메뉴 건너뛰기




Volumn 35, Issue 4, 2015, Pages 406-410

Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Author keywords

BDNF; cortisol; curcumin; depression; IL 1 ; TNF

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CURCUMIN; DEMETHOXYCURCUMIN; HYDROCORTISONE; INTERLEUKIN 1BETA; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CITALOPRAM;

EID: 84936952467     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0000000000000352     Document Type: Article
Times cited : (111)

References (47)
  • 1
    • 0037831023 scopus 로고    scopus 로고
    • The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R)
    • Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289:3095-3105.
    • (2003) JAMA , vol.289 , pp. 3095-3105
    • Kessler, R.C.1    Berglund, P.2    Demler, O.3
  • 2
    • 33644901007 scopus 로고    scopus 로고
    • Multiple biological activities of curcumin: A short review
    • Maheshwari RK, Singh AK, Gaddipati J, et al.Multiple biological activities of curcumin: a short review. Life Sci. 2006;78:2081-2087.
    • (2006) Life Sci , vol.78 , pp. 2081-2087
    • Maheshwari, R.K.1    Singh, A.K.2    Gaddipati, J.3
  • 3
    • 0015785965 scopus 로고
    • Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent
    • Srimal RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol. 1973;25: 447-452.
    • (1973) J Pharm Pharmacol , vol.25 , pp. 447-452
    • Srimal, R.C.1    Dhawan, B.N.2
  • 4
    • 0032902307 scopus 로고    scopus 로고
    • Chemical studies on antioxidant mechanism of curcuminoid: Analysis of radical reaction products from curcumin
    • Masuda T, Hidaka K, Shinohara A, et al. Chemical studies on antioxidant mechanism of curcuminoid: analysis of radical reaction products from curcumin. J Agric Food Chem. 1999;47:71-77.
    • (1999) J Agric Food Chem , vol.47 , pp. 71-77
    • Masuda, T.1    Hidaka, K.2    Shinohara, A.3
  • 5
    • 36549008159 scopus 로고    scopus 로고
    • The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors
    • Wang R, Xu Y, Wu HL, et al. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur J Pharmacol. 2008;578:43-50.
    • (2008) Eur J Pharmacol , vol.578 , pp. 43-50
    • Wang, R.1    Xu, Y.2    Wu, H.L.3
  • 6
    • 22044438403 scopus 로고    scopus 로고
    • The effects of curcumin on depressive-like behaviors in mice
    • Xu Y, Ku BS, Yao HY, et al. The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol. 2005;518:40-46.
    • (2005) Eur J Pharmacol , vol.518 , pp. 40-46
    • Xu, Y.1    Ku, B.S.2    Yao, H.Y.3
  • 7
    • 0035141691 scopus 로고    scopus 로고
    • The use of complementary and alternative therapies to treat anxiety and depression in the United States
    • Kessler RC, Soukup J, Davis RB, et al. The use of complementary and alternative therapies to treat anxiety and depression in the United States. Am J Psychiatry. 2001;158:289-294.
    • (2001) Am J Psychiatry , vol.158 , pp. 289-294
    • Kessler, R.C.1    Soukup, J.2    Davis, R.B.3
  • 8
    • 0025986164 scopus 로고
    • Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder
    • Yehuda R,Giller EL, Southwick SM, et al. Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder. Biol Psychiatry. 1991;30: 1031-1048.
    • (1991) Biol Psychiatry , vol.30 , pp. 1031-1048
    • Yehuda, R.1    Giller, E.L.2    Southwick, S.M.3
  • 9
    • 65549163426 scopus 로고    scopus 로고
    • Salivary cortisol, serum lipids, and adiposity in patients with depressive and anxiety disorders
    • Veen G, Giltay EJ, DeRijk RH, et al. Salivary cortisol, serum lipids, and adiposity in patients with depressive and anxiety disorders. Metabolism. 2009;58:821-827.
