Does platelet-rich plasma deserve a role in the treatment of tendinopathy?

Joint Bone Spine

Volumn 82, Issue 4, 2015, Pages 230-234

  Nourissat, Geoffroy ^a,b   Ornetti, Paul ^c   Berenbaum, Francis ^d   Sellam, Jérémie ^d   Richette, Pascal ^e   Chevalier, Xavier ^f  

^a Radiology Department   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c DIJON UNIVERSITY HOSPITAL   (France)

^d HÔPITAL SAINT ANTOINE   (France)

^e HÔPITAL LARIBOISIÈRE   (France)

^f HENRI MONDOR HOSPITAL   (France)

Author keywords

Platelet rich plasma; Systematic review; Tendinitis; Tendinopathy; Treatment

Indexed keywords

ANESTHETIC AGENT; COLLAGEN; CORTICOSTEROID; ELASTIN; GELATINASE A; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; INTERSTITIAL COLLAGENASE; LUMICAN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 23; METHYLPREDNISOLONE; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; SOMATOMEDIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VERSICAN;

ACHILLES TENDINITIS; ACHILLES TENDON; CLINICAL PROTOCOL; DRUG TREATMENT FAILURE; HUMAN; MEDICAL TERMINOLOGY; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); NONHUMAN; OSTEOARTHRITIS; PATELLA LIGAMENT; PHYSIOTHERAPY; PUBLICATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); ROTATOR CUFF INJURY; ROTATOR CUFF RUPTURE; SHORT SURVEY; SYSTEMATIC REVIEW (TOPIC); TENDINITIS; TENNIS ELBOW; THROMBOCYTE RICH PLASMA; TREATMENT OUTCOME; WOUND HEALING; INJECTION; TENDINOPATHY;

ACHILLES TENDON; HUMANS; INJECTIONS; PLATELET-RICH PLASMA; TENDINOPATHY;

EID: 84937517458     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2015.02.004     Document Type: Short Survey

References (48)

