Citalopram-induced hyponatraemia and parkinsonism: Potentially fatal side-effects not to be missed

BMJ Case Reports

Volumn 2014, Issue , 2014, Pages

  Amiri, Negin Damali ^a   Wijenaike, Nishan ^b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b WEST SUFFOLK HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; DOPAMINE RECEPTOR STIMULATING AGENT; HYPERTONIC SOLUTION; ROTIGOTINE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SODIUM; TOLVAPTAN;

AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONFUSION; CONVALESCENCE; DIFFERENTIAL DIAGNOSIS; DISEASE DURATION; DISEASE EXACERBATION; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG SAFETY; DRUG WITHDRAWAL; ESOPHAGOGASTRODUODENOSCOPY; FALLING; HUMAN; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; MALE; MOOD DISORDER; MOTOR DYSFUNCTION; NAUSEA; PARKINSONISM; PATIENT MONITORING; PHYSIOTHERAPY; PRIORITY JOURNAL; SODIUM BLOOD LEVEL; WEIGHT REDUCTION; CHEMICALLY INDUCED;

AGED; CITALOPRAM; CONFUSION; HUMANS; HYPONATREMIA; MALE; PARKINSONIAN DISORDERS; SEROTONIN UPTAKE INHIBITORS;

EID: 84937232470     PISSN: None     EISSN: 1757790X     Source Type: Journal    
DOI: 10.1136/bcr-2014-206575     Document Type: Article

References (12)

1. Wright DG, Laureno R, Victor M. Pontine and extrapontine myelinolysis. Brain 1979; 102: 361-85.
2. Martin RJ Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. J Neurol Neurosurg Psychiatry 2004; 75(Suppl 3): iii22-8.
3. Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 2007; 356: 2064-72.
4. Menger H, Jorg J. Outcome of central pontine and extrapontine myelinolysis (n=44). J Neurol 1999; 246: 700-5.
5. Iwase R, Shiba H, Gocho T, et al. Syndrome of inappropriate secretion of antidiuretic hormone due to selective serotonin reuptake inhibitors after pancreaticoduodenectomy for carcinoma of the ampulla of Vater: case report. Int Surg 2013; 98: 289-91.
6. Jacob S, Spinler SA. Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults. Ann Pharmacother 2006; 40: 1618-22.
7. Whiskey E, Taylor D. A review of the adverse effects and safety of noradrenergic antidepressants. J Psychopharmacol 2013; 27: 732-9.
8. Gerber PE, Lynd LD. Selective serotonin-reuptake inhibitor-induced movement disorders. Ann Pharmacother 1998; 32: 692-8.
9. Miletic V, Relja M. Citalopram-induced parkinsonian syndrome: case report. Clin Neuropharmacol 2011; 34: 92-3.
10. Ak S, Anil Yagcioglu AE Escitalopram-induced parkinsonism. Gen Hosp Psychiatry 2014; 36: 126-2.
11. Nahshoni E, Weizman A, Shefet D, et al. A case of hyponatremia associated with escitalopram. J Clin Psychiatry 2004; 65: 1722.
12. MacGillivray L, Reynolds KB, Sickand M, et al. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Synapse 2011; 65: 1166-72.