Impact of daily supplementation of Spirulina platensis on the immune system of naïve HIV-1 patients in Cameroon: A 12-months single blind, randomized, multicenter trial

Nutrition Journal

Volumn 14, Issue 1, 2015, Pages

  Ngo Matip, Marthe Elise ^a   Pieme, Constant Anatole ^b   Azabji Kenfack, Marcel ^b   Moukette, Bruno Moukette ^a   Korosky, Emmanuel ^c   Stefanini, Philippe ^d   Ngogang, Jeanne Yonkeu ^b   Mbofung, Carl Moses ^a  

^a UNIVERSITY OF NGAOUNDERE   (Cameroon)

^b UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^c Spirulina Producer's Federation of France ^*  (France)

^d Ecole de Formation Agricole de Hyères   (France)

Author keywords

Balance diet; CD4 cells; Clinical trial; HIV naive; Spirulina platensis; Viral load

Indexed keywords

GLUCOSE; HEMOGLOBIN; TRACE ELEMENT;

ADULT; ARTHROSPIRA PLATENSIS; ARTICLE; CAMEROON; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; DISEASE COURSE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; IMMUNE SYSTEM; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NUTRITIONAL DEFICIENCY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; VIRUS LOAD; BLOOD; BODY MASS; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; DEFICIENCY; DIET; DIETARY SUPPLEMENT; FOLLOW UP; HIV INFECTIONS; METABOLISM; NUTRITIONAL STATUS; SPIRULINA;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SPIRULINA PLATENSIS;

ADULT; BODY MASS INDEX; CAMEROON; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; DIET; DIETARY SUPPLEMENTS; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HUMANS; LONGITUDINAL STUDIES; MALE; MICRONUTRIENTS; NUTRITIONAL STATUS; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SPIRULINA; VIRAL LOAD;

EID: 84937218368     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/s12937-015-0058-4     Document Type: Article

References (26)

