Stopping superbugs, maintaining the microbiota

Science Translational Medicine

Volumn 7, Issue 295, 2015, Pages

  Nizet, Victor ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ALLERGY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTERIAL CLEARANCE; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; DISEASE ASSOCIATION; DISEASE SURVEILLANCE; DRUG MISUSE; EDITORIAL; HEALTH CARE COST; HIGH RISK PATIENT; HOST PATHOGEN INTERACTION; IMMUNOREGULATION; INFECTION CONTROL; INFECTION RISK; INFLAMMATORY DISEASE; INNATE IMMUNITY; KLEBSIELLA PNEUMONIAE; MICROFLORA; MINIMUM INHIBITORY CONCENTRATION; MYCOSIS; OBESITY; OPPORTUNISTIC INFECTION; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; STAPHYLOCOCCUS AUREUS; UNITED STATES; UROPATHOGENIC ESCHERICHIA COLI; HUMAN;

ANTI-INFECTIVE AGENTS; DRUG RESISTANCE, MICROBIAL; HUMANS; MICROBIOTA; UNITED STATES;

EID: 84937118152     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aab2373     Document Type: Editorial

References (7)

1. Antibiotic Resistance Threats In The United States (2013); available at www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf.
2. National Action Plan For Combating Antibiotic-Resistant Bacteria (2015); available at www.whitehouse.gov/sites/default/files/docs/national-action-plan-for-combating-antibotic-resistant-bacteria.pdf.
3. M. J. Blaser, The microbiome revolution. J. Clin. Invest. 124, 4162-4165 (2014).
4. C. K. Cusumano, J. S. Pinkner, Z. Han, S. E. Greene, B. A. Ford, J. R. Crowley, J. P. Henderson, J. W. Janetka, S. J. Hultgren, Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Sci. Transl. Med. 3, 109ra115 (2011).
5. P. Kyme, N. H. Thoennissen, C. W. Tseng, G. B. Thoennissen, A. J. Wolf, K. Shimada, U. O. Krug, K. Lee, C. Müller-Tidow, W. E. Berdel, W. D. Hardy, A. F. Gombart, H. P. Koefer, G. Y. Liu, C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. J. Clin. Invest. 122, 3316-3329 (2012).
6. L. Lin, P. Nonejuie, J. Munguia, A. Hollands, J. Olson, Q. Dam, M. Kumaraswamy, H. Rivera, R. Corriden, M. Rohde, M. E. Hensler, M. D. Burkart, J. Pogliano, G. Sakoulas, V. Nizet, Azithromycin synergizes with cationic antimicrobial peptides to exert bactericidal and therapeutic activity against highly multidrug-resistant Gram-negative bacterial pathogens. eBiomedicine 10.1016/j.ebiom.2015.05.021 (10 June 2015).
7. A. M. Lesokhin, M. K. Callahan, M. A. Postow, J. D. Wolchok, On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation. Sci. Transl. Med. 7, 280sr1 (2015).