J.H.1
Sherker, A.H.2
-
40
-
-
84922770382
-
Cost-effectiveness of all-oral ledipasvir/sofosbuvir regimens in patients with chronic hepatitis C virus genotype 1 infection
-
1:STN:280:DC%2BC2MvpsVGitQ%3D%3D 25619871
-
Younossi ZM, Park H, Saab S, et al. Cost-effectiveness of all-oral ledipasvir/sofosbuvir regimens in patients with chronic hepatitis C virus genotype 1 infection. Aliment Pharmacol Ther. 2015;41(6):544-63.
-
(2015)
Aliment Pharmacol Ther.
, vol.41
, Issue.6
, pp. 544-563
-
-
Younossi, Z.M.1
Park, H.2
Saab, S.3
|