Diagnostic usefulness of cytomegalovirus (CMV)- specific T cell immunity in predicting CMV infection after kidney transplantation: A pilot proof-of-concept study

Infection and Chemotherapy

Volumn 47, Issue 2, 2015, Pages 105-110

  Kim, Sung Han ^a   Lee, Hyun Jeong ^a   Kim, Sun Mi ^a   Jung, Joo Hee ^a   Shin, Sung ^a   Kim, Young Hoon ^a   Sung, Hungseop ^a   Lee, Sang Oh ^a   Choi, Sang Ho ^a   Kim, Yang Soo ^a   Woo, Jun Hee ^a   Han, Duck Jong ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Cytomegalovirus; Enzyme linked immunospot assay; Kidney transplantation

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; GANCICLOVIR; IMMUNOGLOBULIN G; VIRUS ANTIGEN;

ADULT; ARTICLE; CELLULAR IMMUNITY; CMV ANTIGENEMIA ASSAY; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GRAFT RECIPIENT; HOSPITAL ADMISSION; HUMAN; IMMUNOASSAY; KIDNEY TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SURGICAL RISK; VIRUS STRAIN;

EID: 84936932837     PISSN: 20932340     EISSN: 20926448     Source Type: Journal    
DOI: 10.3947/ic.2015.47.2.105     Document Type: Article

References (14)

1. Razonable RR, Humar A: AST Infectious Diseases Community of Practice. Cytomegalovirus in solid organ transplantation. Am J Transplant 2013;13 (Suppl 4):93-106.
2. Bestard O, Lucia M, Crespo E, Van Liempt B, Palacio D, Melilli E, Torras J, Llaudó I, Cerezo G, Taco O, Gil-Vernet S, Grinyó JM, Cruzado JM. PRetransplant immediately early-1-specific T cell responses provide protection for CMV infection after kidney transplantation. Am J Transplant 2013;13:1793-805.
3. Hahn JS, Lee SJ, Park WK, Ko YW, Kim HO, Lee SY. A survey on the cytomegalovirus antibodies in blood donors and the diseased. Korean J Blood Transfus 1990;1:21-34.
4. Mori T, Okamoto S, Matsuoka S, Yajima T, Wakui M, Watanabe R, Ishida A, Iwao Y, Mukai M, Hibi T, Ikeda Y. Risk-adapted pre-emptive therapy for cytomegalovirus disease in patients undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant 2000;25:765-9.
5. Jang EY, Park SY, Lee EJ, Song EH, Chong YP, Lee SO, Choi SH, Woo JH, Kim YS, Kim SH. Diagnostic performance of the cytomegalovirus (CMV) antigenemia assay in patients with CMV gastrointestinal disease. Clin Infect Dis 2009;48:e121-4.
6. Moon SM, Sung H, Kim MN, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH. Diagnostic yield of the cytomegalovirus (CMV) antigenemia assay and clinical features in solid organ transplant recipients and hematopoietic stem cell transplant recipients with CMV pneumonia. Transpl Infect Dis 2012;14:192-7.
7. Kim SH, Cho OH, Park SJ, Lee EM, Kim MN, Lee SO, Choi SH, Kim YS, Woo JH, Lee SA, Kang JK. Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin Infect Dis 2010;50:1349-58.
8. Kumar D, Chernenko S, Moussa G, Cobos I, Manuel O, Preiksaitis J, Venkataraman S, Humar A. Cell-mediated immunity to predict cytomegalovirus disease in high-risk solid organ transplant recipients. Am J Tansplant 2009;9:1214-22.
9. Manuel O, Husain S, Kumar D, Zayas C, Mawhorter S, Levi ME, Kalpoe J, Lisboa L, Ely L, Kaul DR, Schwartz BS, Morris MI, Ison MG, Yen-Lieberman B, Sebastian A, Assi M, Humar A. Assessment of cytomegalovirus-specific cell-mediated immunity for the prediction of cytomegalovirus disease in high-risk solid-organ transplant recipients: a multicenter cohort study. Clin Infect Dis 2013;56:817-24.
10. Bunde T, Kirchner A, Hoffmeister B, Habedank D, Hetzer R, Cherepnev G, Proesch S, Reinke P, Volk HD, Lehmkuhl H, Kern F. Protection from cytomegalovirus after transplantation is correlated with immediate early-1-specific CD8 T cells. J Exp Med 2005;201:1031-6.
11. Malouli D, Hansen SG, Nakayasu ES, Marshall EE, Hughes CM, Ventura AB, Gilbride RM, Lewis MS, Xu G, Kreklywich C, Whizin N, Fischer M, Legasse AW, Viswanathan K, Siess D, Camp DG 2nd, Axthelm MK, Kahl C, DeFilippis VR, Smith RD, Streblow DN, Picker LJ, Früh K. Cytomegalovirus pp65 limits dissemination but is dispensable for presistence. J Clin Invest 2014;124:1928-44.
12. Nickel P, Bold G, Presber F, Biti D, Babel N, Kreutzer S, Pratschke J, Schönemann C, Kern F, Volk HD, Reinke P. High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function. Transpl Immunol 2009;20:238-42.
13. Egli A, Binet I, Binggeli S, Jäger C, Dumoulin A, Schaub S, Steiger J, Sester U, Sester M, Hirsch HH. Cytomegalovirus-specific T-cell responses and viral replication in kindey transplant recipients. J Transl Med 2008;6:29.
14. Pipeling MR, John ER, Orens JB, Lechtzin N, McDyer JF. Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients. J Infect Dis 2011;204:1663-71.