Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 171, Issue 4, 2016, Pages 495-505

  Lehrer, Douglas S ^a,b   Pato, Michele T ^c,d   Nahhas, Ramzi W ^a   Miller, Brian R ^e   Malaspina, Dolores ^f   Buckley, Peter F ^e   Sobell, Janet L ^d   Walsh Messinger, Julie ^g   Pato, Carlos N ^c,d   Abbott, ^d   Azevedo, Maria Helena ^h   Bromet, Evelyn J ⁱ   Escamilla, Michael A ^j   Fanous, Ayman H ^k   Fochtmann, Laura J ⁱ   Kinkead, Becky ^l   Knowles, James A ^d   Macciardi, Fabio ^m   Macedo, Antonio ^h   Marder, Stephen R ⁿ   McCarroll, Steven A ^o,p   Medeiros, Helena ^d   Morley, Christopher P ^q   Nicolini, Humberto ^r   Jeffrey J Rakofsky, ^l   Rapaport, Mark H ^l   Perkins, Diana O ^s   Sklar, Pamela ^g   Smoller, Jordan W ^o   Vawter, Marquis ^m   Cohort Consortium, Genomic Psychiatry ^a   more..

^a WRIGHT STATE UNIVERSITY   (United States)

^b Ohio Department of Mental Health   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

^f NEW YORK UNIVERSITY   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF COIMBRA   (Portugal)

ⁱ STONY BROOK UNIVERSITY   (United States)

^j Paul L Foster School of Medicine   (United States)

^k VETERANS AFFAIRS MEDICAL CENTER   (United States)

^l EMORY UNIVERSITY   (United States)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ UNIVERSITY OF CALIFORNIA   (United States)

^o HARVARD MEDICAL SCHOOL   (United States)

^p BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^q STATE UNIVERSITY OF NEW YORK   (United States)

^r Grupo Medico Carracci   (Mexico)

^s UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Bipolar; Paternal age; Phenotype; Psychosis; Schizophrenia

Indexed keywords

ADULT; ARTICLE; BIPOLAR DISORDER; BLACK PERSON; CONTROLLED STUDY; DEPRESSION; FAMILY HISTORY; FEMALE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PATERNAL AGE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SEX DIFFERENCE; AGE; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; PATERNAL INHERITANCE; PSYCHOLOGY; PSYCHOSIS; YOUNG ADULT;

ADULT; AGE FACTORS; BIPOLAR DISORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; PATERNAL AGE; PATERNAL INHERITANCE; PSYCHOTIC DISORDERS; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; YOUNG ADULT;

EID: 84937611063     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32334     Document Type: Article

References (50)

