New t-butyl based aspartate protecting groups preventing aspartimide formation in Fmoc SPPS

Journal of Peptide Science

Volumn 21, Issue 8, 2015, Pages 680-687

  Behrendt, Raymond ^a   Huber, Simon ^a   Martí, Roger ^b   White, Peter ^c  

^a Merck and Cie Merck Millipore Novabiochem Products ^*  (Switzerland)

^b School of Engineering and Architecture   (Switzerland)

^c Merck Chemicals Ltd   (United Kingdom)

Author keywords

aspartic acid trialkylmethyl ester; aspartimide formation; Fmoc SPPS; protecting groups; racemisation

Indexed keywords

ALANINE; ALCOHOL; ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; FUNCTIONAL GROUP; GLYCINE; ISOLEUCINE; LYSINE; PIPERIDINE; SCORPION VENOM; SERINE; TERT BUTYL GROUP; THREONINE; TYROSINE; UNCLASSIFIED DRUG; VALINE; 9-FLUORENYLMETHOXYCARBONYL; ASPARTIMIDE; FLUORENE DERIVATIVE; PEPTIDE;

ARTICLE; ASPARTIMIDE FORMATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DEPROTECTION REACTION; MICROWAVE COOKING; OPTICS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; ROOM TEMPERATURE; SOLID PHASE SYNTHESIS; STEREOSPECIFICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS;

SCORPIONES;

ASPARTIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORENES; MOLECULAR STRUCTURE; PEPTIDES; SOLID-PHASE SYNTHESIS TECHNIQUES;

EID: 84937524668     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2790     Document Type: Article

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