Myo-inositol Supplementation for Prevention of Gestational Diabetes in Obese Pregnant Women: A Randomized Controlled Trial

Obstetrics and Gynecology

Volumn 126, Issue 2, 2015, Pages 310-315

  D'Anna, Rosario ^a,b,c   Di Benedetto, Antonino ^a,b,c   Scilipoti, Angela ^a,b,c   Santamaria, Angelo ^a,b,c   Interdonato, Maria Lieta ^a,b,c   Petrella, Elisabetta ^a,b,c   Neri, Isabella ^a,b,c   Pintaudi, Basilio ^a,b,c   Corrado, Francesco ^a,b,c   Facchinetti, Fabio ^a,b,c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c OSPEDALE NIGUARDA CA GRANDA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; INOSITOL; PLACEBO; GLUCOSE BLOOD LEVEL; VITAMIN B COMPLEX;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UNIVERSITY HOSPITAL; ANALYSIS; BLOOD; COMORBIDITY; DIABETES, GESTATIONAL; DIET SUPPLEMENTATION; DRUG MONITORING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; PREGNANCY; PREGNANCY OUTCOME; PROCEDURES; TREATMENT OUTCOME;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; COMORBIDITY; DIABETES, GESTATIONAL; DIETARY SUPPLEMENTS; DRUG MONITORING; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INOSITOL; OBESITY; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY TRIMESTERS; TREATMENT OUTCOME; VITAMIN B COMPLEX;

EID: 84937677203     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: 10.1097/AOG.0000000000000958     Document Type: Article

References (19)

1. Gestational diabetes. ACOG Practice Bulletin No. 30 American College of Obstetricians and Gynecologists. Obstet Gynecol 2001;98:525-38.
2. Corrado F, D'Anna R, Di Vieste G, Giordano D, Pintaudi B, Santamaria A, et al. The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes. Diabet Med 2011;28:972-5.
3. D'Anna R, Scilipoti A, Giordano D, Caruso C, Cannata ML, Interdonato ML, et al. myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes. Diabetes Care 2013;36:854-7.
4. Saltiel AR. Second messengers of insulin action. Diabetes Care 1990;13:244-56.
5. Baillargeon JP, Iuorno MJ, Apridonidze T, Nestler JE. Uncoupling between insulin and release of a D-chiro-inositol-containing inositol phosphoglycan mediator of insulin action in obese women with polycystic ovary syndrome. Metab Syndr Relat Disord 2010;8:127-36.
6. Hauser G, Finelli VN. The biosynthesis of free and phosphatide myo-inositol from glucose by mammalian slices. J Biol Chem 1963;238:3224-8.
7. Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio Heart study. Diabetes Care 1997;20:1087-92.
8. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.
9. International Association of Diabetes and Pregnancy Study Groups Consensus Panel; Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010;33:676-82.
10. American Diabetes Association. Standards of medical care in diabetes-2011. Diabetes Care 2011;34(suppl 1):s11-s61.
11. Recommended levels intake of energy and nutrients for the Italian population, LARN (Livelli di Assunzione Raccomandati di Energia e di Nutrienti per la Popolazione Italiana). EDRA, Medical Publishing & New Media; Milan, Italy, 2012.
12. Istituto Superiore di Sanità, Linee Guida per la gravidanza fisiologica. Available at: http://www.snlg-iss.it/cms/files/LG-Gravidanza.pdf. Retrieved September 2011.
13. Pintaudi B, Di Vieste G, Corrado F, Lucisano G, Pellegrini F, Giunta L, et al. Improvement of selective screening strategy for gestational diabetes through a more accurate definition of high risk groups. Eur J Endocrinol 2014;170:87-93.
14. D'Anna R, Benedetto V, Rizzo P, Raffone E, Interdonato ML, Corrado F, et al. Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol Endocrinol 2012;28:440-2.
15. Giordano D, Corrado F, Santamaria A, Quattrone S, Pintaudi B, Di Benedetto A, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause 2011;18:102-4.
16. Matarrelli B, Vitacolonna E, D'Angelo M, Pavone G, Mattei PA, Liberati M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized, controlled trial. J Matern Fetal Neonatal Med 2013;26: 967-72.
17. Scioscia M, Kunjara S, Gumaa K, McLean P, Rodeck CH, Rademacher TW. Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus. Diabet Med 2007;24: 1300-4.
18. Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 2013;95: 1811-27.
19. Staat BC, Galan HL, Harwood JEF, Lee G, Marconi AM, Paolini CL, et al. Transplacental supply of mannose and inositol in uncomplicated pregnancies using stable isotopes. J Clin Endocrinol Metab 2012;98:2497-502.