Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009-2013

Journal of Medical Virology

Volumn 87, Issue 9, 2015, Pages 1471-1479

  Huang, Yun ^a   Zhou, Yuanping ^a   Lu, Hong ^a   Yang, Hong ^b   Feng, Qianjin ^c   Dai, Yingchun ^a   Chen, Long ^b   Yu, Shouyi ^a   Yao, Xiangjie ^b   Zhang, Hailong ^b   Jiang, Ming ^b   Wang, Yujie ^a   Han, Ning ^d   Hu, Guifang ^a   He, Yaqing ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Clinical features; Enterovirus; Hand, foot, and mouth disease; Pathogen

Indexed keywords

AGE DISTRIBUTION; ARTICLE; ASEPTIC MENINGITIS; CHILD; CHINA; CLINICAL FEATURE; CONTROLLED STUDY; COXSACKIE VIRUS INFECTION; COXSACKIEVIRUS A10; COXSACKIEVIRUS A16; COXSACKIEVIRUS A6; DISEASE SEVERITY; ENTEROVIRUS; ENTEROVIRUS 71; FATALITY; FEMALE; FEVER; HAND FOOT AND MOUTH DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MYOCLONUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENETIC TREE; SEQUENCE ANALYSIS; SEX RATIO; SORE THROAT; SYMPTOM; VIRUS ENCEPHALITIS; VIRUS STRAIN; VOMITING; CLASSIFICATION; COMPLICATION; DNA SEQUENCE; ENTEROVIRUS A; EPIDEMIC; FECES; HAND, FOOT AND MOUTH DISEASE; INFANT; ISOLATION AND PURIFICATION; MORTALITY; PATHOGENICITY; PHYLOGENY; PRESCHOOL CHILD; SEROTYPE; TIME FACTOR; VIROLOGY;

COXSACKIEVIRUS; ENTEROVIRUS; HUMAN ENTEROVIRUS 71;

CHILD, PRESCHOOL; CHINA; DISEASE OUTBREAKS; ENTEROVIRUS; ENTEROVIRUS A, HUMAN; FECES; FEMALE; HAND, FOOT AND MOUTH DISEASE; HUMANS; INFANT; MALE; PHYLOGENY; SEQUENCE ANALYSIS, DNA; SEROGROUP; TIME FACTORS;

EID: 84937074350     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.24200     Document Type: Article

References (44)

