AH-7921: the list of new psychoactive opioids is expanded

Forensic Toxicology

Volumn 33, Issue 2, 2015, Pages 195-201

  Katselou, Maria ^a   Papoutsis, Ioannis ^a   Nikolaou, Panagiota ^a   Spiliopoulou, Chara ^a   Athanaselis, Sotiris ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

AH 7921; Doxylam; New psychoactive substance; Pharmacology and toxicology; Opioid receptor agonist

Indexed keywords

AH 7921; MORPHINE; NARCOTIC ANALGESIC AGENT; PSYCHOTROPIC AGENT; UNCLASSIFIED DRUG;

ANTINOCICEPTION; ARTICLE; DRUG ABUSE; DRUG MECHANISM; DRUG STRUCTURE; FATALITY; GASTROINTESTINAL SYMPTOM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOTHERMIA; INTOXICATION; LEGAL ASPECT; MASS FRAGMENTOGRAPHY; MIOSIS; NONHUMAN; PRIORITY JOURNAL; RESPIRATION DEPRESSION; SEDATION; SELF REPORT; TANDEM MASS SPECTROMETRY; WITHDRAWAL SYNDROME;

ANIMALIA;

EID: 84937513144     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-015-0271-z     Document Type: Article

References (34)

1. Kikura-Hanajiri R, Uchiyama N, Kawamura M, Goda Y (2013) Changes in the prevalence of synthetic cannabinoids and cathinone derivatives in Japan until early 2012. Forensic Toxicol 31:44–53
2. ® immunoassays. Forensic Toxicol 31:133–137
3. Uchiyama N, Shimokawa Y, Kawamura M, Kikura-Hanajiri R, Hakamatsuka T (2014) Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products. Forensic Toxicol 32:266–281
4. European Monitoring Centre for Drugs and Drug Addition (EMCDDA) (2012) Annual report on the state of the drugs problem in Europe. http://www.emcdda.europa.eu/publications/annual-report/2012. Accessed 3 Nov 2014
5. Hill SL, Thomas SHL (2011) Clinical toxicology of newer recreational drugs. Clin Toxicol 49:705–719
6. European Monitoring Centre for Drugs and Drug Addition (EMCDDA) (2014) Risk assessment report of a new psychoactive substance: 3,4-dicholo-N-{[1-(dimethylamino)cyclohexyl]methyl}benzamide (AH-7921) in the frame work of the Council Decision on new phychoactive substances. EMCDDA, Lisbon, pp 1–23
7. Coppola M, Mondola R (2015) AH-7921: a new synthetic opioid of abuse. Drug Alcohol Rev 34:109–110
8. Hayes AG, Tyers MB (1983) Determination of receptors that mediate opiate side effects in the mouse. Br J Pharmacol 79:731–736
9. Kronstrand R, Thelander G (2013) http://www.soft-tox.org/files/Designer_Drugs/AH-7921_January_2013.pdf. Accessed 1 Nov 2014
10. Presidenza del Consiglio dei Ministri. Dipartimento Politiche Antidroga. Sistema Nazionale di Allerta Precoce. National early warning system (2013) 3,4-Dicloro-N-[(1-(dimetilammino) cicloesil)metil] benzamide (AH-7921). Italy, pp 1379–1385
11. Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y (2013) Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicol 31:223–240
12. Cayman Chemical (2014) https://www.caymanchem.com/app/template/Product.vm/catalog/12036/promo/emolecules. Accessed 5 Nov 2014
13. Cerilliant Corporation (2014) http://www.cerilliant.com/ShopOnline/Item_Details.aspx?itemno=98ce2a1d-a5dc-417b-b614-7d4a2c8c747a. Accessed 5 Nov 2014
14. European Monitoring Centre for Drugs and Drug Addition (EMCDDA) (2014) AH-7921. EMCDDA-Europol joint report on a new psychoactive substance: AH-7921 3,4-dicholo-N-{[1-(dimethylamino)cyclohexyl]methyl}benzamide. In accordance with Article 5 of council decision 2005/387/JHA on the information exchange, risk assessment and control of new psychoactive substances. EMCDDA, Lisbon
