Polyreactive Antibodies: Function and Quantification

Journal of Infectious Diseases

Volumn 212, Issue , 2015, Pages S42-S46

  Gunti, Sreenivasulu ^a   Notkins, Abner Louis ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Apoptotic cells; Bacteria; Natural antibody; Phagocytosis; Polyreactive antibody

Indexed keywords

BACTERIUM ANTIBODY; ANTIBODY; ANTIGEN;

ACTINOMYCES NAESLUNDII; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY TITER; APOPTOSIS; BACTERIAL GROWTH; BINDING SITE; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; ESCHERICHIA COLI; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; MACROPHAGE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STREPTOCOCCUS GORDONII; STREPTOCOCCUS MITIS; STREPTOCOCCUS ORALIS; T LYMPHOCYTE; ANIMAL; ANTIBODY SPECIFICITY; BACTERIUM; IMMUNOLOGY; MOUSE;

ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; ANTIGENS; APOPTOSIS; BACTERIA; HUMANS; MICE; PHAGOCYTOSIS; T-LYMPHOCYTES;

EID: 84937458567     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu512     Document Type: Conference Paper

References (15)

1. Tauber AI, Podolsky SH. The generation of diversity: clonal selection theory and the rise of molecular immunology. Cambridge, MA: Harvard University Press, 1997.
2. Haspel MV, Onodera T, Prabhakar BS, et al. Multiple organ-reactive monoclonal autoantibodies. Nature 1983; 304:73-6.
3. Satoh J, Prabhakar BS, Haspel MV, Ginsbergfellner F, Notkins AL. Human monoclonal autoantibodies that react with multiple endocrine organs. New Engl J Med 1983; 309:217-20.
4. Prabhakar BS, Saegusa J, Onodera T, Notkins AL. Lymphocytes capable of making monoclonal autoantibodies that react with multiple organs are a common feature of the normal B-cell repertoire. J Immunol 1984; 133:2815-7.
5. Dighiero G, Lymberi P, Mazie JC, et al. Murine hybridomas secreting natural monoclonal-antibodies reacting with self antigens. J Immunol 1983; 131:2267-72.
6. Bosshard HR. Molecular recognition by induced fit: how fit is the concept? News Physiol Sci 2001; 16:171-3.
7. James LC, Roversi P, Tawfik DS. Antibody multispecificity mediated by conformational diversity. Science 2003; 299:1362-7.
8. Rini JM, Schulzegahmen U, Wilson IA. Structural evidence for induced fit as a mechanism for antibody-antigen recognition. Science 1992; 255: 959-65.
9. Notkins AL. Polyreactivity of antibody molecules. Trends Immunol 2004; 25:174-9.
10. Gordon J, Carter HS. The bactericidal power of normal serum. J Pathol Bacteriol 1932; 35:549-55.
11. Michael JG, Whitby JL, Landy M. Studies on natural antibodies to gram-negative bacteria. J Exp Med 1962; 115:131-46.
12. Zhou ZH, Zhang YH, Hu YF, Wahl LM, Cisar JO, Notkins AL. The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies. Cell Host Microbe 2007; 1:51-61.
13. Chen Y, Park YB, Patel E, Silverman GJ. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J Immunol 2009; 182:6031-43.
14. Kaveri SV, Silverman GJ, Bayry J. Natural IgM in immune equilibrium and harnessing their therapeutic potential. J Immunol 2012; 188: 939-45.
15. Zhou ZH, Wild T, Xiong Y, et al. Polyreactive antibodies plus complement enhance the phagocytosis of cells made apoptotic by UV-light or HIV. Sci Rep 2013; 3:2271.