Epidemiological and statistical considerations for interpreting and communicating oncology clinical trials

Veterinary Journal

Volumn 205, Issue 2, 2015, Pages 233-237

  Heller, Jane ^a  

^a CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Epidemiology; Oncology; Randomised controlled trial; Risk; Statistics; Veterinary

Indexed keywords

CANCER PROGNOSIS; CANCER RECURRENCE; CANCER RESEARCH; CENSORSHIP; DATA PROCESSING; DISEASE FREE SURVIVAL; EPIDEMIOLOGICAL DATA; MORTALITY; NONHUMAN; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRACTICE GUIDELINE; PROGRESSION FREE SURVIVAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; SAMPLE SIZE; STATISTICAL ANALYSIS; STUDY DESIGN; VETERINARY MEDICINE; ANIMAL; BIOMETRY; METHODOLOGY; NEOPLASMS; PROCEDURES; STATISTICS AND NUMERICAL DATA; VETERINARY;

ANTINEOPLASTIC AGENT;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOMETRY; NEOPLASMS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN;

EID: 84937521185     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2015.02.014     Document Type: Review

References (26)

1. Akl E.A., Oxman A.D., Herrin J., Vist G.E., Terrenato I., Sperati F., Costiniuk C., Blank D., Schunemann H. Using alternative statistical formats for presenting risks and risk reductions. Cochrane Database of Systematic Reviews 2011, (3). CD006776.
2. Alderson P. Absence of evidence is not evidence of absence. British Medical Journal 2004, 328:476-477.
3. Altman D.G., Bland J.M. Absence of evidence is not evidence of absence. British Medical Journal 1995, 311:485.
4. Begg C., Cho M., Eastwood S., Horton R., Moher D., Olkin I., Pitkin R., Rennie D., Schulz K.F., Simel D., et al. Improving the quality of reporting of randomized controlled trials. The Consort statement. Journal of the American Medical Association 1996, 276:637-639.
5. Bodemer N., Meder B., Gigerenzer G. Communicating relative risk changes with baseline risk: Presentation format and numeracy matter. Medical Decision Making 2014, 34:615-626.
6. Bogardus S.T., Holmboe E., Jekel J.F. Perils, pitfalls, and possibilities in talking about medical risk. Journal of the American Medical Association 1999, 281:1037-1041.
7. Buchter R.B., Fechtelpeter D., Knelangen M., Ehrlich M., Waltering A. Words or numbers? Communicating risk of adverse effects in written consumer health information: A systematic review and meta-analysis. BMC Medical Informatics and Decision Making 2014, 14:76.
8. Bunge M., Muhlhauser I., Steckelberg A. What constitutes evidence-based patient information? Overview of discussed criteria. Patient Education and Counseling 2010, 78:316-328.
9. Caverly T.J., Prochazka A.V., Binswanger I.A., Kutner J.S., Matlock D.D. Confusing relative risk with absolute risk is associated with more enthusiastic beliefs about the value of cancer screening. Medical Decision Making 2014, 34:686-692.
10. Clark T.G., Bradburn M.J., Love S.B., Altman D.G. Survival analysis part I: Basic concepts and first analyses. British Journal of Cancer 2003, 89:232-238.
11. Coulter A. Evidence based patient information is important, so there needs to be a national strategy to ensure it. British Medical Journal 1998, 317:225-226.
12. Day S.J., Altman D.G. Statistics notes: Blinding in clinical trials and other studies. British Medical Journal 2000, 321:504.
13. Delgado-Rodriguez M., Llorca J. Bias. Journal of Epidemiology and Community Health 2004, 58:635-641.
14. Dohoo I.R., Martin W., Stryhn H. Veterinary Epidemiologic Research 2009, VER Inc, Prince Edward Island, Canada. Second Ed.
15. Fagerlin A., Zikmund-Fisher B.J., Ubel P.A. Helping patients decide: Ten steps to better risk communication. Journal of the National Cancer Institute 2011, 103:1436-1443.
16. Kristiansen V.M., Nodtvedt A., Breen A.M., Langeland M., Teige J., Goldschmidt M., Jonasdottir T.J., Grotmol T., Sorenmo K. Effect of ovariohysterectomy at the time of tumor removal in dogs with benign mammary tumors and hyperplastic lesions: A randomized controlled clinical trial. Journal of Veterinary Internal Medicine 2013, 27:935-942.
17. La Rochelle P. Basic learning concepts in Ebm: The bidimensional hierarchy of evidence. Evidence-based Medicine 2014, 19:83-84.
18. Marewski J.N., Gigerenzer G. Heuristic decision making in medicine. Dialogues in Clinical Neuroscience 2012, 14:77-89.
19. Moher D., Jones A., Lepage L., Group C. Use of the Consort statement and quality of reports of randomized trials: A comparative before-and-after evaluation. Journal of the American Medical Association 2001, 285:1992-1995.
20. Moher D., Hopewell S., Schulz K.F., Montori V., Gotzsche P.C., Devereaux P.J., Elbourne D., Egger M., Altman D.G. Consort 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. British Medical Journal 2010, 340:c869.
21. Petrie A., Watson P. Statistics for Veterinary and Animal Science 2006, Wiley-Blackwell, West Sussex, UK. Second Ed.
22. Pilz L.R., Manegold C., Schmid-Bindert G. Statistical considerations and endpoints for clinical lung cancer studies: Can progression free survival (Pfs) substitute overall survival (Os) as a valid endpoint in clinical trials for advanced non-small-cell lung cancer?. Translational Lung Cancer Research 2012, 1:26-35.
23. Politi M.C., Han P.K., Col N.F. Communicating the uncertainty of harms and benefits of medical interventions. Medical Decision Making 2007, 27:681-695.
24. Sargeant J.M., O'Connor A.M., Gardner I.A., Dickson J.S., Torrence M.E. The REFLECT statement: Reporting guidelines for randomized controlled trials in livestock and food safety: Explanation and elaboration. Zoonoses and Public Health 2010, 57:105-136. Consensus Meeting, P.
25. Schulz K.F., Altman D.G., Moher D., Group C. Consort 2010 statement: Updated guidelines for reporting parallel group randomised trials. British Medical Journal 2010, 340:c332.
26. Wakkee M., Hollestein L.M., Nijsten T. Multivariable analysis. Journal of Investigative Dermatology 2014, 134:e20.