15. World Health Organization (2014) AH-7921. Critical review report. Agenda item 4.21. Expert committee on drug dependence. Thirty-sixth meeting. Geneva, 16–20 June 2014
16. Erowid (2013) AH-7921 (experience vaults). Extreme relaxation: an experience with AH-7921 (ID 93949) by Samuel. http://www.erowid.org/experiences/exp.php?ID=93949. Accessed 15 May 2014
17. Erowid (2014) AH-7921, alcohol & cannabis by Selggurkim Citation: Selggurkim. “Ups downs AH town: an experience with AH-7921, alcohol & cannabis (ID 102804)”. https://www.erowid.org/experiences/exp.php?ID=102804. Accessed 14 May 2014
18. Bluelight (2014) http://www.bluelight.org/vb/threads/689803-The-AH-7921-Side-effect-and-withdrawal-WARNING. Accessed 15 May 2014
19. Tyers MB (1980) A classification of opiate receptors that mediate antinociceptive in animals. Br J Pharmacol 69:503–512
20. Brittain RT, Kellett DN, Neat ML, Stables R (1973) Anti-nociceptive effects in N-substituted cyclohexylmethylbenzamides. Br J Pharmacol 49:158–159
21. Sewell RDE, Spencer PSJ (1974) Biogenic amines and the anti-nociceptive activities of agents with a non-opiate structure. J Pharm Pharmacol 26(Supplement):92–93
22. Loew G, Lawson J, Toll L, Frenking G, Berzetei-Gurske I, Polgar W (1988) Structure activity studies of two classes of beta-amino-amides: the search for kappa-selective opioids. In: Harris LS (ed) Problems of drug dependence. Proceedings of the 50th annual scientific meeting. The committee on problems of drug dependence. NIDA Research Monograph 90, NIDA, Baltimore
23. Erowid (2013) For science AH-7921. http://erowid.org/experiences/exp.php?ID=100939. Accessed 15 May 2014
24. Drugs-Forum (2014) http://www.drugs-forum.com/forum/showthread.php?t=234846#ixzz31gWqcyE7. Accessed 5 Nov 2014
25. Elliot S, Evans J (2014) A 3-year review of new psychoactive substances in casework. Forensic Sci Int 243:55–60
26. Vorce SP, Knittel JL, Holler JM, Magluilo J Jr, Levine B, Berran P, Bosy TZ (2014) A fatality involving AH-7921. J Anal Toxicol 38:226–230
27. Soh YN, Elliott S (2013) An investigation of the stability of emerging new psychoactive substances. Drug Test Anal 6:696–704
28. Uchiyama N, Matsuda S, Wakana D, Kikura-Hanakiri R, Goda Y (2013) New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)- 1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products. Forensic Toxicol 31:93–100
29. EMCDDA (2014) https://ednd.emcdda.europa.eu/html.cfm/index7246EN.html?SUB_ID=258&detail. Accessed 5 Nov 2014
30. Southern Association of Forensic Scientists (2014) http://forendex.southernforensic.org/index.php/detail/index/1249. Accessed 5 Nov 2014
31. Scientific Working Group for the Analysis of Seized Drugs (2014) http://www.swgdrug.org/Monographs/AH-7921.pdf. Accessed 5 Nov 2014
32. European Commission (2014) Proposal for a council decision on subjecting 4-iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe), 3,4-dichloro-N-{[1-(dimethylamino)cyclohexyl]methyl} benzamide (AH-7921), 3,4-methylenedioxypyrovalerone (MDPV) and 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone (methoxetamine) to control measures. Brussels, 16.6.2014. COM(2014) 362 final. 2014/0183 (NLE)
33. Government of Israel (2014) http://www.health.gov.il/LegislationLibrary/Homarim-12092013.pdf. Accessed 5 Nov 2014
34. Anthony Gill, Delegate of the Secretary of the Department of Health, Australian Government (2014) Act 1989. Poisons standard amendment no. 2 of 2014. Australian Government, Camberra