    • (2009) Metabolism , vol.58 , pp. 821-827
    • Veen, G.1    Giltay, E.J.2    Derijk, R.H.3
  • 10
    • 33750718770 scopus 로고    scopus 로고
    • Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB
    • Xu Y, Ku B, Tie L, et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res. 2006;1122:56-64.
    • (2006) Brain Res , vol.1122 , pp. 56-64
    • Xu, Y.1    Ku, B.2    Tie, L.3
  • 12
    • 33745208951 scopus 로고    scopus 로고
    • A neurotrophic model for stress-related mood disorders
    • Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 2006;59:1116-1127.
    • (2006) Biol Psychiatry , vol.59 , pp. 1116-1127
    • Duman, R.S.1    Monteggia, L.M.2
  • 13
    • 79952899810 scopus 로고    scopus 로고
    • Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats
    • Huang Z, ZhongXM, LiZY, et al. Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neurosci Lett. 2011;493:145-148.
    • (2011) Neurosci Lett , vol.493 , pp. 145-148
    • Huang, Z.1    Zhong, X.M.2    Li, Z.Y.3
  • 14
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression
    • Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65:732-741.
    • (2009) Biol Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 15
    • 28544432213 scopus 로고    scopus 로고
    • Hostilemarital interactions, proinflammatory cytokine production, and wound healing
    • Kiecolt-Glaser JK, Loving TJ, Stowell JR, et al. Hostilemarital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatry. 2005;62:1377-1384.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 1377-1384
    • Kiecolt-Glaser, J.K.1    Loving, T.J.2    Stowell, J.R.3
  • 16
    • 0035161111 scopus 로고    scopus 로고
    • The relationship of depression and stressors to immunological assays: A meta-analytic review
    • Zorrilla EP, Luborsky L, McKay JR, et al. The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain Behav Immun. 2001;15:199-226.
    • (2001) Brain Behav Immun , vol.15 , pp. 199-226
    • Zorrilla, E.P.1    Luborsky, L.2    McKay, J.R.3
  • 17
    • 80054745701 scopus 로고    scopus 로고
    • The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: A meta-analysis
    • Hannestad J, DellaGioia N, Bloch M. The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology. 2011;36:2452-2459.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2452-2459
    • Hannestad, J.1    Dellagioia, N.2    Bloch, M.3
  • 18
    • 84874784858 scopus 로고    scopus 로고
    • Curcumin attenuates diabetic neuropathic pain by downregulating TNF-alpha in a rat model
    • Li Y, Zhang Y, Liu DB, et al. Curcumin attenuates diabetic neuropathic pain by downregulating TNF-alpha in a rat model. Int J Med Sci. 2013;10:377-381.
    • (2013) Int J Med Sci , vol.10 , pp. 377-381
    • Li, Y.1    Zhang, Y.2    Liu, D.B.3
  • 19
    • 84876265971 scopus 로고    scopus 로고
    • Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression
    • Rinwa P, Kumar A, Garg S. Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression. PLoS One. 2013;8:e61052.
    • (2013) PLoS One , vol.8 , pp. e61052
    • Rinwa, P.1    Kumar, A.2    Garg, S.3
  • 21
    • 84898004438 scopus 로고    scopus 로고
    • Efficacy and safety of curcumin in major depressive disorder: A randomized controlled trial
    • Sanmukhani J, Satodia V, Trivedi J, et al. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res. 2014;28:579-585.
    • (2014) Phytother Res , vol.28 , pp. 579-585
    • Sanmukhani, J.1    Satodia, V.2    Trivedi, J.3
  • 22
    • 33747204323 scopus 로고    scopus 로고
    • Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients
    • Palomino A, Vallejo-Illarramendi A, Gonzalez-Pinto A, et al. Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients. Schizophr Res. 2006;86:321-322.
    • (2006) Schizophr Res , vol.86 , pp. 321-322
    • Palomino, A.1    Vallejo-Illarramendi, A.2    Gonzalez-Pinto, A.3
  • 23
    • 84872145819 scopus 로고    scopus 로고
    • Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
    • Ruiz de Azua S, Matute C, Stertz L, et al. Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis. BMC Psychiatry. 2013;13:27.
