Cancer nanomedicine: Addressing the dark side of the enhanced permeability and retention effect

Nanomedicine

Volumn 10, Issue 13, 2015, Pages 1993-1995

  Huynh, Elizabeth ^a,b   Zheng, Gang ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

cancer therapy; drug delivery; EPR effect; imaging; microbubbles; nanoparticles; tumor microenvironment

Indexed keywords

NANOPARTICLE;

CANCER THERAPY; ENHANCED PERMEABILITY AND RETENTION EFFECT; HUMAN; NANOMEDICINE; NANOTECHNOLOGY; NONHUMAN; PHYSICAL PHENOMENA; PRIORITY JOURNAL; REVIEW; DRUG DELIVERY SYSTEM; METABOLISM; NEOPLASMS; PERMEABILITY; PROCEDURES; TUMOR MICROENVIRONMENT; VASCULARIZATION;

DRUG DELIVERY SYSTEMS; HUMANS; NANOMEDICINE; NANOPARTICLES; NEOPLASMS; PERMEABILITY; TUMOR MICROENVIRONMENT;

EID: 84937411588     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.15.86     Document Type: Review

References (19)

1. Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46(12 Pt 1), 6387-6392 (1986).
2. Trédan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J. Natl Cancer Inst. 99(19), 1441-1454 (2007).
3. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 407(6801), 249-257 (2000).
4. Suzuki M, Hori K, Abe I, Saito S, Sato H. A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II. J. Natl Cancer Inst. 67(3), 663-669 (1981).
5. Nagamitsu A, Greish K, Maeda H. Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors. Jpn. J. Clin. Oncol. 39(11), 756-766 (2009).
6. Mozaffarian D, Benjamin EJ, Go AS et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 131(4), e29-322 (2015).
7. Chauhan VP, Stylianopoulos T, Martin JD et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat. Nanotechnol. 7(6), 383-388 (2012).
8. Kong G, Braun RD, Dewhirst MW. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res. 60(16), 4440-4445 (2000).
9. Lammers T, Peschke P, Kühnlein R et al. Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems. J. Control. Release 117(3), 333-341 (2007).
10. Weinstein JN, van Osdol W. Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the binding site barrier. Cancer Res. 52(9 Suppl.), 2747s-2751s (1992).
11. Sano K, Nakajima T, Choyke PL, Kobayashi H. Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors. ACS Nano 7(1), 717-724 (2013).
12. DeNardo SJ, Kukis DL, Kroger LA et al. Synergy of Taxol and radioimmunotherapy with yttrium-90-labeled chimeric L6 antibody: efficacy and toxicity in breast cancer xenografts. Proc. Natl Acad. Sci. USA 94(8), 4000-4004 (1997).
13. Prabhakar U, Maeda H, Jain RK et al. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res. 73(8), 2412-2417 (2013).
14. Ye D, Shuhendler AJ, Cui L et al. Bioorthogonal cyclizationmediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo. Nat. Chem. 6(6), 519-526 (2014).
15. Perrault SD, Chan WC. In vivo assembly of nanoparticle components to improve targeted cancer imaging. Proc. Natl Acad. Sci. USA 107(25), 11194-11199 (2010).
16. Ferrara K, Pollard R, Borden M. Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Ann. Rev. Biomed. Eng. 9, 415-447 (2007).
17. Huynh E, Leung BY, Helfield BL et al. In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging. Nat. Nanotechnol. 10(4), 325-332 (2015).
18. Lanza GM. Theranostic agents: from micro to nano in seconds. Nat. Nanotechnol. 10(4), 301-302 (2015).
19. Heneweer C, Holland JP, Divilov V, Carlin S, Lewis JS. Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system. J. Nucl. Med. 52(4), 625-633 (2011).