Reactive Granulomatous Dermatitis: A Review of Palisaded Neutrophilic and Granulomatous Dermatitis, Interstitial Granulomatous Dermatitis, Interstitial Granulomatous Drug Reaction, and a Proposed Reclassification

Dermatologic Clinics

Volumn 33, Issue 3, 2015, Pages 373-387

  Rosenbach, Misha ^a   English, Joseph C ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Granuloma annulare; Granulomatous dermatitis; Granulomatous drug reaction; Interstitial granulomatous dermatitis; Interstitial granulomatous drug reaction; Palisaded neutrophilic and granulomatous dermatitis; Reactive granulomatous dermatitis

Indexed keywords

ALLOPURINOL; AMFEBUTAMONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BROMPHENIRAMINE; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN; COLCHICINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DAPSONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ETANERCEPT; FLUINDIONE; FUROSEMIDE; GEMFIBROZIL; HERBACEOUS AGENT; HYDROXYCHLOROQUINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN; INFLIXIMAB; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; RANITIDINE; SENNOSIDE; THALIDOMIDE; TRASTUZUMAB; TUMOR NECROSIS FACTOR INHIBITOR; UNINDEXED DRUG;

ADVERSE DRUG REACTION; CLINICAL ASSESSMENT; DERMATITIS; DISEASE ASSESSMENT; DISEASE ASSOCIATION; DISEASE COURSE; HISTOLOGY; HUMAN; INTERSTITIAL GRANULOMATOUS DERMATITIS; INTERSTITIAL GRANULOMATOUS DRUG REACTION; PALISADED NEUTROPHILIC AND GRANULOMATOUS DERMATITIS; PATHOGENESIS; PRIORITY JOURNAL; REACTIVE GRANULOMATOUS DERMATITIS; REVIEW; CLASSIFICATION; DRUG ERUPTION; GRANULOMA; NEUTROPHIL; PATHOLOGY; SKIN;

DERMATITIS; DRUG ERUPTIONS; GRANULOMA; HUMANS; NEUTROPHILS; SKIN;

EID: 84937163778     PISSN: 07338635     EISSN: 15580520     Source Type: Journal    
DOI: 10.1016/j.det.2015.03.005     Document Type: Review

References (112)