    • (2013) BMC Psychiatry , vol.13 , pp. 27
    • Ruiz De Azua, S.1    Matute, C.2    Stertz, L.3
  • 24
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
    • Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J Biol Chem. 1995;270:24995-25000.
    • (1995) J Biol Chem , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 25
    • 79954598830 scopus 로고    scopus 로고
    • Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    • MaesM.Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:664-675.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 664-675
    • Maes, M.1
  • 26
    • 84884169056 scopus 로고    scopus 로고
    • The role of inflammatory cytokines on the aetiopathogenesis of depression
    • Makhija K, Karunakaran S. The role of inflammatory cytokines on the aetiopathogenesis of depression. Aust N Z J Psychiatry. 2013;47:828-839.
    • (2013) Aust N Z J Psychiatry , vol.47 , pp. 828-839
    • Makhija, K.1    Karunakaran, S.2
  • 27
    • 4444256765 scopus 로고    scopus 로고
    • Cytokines: Abnormalities in major depression and implications for pharmacological treatment
    • O'Brien SM, Scott LV, Dinan TG. Cytokines: abnormalities in major depression and implications for pharmacological treatment. Hum Psychopharmacol. 2004;19:397-403.
    • (2004) Hum Psychopharmacol , vol.19 , pp. 397-403
    • O'Brien, S.M.1    Scott, L.V.2    Dinan, T.G.3
  • 28
    • 75849155537 scopus 로고    scopus 로고
    • A meta-analysis of cytokines in major depression
    • Dowlati Y, Herrmann N, SwardfagerW, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67:446-457.
    • (2010) Biol Psychiatry , vol.67 , pp. 446-457
    • Dowlati, Y.1    Herrmann, N.2    Swardfager, W.3
  • 29
    • 49949097651 scopus 로고    scopus 로고
    • Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits
    • Huang WT, Niu KC, Chang CK, et al. Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits. Eur J Pharmacol. 2008;593:105-111.
    • (2008) Eur J Pharmacol , vol.593 , pp. 105-111
    • Huang, W.T.1    Niu, K.C.2    Chang, C.K.3
  • 30
    • 79952253826 scopus 로고    scopus 로고
    • Efficacy and safety ofMeriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients
    • Belcaro G, CesaroneMR, DugallM, et al. Efficacy and safety ofMeriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010;15:337-344.
    • (2010) Altern Med Rev , vol.15 , pp. 337-344
    • Belcaro, G.1    Cesarone, M.R.2    Dugall, M.3
  • 31
    • 46349109182 scopus 로고    scopus 로고
    • Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: A randomized, parallel-group, placebo-controlled, 8-week study
    • Usharani P, Mateen AA, Naidu MU, et al. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D. 2008;9:243-250.
    • (2008) Drugs R D , vol.9 , pp. 243-250
    • Usharani, P.1    Mateen, A.A.2    Naidu, M.U.3
  • 32
    • 0034589368 scopus 로고    scopus 로고
    • Histopathology of the prefrontal cortex in major depression: What does it tell us about dysfunctional monoaminergic circuits?
    • Rajkowska G. Histopathology of the prefrontal cortex in major depression: what does it tell us about dysfunctional monoaminergic circuits? Prog Brain Res. 2000;126:397-412.
    • (2000) Brain Res , vol.126 , pp. 397-412
    • Rajkowska, G.1
  • 33
    • 0035016906 scopus 로고    scopus 로고
    • Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
    • Cotter D, Mackay D, Landau S, et al. Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry. 2001;58:545-553.
    • (2001) Arch Gen Psychiatry , vol.58 , pp. 545-553
    • Cotter, D.1    Mackay, D.2    Landau, S.3
  • 34
    • 33646832026 scopus 로고    scopus 로고
    • An update on regional brain volume differences associated with mood disorders
    • Campbell S,MacQueen G.An update on regional brain volume differences associated with mood disorders. Curr Opin Psychiatry. 2006;19:25-33
    • (2006) Curr Opin Psychiatry , vol.19 , pp. 25-33
    • Campbell, S.1    Macqueen, G.2
  • 35
    • 84886508006 scopus 로고    scopus 로고
    • Neurobiology of major depressive disorder
    • Villanueva R. Neurobiology of major depressive disorder. Neural Plast. 2013;2013:873278.
