Associations of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D with Bone Mineral Density, Bone Mineral Density Change, and Incident Nonvertebral Fracture

Journal of Bone and Mineral Research

Volumn 30, Issue 8, 2015, Pages 1403-1413

  Swanson, Christine M ^a,b   Srikanth, Priya ^b   Lee, Christine G ^a,b,c   Cummings, Steven R ^d   Jans, Ivo ^e   Cauley, Jane A ^f   Bouillon, Roger ^e   Vanderschueren, Dirk ^e   Orwoll, Eric S ^a,b   Nielson, Carrie M ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

^d California Pacific Medical Research Institute   (United States)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

1,25 DIHYDROXYVITAMIN D; 25 HYDROXYVITAMIN D; BONE MINERAL DENSITY (BMD); CALCITRIOL; FRACTURE

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; VITAMIN D; 1,25-DIHYDROXYVITAMIN D; 25-HYDROXYVITAMIN D;

AGED; ARTICLE; BONE DENSITY; BONE TURNOVER; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OSTEOLYSIS; RISK FACTOR; ANALOGS AND DERIVATIVES; BLOOD; CLINICAL TRIAL; DIAGNOSTIC IMAGING; FOLLOW UP; HIP FRACTURES; MULTICENTER STUDY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BONE DENSITY; FOLLOW-UP STUDIES; HIP FRACTURES; HUMANS; INCIDENCE; MALE; RADIOGRAPHY; RISK FACTORS; VITAMIN D;

EID: 84937163488     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2487     Document Type: Article

References (45)

