Alternative outcomes for the multiple breath washout in children with CF

Journal of Cystic Fibrosis

Volumn 14, Issue 4, 2015, Pages 490-496

  Stanojevic, Sanja ^a,b,c   Jensen, Renee ^a   Sundaralingam, Dasiga ^a   Salazar, Juliana Giraldo ^a   Yammine, Sophie ^d   Singer, Florian ^d,e   Latzin, Philipp ^d,f   Amin, Reshma ^a,c   Subbarao, Padmaja ^a,b,c   Gustafsson, Per ^g   Ratjen, Felix ^a,b,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^e UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^f UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^g CENTRAL HOSPITAL   (Sweden)

Author keywords

Clinical trials; Cystic fibrosis; Multiple breath washout

Indexed keywords

DORNASE ALFA; SODIUM CHLORIDE; SULFUR HEXAFLUORIDE; DEOXYRIBONUCLEASE I; RECOMBINANT PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYSTIC FIBROSIS; DISEASE SEVERITY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LUNG CLEARANCE; LUNG CLEARANCE INDEX; LUNG VOLUME; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MULTIPLE BREATH WASHOUT; RESPIRATORY TRACT EXAMINATION; SENSITIVITY AND SPECIFICITY; BREATH ANALYSIS; COMPLICATION; FEMALE; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; MALE; OUTCOME ASSESSMENT; PROCEDURES; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ADOLESCENT; BREATH TESTS; CHILD; CROSS-SECTIONAL STUDIES; CYSTIC FIBROSIS; DEOXYRIBONUCLEASE I; FEMALE; HUMANS; MALE; OUTCOME ASSESSMENT (HEALTH CARE); RECOMBINANT PROTEINS; RESPIRATORY FUNCTION TESTS; SALINE SOLUTION, HYPERTONIC; SENSITIVITY AND SPECIFICITY;

EID: 84937630466     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2014.12.008     Document Type: Article

References (33)

