New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome

Human molecular genetics

Volumn 23, Issue 24, 2014, Pages 6553-6566

  Inoue, Shin Ichi ^a   Moriya, Mitsuji ^a   Watanabe, Yusuke ^a   Miyagawa Tomita, Sachiko ^a   Niihori, Tetsuya ^a   Oba, Daiju ^a   Ono, Masao ^a   Kure, Shigeo ^b   Ogura, Toshihiko ^a   Matsubara, Yoichi ^a   Aoki, Yoko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BENZAMIDE DERIVATIVE; BENZAZEPINE DERIVATIVE; BRAF PROTEIN, MOUSE; DIPHENYLAMINE; GSK-J4; HISTONE DEACETYLASE INHIBITOR; HISTONE DEMETHYLASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; CONGENITAL MALFORMATION; DISEASE MODEL; DRUG EFFECTS; DRUG POTENTIATION; ECTODERMAL DYSPLASIA; FACIES; FAILURE TO THRIVE; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; HEART DEFECTS, CONGENITAL; HEART MUSCLE; HUMAN; LETHAL GENE; LIVER; MALE; METABOLISM; MOUSE; MUTATION; PATHOLOGY; SIGNAL TRANSDUCTION; SKULL; TRANSGENIC MOUSE;

ANIMALS; BENZAMIDES; BENZAZEPINES; DIPHENYLAMINE; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; ECTODERMAL DYSPLASIA; EMBRYO, MAMMALIAN; FACIES; FAILURE TO THRIVE; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; GENES, LETHAL; HEART DEFECTS, CONGENITAL; HISTONE DEACETYLASE INHIBITORS; HISTONE DEMETHYLASES; HUMANS; LIVER; MALE; MAP KINASE KINASE KINASES; MICE; MICE, TRANSGENIC; MUTATION; MYOCARDIUM; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRIMIDINES; SIGNAL TRANSDUCTION; SKULL;

EID: 84936805454     PISSN: None     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu376     Document Type: Article

References (0)