Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages E3564-E3573

  Duchez, Anne Claire ^a   Boudreau, Luc H ^a   Bollinger, James ^b   Belleannée, Clémence ^a   Cloutier, Nathalie ^a   Laffont, Benoit ^a   Mendoza Villarroel, Raifish E ^a   Lévesque, Tania ^a   Rollet Labelle, Emmanuelle ^a   Rousseau, Matthieu ^a   Allaeys, Isabelle ^a   Tremblay, Jacques J ^a   Poubelle, Patrice E ^a   Lambeau, Gérard ^c   Pouliot, Marc ^a   Provost, Patrick ^a   Soulet, Denis ^a   Gelb, Michael H ^b   Boilard, Eric ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

12 lipoxygenase; Microparticles; Neutrophils; Phospholipase A2; Platelets

Indexed keywords

12 HYDROXYEICOSATETRANOIC ACID; ARACHIDONATE 12 LIPOXYGENASE; DNA; ICOSANOID; MESSENGER RNA; MICRORNA; PHOSPHOLIPASE A2 GROUP II; THROMBOXANE B2; UNCLASSIFIED DRUG; 12 HYDROXYICOSATETRAENOIC ACID; RNA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COMMUNICATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; ENANTIOMER; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; INTERNALIZATION; LEUKOCYTE ACTIVATION; LIPIDOMICS; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RECEPTOR BINDING; RHEUMATOID ARTHRITIS; SKIN FIBROBLAST; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; CONFOCAL MICROSCOPY; ELECTRON MICROSCOPY; ENDOCYTOSIS; ENZYMOLOGY; EXPERIMENTAL ARTHRITIS; GENETICS; IMMUNOBLOTTING; KNOCKOUT MOUSE; MEMBRANE MICROPARTICLE; METABOLISM; MITOCHONDRION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIAL FLUID; THROMBOCYTE; ULTRASTRUCTURE;

MUS;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BLOOD PLATELETS; CELL LINE; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; ENDOCYTOSIS; GROUP II PHOSPHOLIPASES A2; HUMANS; IMMUNOBLOTTING; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MITOCHONDRIA; NEUTROPHILS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SYNOVIAL FLUID;

EID: 84936761139     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507905112     Document Type: Article

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