1. Ensrud KE, Taylor BC, Paudel ML, et al., Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men. J Clin Endocrinol Metab. 2009; 94 (8): 2773-80.
2. Stone K, Bauer DC, Black DM, Sklarin P, Ensrud KE, Cummings SR., Hormonal predictors of bone loss in elderly women: a prospective study. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res. 1998; 13 (7): 1167-74.
3. Holick MF., Vitamin D deficiency. N Engl J Med. 2007; 357 (3): 266-81.
4. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, et al., Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. 2009; 339: b 3692.
5. Looker AC., Serum 25-hydroxyvitamin D and risk of major osteoporotic fractures in older U.S. adults. J Bone Miner Res. 2013; 28 (5): 997-1006.
6. Cauley JA, Parimi N, Ensrud KE, et al., Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res. 2010; 25 (3): 545-53.
7. Fujiyoshi A, Polgreen LE, Hurley DL, Gross MD, Sidney S, Jacobs DR Jr. A cross-sectional association between bone mineral density and parathyroid hormone and other biomarkers in community-dwelling young adults: the CARDIA study. J Clin Endocrinol Metab. 2013; 98 (10): 4038-46.
8. Vanderschueren D, Pye SR, O'Neill TW, et al., Active vitamin D (1,25-dihydroxyvitamin D) and bone health in middle-aged and elderly men: the European Male Aging Study (EMAS). J Clin Endocrinol Metab. 2013; 98 (3): 995-1005.
9. Lips P, van Ginkel FC, Jongen MJ, Rubertus F, van der Vijgh WJ, Netelenbos JC., Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr. 1987; 46 (6): 1005-10.
10. Cummings SR, Browner WS, Bauer D, et al., Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1998; 339 (11): 733-8.
11. Casetta B, Jans I, Billen J, Vanderschueren D, Bouillon R., Development of a method for the quantification of 1alpha,25(OH) 2-vitamin D3 in serum by liquid chromatography tandem mass spectrometry without derivatization. Eur J Mass Spectrom (Chichester, Eng). 2010; 16 (1): 81-9.
12. Blank JB, Cawthon PM, Carrion-Petersen ML, et al., Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials. 2005; 26 (5): 557-68.
13. Orwoll E, Blank JB, Barrett-Connor E, et al., Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study-a large observational study of the determinants of fracture in older men. Contemp Clin Trials. 2005; 26 (5): 569-85.
14. Orwoll E, Nielson CM, Marshall LM, et al., Vitamin D deficiency in older men. J Clin Endocrinol Metab. 2009; 94 (4): 1214-22.
15. Swanson CM, Nielson CM, Shrestha S, et al., Higher 25(OH)D2 is associated with lower 25(OH)D3 and 1,25(OH) 2D3. J Clin Endocrinol Metab. 2014; 99 (8): 2736-44.
16. Bauer DC, Garnero P, Harrison SL, et al., Biochemical markers of bone turnover, hip bone loss, and fracture in older men: the MrOS study. J Bone Miner Res. 2009; 24 (12): 2032-8.
17. Lhoste Y, Garnero P., Validation report for the measurements of degradation products of C-terminal telopeptides of type I collage in human urine (U-Alpha-CTX-I) (ALPHA CrossLaps, Nordic Bioscience Diagnostics). Synarc, 2007.
18. Garnero P, Lhoste Y., Validation report for the measurements of type I collagen peptide in urine sample (U-CTX-I Elecsys) (Beta CrossLaps, ELECSYS 2010 System, Roche Diagnostics). Synarc, 2005.
19. Boudou P, Ibrahim F, Cormier C, Chabas A, Sarfati E, Souberbielle JC., Third- or second-generation parathyroid hormone assays: a remaining debate in the diagnosis of primary hyperparathyroidism. J Clin Endocrinol Metab. 2005; 90 (12): 6370-2.
20. Curtis JR, Ewing SK, Bauer DC, et al., Association of intact parathyroid hormone levels with subsequent hip BMD loss: the Osteoporotic Fractures in Men (MrOS) Study. J Clin Endocrinol Metab. 2012; 97 (6): 1937-44.
21. Lane NE, Parimi N, Corr M, et al., Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res. 2013; 28 (11): 2325-32.
22. Shin MH, Zmuda JM, Barrett-Connor E, et al., Race/ethnic differences in associations between bone mineral density and fracture history in older men. Osteoporos Int. 2014; 25 (3): 837-45.
23. Cummings SR, Bates D, Black DM., Clinical use of bone densitometry: scientific review. JAMA 288 (15): 1889-97.
24. Lewis CE, Ewing SK, Taylor BC, et al., Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res. 2007; 22 (2): 211-9.
25. Parsons JK, Mougey J, Lambert L, et al., Lower urinary tract symptoms increase the risk of falls in older men. BJU Int. 2009; 104 (1): 63-8.
26. Block G, Hartman AM, Naughton D., A reduced dietary questionnaire: development and validation. Epidemiology. 1990; 1 (1): 58-64.
27. Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin P., Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol. 1994; 10 (4): 405-11.
28. Shannon J, Shikany JM, Barrett-Connor E, et al., Demographic factors associated with the diet quality of older US men: baseline data from the Osteoporotic Fractures in Men (MrOS) study. Public Health Nutr. 2007; 10 (8): 810-8.
29. Washburn RA, Smith KW, Jette AM, Janney CA., The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993; 46 (2): 153-62.
30. Levey AS, Coresh J, Greene T, et al., Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem. 2007; 53 (4): 766-72.
31. Daniels NA, Nielson CM, Hoffman AR, Bauer DC, Osteoporotic Fractures in Men Study. Sex hormones and the risk of incident prostate cancer. Urology. 2010; 76 (5): 1034-40.
32. Melton LJ 3rd, Khosla S, Atkinson EJ, O'Fallon WM, Riggs BL. Relationship of bone turnover to bone density and fractures. J Bone Miner Res. 1997; 12 (7): 1083-91.
33. Bauer DC, Sklarin PM, Stone KL, et al., Biochemical markers of bone turnover and prediction of hip bone loss in older women: the study of osteoporotic fractures. J Bone Miner Res. 1999; 14 (8): 1404-10.
34. Mirza MA, Karlsson MK, Mellstrom D, et al., Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men. J Bone Miner Res. 2011; 26 (4): 857-64.
35. Jovanovich A, Buzkova P, Chonchol M, et al., Fibroblast growth factor 23, bone mineral density, and risk of hip fracture among older adults: the cardiovascular health study. J Clin Endocrinol Metab. 2013; 98 (8): 3323-31.
36. Ceglia L, Simpson RU,. Vitamin D and skeletal muscle function. In:, Feldman D, Pike JW, Adams JS, editors. Vitamin D. 3rd ed. San Diego, CA: Academic Press/Elsevier; 2011.
37. Simpson RU, Thomas GA, Arnold AJ., Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem. 1985; 260 (15): 8882-91.
38. Bischoff HA, Borchers M, Gudat F, et al., In situ detection of 1, 25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001; 33 (1): 19-24.
39. Wang Y, DeLuca HF., Is the vitamin D receptor found in muscle? Endocrinology. 2011; 152 (2): 354-63.
40. Girgis CM, Mokbel N, Minn Cha K, et al., The Vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology. 2014 en 20141016.
41. Gallagher JC., The effects of calcitriol on falls and fractures and physical performance tests. J Steroid Biochem Mol Biol. 2004; 89-90(1-5): 497-501.
42. Verhaar HJ, Samson MM, Jansen PA, de Vreede PL, Manten JW, Duursma SA., Muscle strength, functional mobility and vitamin D in older women. Aging. 2000; 12 (6): 455-60.
43. Avenell A, Gillespie WJ, Gillespie LD, O'Connell D., Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev. 2009 (2): CD000227.
44. Hannan MT, Gagnon MM, Aneja J, et al., Optimizing the tracking of falls in studies of older participants: comparison of quarterly telephone recall with monthly falls calendars in the MOBILIZE Boston Study. Am J Epidemiol. 2010; 171 (9): 1031-6.
45. Eisman JA, Bouillon R, Vitamin D: direct effects of vitamin D metabolites on bone: lessons from genetically modified mice Bonekey Rep. 2014; 3 499