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Volumn 193, Issue 4, 2015, Pages 567-570

Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension

Author keywords

Biomarker; BMP antagonists; BMPR2; Bone morphogenetic protein; Gremlin 1; Pulmonary arterial hypertension

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CYTOKINE RECEPTOR ANTAGONIST; GREMLIN 1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN; BRAIN NATRIURETIC PEPTIDE; GREM1 PROTEIN, HUMAN; PEPTIDE FRAGMENT; PRO-BRAIN NATRIURETIC PEPTIDE (1-76); SIGNAL PEPTIDE;

EID: 84937521023     PISSN: 03412040     EISSN: 14321750     Source Type: Journal    
DOI: 10.1007/s00408-015-9735-5     Document Type: Article
Times cited : (17)

References (15)
  • 1
    • 84870523226 scopus 로고    scopus 로고
    • Molecular pathogenesis of pulmonary arterial hypertension
    • COI: 1:CAS:528:DC%2BC38XhvVakt7jN, PID: 23202738
    • Rabinovitch M (2012) Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 122:4306–4313
    • (2012) J Clin Invest , vol.122 , pp. 4306-4313
    • Rabinovitch, M.1
  • 2
    • 63749109111 scopus 로고    scopus 로고
    • Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
    • COI: 1:CAS:528:DC%2BD1MXltFyhsr4%3D, PID: 19206171
    • Hamid R, Cogan JD, Hedges LK et al (2009) Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele. Hum Mutat 30:649–654
    • (2009) Hum Mutat , vol.30 , pp. 649-654
    • Hamid, R.1    Cogan, J.D.2    Hedges, L.K.3
  • 3
    • 52149085463 scopus 로고    scopus 로고
    • Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension
    • COI: 1:CAS:528:DC%2BD1cXhtVaktrfI, PID: 18469115
    • Costello CM, Howell K, Cahill E et al (2008) Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 295:L272–L284
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , pp. L272-L284
    • Costello, C.M.1    Howell, K.2    Cahill, E.3
  • 4
    • 84857522999 scopus 로고    scopus 로고
    • Gremlin plays a key role in the pathogenesis of pulmonary hypertension
    • COI: 1:CAS:528:DC%2BC38Xls1Cjs7w%3D, PID: 22247494
    • Cahill E, Costello CM, Rowan SC et al (2012) Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation 125:920–930
    • (2012) Circulation , vol.125 , pp. 920-930
    • Cahill, E.1    Costello, C.M.2    Rowan, S.C.3
  • 5
    • 84886693789 scopus 로고    scopus 로고
    • Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice
    • COI: 1:CAS:528:DC%2BC3sXhs1OqsLfK, PID: 24160323
    • Ciuclan L, Sheppard K, Dong L et al (2013) Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice. Am J Pathol 183:1461–1473
    • (2013) Am J Pathol , vol.183 , pp. 1461-1473
    • Ciuclan, L.1    Sheppard, K.2    Dong, L.3
  • 6
    • 84890738424 scopus 로고    scopus 로고
    • Updated clinical classification of pulmonary hypertension
    • PID: 24355639
    • Simonneau G, Gatzoulis MA, Adatia I et al (2013) Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 62:D34–D41
    • (2013) J Am Coll Cardiol , vol.62 , pp. D34-D41
    • Simonneau, G.1    Gatzoulis, M.A.2    Adatia, I.3
  • 7
    • 78149300188 scopus 로고    scopus 로고
    • Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
    • COI: 1:CAS:528:DC%2BC3cXhsVKksbzO, PID: 20660291
    • Mitola S, Ravelli C, Moroni E et al (2010) Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 116:3677–3680
    • (2010) Blood , vol.116 , pp. 3677-3680
    • Mitola, S.1    Ravelli, C.2    Moroni, E.3
  • 8
    • 33847402760 scopus 로고    scopus 로고
    • Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor
    • COI: 1:CAS:528:DC%2BD2sXjtFeqt70%3D, PID: 17077323
    • Stabile H, Mitola S, Moroni E et al (2007) Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood 109:1834–1840
    • (2007) Blood , vol.109 , pp. 1834-1840
    • Stabile, H.1    Mitola, S.2    Moroni, E.3
  • 9
    • 39149099992 scopus 로고    scopus 로고
    • Gremlin promotes vascular smooth muscle cell proliferation and migration
    • COI: 1:CAS:528:DC%2BD1cXitVehsLY%3D, PID: 18086474
    • Maciel TT, Melo RS, Schor N et al (2008) Gremlin promotes vascular smooth muscle cell proliferation and migration. J Mol Cell Cardiol 44:370–379
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 370-379
    • Maciel, T.T.1    Melo, R.S.2    Schor, N.3
  • 10
    • 0028885005 scopus 로고
    • Chronic inhibition of endothelium-derived nitric oxide synthesis uses coronary microvascular structural changes and hyperreactivity to serotonin in pigs
    • COI: 1:CAS:528:DyaK28XktFSnsg%3D%3D, PID: 7586367
    • Ito A, Egashira K, Kadokami T et al (1995) Chronic inhibition of endothelium-derived nitric oxide synthesis uses coronary microvascular structural changes and hyperreactivity to serotonin in pigs. Circulation 92:2636–2644
    • (1995) Circulation , vol.92 , pp. 2636-2644
    • Ito, A.1    Egashira, K.2    Kadokami, T.3
  • 11
    • 80053020850 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation
    • COI: 1:CAS:528:DC%2BC3MXhtFOit77P, PID: 21808054
    • Gangopahyay A, Oran M, Bauer EM et al (2011) Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation. J Biol Chem 286:33134–33140
    • (2011) J Biol Chem , vol.286 , pp. 33134-33140
    • Gangopahyay, A.1    Oran, M.2    Bauer, E.M.3
  • 12
    • 84963662388 scopus 로고    scopus 로고
    • Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension
    • Maruyama H, Dewachter C, Belhaj A et al (2014) Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension. J Heart Lung Transplant S1053-2498:01346-1
    • (2014) J Heart Lung Transplant , vol.S1053-2498
    • Maruyama, H.1    Dewachter, C.2    Belhaj, A.3
  • 13
    • 84885912356 scopus 로고    scopus 로고
    • Gremlin-1 identifies fibrosis and predicts adverse outcome in patients with heart failure undergoing endomyocardial biopsy
    • COI: 1:CAS:528:DC%2BC3sXhs1WjsLjL, PID: 24125106
    • Mueller KA, Tavlaki E, Schneider M et al (2013) Gremlin-1 identifies fibrosis and predicts adverse outcome in patients with heart failure undergoing endomyocardial biopsy. J Card Fail 19:678–684
    • (2013) J Card Fail , vol.19 , pp. 678-684
    • Mueller, K.A.1    Tavlaki, E.2    Schneider, M.3
  • 14
    • 84898070133 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein
    • PID: 24550394
    • O’Reilly S, Ciechomska M, Cant R et al (2014) Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J Biol Chem 289:9952–9960
    • (2014) J Biol Chem , vol.289 , pp. 9952-9960
    • O’Reilly, S.1    Ciechomska, M.2    Cant, R.3
  • 15
    • 84905851461 scopus 로고    scopus 로고
    • Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection
    • PID: 25116393
    • Wellbrock J, Sheikhzadeh S, Oliveira-Ferrer L et al (2014) Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection. PLoS One 9:e104742
    • (2014) PLoS One , vol.9 , pp. e104742
    • Wellbrock, J.1    Sheikhzadeh, S.2    Oliveira-Ferrer, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.