Phosphohistone-H3 (PHH3) is prognostic relevant in Merkel cell carcinomas but Merkel cell polyomavirus is a more powerful prognostic factor than AJCC clinical stage, PHH3, Ki-67 or mitotic indices

Pathology International

Volumn 65, Issue 8, 2015, Pages 404-409

  Iwasaki, Takeshi ^a   Matsushita, Michiko ^a   Nonaka, Daisuke ^b   Kato, Masako ^a   Nagata, Keiko ^a   Murakami, Ichiro ^a   Hayashi, Kazuhiko ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Ki 67; Merkel cell carcinoma; Merkel cell polyomavirus; Mitotic index; PHH3; Phosphohistone H3

Indexed keywords

EOSIN; HEMATOXYLIN; HISTONE H3; KI 67 ANTIGEN; PHOSPHOHISTONE H3; UNCLASSIFIED DRUG; HISTONE; TUMOR MARKER;

AMERICAN JOINT COMMITTEE OF CANCER STAGE; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CELL COUNT; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOREACTIVITY; LABELING INDEX; MALE; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; MITOSIS INDEX; PRIORITY JOURNAL; METABOLISM; MIDDLE AGED; MITOSIS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; POLYOMAVIRUS INFECTION; PROGNOSIS; SKIN TUMOR; VIRUS INFECTION;

BIOMARKERS, TUMOR; CARCINOMA, MERKEL CELL; FEMALE; HISTONES; HUMANS; KI-67 ANTIGEN; MALE; MERKEL CELL POLYOMAVIRUS; MIDDLE AGED; MITOSIS; NEOPLASM STAGING; PHOSPHORYLATION; POLYOMAVIRUS INFECTIONS; PROGNOSIS; SKIN NEOPLASMS; TUMOR VIRUS INFECTIONS;

EID: 84937725436     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12305     Document Type: Article

References (11)

1. Kuwamoto S. Recent advances in the biology of Merkel cell carcinoma. Hum Pathol 2011; 42: 1063-1077.
2. Fleming KE, Ly TY, Pasternak S, Godlewski M, Doucette S, Walsh NM. Support for p63 expression as an adverse prognostic marker in Merkel cell carcinoma: Report on a Canadian cohort. Hum Pathol 2014; 45: 952-960.
3. Brunner A, Riss P, Heinze G. Brustmann H pHH3 and survivin are co-expressed in high-risk endometrial cancer and are prognostic relevant. Br J Cancer 2012; 107: 84-90.
4. Higaki-Mori H, Kuwamoto S, Iwasaki T etal. Association of Merkel cell polyomavirus infection with clinicopathological differences in Merkel cell carcinoma. Hum Pathol 2012; 43: 2282-2291.
5. Iwasaki T, Matsushita M, Kuwamoto S etal. Usefulness of significant morphologic characteristics in distinguishing between Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative Merkel cell carcinomas. Hum Pathol 2013; 44: 1912-1917.
6. Matsushita M, Iwasaki T, Kuwamoto S etal. Merkel cell polyomavirus (MCPyV) strains in Japanese merkel cell carcinomas (MCC) are distinct from Caucasian type MCPyVs: genetic variability and phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCs. Virus Genes 2014; 48: 233-242.
7. Kuwamoto S, Higaki H, Kanai K etal. Association of Merkel cell polyomavirus infection with morphologic differences in Merkel cell carcinoma. Hum Pathol 2011; 42: 632-640.
8. Fukushima S, Terasaki M, Sakata K etal. Sensitivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases. Brain Tumor Pathol 2009; 26: 51-57.
9. Hendzel MJ, Nishioka WK, Raymond Y, Allis CD, Bazett-Jones DP, Th'ng JP. Chromatin condensation is not associated with apoptosis. J Biol Chem 1998; 273: 24470-24478.
10. Nowak M, Svensson MA, Carlsson J etal. Prognostic significance of phospho-histone H3 in prostate carcinoma. World J Urol 2014; 32: 703-707.
11. Vujic I, Marker M, Posch C etal. Merkel cell carcinoma: Mitoses, expression of Ki-67 and bcl-2 correlate with disease progression. J Eur Acad Dermatol Venereol 2015; 29: 542-548.