1. American Psychiatric Association 2000. Diagnostic and statistical manual of mental disorders DSM-IV-TR Fourth Edition. Washington, DC: American Psychiatric Association.
2. Arnedo J, Svrakic D, Del Val C, Romero-Zaliz R, Hernandez-Cuervo H, Fanous A, et al. 2014. Uncovering the hidden risk architecture of the schizophrenias: Confirmation in three independent genome-wide association studies. Am J Psychiatry 172(2):139-153.
3. Bertranpetit J, Fañanás L. 1993. Parental age in schizophrenia in a case-controlled study. Br J Psychiatry 162:574.
4. Brown A, Bao Y, McKeague I, Shen L, Schaefer C. 2013. Parental age and risk of bipolar disorder in offspring. Psychiatry Res 208(3):225-231.
5. Brown A, Schaefer C, Wyatt R, Begg M, Goetz R, Bresnahan M, et al. 2002. Paternal age and risk of schizophrenia in adult offspring. Am J Psychiatry 159(9):1528-1533.
6. Buizer-Voskamp J, Laan W, Staal W, Hennekam E, Aukes M, Termorshuizen F, et al. 2011. Paternal age and psychiatric disorders: Findings from a Dutch population registry. Schizophr Res 129(2-3):128-132.
7. Byrne M, Agerbo E, Ewald H, Eaton W, Mortensen PB. 2003. Parental age and risk of schizophrenia: A case-control study. Arch Gen Psychiatry 60(7):673-678.
8. Chudal R, Gissler M, Sucksdorff D, Lehti V, Suominen A, Hinkka-Yli-Salomäki S, et al. 2014. Parental age and the risk of bipolar disorders. Bipolar Disord 16(6):624-632.
9. Cuthbert B, Insel T. 2013. Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Med 11:126.
10. D'Onofrio B, Rickert M, Frans E, Kuja-Halkola R, Almqvist C, Sjölander A, et al. 2014. Paternal age at childbearing and offspring psychiatric and academic morbidity. JAMA Psychiatry 71(4):432-438.
11. Ek M, Wicks S, Svensson A, Idring S, Dalman C. 2014. Advancing paternal age and schizophrenia: The impact of delayed fatherhood. Schizophr Bull Nov 4. pii: sbu154. [Epub ahead of print].
12. Fanous A, van den Oord E, Riley B, Aggen S, Neale M, O'Neill F, et al. 2005. Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. Am J Psychiatry 162(10):1824-1832.
13. Ford J, Morris S, Hoffman R, Sommer I, Waters F, McCarthy-Jones S, et al. 2014. Studying hallucinations within the NIMH RDoC framework. Schizophr Bull 40(Suppl 4):S295-S304.
14. Frans E, Sandin S, Reichenberg A, Lichtenstein P, Långström N, Hultman C. 2008. Advancing paternal age and bipolar disorder. Arch Gen Psychiatry 65(9):1034-1040.
15. Frans E, McGrath J, Sandin S, Lichtenstein P, Reichenberg A, Långström N, Hultman C. 2011. Advanced paternal and grandpaternal age and schizophrenia: A three-generation perspective. Schizophr Res 133(1-3):120-124.
16. Garver D, Holcomb J, Christensen J. 2000. Heterogeneity of response to antipsychotics from multiple disorders in the schizophrenia spectrum. J Clin Psychiatry 61(12):964-972.
17. Goriely A, McGrath J, Hultman C, Wilkie A, Malaspina D. 2013. " Selfish spermatogonial selection": A novel mechanism for the association between advanced paternal age and neurodevelopmental disorders. Am J Psychiatry 170(6):599-608.
18. Granville-Grossman K. 1966. Parental age and schizophrenia. Br J Psychiatry 112(490):899-905.
19. Hare E, Moran P. 1979. Raised parental age in psychiatric patients: Evidence for the constitutional hypothesis. Br J Psychiatry 134:169-177.
20. Holm S. 1979. A simple sequentially rejective multiple test procedure. Scand J Stat 6(2):65-70.
21. Hubert A, Szöke A, Leboyer M, Schürhoff F. 2011. Influence of paternal age in schizophrenia. Encephale 37(3):199-206.
22. Johanson E. 1958. A study of schizophrenia in the male: A psychiatric and social study based on 138 cases with follow up. Acta Psychiatrica Neurol Scand 125:1-132.
23. Kong A, Frigge M, Masson G, Besenbacher S, Sulem P, Magnusson G, et al. 2012. Rate of de novo mutations and the importance of father's age to disease risk. Nature 488(7412):471-475.
24. Laursen T, Munk-Olsen T, Nordentoft M, Bo-Mortensen P. 2007. A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a danish population-based cohort. J Clin Psychiatry 68(11):1673-1681.
25. Lee H, Malaspina D, Ahn H, Perrin M, Opler M, Kleinhaus K, et al. 2011. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis. Schizophr Res 128(1-3):143-149.