    • (2013) Neural Plast , vol.2013 , pp. 873278
    • Villanueva, R.1
  • 36
    • 83755187878 scopus 로고    scopus 로고
    • Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide
    • Park SE, Lawson M, Dantzer R, et al. Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide. J Neuroinflammation. 2011;8:179.
    • (2011) J Neuroinflammation , vol.8 , pp. 179
    • Park, S.E.1    Lawson, M.2    Dantzer, R.3
  • 37
    • 0028970281 scopus 로고
    • Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
    • Smith MA, Makino S, Kvetnansky R, et al. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 1995;15: 1768-1777.
    • (1995) J Neurosci , vol.15 , pp. 1768-1777
    • Smith, M.A.1    Makino, S.2    Kvetnansky, R.3
  • 39
    • 77955051986 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects
    • Pandey GN, Dwivedi Y, Rizavi HS, et al. Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:645-651.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry , vol.34 , pp. 645-651
    • Pandey, G.N.1    Dwivedi, Y.2    Rizavi, H.S.3
  • 40
    • 0029992189 scopus 로고    scopus 로고
    • Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
    • Nibuya M, Nestler EJ, Duman RS. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci. 1996;16:2365-2372.
    • (1996) J Neurosci , vol.16 , pp. 2365-2372
    • Nibuya, M.1    Nestler, E.J.2    Duman, R.S.3
  • 41
    • 40149097433 scopus 로고    scopus 로고
    • Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy
    • Adachi M, Barrot M, Autry AE, et al. Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry. 2008;63:642-649.
    • (2008) Biol Psychiatry , vol.63 , pp. 642-649
    • Adachi, M.1    Barrot, M.2    Autry, A.E.3
  • 42
    • 50549092885 scopus 로고    scopus 로고
    • The HPA axis in major depression: Classical theories and new developments
    • Pariante CM, Lightman SL. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 2008;31:464-468.
    • (2008) Trends Neurosci , vol.31 , pp. 464-468
    • Pariante, C.M.1    Lightman, S.L.2
  • 43
    • 0036212671 scopus 로고    scopus 로고
    • Organization of the stress system and its dysregulation in melancholic and atypical depression: High vs low CRH/NE States
    • Gold PW, Chrousos GP. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE States. Mol Psychiatry. 2002;7:254-275.
    • (2002) Mol Psychiatry , vol.7 , pp. 254-275
    • Gold, P.W.1    Chrousos, G.P.2
  • 44
    • 0037225061 scopus 로고    scopus 로고
    • Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: The Harvard Study of Moods and Cycles
    • Harlow BL, Wise LA, Otto MW, et al. Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: the Harvard Study of Moods and Cycles. Arch Gen Psychiatry. 2003;60:29-36.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 29-36
    • Harlow, B.L.1    Wise, L.A.2    Otto, M.W.3
  • 45
    • 62849090443 scopus 로고    scopus 로고
    • Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats
    • Li YC, Wang FM, Pan Y, et al. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:435-449.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 435-449
    • Li, Y.C.1    Wang, F.M.2    Pan, Y.3
  • 46
    • 40849118407 scopus 로고    scopus 로고
    • Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase
    • Kumamaru E, Numakawa T, Adachi N, et al. Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol. 2008;22:546-558.
    • (2008) Mol Endocrinol , vol.22 , pp. 546-558
    • Kumamaru, E.1    Numakawa, T.2    Adachi, N.3
  • 47
    • 84872225618 scopus 로고    scopus 로고
    • Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
    • Volak LP, Hanley MJ, Masse G, et al. Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. Br J Clin Pharmacol. 2013;75:450-462.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 450-462
    • Volak, L.P.1    Hanley, M.J.2    Masse, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.