1. Hawryluk E.B., Izikson L., English J.C. Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions. Am J Clin Dermatol 2010, 11:171-181.
2. Chu P., Connolly M.K., LeBoit P.E. The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol 1994, 130:1278-1283.
3. Finan M.C., Winkelmann R.K. The cutaneous extravascular necrotizing granuloma (Churg-Strauss granuloma) and systemic disease: a review of 27 cases. Medicine (Baltimore) 1983, 62:142-158.
4. Finan M.C. Rheumatoid papule, cutaneous extravascular necrotizing granuloma, and Churg-Strauss granuloma: are they the same entity?. JAm Acad Dermatol 1990, 22:142-143.
5. Misago N., Shinoda Y., Tago M., et al. Palisaded neutrophilic granulomatous dermatitis with leukocytoclastic vasculitis in a patient without any underlying systemic disease detected to date. JCutan Pathol 2010, 37:1092-1097.
6. Kim S.K., Park C.K., Park Y.W., et al. Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with Behçet's disease. Scand J Rheumatol 2005, 34:324-327.
7. Al-Daraji W.I., Coulson I.H., Howat A.J. Palisaded neutrophilic and granulomatous dermatitis. Clin Exp Dermatol 2005, 30:578-579.
8. Hantash B.M., Chiang D., Kohler S., et al. Palisaded neutrophilic and granulomatous dermatitis associated with limited systemic sclerosis. JAm Acad Dermatol 2008, 58:661-664.
9. Hunt R.D., Hartman R.D., Molho-Pessach V., et al. Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. JAm Acad Dermatol 2012, 67:e164-e166.
10. Kwon E.J., Hivnor C.M., Yan A.C., et al. Interstitial granulomatous lesions as part of the spectrum of presenting cutaneous signs in pediatric sarcoidosis. Pediatr Dermatol 2007, 24:517-524.
11. Sangueza O.P., Caudell M.D., Mengesha Y.M., et al. Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. JAm Acad Dermatol 2002, 47:251-257.
12. Asahina A., Fujita H., Fukunaga Y., et al. Early lesion of palisaded neutrophilic granulomatous dermatitis in ulcerative colitis. Eur J Dermatol 2007, 17:234-237.
13. Brecher A. Palisaded neutrophilic and granulomatous dermatitis. Dermatol Online J 2003, 9:1.
14. Muscardin L.M., Cota C., Amorosi B., et al. Erythema elevatum diutinum in the spectrum of palisaded neutrophilic granulomatous dermatitis: description of a case with rheumatoid arthritis. JEur Acad Dermatol Venereol 2007, 21:104-105.
15. Gordon K., Miteva M., Torchia D., et al. Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis. Cutan Ocul Toxicol 2012, 31:338-340.
16. Heidary N., Mengden S., Pomeranz M.K. Palisaded neutrophilic and granulomatous dermatosis. Dermatol Online J 2008, 14:17.
17. Stephenson S.R., Campbell S.M., Drew G.S., et al. Palisaded neutrophilic and granulomatous dermatitis presenting in a patient with rheumatoid arthritis on adalimumab. JCutan Pathol 2011, 38:644-648.
18. Gordon E.A., Schmidt A.N., Boyd A.S. Palisaded neutrophilic and granulomatous dermatitis: a presenting sign of sarcoidosis?. JAm Acad Dermatol 2011, 65:664-665.
19. Mahmoodi M., Ahmad A., Bansal C., et al. Palisaded neutrophilic and granulomatous dermatitis in association with sarcoidosis. JCutan Pathol 2011, 38:365-368.
20. Germanas J.P., Mehrabi D., Carder K.R. Palisaded neutrophilic granulomatous dermatitis in a 12-year-old girl with systemic lupus erythematosus. JAm Acad Dermatol 2006, 55:S60-S62.
21. Singh M., Comfere N. Palisaded neutrophilic and granulomatous dermatitis. NEngl J Med 2012, 366:e33.
22. Collaris E.J., van Marion A.M., Frank J., et al. Cutaneous granulomas in rheumatoid arthritis. Int J Dermatol 2007, 46:33-35.
23. Bremner R., Simpson E., White C.R., et al. Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. Semin Arthritis Rheum 2004, 34:610-616.
24. Wilmoth G.J., Perniciaro C. Cutaneous extravascular necrotizing granuloma (Winkelmann granuloma): confirmation of the association with systemic disease. JAm Acad Dermatol 1996, 34:753-759.
25. Pastar Z., Radoš J., Pavic I., et al. Palisaded neutrophilic and granulomatous dermatitis in association with subcutaneous nodular and systemic sarcoidosis. Acta Dermatovenerol Croat 2013, 21:245-249.
26. He Y., Maverakis E., Ramirez-Maverakis D., et al. Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. Dermatol Online J 2013, 19:17.
27. Fett N., Kovarik C., Bennett D. Palisaded neutrophilic granulomatous dermatitis without a definable underlying disorder treated with dapsone. JAm Acad Dermatol 2011, 65:e92-e93.