26. Lehrer D, Christian B, Kirbas C, Chiang M, Sidhu S, Short H, et al. 2010. 18F-fallypride binding potential in patients with schizophrenia compared to healthy controls. Schizophr Res 122(1-3):43-52.
27. Malaspina D, Corcoran C, Fahim C, Berman A, Harkavy-Friedman J, Yale S, et al. 2002. Paternal age and sporadic schizophrenia: Evidence for de novo mutations. Am J Med Genet 114(3):299-303.
28. Malaspina D, Dracxler R, Walsh-Messinger J, Harlap S, Goetz R, Keefe D, Perrin M. 2014. Telomere length, family history, and paternal age in schizophrenia. Mol Genet Genom Med 2(4):326-331.
29. Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser E. 2001. Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry 58(4):361-367.
30. Matheson S, Shepherd A, Laurens K, Carr V. 2011. A systematic meta-analysis grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia. Schizophr Res 133:133-142.
31. McGuffin P, Farmer A, Harvey I. 1991. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 48(8):764-770.
32. Miller B, Messias E, Miettunen J, Alaräisänen A, Järvelin M, Koponen H, et al. 2011a. Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr Bull 37(5):1039-1047.
33. Miller B, Suvisaari J, Miettunen J, Järvelin M, Haukka J, Tanskanen A, et al. 2011b. Advanced paternal age and parental history of schizophrenia. Schizophr Res 133(1-3):125-132.
34. Nurnberger J, Blehar M, Kaufmann C, York-Cooler C, Simpson S, Harkavy-Friedman J, et al. 1994. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51(11):849-859.
35. Opler M, Malaspina D, Gopal S, Nuamah I, Savitz A, Singh J, Hough D. 2013. Effect of paternal age on treatment response in adolescents with schizophrenia. Schizophr Res 151(1-3):185-190.
36. Pato M, Sobell J, Medeiros H, Abbott C, Sklar B, et al. 2013. The genomic psychiatry cohort: Partners in discovery. Am J Med Genet B 162B(4):306-312.
37. Petersen L, Mortensen P, Pedersen C. 2011. Paternal age at birth of first child and risk of schizophrenia. Am J Psychiatry 168(1):82-88.
38. Rosenfield P, Kleinhaus K, Opler M, Perrin M, Learned N, Goetz R, et al. 2010. Later paternal age and sex differences in schizophrenia symptoms. Schizophr Res 116(2-3):191-195.
39. SAS Institute, Inc. 2010. SAS Version 9.3. Cary, N.C.: SAS Institute Inc.
40. Schulze T, Ohlraun S, Czerski P, et al. 2005. Genotype-phenotype studies in bipolar disorder showing association between theDAOA/G30 locus and persecutory delusions: A first step toward a molecular genetic classification of psychiatric phenotypes. Am J Psychiatry 162(11):2101-2108.
41. Seeman P. 2011. All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors. CNS Neurosc Ther 17(2):118-132.
42. Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon D, Gunnell D. 2004. Paternal age and schizophrenia: A population based cohort study. BMJ 329:1070.
43. Swerdlow N, Light G, Sprock J, Calkins M, Green M, Greenwood T, et al. 2014. Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS. Schizophr Res 152(2-3):503-512.
44. Talvik M, Nordström A, Olsson H, Halldin C, Farde L. 2003. Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: A PET study with [11C]FLB 457. Int J Neuropsychopharmacol 6(4):361-370.
45. Torrey E, Buka S, Cannon T, Goldstein J, Seidman L, Liu T, et al. 2009. Paternal age as a risk factor for schizophrenia: How important is it?. Schizophr Res 114(1-3):1-5.
46. Tsuang D, Esterberg M, Braff D, Calkins M, Cadenhead K, et al. 2014. Is there an association between advanced paternal age and endophenotype deficit levels in schizophrenia? PLoS ONE 9(2):e88379.
47. Weiser M, Reichenberg A, Werbeloff N, Kleinhaus K, Lubin G, Shmushkevitch M, et al. 2008. Advanced parental age at birth is associated with poorer social functioning in adolescent males: Shedding light on a core symptom of schizophrenia and autism. Schizophr Bull 34(6):1042-1046.
48. Williams J, Farmer A, Ackenheil M, Kaufmann C, McGuffin P. 1996. A multicentre inter-rater reliability study using the OPCRIT computerized diagnostic system. Psychol Med 26(4):775-783.
49. Wohl M, Gorwood P. 2007. Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring. Eur Psychiatry 22(1):22-26.
50. Zammit S, Allebeck P, Dalman C, Lundberg I, Hemmingson T, Owen M, Lewis G. 2003. Paternal age and risk for schizophrenia. Br J Psychiatry 183:405-408.