Perfusion computed tomography to assist decision making for stroke thrombolysis

Brain

Volumn 138, Issue 7, 2015, Pages 1919-1931

  Bivard, Andrew ^a   Levi, Christopher ^a   Krishnamurthy, Venkatesh ^a   McElduff, Patrick ^a   Miteff, Ferdi ^a   Spratt, Neil J ^a   Bateman, Grant ^a   Donnan, Geoffrey ^b   Davis, Stephen ^b   Parsons, Mark ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

acute stroke; infarct; perfusion CT; time to treatment

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN HEMATOMA; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; BRAIN SCINTISCANNING; CEREBROVASCULAR ACCIDENT; CLINICAL DECISION MAKING; COHORT ANALYSIS; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; FIBRINOLYTIC THERAPY; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MAJOR CLINICAL STUDY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANKIN SCALE; TIME TO TREATMENT; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE AGED; PROCEDURES; STROKE; VERY ELDERLY;

ADMINISTRATION, INTRAVENOUS; ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84936805142     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv071     Document Type: Article

References (29)

1. Agarwal S, Jones PS, Alawneh JA, Antoun NM, Barry PJ, et al. Does perfusion computed tomography facilitate clinical decision making for thrombolysis in unselected acute patients with suspected ischaemic stroke? Cerebrovasc Dis 2011; 32: 227-33.
2. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (defuse) study. Ann Neurol 2006; 60: 508-17.
3. Bivard A, Levi C, Spratt N, Parsons M. Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra. Radiology 2013; 267: 543-50.
4. Bivard A, McElduff P, Spratt N, Levi C, Parsons M. Defining the extent of irreversible brain ischemia using perfusion computed tomography. Cerebrovasc Dis 2011a; 31: 238-45.
5. Bivard A, Parsons M. ASPECTaSaurus (a dinosaur)? Int J Stroke 2012; 7: 564.
6. Bivard A, Spratt N, Levi CR, Parsons MW. Acute stroke thrombolysis: time to dispense with the clock and move to tissue-based decision making? Expert Rev Cardiovasc Ther 2011b; 9: 451-61.
7. Campbell B, Christensen S, Butcher K, Gordon I, Parsons MW, Desmond PM, et al. Regional very low cerebral blood volume predicts haemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke. Stroke 2010; 41: 82-8.
8. Campbell BC, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, et al. Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core. Stroke 2011; 42: 3435-40.
9. Churilov L, Liu D, Ma H, Christensen S, Nagakane Y, Campbell B, et al. Multiattribute selection of acute stroke imaging software platform for Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND) clinical trial. Int J Stroke 2013; 8: 204-10.
10. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebocontrolled randomised trial. Lancet Neurol 2008; 7: 299-309.
11. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008; 359: 1317-29.
12. Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol 2009; 8: 141-50.
13. Lansberg MG, Straka M, Kemp S, Mlynash M, Wechsler LR, Jovin TG, et al. MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012; 11: 860-7. doi: 10.1016/S1474-4422(12)70203-X
14. LinglongTin L, Bivard A, Parsons M. Perfusion Patterns of Ischemic Stroke on CTP. J Stroke 2013; 15: 164-73.
15. Marion AS, Helen MD, Leonid C, Niaz A, Christopher FB, David S, et al. Thrombolysis for acute stroke in Australia: outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002-2008). Med J 2010; 193: 439-43.
16. Meretoja A, Keshtkaran M, Saver JL, Tatlisumak T, Parsons MW, Kaste M, et al. Stroke Thrombolysis: save a minute, save a day. Stroke 2014; 45: 1053-8.
17. Morris S, Hunter RM, Ramsay A, Boaden R, McKevitt C, et al. Impact of centralising acute stroke services in English metropolitan areas on mortality and length of hospital stay: difference-in-differences analysis. BMJ 2014; 349: g4757.
18. Murphy BD, Fox AJ, Lee DH, Sahlas DJ, Black SE, Hogan MJ, et al. Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements. Stroke 2006; 37: 1771-7.
19. Muir KW, Baird-Gunning J, Walker L, Baird T, McCormick M, Coutts SB. Can the ischemic penumbra be identified on noncontrast CT of acute stroke? Stroke 2007; 38: 2485-90.
20. Ogata T, Christensen S, Nagakane Y, Ma H, Campbell BC, Churilov L, et al. The effects of alteplase 3 to 6 hours after stroke in the EPITHET-DEFUSE combined dataset: post hoc case-control study. Stroke 2013; 44: 87-93.
21. Parsons MW, Pepper EM, Chan V, Siddique S, Rajaratnam S, Bateman GA, et al. Perfusion computed tomography: prediction of final infarct extent and stroke outcome. Ann Neurol 2005; 58: 672-9.
22. Parsons MW, Pepper EM, Bateman GA, Wang Y, Levi CR. Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT. Neurology 2007; 68: 730-6.
23. Parsons MW, Miteff F, Bateman GA, Spratt N, Loiselle A, Attia J, et al. Acute ischemic stroke: imaging-guided tenecteplase treatment in an extended time window. Neurology 2009; 72: 915-21.
24. Parsons M, Spratt N, Bivard A, Campbell B, Chung K, Miteff F, et al. A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke. N Engl J Med 2012; 366: 1099-107.
25. Qiao Y, Zhu G, Patrie J, Xin W, Michel P, Eskandari A, et al. Optimal perfusion computed tomographic thresholds for ischemic core and penumbra are not time dependent in the clinically relevant time window. Stroke 2014; 45: 1355-62.
26. Wintermark M, Fralnders AE, Velthuis B, Meuli R, van Leeuwen M, Goldsher D, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 2006; 37: 979-85.
27. Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, et al. Stroke Imaging Research (STIR) and Virtual International Stroke Trials Archive (VISTA)-imaging investigators. Acute stroke imaging research roadmap II. Stroke 2013; 44: 2628-39.
28. Wright L, Hill KM, Bernhardt J, Lindley R, Ada L, Bajorek BV, et al. National stroke foundation stroke guidelines expert working group stroke management: updated recommendations for treatment. Intern Med J 2012; 42: 562-9.
29. Yassi N, Parsons MW, Christensen S, Sharma G, Bivard A, Donnan GA, et al. Prediction of poststroke hemorrhagic transformation using computed tomography perfusion. Stroke 2013; 44: 3039-43.