28. Martin J.A., Jarrett P. Rheumatoid papules treated with dapsone. Clin Exp Dermatol 2004, 29:387.
29. Lee M.W., Jang K.A., Lim Y.S., et al. Cutaneous extravascular necrotizing granuloma (Churg Strauss granuloma). Clin Exp Dermatol 1999, 24:193-195.
30. Ackerman A.B. Histologic diagnosis of inflammatory skin diseases: interstitial granulomatous dermatitis with arthritis. Clues to diagnosis in dermatopathology 1993, 309-312. ASCP Press, Chicago. 1st edition. A.B. Ackerman, Y. Guo, P. Vitale (Eds.).
31. Verneuil L., Dompmartin A., Comoaz F., et al. Interstitial granulomatous dermatitis with cutaneous cords and arthritis: a disorder associated with autoantibodies. JAm Acad Dermatol 2001, 45:286-291.
32. Dykman C.J., Galens G.J., Good A.E. Linear subcutaneous bands in rheumatoid arthritis. Ann Intern Med 1965, 63:134-140.
33. Betloch I., Moragon M., Jorda E., et al. Linear rheumatoid nodule. Int J Dermatol 1988, 27:645-656.
34. Harpster E.F., Mauro T., Barr R.J. Linear granuloma annulare. JAm Acad Dermatol 1989, 21:1138-1141.
35. Aloi F.G., Tomasini C.F., Molinero A. Railway track-like dermatitis: an atypical Mondor's disease. JAm Acad Dermatol 1989, 20:920-923.
36. Dubey S., Merry P. Interstitial granulomatous dermatitis (Ackerman's syndrome) in SLE presenting with the rope sign. Rheumatology 2007, 46:80.
37. Flecht M., Faulhaber J., Gottmann U., et al. Interstitial granulomatous dermatitis (Ackerman's syndrome). Eur J Dermatol 2010, 20:661-662.
38. Peroni A., Colato C., Schena D., et al. Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. Br J Dermatol 2011, 166:775-783.
39. Blaise S., Salameire D., Carpentier P.H. Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus. Clin Exp Dermatol 2008, 33:712-714.
40. Tomasini C., Pippione M. Interstitial granulomatous dermatitis with plaques. JAm Acad Dermatol 2002, 46:892-899.
41. Moon H.R., Lee J.H., Won C.H., et al. Achild with IGD and juvenile idiopathic arthritis. Pediatr Dermatol 2013, 30:e272-e273.
42. Warycha M.A., Fangman W., Kamino H., et al. Interstitial granulomatous dermatitis in a child with chronic uveitis. JAm Acad Dermatol 2008, 58:S100-S102.
43. Worsnop F.S., Ostlere L. Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. Clin Exp Dermatol 2013, 38:564-565.
44. Johnson H., Mengden S., Brancaccio R.R. Interstitial granulomatous dermatitis. Dermatol Online J 2008, 14:18.
45. Long D., Thiboutot D.M., Majeski J.T., et al. Interstitial granulomatous dermatitis with arthritis. JAm Acad Dermatol 1996, 34:957-961.
46. Busquets-Perez N., Narvaez J., Valverde-Garcia J. Interstitial granulomatous dermatitis with arthritis (Ackerman syndrome). JRheumatol 2006, 33:1207-1209.
47. Zoli A., Massi G., Pinelli M., et al. Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. Clin Rheumatol 2010, 29:99-101.
48. Walling H.W., Swick B.L. Interstitial granulomatous dermatitis associated with chronic inflammatory demyelinating polyneuropathy. Cutis 2012, 90:30-32.
49. Jabbari A., Cheung W., Kamino H., et al. Interstitial granulomatous dermatitis with arthritis. Dermatol Online J 2009, 15:22.
50. Leloup P., Aubert H., Causse S., et al. Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. JAMA Dermatol 2013, 149:626-627.
51. Nakamura N., Asai J., Daito J., et al. Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. JDermatol 2011, 38:382-385.
52. Lee K.J., Lee E.S., Lee D.Y., et al. Interstitial granulomatous dermatitis associated with autoimmune hepatitis. JEur Acad Dermatol Venereol 2007, 21:684-685.
53. Patsatsi A., Kyriakou A., Triantafyllidou E., et al. Interstitial granulomatous dermatitis: another clinical variant. Case Rep Dermatol 2011, 3:195-200.
54. Altaykan A., Erkin G., Boztepe G., et al. Interstitial granulomatous dermatitis with arthritis. Hum Pathol 2004, 35:892-894.
55. Lucas A., Bañuls J., Mataix J., et al. Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. Clin Exp Dermatol 2009, 34:e102-e105.
56. Dyson S.W., Hirsch A., Jaworsky C. Interstitial granulomatous dermatitis secondary to soy. JAm Acad Dermatol 2004, 51:S105-S107.
57. Mason H.R., Swanson J.K., Ho J., et al. Interstitial granulomatous dermatitis associated with darifenacin. JDrugs Dermatol 2008, 7:895-897.
58. Martin G., Cañueto J., Santos-Briz A., et al. Interstitial granulomatous dermatitis with arthritis associated with trastuzumab. JEur Acad Dermatol Venereol 2010, 24:493-501.