1. Ornetti P, Nourissat G, Berenbaum F, et al. Does platelet-rich plasma have a role in the treatment of osteoarthritis. Joint Bone Spine in press.
2. Sharma P., Maffulli N. Tendon injury and tendinopathy: healing and repair. J Bone Joint Surg Am 2005, 87:187-202.
3. Magnusson S.P., Langberg H., Kjaer M. The pathogenesis of tendinopathy: balancing the response to loading. Nat Rev Rheumatol 2010, 6:262-268.
4. Riley G. Tendinopathy - from basic science to treatment. Nat Clin Pract Rheumatol 2008, 4:82-89.
5. Nourissat G., Houard X., Sellam J., et al. Use of autologous growth factors in aging tendon and chronic tendinopathy. Front Biosci (Elite Ed) 2013, 5:911-921.
6. Molloy T., Wang Y., Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med 2003, 33:381-394.
7. Foster T.E., Puskas B.L., Mandelbaum B.R., et al. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med 2009, 37:2259-2272.
8. Sheth U., Simunovic N., Klein G., et al. Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis. J Bone Joint Surg Am 2012, 94:298-307.
9. Leadbetter W.B. Cell-matrix response in tendon injury. Clin Sports Med 1992, 11:533-578.
10. Paavola M., Kannus P., Järvinen T.A., et al. Achilles tendinopathy. J Bone Joint Surg Am 2002, 84-A:2062-2076.
11. Baksh N., Hannon C.P., Murawski C.D., et al. Platelet-rich plasma in tendon models: a systematic review of basic science literature. Arthroscopy 2013, 29:596-607.
12. Schnabel L.V., Mohammed H.O., Miller B.J., et al. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 2007, 25:230-240.
13. McCarrel T., Fortier L. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res 2009, 27:1033-1042.
14. Morizaki Y., Zhao C., An K.-N., et al. The effects of platelet-rich plasma on bone marrow stromal cell transplants for tendon healing in vitro. J Hand Surg Am 2010, 35:1833-1841.
15. Zhang J., Wang J.H.C. Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes. Am J Sports Med 2010, 38:2477-2486.
16. Visser L.C., Arnoczky S.P., Caballero O., et al. Growth factor-rich plasma increases tendon cell proliferation and matrix synthesis on a synthetic scaffold: an in vitro study. Tissue Eng Part A 2010, 16:1021-1029.
17. Visser L.C., Arnoczky S.P., Caballero O., et al. Platelet-rich fibrin constructs elute higher concentrations of transforming growth factor-b1 and increase tendon cell proliferation over time when compared to blood clots: a comparative in vitro analysis. Vet Surg 2010, 39:811-817.
18. Tohidnezhad M., Varoga D., Wruck C.J., et al. Platelet-released growth factors can accelerate tenocyte proliferation and activate the anti-oxidant response element. Histochem Cell Biol 2011, 135:453-460.
19. Anitua E., Sanchez M., Nurden A.T., et al. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A 2006, 77:285-293.
20. de Mos M., Koevoet W., van Schie H.T., et al. In vitro model to study chondrogenic differentiation in tendinopathy. Am J Sports Med 2009, 37:1214-1222.
21. de Mos M., van der Windt A.E., Jahr H., et al. Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 2008, 36:1171-1178.
22. Anitua E., Sánchez M., Zalduendo M.M., et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif 2009, 42:162-170.
23. Zargar Baboldashti N., Poulsen R.C., Franklin S.L., et al. Platelet-rich plasma protects tenocytes from adverse side effects of dexamethasone and ciprofloxacin. Am J Sports Med 2011, 39:1929-1935.
24. Zhai W., Wang N., Qi Z., et al. Platelet-rich plasma reverses the inhibition of tenocytes and osteoblasts in tendon-bone healing. Orthopedics 2012, 35:e520-e525.
25. Jo C.H., Kim J.E., Yoon K.S., et al. Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears. Am J Sports Med 2012, 40:1035-1045.
26. Carofino B., Chowaniec D.M., McCarthy M.B., et al. Corticosteroids and local anesthetics decrease positive effects of platelet-rich plasma: an in vitro study on human tendon cells. Arthroscopy 2012, 28:711-719.
27. Mishra A., Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 2006, 34:1774-1778.
28. Peerbooms J.C., Sluimer J., Bruijn D.J., et al. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet rich plasma versus corticosteroid injection with a 1-year follow- up. Am J Sports Med 2010, 38:255-262.
29. Hechtman K.S., Uribe J.W., Botto-vanDemden A., et al. Platelet-rich plasma injection reduces pain in patients with recalcitrant epicondylitis. Orthopedics 2011, 34:92.
30. Creaney L., Wallace A., Curtis M., et al. Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections. Br J Sports Med 2011, 45:966-971.
31. de Vos RJ1, Windt J., Weir A. Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: a systematic review. Br J Sports Med 2014, 48:952-956. [Epub 2014 Feb 21]. 10.1136/bjsports-2013-093281.
32. de Vos R.J., Weir A., van Schie H.T., et al. Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA 2010, 303:144-149.
33. de Vos R.J., Weir A., Tol J.L., et al. No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy. Br J Sports Med 2011, 45:387-392.
34. Gaweda K., Tarczynska M., Krzyzanowski W. Treatment of Achilles tendinopathy with platelet-rich plasma. Int J Sport Med 2010, 31:577-583.
35. Sánchez M., Anitua E., Azofra J., et al. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 2007, 35:245-251.
36. Schepull T., Kvist J., Norrman H., et al. Autologous platelets have no effect on the healing of human Achilles tendon ruptures: a randomized single-blind study. Am J Sport Med 2011, 39:38-47.
37. Kon E., Filardo G., Delcogliano M., et al. Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper's knee. Injury 2009, 40:598-603.
38. Filardo G., Kon E., Della Villa S., et al. Use of platelet-rich plasma for the treatment of refractory jumper's knee. Int Orthop 2010, 34:909-915.
39. Vetrano M., Castorina A., Vulpiani M.C., et al. Platelet-rich plasma versus focused shock waves in the treatment of jumper's knee in athletes. Am J Sports Med 2013, 41:795-803.
40. Smith J., Sellon J.L. Comparing PRP injections with ESWT for athletes with chronic patellar tendinopathy. Clin J Sport Med 2014, 24:88-89.
41. Charousset C., Zaoui A., Bellaiche L., et al. Are multiple platelet-rich plasma injections useful for treatment of chronic patellar tendinopathy in athletes?. A prospective study. Am J Sports Med 2014, 42:906-911.
42. Kesikburun S., Tan A.K., Yilmaz B., et al. Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. Am J Sports Med 2013, 41:2609-2616.
43. Scarpone M., Rabago D., Snell E., et al. Effectiveness of platelet-rich plasma injection for rotator cuff tendinopathy: a prospective open-label study. Glob Adv Health Med 2013, 2:26-31.
44. Randelli P., Arrigoni P., Ragone V., et al. Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. J Shoulder Elbow Surg 2011, 20:518-528.
45. Castricini R., Longo U.G., De Benedetto M., et al. Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. Am J Sport Med 2011, 39:258-265.
46. Jo C.H., Kim J.E., Yoon K.S., et al. Does platelet-rich plasma accelerate recovery after rotator cuff repair? A prospective cohort study. Am J Sport Med 2011, 39:2082-2090.
47. Barber F.A., Hrnack S.A., Snyder S.J., et al. Rotator cuff repair healing influenced by platelet-rich plasma construct augmentation. Arthroscopy 2011, 27:1029-1035.
48. Charousset C., Zaoui A., Bellaïche L., et al. Does autologous leukocyte-platelet-rich plasma improve tendon healing in arthroscopic repair of large or massive rotator cuff tears?. Arthroscopy 2014, 30:428-435.