1. Bracho MA, González-Candelas F, Valero A, Córdoba J, Salazar A. 2011. Enterovirus Co-infections and Onychomadesis after Hand, Foot, and Mouth Disease, Spain, 2008. Emerg Infect Dis 17:2223-2231.
2. Brown EG, Chen Y-J, Chang S-C, Tsao K-C, Shih S-R, Yang S-L, Lin T-Y, Huang Y-C. 2012. Comparative genomic analysis of coxsackievirus A6 strains of different clinical disease entities. PLoS ONE 7:e52432.
3. Cardosa MJ, Perera D, Brown BA, Cheon D, Chan HM, Chan KP, Cho H, McMinn P. 2003. Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: Comparative analysis of the VP1 and VP4 genes. Emerg Infect Dis 9:461-468.
4. Chan LG, Parashar UD, Lye MS, Ong FG, Zaki SR, Alexander JP, Ho KK, Han LL, Pallansch MA, Suleiman AB, Jegathesan M, Anderson LJ. 2000. Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: Clinical and pathological characteristics of the disease. For the Outbreak Study Group. Clin Infect Dis 31:678-683.
5. Chan KP, Goh KT, Chong CY, Teo ES, Lau G, Ling AE. 2003. Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. Emerg Infect Dis 9:78-85.
6. Chang LY, Lee CY, Kao CL, Fang TY, Lu CY, Lee PI, Huang LM. 2007. Hand, foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980-1981. J Formos Med Assoc 106:173-176.
7. Chang S-C, Li W-C, Chen G-W, Tsao K-C, Huang C-G, Huang Y-C, Chiu C-H, Kuo C-Y, Tsai K-N, Shih S-R, Lin T-Y. 2012. Genetic characterization of enterovirus 71 isolated from patients with severe disease by comparative analysis of complete genomes. J Med Virol 84:931-939.
8. Chen KT, Chang HL, Wang ST, Cheng YT, Yang JY. 2007a. Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. Pediatrics 120:e244-252.
9. Chen SC, Chang HL, Yan TR, Cheng YT, Chen KT. 2007b. An eight-year study of epidemiologic features of enterovirus 71 infection in Taiwan. Am J Trop Med Hyg 77:188-191.
10. Davia JL, Bel PH, Ninet VZ, Bracho MA, González-Candelas F, Salazar A, Gobernado M, Bosch IF. 2011. Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses. Pediatr Dermatol 28:1-5.
11. Di B, Zhang Y, Xie H, Li X, Chen C, Ding P, He P, Wang D, Geng J, Luo L, Bai Z, Yang Z, Wang M. 2014. Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012. Virol J 11:157.
12. Fujimoto T, Chikahira M, Yoshida S, Ebira H, Hasegawa A, Totsuka A, Nishio O. 2002. Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: Detection and molecular epidemiology of enterovirus 71. Microbiol Immunol 46:621-627.
13. Fujimoto T, Iizuka S, Enomoto M, Abe K, Yamashita K, Hanaoka N, Okabe N, Yoshida H, Yasui Y, Kobayashi M, Fujii Y, Tanaka H, Yamamoto M, Shimizu H. 2012. Hand, foot, and mouth disease caused by coxsackievirus A6, Japan, 2011. Emerg Infect Dis 18:337-339.
14. Han JF, Xu S, Zhang Y, Zhu SY, Wu DL, Yang XD, Liu H, Sun BX, Wu XY, Qin CF. 2014. Hand, foot, and mouth disease outbreak caused by coxsackievirus A6, China, 2013. J Infect 69:303-305.
15. Hayman R, Shepherd M, Tarring C, Best E. 2014. Outbreak of variant hand-foot-and-mouth disease caused by coxsackievirus A6 in Auckland, New Zealand. J Paediatr Child Health 50:751-755.
16. He YQ, Chen L, Xu WB, Yang H, Wang HZ, Zong WP, Xian HX, Chen HL, Yao XJ, Hu ZL, Luo M, Zhang HL, Ma HW, Cheng JQ, Feng QJ, Zhao DJ. 2013. Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6- and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China. J Clin Microbiol 51:3560-3566.
17. Huang WC, Huang LM, Lu CY, Cheng AL, Chang LY. 2013. Atypical hand-foot-mouth disease in children: A hospital-based prospective cohort study. Virol J 10:209.
18. Jee YM, Cheon DS, Kim K, Cho JH, Chung YS, Lee J, Lee SH, Park KS, Lee JH, Kim EC, Chung HJ, Kim DS, Yoon JD, Cho HW. 2003. Genetic analysis of the VP1 region of human enterovirus 71 strains isolated in Korea during 2000. Arch Virol 148:1735-1746.
19. Li W, Yi L, Su J, Lu J, Ke C, Zeng H, Guan D, Ma C, Zhang W, Xiao H, Li H, Lin J, Zhang Y. 2013. Seroprevalence of human enterovirus 71 and coxsackievirus A16 in Guangdong, China, in pre- and post-2010 HFMD epidemic period. PLoS ONE 8:e80515.
20. Lin TY, Hsia SH, Huang YC, Wu CT, Chang LY. 2003. Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system. Clin Infect Dis 36:269-274.
21. Liu CC, Tseng HW, Wang SM, Wang JR, Su IJ. 2000. An outbreak of enterovirus 71 infection in Taiwan, 1998: Epidemiologic and clinical manifestations. J Clin Virol 17:23-30.
