Enhancing the Predictive Power of Mutations in the C-Terminus of the KCNQ1-Encoded Kv7.1 Voltage-Gated Potassium Channel

Journal of Cardiovascular Translational Research

Volumn 8, Issue 3, 2015, Pages 187-197

  Kapplinger, Jamie D ^a,b,c   Tseng, Andrew S ^a   Salisbury, Benjamin A ^d   Tester, David J ^b,c   Callis, Thomas E ^e   Alders, Marielle ^f   Wilde, Arthur A M ^f,g   Ackerman, Michael J ^a,b,c  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MAYO CLINIC   (United States)

^d Knome Inc   (United States)

^e TRANSGENOMIC INC   (United States)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

^g Princess Al Jawhara Al Brahim Centre of Excellence in Research of Hereditary Disorders   (Saudi Arabia)

Author keywords

Conservation analysis; Estimated predictive value; KCNQ1 (Kv7.1); Long QT syndrome

Indexed keywords

KCNQ1 PROTEIN, HUMAN; POTASSIUM CHANNEL KCNQ1;

AMINO ACID SEQUENCE; CASE CONTROL STUDY; COMPUTER SIMULATION; CONSERVED SEQUENCE; DNA MUTATIONAL ANALYSIS; GENETIC ASSOCIATION STUDY; GENETIC DATABASE; GENETIC PREDISPOSITION; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PATHOPHYSIOLOGY; PHENOTYPE; PREDICTIVE VALUE; PROTEIN CONFORMATION; RISK FACTOR; ROMANO-WARD SYNDROME; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CASE-CONTROL STUDIES; COMPUTER SIMULATION; CONSERVED SEQUENCE; DATABASES, GENETIC; DNA MUTATIONAL ANALYSIS; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KCNQ1 POTASSIUM CHANNEL; MUTATION, MISSENSE; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROTEIN CONFORMATION; RISK FACTORS; ROMANO-WARD SYNDROME; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937759497     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-015-9622-8     Document Type: Article

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