Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 94, Issue , 2015, Pages 427-435

  Soema, Peter C ^a   Willems, Geert Jan ^a   Jiskoot, Wim ^b   Amorij, Jean Pierre ^a   Kersten, Gideon F ^a,b  

^a Institute for Translational Vaccinology (Intravacc)   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Cationic lipids; Dendritic cells; Design of experiments; Liposomes; Maturation markers; Prediction models

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; 3BETA [N (N',N' DIMETHYLAMINOETHANE)CARBAMOYL]CHOLESTEROL; B7 ANTIGEN; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; DIOLEOYLPHOSPHATIDYLCHOLINE; EGG PHOSPHATIDYLCHOLINE; LIPOSOME; UNCLASSIFIED DRUG; DRUG CARRIER; IMMUNOLOGICAL ADJUVANT; LEUKOCYTE ANTIGEN; LIPID; VACCINE;

ARTICLE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DESIGN OF EXPERIMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; LASER DOPPLER FLOWMETRY; LIGHT SCATTERING; LIPID COMPOSITION; LIPOSOMAL DELIVERY; LIPOSOME SIZE; PARTICLE SIZE; PREDICTION; STATISTICAL ANALYSIS; SURFACE CHARGE; ZETA POTENTIAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; METHODOLOGY; PROGNOSIS; REGRESSION ANALYSIS; SURFACE PROPERTY;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, CD; CELLS, CULTURED; DENDRITIC CELLS; DRUG CARRIERS; HUMANS; LIPIDS; LIPOSOMES; MODELS, IMMUNOLOGICAL; PARTICLE SIZE; PROGNOSIS; REGRESSION ANALYSIS; RESEARCH DESIGN; SURFACE PROPERTIES; VACCINES;

EID: 84936858341     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.06.026     Document Type: Article

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