1. Aurora P., Bush A., Gustafsson P., Oliver C., Wallis C., Price J., et al. Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med 2005, 171:249-256.
2. Aurora P., Stanojevic S., Wade A., Oliver C., Kozlowska W., Lum S., et al. Lung clearance index at 4years predicts subsequent lung function in children with cystic fibrosis. Am J Respir Crit Care Med 2011, 183:752-758.
3. Gustafsson P.M. Inert gas washout in preschool children. Paediatr Respir Rev 2005, 6:239-245.
4. Amin R., Subbarao P., Jabar A., Balkovec S., Jensen R., Kerrigan S., et al. Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function. Thorax 2010, 65:379-383.
5. Amin R., Subbarao P., Lou W., Jabar A., Balkovec S., Jensen R., et al. The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis. Eur Respir J 2011, 37:806-812.
6. Yammine S., Singer F., Abbas C., Roos M., Latzin P. Multiple-breath washout measurements can be significantly shortened in children. Thorax 2013, 68:586-587.
7. Robinson P.D., Latzin P., Verbanck S., Hall G.L., Horsley A., Gappa M., et al. Consensus statement for inert gas washout measurement using multiple- and single- breath tests. Eur Respir J 2013, 41:507-522.
8. Gustafsson P.M., Aurora P., Lindblad A. Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis. Eur Respir J 2003, 22:972-979.
9. Larsson A., Jonmarker C., Werner O. Ventilation inhomogeneity during controlled ventilation. Which index should be used?. J Appl Physiol 1988, 65:2030-2039.
10. Yammine S., Singer F., Gustafsson P., Latzin P. Impact of different breathing protocols on multiple-breath washout outcomes in children. J Cyst Fibros 2014, 13:190-197.
11. Habib R.H., Lutchen K.R. Moment analysis of a multibreath nitrogen washout based on an alveolar gas dilution number. Am Rev Respir Dis 1991, 144:513-519.
12. Edelman N.H., Mittman C., Norris A.H., Shock N.W. Effects of respiratory pattern on age differences in ventilation uniformity. J Appl Physiol 1968, 24:49-53.
13. Robinson P.D., Stocks J., Aurora P., Lum S. Abbreviated multi-breath washout for calculation of lung clearance index. Pediatr Pulmonol 2013, 48:336-343.
14. Kraemer R., Zehnder M., Meister B. Intrapulmonary gas distribution in healthy children. Respir Physiol 1986, 65:127-137.
15. Fleming G.M., Chester E.H., Saniie J., Saidel G.M. Ventilation inhomogeneity using multibreath nitrogen washout: comparison of moment ratios and other indexes. Am Rev Respir Dis 1980, 121:789-794.
16. Hutchison A.A., Sum A.C., Demis T.A., Erben A., Landau L.I. Moment analysis of multiple breath nitrogen washout in children. Am Rev Respir Dis 1982, 125:28-32.
17. Kraemer R., Meister B. Fast real-time moment-ratio analysis of multibreath nitrogen washout in children. J Appl Physiol 1985, 59:1137-1144.
18. Saidel G.M., Salmon R.B., Chester E.H. Moment analysis of multibreath lung washout. J Appl Physiol 1975, 38:328-334.
19. Saidel G.M., Saniie J., Chester E.H. Modeling and moments of multibreath lung washout. Ann Biomed Eng 1978, 6:126-137.
20. Hall G.L., Logie K.M., Parsons F., Schulzke S.M., Nolan G., Murray C., et al. Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening. PLoS ONE 2011, 6:e23932.
21. Hannon D., Bradley J.M., Bradbury I., Bell N., Elborn J.S., O'Neil K. Shortened Lung Clearance Index is a repeatable and sensitive test in children and adults with cystic fibrosis. BMJ Open Respir Res 2014, 1:e000031-e000037.
22. Jensen R., Stanojevic S., Gibney K., Salazar J.G., Gustafsson P., Subbarao P., et al. Multiple breath nitrogen washout: a feasible alternative to mass spectrometry. PLoS ONE 2013, 8:e56868.
23. Robinson P.D., Goldman M.D., Gustafsson P.M. Inert gas washout: theoretical background and clinical utility in respiratory disease. Respiration 2009, 78:339-355.
24. Jones B., Kenward M.G. Design and analysis of cross-over trials 2003, Chapman and Hall/CRC. 2nd ed.
25. Kenward M.G., Roger J.H. The use of baseline covariates in crossover studies. Biostatistics 2010, 11:1-17.
26. Stick S., Tiddens H., Aurora P., Gustafsson P., Ranganathan S., Robinson P., et al. Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?. Eur Respir J 2013, 42:527-538.
27. Schibler A., Schneider M., Frey U., Kraemer R. Moment ratio analysis of multiple breath nitrogen washout in infants with lung disease. Eur Respir J 2000, 15:1094-1101.
28. Shao H., Sandberg K., Sjoqvist B.A., Hjalmarson O. Moment analysis of multibreath nitrogen washout in healthy preterm infants. Pediatr Pulmonol 1998, 25:52-58.
29. Wall M.A. Moment analysis of multibreath nitrogen washout in young children. J Appl Physiol 1985, 59:274-279.
30. Kraemer R., Schoni M.H. Ventilatory inequalities, pulmonary function and blood oxygenation in advanced states of cystic fibrosis. Respiration 1990, 57:318-324.
31. Vanderhelst E., De Meirleir L., Schuermans D., Malfroot A., Vincken W., Verbanck S. Evidence of an acinar response following treatment for exacerbation in adult patients with cystic fibrosis. Respiration 2014, 87:492-498.
32. Singer F., Stanojevic S., Yammine S., Subbarao P., Jensen R., Amin R., et al. Effects of dornase alfa and hypertonic saline on gas mixing in lung periphery in children with cystic fibrosis. Eur Respir J 2014, 1976.
33. Gustafsson P.M., Robinson P.D., Gilljam M., Lindblad A., Houltz B.K. Slow and fast lung compartments in cystic fibrosis measured by nitrogen multiple-breath washout. J Appl Physiol 2014, 117:720-729.