Propofol depresses cerebellar Purkinje cell activity via activation of GABAA and glycine receptors in vivo in mice

European Journal of Pharmacology

Volumn 764, Issue , 2015, Pages 87-93

  Jin, Ri ^a   Liu, Heng ^a   Jin, Wen Zhe ^a   Shi, Jin Di ^a   Jin, Qing Hua ^a   Chu, Chun Ping ^a   Qiu, De Lai ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

Cell attached recording; Cerebellar Purkinje cell; GABAergic receptor; Glycine receptor; Propofol

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; GLYCINE RECEPTOR; PROPOFOL; SACLOFEN; STRYCHNINE; URETHAN; ANESTHETIC AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN PERFUSION; CELL ACTIVITY; CELL ADHESION; CEREBELLUM CORTEX; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GABAERGIC TRANSMISSION; IC50; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NERVE CELL INHIBITION; NEUROMODULATION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PURKINJE CELL; SPIKE WAVE; ANIMAL; CYTOLOGY; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM;

ANESTHETICS, GENERAL; ANIMALS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED ICR; PROPOFOL; PURKINJE CELLS; RECEPTORS, GABA-A; RECEPTORS, GLYCINE;

EID: 84936765438     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.06.052     Document Type: Article

References (27)

1. D. Bai, P.S. Pennefather, J.F. MacDonald, and B.A. Orser The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors J. Neurosci. 19 1999 10635 10646
2. D. Bai, G. Zhu, P. Pennefather, M.F. Jackson, J.F. MacDonald, and B.A. Orser Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons Mol. Pharmacol. 59 2001 814 824
3. C.P. Chu, Y.H. Bing, H. Liu, and D.L. Qiu Roles of Molecular Layer Interneurons in Sensory Information Processing in Mouse Cerebellar Cortex Crus II PLoS One 7 5 2012 e37031
4. C.P. Chu, Y.H. Bing, and D.L. Qiu Sensory stimulus evokes inhibition rather than excitation in cerebellar Purkinje cells in vivo in mice Neurosci. Lett. 487 2011 182 186
5. G.G. Collins Effects of the anaesthetic 2,6-diisopropylphenol on synaptic transmission in the rat olfactory cortex slice Br. J. Pharmacol. 95 1988 939 949
6. E. De Schutter, and J.M. Bower An active membrane model of the cerebellar Purkinje cell. II. Stimulation of synaptic responses J. Neurophysiol. 71 1994 401 419
7. S. Dieudonne Glycinergic synaptic currents in Golgi cells of the rat cerebellum Proc. Natl. Acad. Sci. USA 92 1995 1441 1445
8. X.P. Dong, and T.L. Xu The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat Anesth. Analg. 95 2002 907 914
9. A. Dumoulin, A. Triller, and S. Dieudonne IPSC kinetics at identified GABAergic and mixed GABAergic and glycinergic synapses onto cerebellar Golgi cells J. Neurosci. 21 2001 6045 6057
10. L. Elster, T. Banke, U. Kristiansen, A. Schousboe, and P. Wahl Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells Neuroscience 84 1998 519 528
11. G. GarcÍa-Alcocer, C. MejÍa, L.C. Berumen, R. Miledi, and A. MartÍnez-Torres Developmental expression of glycine receptor subunits in rat cerebellum Int. J. Dev. Neurosci. 26 2008 319 322
12. C. Grasshoff, and B. Antkowiak Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets Anesthesiology 101 2004 1167 1176
13. T.G. Hales, and J.J. Lambert The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones Br. J. Pharmacol. 104 1991 619 628
14. M. Hara, Y. Kai, and Y. Ikemoto Enhancement by propofol of the gamma-aminobutyric acidA response in dissociated hippocampal pyramidal neurons of the rat Anesthesiology 81 1994 988 994
15. Z.J. Huang, G. Di Cristo, and F. Ango Development of GABA innervation in the cerebral and cerebellar cortices Nat. Rev. Neurosci. 8 2007 673 686
16. B.A. Jewett, L.M. Gibbs, A. Tarasiuk, and J.J. Kendig Propofol and barbiturate depression of spinal nociceptive neurotransmission Anesthesiology 77 1992 1148 1154
17. K. Kawa Glycine facilitates transmitter release at developing synapses: a patch clamp study from Purkinje neurons of the newborn rat Dev. Brain Res. 144 1 2003 57 71
18. A. Kitamura, R. Sato, W. Marszalec, J.Z. Yeh, R. Ogawa, and T. Narahashi Halothane and propofol modulation of gamma-aminobutyric acid A receptor single-channel currents Anesth. Analg. 99 2004 409 415
19. H. Liu, S.N. Zhao, G.Y. Zhao, L. Sun, C.P. Chu, and D.L. Qiu N-methyl-d-aspartate inhibits cerebellar Purkinje cell activity via the excitation of molecular layer interneurons under in vivo conditions in mice Brain Res. 1560 2014 1 9
20. G. Martella, C. De Persis, P. Bonsi, S. Natoli, D. Cuomo, G. Bernardi, P. Calabresi, and A. Pisani Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity Epilepsia 46 2005 624 635
21. H.T. Nguyen, K.Y. Li, R.L. daGraca, E. Delphin, M. Xiong, and J.H. Ye Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors Anesthesiology 110 2009 326 332
22. S.M. O'Shea, L. Becker, H. Weiher, H. Betz, and B. Laube Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice J. Neurosci. 24 2004 2322 2327
23. S.L. Palay, and V. Chan-Palay Cerebellar Cortex: Cytology and Organization 1974 Springer Berlin 242 287
24. M. Pistis, D. Belelli, J.A. Peters, and J.J. Lambert The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: A comparative study Br. J. Pharmacol. 122 1997 1707 1719
25. B-receptors: an electrophysiological study in rat Life Sci. 72 2003 2793 2801
26. T. Shirasaka, Y. Yoshimura, D.L. Qiu, and M. Takasaki The effects of propofol on hypothalamic paraventricular nucleus neurons in the rat Anesth. Analg. 98 2004 1017 1023
27. J.Y. Yeung, K.J. Canning, G. Zhu, P. Pennefather, J.F. MacDonald, and B.A. Orser Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA Mol. Pharmacol. 63 2003 2 8