22. Lo SH, Huang YC, Huang CG, Tsao KC, Li WC, Hsieh YC, Chiu CH, Lin TY. 2011. Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009. J Microbiol Immunol Infect 44:252-257.
23. Lott JP, Liu K, Landry M-L, Nix WA, Oberste MS, Bolognia J, King B. 2013. Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection. J Am Acad Dermatol 69:736-741.
24. Lu J, Zeng H, Zheng H, Yi L, Guo X, Liu L, Sun L, Tan X, Li H, Ke C, Lin J. 2014. Hand, foot and mouth disease in Guangdong, China, in 2013: New trends in the continuing epidemic. Clin Microbiol Infect 20:O442-445.
25. Ma E, Lam T, Chan KC, Wong C, Chuang SK. 2010. Changing epidemiology of hand, foot, and mouth disease in Hong Kong, 2001-2009. Jpn J Infect Dis 63:422-426.
26. McMinn P, Stratov I, Nagarajan L, Davis S. 2001. Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia. Clin Infect Dis 32:236-242.
27. Mirand A, Henquell C, Archimbaud C, Chambon M, Charbonne F, Peigue-Lafeuille H, Bailly JL. 2008. Prospective identification of enteroviruses involved in meningitis in 2006 through direct genotyping in cerebrospinal fluid J Clin Microbiol 46:87-96.
28. Mirand A, Schuffenecker I, Henquell C, Billaud G, Jugie G, Falcon D, Mahul A, Archimbaud C, Terletskaia-Ladwig E, Diedrich S, Huemer HP, Enders M, Lina B, Peigue-Lafeuille H, Bailly JL. 2010. Phylogenetic evidence for a recent spread of two populations of human enterovirus 71 in European countries. J Gen Virol 91:2263-2277.
29. Mirand A, Henquell C, Archimbaud C, Ughetto S, Antona D, Bailly JL, Peigue-Lafeuille H. 2012. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: A large citywide, prospective observational study. Clin Microbiol Infect 18:E110-E118.
30. Mou J, Dawes M, Li Y, He Y, Ma H, Xie X, Griffiths S, Cheng J. 2013. Severe hand, foot and mouth disease in Shenzhen, South China: What matters most? Epidemiol Infect 142:776-788.
31. Mou J, Dawes M, Li Y, He Y, Ma H, Xie X, Griffiths S, Cheng J. 2014. Severe hand, foot and mouth disease in Shenzhen, South China: What matters most? Epidemiol Infect 142:776-788.
32. Nix WA, Oberste MS, Pallansch MA. 2006. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol 44:2698-2704.
33. Ortner B, Huang C-W, Schmid D, Mutz I, Wewalka G, Allerberger F, Yang J-Y, Huemer HP. 2009. Epidemiology of enterovirus types causing neurological disease in Austria 1999-2007: Detection of clusters of echovirus 30 and enterovirus 71 and analysis of prevalent genotypes. J Med Virol 81:317-324.
34. Österback R, Vuorinen T, Linna M, Susi P, Hyypiä T, Waris M. 2009. Coxsackievirus A6 and Hand, Foot, and Mouth Disease, Finland. Emerg Infect Dis 15:1485-1488.
35. Pyrc K, Wang X, Zhu C, Bao W, Zhao K, Niu J, Yu X-F, Zhang W. 2012. Characterization of full-length enterovirus 71 strains from severe and mild disease patients in northeastern China. PLoS ONE 7:e32405.
36. Sinclair C, Gaunt E, Simmonds P, Broomfield D, Nwafor N, Wellington L, Templeton K, Willocks L, Schofield O, Harvala H. 2014. Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014. Euro Surveill 19:20745.
37. Tu PV, Thao NT, Perera D, Huu TK, Tien NT, Thuong TC, How OM, Cardosa MJ, McMinn PC. 2007. Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005. Emerg Infect Dis 13:1733-1741.
38. Wei S-H, Huang Y-P, Liu M-C, Tsou T-P, Lin H-C, Lin T-L, Tsai C-Y, Chao Y-N, Chang L-Y, Hsu C-M. 2011. An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010. BMC Infect Dis 11:346.
39. Weng K-F, Chen L-L, Huang P-N, Shih S-R. 2010. Neural pathogenesis of enterovirus 71 infection. Microbes Infect 12:505-510.
40. Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, Quak SH, Chow VTK. 2010. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: The role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis 14:e1076-e1081.
41. Xu W, Liu C-f, Yan L, Li J-j, Wang L-j, Qi Y, Cheng R-b, Xiong X-y. 2012. Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications Virol J 9:8.
42. Yang F, Ren L, Xiong Z, Li J, Xiao Y, Zhao R, He Y, Bu G, Zhou S, Wang J, Qi J. 2009. Enterovirus 71 outbreak in the People's Republic of China in 2008. J Clin Microbiol 47:2351-2352.
43. Zhang Y, Tan XJ, Wang HY, Yan DM, Zhu SL, Wang DY, Ji F, Wang XJ, Gao YJ, Chen L, An HQ, Li DX, Wang SW, Xu AQ, Wang ZJ, Xu WB. 2009. An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol 44:262-267.
44. Zhang J, Sun J, Chang Z, Zhang W, Wang Z, Feng Z. 2011. Characterization of hand, foot, and mouth disease in China between 2008 and 2009. Biomed Environ Sci 24:214-221.