59. Perrin C., Lacour J.P., Castanet J., et al. Interstitial granulomatous drug reaction with a histological pattern of interstitial granulomatous dermatitis. Am J Dermatopathol 2001, 23:295-298.
60. Deng A., Harvey V., Sina B., et al. Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor inhibitors. Arch Dermatol 2006, 142:198-202.
61. Magro C.M., Crowson A.N., Schapiro B.L. The interstitial granulomatous drug reaction: a distinctive clinical and pathological entity. JCutan Pathol 1998, 25:72-78.
62. Lee H.W., Yun W.J., Lee M.W., et al. Interstitial granulomatous drug reaction caused by Chinese herbal medication. JAm Acad Dermatol 2005, 52:712-713.
63. Siami K., Wilkerson M., Clark S.H., et al. An indurated plaque on the ankle of a 74-year-old woman. Arch Pathol Lab Med 2004, 128:e129-e130.
64. Chen Y.C., Hsiao C.H., Tsai T.F. Interstitial granulomatous drug reaction presenting as erythroderma: remission after discontinuation of enalapril maleate. Br J Dermatol 2008, 158:1143-1144.
65. Yazgano K.D., Tambay E., Mete O., et al. Interstitial granulomatous drug reaction due to thalidomide. JEur Acad Dermatol Venereol 2009, 23:490-493.
66. Marcollo Pini A., Kerl K., Kamarachev J., et al. Interstitial granulomatous drug reaction following intravenous ganciclovir. Br J Dermatol 2008, 158:1391-1392.
67. Lee M.W., Choi J., Sung K.J., et al. Interstitial and granulomatous drug reaction presenting as erythema nodosum-like lesions. Acta Derm Venereol 2002, 82:473-474.
68. Magro C.M., Cruz-Inigo A.E., Votava H., et al. Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction. JCutan Pathol 2010, 37:96-111.
69. Kim M.S., Lee J.H., Park K., et al. Allopurinol-induced DRESS syndrome with a histologic pattern consistent with interstitial granulomatous drug reaction. Am J Dermatopathol 2014, 36:193-195.
70. Aloi F., Tomasini C., Pippione M. Interstitial granulomatous dermatitis with plaques. Am J Dermatopathol 1999, 21:320-323.
71. Alghamdi R., Bejar C., Steff M., et al. Intravenous immunoglobulins as a treatment of interstitial granulomatous dermatitis with arthritis. Br J Dermatol 2012, 167:218-220.
72. Schanz S., Schmalzing M., Guenova E., et al. Interstitial granulomatous dermatitis with arthritis responding to tocilizumab. Arch Dermatol 2012, 148:17-20.
73. Banuls J., Betlloch I., Botella R., et al. Interstitial granulomatous dermatitis with plaques and arthritis. Eur J Dermatol 2003, 13:308-310.
74. Kreuter A., Gambichler T., Altmeyer P. Infliximab therapy for interstitial granulomatous dermatitis. JEur Acad Dermatol Venereol 2007, 21:251-252.
75. Szepetiuk G., Lesuisse M., Pierard G.E., et al. Autoimmunity-related granulomatous dermatitis in association with hepatitis. Case Rep Dermatol 2012, 4:80-84.
76. Gulati A., Paige D., Yagoob M., et al. Palisaded neutrophilic granulomatous dermatitis associated with systemic lupus erythematosus presenting with the burning rope sign. JAm Acad Dermatol 2009, 61:711-714.
77. Balin S.J., Wetter D.A., Kurtin P.J., et al. Myelodysplastic syndrome presenting as generalized granulomatous dermatitis. Arch Dermatol 2011, 147:331-335.
78. Ball R.A., Kinchelow T., ISR Substudy Group Injection site reactions with the HIV-1 fusion inhibitor enfuvirtide. JAm Acad Dermatol 2003, 49:826-831.
79. Park J.J., Hawryluk E.B., Tahan S.R., et al. Cutaneous granulomatous eruption and successful response to potent topical steroids in patients undergoing targeted BRAF inhibitor treatment for metastatic melanoma. JAMA Dermatol 2014, 150:307-311.
80. Requena L., Kutzner H., Palmedo G., et al. Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. Arch Dermatol 2005, 141:834-842.
81. Misago N., Inoue H., Inoue T., et al. Palisaded neutrophilic granulomatous dermatitis in systemic lupus erythematosus with a butterfly rash-like lesion. Eur J Dermatol 2010, 20:128-129.
82. Perniciaro C., Winkelmann R.K. Cutaneous extravascular necrotizing granuloma in a patient with Takayasu's aortitis. Arch Dermatol 1986, 122:201.
83. de Unamuno Bustos B., Rabasco A.G., Sanhez R.B., et al. Palisaded neutrophilic and granulomatous dermatitis associated with ankylosing spondylitis. Am J Dermatopathol 2013, 35:847-850.
84. Calonje J.E., Greaves M.W. Cutaneous extravascular necrotizing granuloma (Churg-Strauss) as a paraneoplastic manifestation of non-Hodgkin's B-cell lymphoma. JR Soc Med 1993, 86:549-550.
85. Biswas A., Chittari K., Gey van Pittius D., et al. Palisaded neutrophilic and granulomatous dermatitis in a child with type I diabetes mellitus and coeliac disease. Br J Dermatol 2008, 159:488-489.
