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Volumn 23, Issue 13, 2015, Pages 3228-3236
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Discovery of biphenyl-aryl ureas as novel VEGFR-2 inhibitors. Part 4: Exploration of diverse hinge-binding fragments
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Author keywords
Biphenyl; Hinge region; Structural diversity; Urea; VEGFR 2 inhibitors
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Indexed keywords
4 PYRIDIN 3 YLANILINE;
5 BROMOPYRIDINE 2 CARBONYL CHLORIDE;
5 BROMOPYRIDINE 2 CARBOXYLIC ACID;
EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR;
N (2,4 DICHLOROPHENYL)N (4 PYRIDIN 3 YLPHENYL)UREA;
N (3,4 DICHLOROPHENYL) N (4 PYRIDIN 3 YLPHENYL)UREA;
N (3,4 DIFLUOROPHENYL) N (4 PYRIDIN 3 YLPHENYL)UREA;
N (5 BROMOPYRIDIN 2 YL) 2,2 DIMETHYLPROPANAMIDE;
N [2 BROMO 4 (TRIFLUOROMETHOXY)PHENYL] N (4 PYRIDIN 3 YLPHENYL)UREA;
N [2 BROMO 5 (TRIFLUOROMETHOXY)PHENYL] N (4 PYRIDIN 3 YLPHENYL)UREA;
N [3 BROMO 5 (TRIFLUOROMETHYL)PHENYL] N (4 PYRIDIN 3 YLPHENYL)UREA;
N [3,5 BIS(TRIFLUOROMETHYL)PHENYL] N (4 PYRIDIN 3 YLPHENYL)UREA;
N [4 BROMO 2 (TRIFLUOROMETHOXY)PHENYL] N (4 PYRIDIN 3 YLPHENYL)UREA;
N [5 (4 AMINOPHENYL)PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 BROMO 2 (TRIFLUOROMETHOXY)PHENYL] N (4 PYRIDIN 3 YLPHENYL)UREA;
N [5 [4 [[[(2,4 DICHLOROPHENYL)AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[(3,4 DICHLOROPHENYL)AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[(3,4 DIFLUOROPHENYL)AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[2 BROMO 4 (TRIFLUOROMETHOXY)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[2 BROMO 5 (TRIFLUOROMETHOXY)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[3 BROMO 2 (TRIFLUOROMETHOXY)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[3 BROMO 5 (TRIFLUOROMETHYL)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[3 FLUORO 4 (2 PIPERIDIN 1 YLETHOXY)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[3 FLUORO 4 (3 MORPHOLIN 4 YLPROPOXY)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[3,5 BIS(TRIFLUOROMETHYL)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[4 [3 (DIMETHYLAMINO)PROPOXY] 3 FLUOROPHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
N [5 [4 [[[[5 BROMO 2 (TRIFLUOROMETHOXY)PHENYL]AMINO]CARBONYL]AMINO]PHENYL]PYRIDIN 2 YL] 2,2 DIMETHYLPROPANAMIDE;
SORAFENIB;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
VASCULOTROPIN RECEPTOR 2;
ANTINEOPLASTIC AGENT;
CARBANILAMIDE DERIVATIVE;
PROTEIN BINDING;
PROTEIN KINASE INHIBITOR;
PYRIDINE DERIVATIVE;
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN;
A549 CELL LINE;
ANTINEOPLASTIC ACTIVITY;
ANTIPROLIFERATIVE ACTIVITY;
ARTICLE;
CANCER INHIBITION;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DRUG BINDING;
DRUG DESIGN;
DRUG POTENCY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HEPATOCELLULAR CARCINOMA CELL LINE;
HUMAN;
HUMAN CELL;
HYDROGEN BOND;
IC50;
MOLECULAR DOCKING;
SMMC 7721 CELL LINE;
ANTAGONISTS AND INHIBITORS;
CELL PROLIFERATION;
CHEMISTRY;
DRUG EFFECTS;
ENZYME ACTIVE SITE;
KINETICS;
METABOLISM;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
TUMOR CELL LINE;
ANTINEOPLASTIC AGENTS;
CATALYTIC DOMAIN;
CELL LINE, TUMOR;
CELL PROLIFERATION;
HUMANS;
HYDROGEN BONDING;
KINETICS;
MOLECULAR DOCKING SIMULATION;
PHENYLUREA COMPOUNDS;
PROTEIN BINDING;
PROTEIN KINASE INHIBITORS;
PYRIDINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;
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EID: 84937435978
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2015.04.071 Document Type: Article |
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Times cited : (18)
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References (20)
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