Estrogen, stress, and depression: A neurocognitive model

JAMA Psychiatry

Volumn 72, Issue 7, 2015, Pages 727-729

  Newhouse, Paul ^a,b   Albert, Kimberly ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Valley Health   (United States)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTRADIOL;

AMYGDALOID NUCLEUS; COGNITION; DEPRESSION; DISEASE PREDISPOSITION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MENTAL STRESS; PREFRONTAL CORTEX; REVIEW; RISK ASSESSMENT; STRESS; CLIMACTERIUM; DEPRESSIVE DISORDER; FEMALE; PSYCHOLOGY;

DEPRESSION; DEPRESSIVE DISORDER; ESTRADIOL; ESTROGENS; FEMALE; HUMANS; PERIMENOPAUSE;

EID: 84937401733     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2015.0487     Document Type: Review

References (10)

1. Schmidt PJ, Ben Dor R, Martinez PE, et al. Effects of estradiol withdrawal on mood in women with past perimenopausal depression: a randomized clinical trial [published onlineMay 27, 2015]. JAMA Psychiatry. doi: 10.1001/jamapsychiatry.2015.0111.
2. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry. 2003;54(5):504-514.
3. Pruessner JC, Dedovic K, Pruessner M, et al. Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations-2008 Curt RichterAward winner. Psychoneuroendocrinology. 2010;35(1):179-191.
4. Zeidan MA, Igoe SA, Linnman C, et al. Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats. Biol Psychiatry. 2011;70(10):920-927.
5. Goldstein JM, JerramM, Poldrack R, et al. Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. J Neurosci. 2005;25(40):9309-9316.
6. Frey BN, Hall GB, Attard S, et al. Shift in the brain network of emotional regulation inmidlife women: is the menopausal transition the turning point? Menopause. 2010;17(4):840-845.
7. Kim JJ, Diamond DM. The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci. 2002;3(6):453-462.
8. Albert K, Pruessner J, Newhouse PA. Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle. Psychoneuroendocrinology. In press.
9. Newhouse PA, Dumas J, Hancur-Bucci C, et al. Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal women. Neuropsychopharmacology. 2008;33(7):1514-1527.
10. McEwen BS, Akama KT, Spencer-Segal JL, Milner TA, Waters EM. Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms. Behav Neurosci. 2012;126(1):4-16.