86. Misago N., Narisawa Y., Tada Y., et al. Palisaded neutrophilic granulomatous dermatitis caused by cellulitis in a patient with systemic lupus erythematosus. Int J Dermatol 2011, 50:1583-1585.
87. Golden B.D., Wong D.C., Dicostanzo D., et al. Rheumatoid papules in a patient with acquired immune deficiency syndrome and symmetric poylarthritis. JRheumatol 1996, 23:760.
88. Wong H.K., Kaffenberger B.H., Zirwas M. Apalpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. JAMA Dermatol 2013, 149:609-614.
89. Marmon S., Robinson M., Meehan S.A., et al. Lupus-erythematosus-associated interstitial granulomatous dermatitis. Dermatol Online J 2012, 18:31.
90. Comte C., Guillot B., Durand L., et al. Dermatite granulomateuse interstitielle avec arthritis: quatre cas. Ann Dermatol Venereol 2008, 135:38-43. [in French].
91. Chen D.L., Chong A.H., Green J., et al. Anovel case of polyfibromatosis and interstitial granulomatous dermatitis with arthritis. JAm Acad Dermatol 2006, 55:S32-S37.
92. Wollina U., Schönlebe J., Unger L., et al. Interstitial granulomatous dermatitis with plaques and arthritis. Clin Rheumatol 2003, 22:347-349.
93. Choi M.J., Shin D., Kim Y.C., et al. Interstitial granulomatous dermatitis with arthritis accompanied by anaplastic large cell lymphoma. JDermatol 2014, 41:363-364.
94. Michailidou D., Voulgarelis M., Pikazis D. Exacerbation of IGD with arthritis by anakinra in a patient with diffuse large B-cell lymphoma. Clin Exp Rheumatol 2014, 32:259-261.
95. Patsinakidis N., Susok L., Hessam S., et al. IGD associated with myelodysplastic syndrome - complete clearance under therapy with 5-azacytidine. Acta Derm Venereol 2014, 94(6):725-726.
96. Cornejo K.M., Lum C.A., Izumi A.K. Acutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. Am J Dermatopathol 2013, 35:e26-e29.
97. Swing D.C., Sheehan D.J., Sangueza O.P., et al. Interstitial granulomatous dermatitis secondary to acute promyelocytic leukemia. Am J Dermatopathol 2008, 30:197-199.
98. Schreckenberg C., Asch P.H., Sibilia J., et al. Interstitial granulomatous dermatitis and paraneoplastic rheumatoid polyarthritis disclosing cancer of the lung. Ann Dermatol Venereol 1998, 125:585-588. [in French].
99. Moyano Almagro B., López Navarro N., Contreras Steyls M., et al. IGD and arthritis revealing oesophageal carcinoma. Clin Exp Dermatol 2013, 38:501-503.
100. Sakaizawa K., Hasegawa J., Kawachi S., et al. Interstitial granulomatous dermatitis with plaques. Eur J Dermatol 2008, 18:600-601.
101. Antunes J., Pacheco D., Travassos A.R., et al. Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis. An Bras Dermatol 2012, 87:748-751.
102. Lee H.W., Chang S.E., Lee M.W., et al. Interstitial granulomatous dermatitis with plaques associated with antiphospholipid syndrome. Br J Dermatol 2005, 152:814-816.
103. DiCaudo D.J., Connolly S.M. Interstitial granulomatous dermatitis associated with pulmonary coccidioidomycosis. JAm Acad Dermatol 2001, 45:840-845.
104. Kroesen S., Itin P.H., Hasler P. Arthritis and interstitial granulomatous dermatitis (Ackerman syndrome) with pulmonary silicosis. Semin Arthritis Rheum 2003, 32:334-340.
105. Moreno C., Kutzner H., Palmedo G., et al. Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. JAm Acad Dermatol 2003, 48:376-384.
106. Fujita Y., Shimizu T., Shimizu H. Acase of interstitial granulomatous drug reaction due to sennoside. Br J Dermatol 2004, 150:1035-1037.
107. Hernandez N., Peñate Y., Borrego L. Generalized erythematous-violaceous plaques in a patient with a history of dyslipidemia. Int J Dermatol 2013, 52:393-394.
108. Martinez-Moran C., Nájera L., Ruiz-Casado A.I., et al. Interstitial granulomatous drug reaction to sorafenib. Arch Dermatol 2011, 147:1118-1119.
109. Regula C.G., Hennessy J., Clarke L.E., et al. Interstitial granulomatous drug reaction to anakinra. JAm Acad Dermatol 2008, 59:S25-S27.
110. Martorell-Calatayud A., Balmer N., Cardona L.F., et al. Interstitial granulomatous drug reaction to adalimumab. Am J Dermatopathol 2010, 32:408-409.
111. Atzori L., Luca P., Pinna A.L. Interstitial granulomatous drug reaction due to febuxostat. Indian J Dermatol Venereol Leprol 2014, 80:182-184.
112. Groves C., McMenamin M.E., Casey M., et al. Interstitial granulomatous reaction to strontium ranelate. Arch Dermatol 2008, 144:268-269.