1. Rapport national de suivi de la déclaration politique sur le VIH/SIDA Cameroun: Global Aids Response Progress (GARP) 2013; http://www.unaids.org/sites/default/files/country/documents/CMR-narrative-report-2014.pdf.
2. Ngo-Matip ME, Pieme CA, Azabji-Kenfack M, Biapa Nya PC, Nkenfack G, Heike E, et al. Effects of Spirulina platensis supplementation on lipid profile in HIV-infected antiretroviral naïve patients in Yaounde - Cameroon: a randomized trial study. Lipid Health Dis. 2014;13:191.
3. Kalofonos IP. "All I Eat is ARVs": The paradox of AIDS treatment in central Mozambique. Med Anthropol Q. 2010;24(3):363-80.
4. Gillespie S, Kadayila S. HIV/AIDS and Food and Nutrition Security: From Evidence to Action. Food Policy. Washington, DC: IFPRI; 2005. p. 7.
5. Friis H. Micronutrient interventions and HIV infection: a review of current evidence. Trop Med Int Health. 2006;11(12):1849-57.
6. Semba RD, Darnton-Hill I, De Pee S. Addressing tuberculosis in the context of malnutrition and HIV co infection. Food Nutr Bull. 2010;31:S345-64.
7. Tabi M, Vogel RL. Nutritional counselling: an intervention for HIV-positive patients. J Adv Nurs. 2006;54(6):676-82.
8. World Health Organization (WHO). Nutrient Requirements for People Living with HIV/AIDS: Report of a Technical Consultation. Geneva: WHO; 2003.
9. Ivers LC, Yuchiao C, Gregory J, Kenneth AF. Food assistance is associated with improved body mass index, food security and attendance at clinic in an HIV program in central Haiti: a prospective observational cohort study. AIDS Res Therapy. 2010;7:33.
10. Kalichman SC, Cherry C, White D, Jones M, Kalichman MO, Detorio MA, et al. Use of dietary supplements among people living with HIV/AIDS is associated with vulnerability to medical misinformation on the internet. AIDS Res Therap. 2012;9(1):1-8.
11. De Pee S, Semba RD. Role of nutrition in HIV infection: review of evidence for more effective programming in resource-limited settings. Food Nut Bull. 2010;31(4):313-44.
12. Bhavisha R, Parula P. Spirulina: Potential clinical therapeutic application. J Pharm Res. 2010;3(8):1726-32.
13. Lee JB, Srisomporn P, Hayashi K, Tanaka T, Sankaw U, Hayashi T. Effects of Structural Modification of Calcium Spirulan, a Sulfated Polysaccharide from Spirulina platensis, on Antiviral Activity. Chem Pharm Bull. 2001;49(1):108-10.
14. Azabji-Kenfack M, Loni GE, Sobngwi E, Onana EA, Edie DS, von der Weid D, et al. The Effect of Spirulina platensis versus Soybean on Insulin Resistance in HIV-Infected Patients: A Randomized Pilot Study. Nutrients. 2011;3:712-24.
15. Nkengfack G, Torimiro J, Ngogang J, Heike E. Effects of nutritional education and lifestyle modification on the nutritional status of HIV positive patients: results of a cluster randomized intervention over a period of six months. Global Epidemic Obesity. 2013;1(5):2-8.
16. Moura LP, Puga MG, Wladimir RB, Teixeira IP, Ghezzi C, Silva AG, et al. Exercise and spirulina control nonalcoholic hepatic steatosis and lipid profile in diabetic Wistar rats. Lipid Health Dis. 2011;10:77.
17. Layam A, Reddy CLK. Antidiabetic property of spirulina. Diabetol Croat. 2007;35:27-48.
18. Winter FS, Emakam F, Kfutwah A, Hermann J, Azabji-Kenfack M, Krawinkel MB. The Effect of Arthrospira platensis Capsules on CD4 T-Cells and Antioxidative Capacity in a Randomized Pilot Study of Adult Women Infected with Human Immunodeficiency Virus Not under HAART in Yaoundé, Cameroon. Nutrients. 2014;6:2973-86.
19. Mahlungulu S, Grobler LA, Visser ME, Volmink J. Nutritional interventions for reducing morbidity and mortality in people with HIV Cochrane. Database Syst Rev. 2007;3:CD004536.
20. Swaminathan S, Padmapriyadarsini C, Yoojin L, Sukumar B, Iliayas S, Karthipriya J, et al. Nutritional supplementation in HIV-infected individuals in South India: a prospective interventional study. Clin Infect Dis. 2010;51:51-7.
21. Belay A, Ota Y, Miyakawa K, Shimatsu H. Current knowledge on potential health benefits of spiruline. J Appl Phys. 1993;5:235-41.
22. Fawzi WW, Msamanga IG, Wei R, Spiegelman D, Antelman G, Villamor E, et al. Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus-Infected, Lactating Mothers on the Child's Morbidity and CD4+ Cell Counts. Clin Infect Dis, 2003;36(8):1053-1062.
23. Qureshi MA, Garlich JD, Kidd MT. Dietary Spirulina enhances humoral and cell-mediated immune functions in chickens. Immunopharm Immunot. 1996;18(3):465-76.
24. Ayehunie S, Belay A, Hu Y, Baba T, Ruprecht R. Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis). J Acquir Immune Defic Syndr Hum Retrovirol. 1998;18(1):7-12.
25. Hayashi T, Hayashi K, Maeda M, Kojima I. Calcium Spirulan, an Inhibitor of Enveloped Virus Replication, from a Blue- Green Alga Spirulina platensis. J Nat Prod. 1996;59(1):83-7.
26. Borchers AT, Belay A, Keen CL, Gershwin ME. Spirulina and Immunity. In Spirulina in Human Nutrition and Health. E.M. Gershwin & Amha Belay, editor. CRC Press: 2007. p. 177-193.