-
1
-
-
0020678221
-
-
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl] - guanine]
-
Colla, L., De Clercq, E., Busson, R., and Vanderhaeghe, H. Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl] - guanine]. J. Med. Chem., 26, 602–604 (1983).
-
(1983)
J. Med. Chem.
, vol.26
, pp. 602-604
-
-
Colla, L.1
De Clercq, E.2
Busson, R.3
Vanderhaeghe, H.4
-
2
-
-
0021090403
-
-
Disposition in the dog and the rat of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine (A134U), a potential prodrug of acyclovir
-
Good, S. S., Krasny, H. C., Elion, G. B., and de Miranda, P. Disposition in the dog and the rat of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine (A134U), a potential prodrug of acyclovir. J. Pharmacol. Exp. Ther., 227, 644–651 (1983).
-
(1983)
J. Pharmacol. Exp. Ther.
, vol.227
, pp. 644-651
-
-
Good, S.S.1
Krasny, H.C.2
Elion, G.B.3
De Miranda, P.4
-
3
-
-
0343258430
-
6-Deoxyacyclovir: A xanthine oxidase-activated prodrug of acyclovir
-
USA
-
Krenitsky, T. A., Hall, W. W., de Miranda, P., Beauchamp, L. M., Schaeffer, H. J., and Whiteman, P. D. 6-Deoxyacyclovir: A xanthine oxidase-activated prodrug of acyclovir. Proc. Natl. Acad. Sci. USA, 81, 3209–3213 (1984)
-
(1984)
Proc. Natl. Acad. Sci.
, vol.81
, pp. 3209-3213
-
-
Krenitsky, T.A.1
Hall, W.W.2
De Miranda, P.3
Beauchamp, L.M.4
Schaeffer, H.J.5
Whiteman, P.D.6
-
4
-
-
0021360070
-
Topical treatment of experimental herpes simplex keratouveitis with 2!-0-glycylacyclovir
-
Maudgal, P. C., De Clercq, E., Descamps, J., and Missotten, L. Topical treatment of experimental herpes simplex keratouveitis with 2!-0-glycylacyclovir. Arch. Ophthalmol,, 102, 140–142 (1984).
-
(1984)
Arch. Ophthalmol
, vol.102
, pp. 140-142
-
-
Maudgal, P.C.1
De Clercq, E.2
Descamps, J.3
Missotten, L.4
-
5
-
-
0020973668
-
A single-tube radioimmunoassay for the antiviral agent 2,6-diamino-9-(2-hydroxyethoxy-methyl)purine (A134U)
-
Quinn, R. P., Good, S. S., Gerald, L., and Sabatka, J. J. A single-tube radioimmunoassay for the antiviral agent 2,6-diamino-9-(2-hydroxyethoxy-methyl)purine (A134U). Anal. Biochem., 16–25 (1983).
-
(1983)
Anal. Biochem.
, vol.1
, pp. 6-25
-
-
Quinn, R.P.1
Good, S.S.2
Gerald, L.3
Sabatka, J.J.4
-
6
-
-
0020617884
-
III. Conversion of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine to acyclovir as catalyzed by adenosine deaminase
-
Spector, T., Jones, T. E., and Beacham, L. M., III. Conversion of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine to acyclovir as catalyzed by adenosine deaminase. Biochem. Pharmacol., 32, 2505–2509 (1983).
-
(1983)
Biochem. Pharmacol.
, vol.32
, pp. 2505-2509
-
-
Spector, T.1
Jones, T.E.2
Beacham, L.M.3
-
7
-
-
0019720660
-
The in vitro activity of acyclovir and related compounds against cytomegalovirus infections
-
Tyms, A. S., Seamans, E. M., and Naim, H. M. The in vitro activity of acyclovir and related compounds against cytomegalovirus infections. J. Antimicrob. Chemother., 8, 65–72 (1981)
-
(1981)
J. Antimicrob. Chemother.
, vol.8
, pp. 65-72
-
-
Tyms, A.S.1
Seamans, E.M.2
Naim, H.M.3
-
8
-
-
0018838514
-
A direct method for the preparation of 2-hydroxyethoxymethyl derivatives of guanine, adenine, and cytosine
-
Barrio, J. R., Bryant, J. D., and Keyser, G. E. A direct method for the preparation of 2-hydroxyethoxymethyl derivatives of guanine, adenine, and cytosine. J. Med. Chem., 23, 572–574 (1980).
-
(1980)
J. Med. Chem.
, vol.23
, pp. 572-574
-
-
Barrio, J.R.1
Bryant, J.D.2
Keyser, G.E.3
-
9
-
-
0018636816
-
Acyclic nucleoside analogues: Synthesis of open-ring riboside or deoxyriboside analogues lacking C(3' ‘) or the C(3f)-C(4' ‘) bond
-
Bryant, J. D., Keyser, G. E., and Barrio, J. R. Acyclic nucleoside analogues: Synthesis of open-ring riboside or deoxyriboside analogues lacking C(3' ‘) or the C(3f)-C(4' ‘) bond. J. Qrg. Chem., 44, 3733–3734 (1979).
-
(1979)
J. Qrg. Chem.
, vol.44
, pp. 3733-3734
-
-
Bryant, J.D.1
Keyser, G.E.2
Barrio, J.R.3
-
10
-
-
0020683151
-
Cyclic aldehyde derivatives as alkylating reagents
-
I. Acyclo and azaacyclo analogs of nucleosides.
-
Griengl, H., Hayden, W., Schindler, E., and Wanek, E. Cyclic aldehyde derivatives as alkylating reagents, I. Acyclo and azaacyclo analogs of nucleosides. Arch. Pharm., 316, 146–153 (1983).
-
(1983)
Arch. Pharm.
, vol.316
, pp. 146-153
-
-
Griengl, H.1
Hayden, W.2
Schindler, E.3
Wanek, E.4
-
11
-
-
0008813885
-
Synthesis of N-(2,3-dihydroxy propyl) derivatives of heterocyclic bases
-
Holy, A. Synthesis of N-(2,3-dihydroxy propyl) derivatives of heterocyclic bases. Collect. Czech. Chem. Commun., 43, 2054–2061 (1978).
-
(1978)
Collect. Czech. Chem. Commun.
, vol.43
, pp. 2054-2061
-
-
Holy, A.1
-
12
-
-
0010048149
-
Synthesis of new mono- and disubstituted hydroxyalkyl and aminoalkyl derivatives of heterocyclic bases
-
Holy, A. Synthesis of new mono- and disubstituted hydroxyalkyl and aminoalkyl derivatives of heterocyclic bases. Collect. Czech. Chem. Commun., 43, 3444–3465 (1978).
-
(1978)
Collect. Czech. Chem. Commun.
, vol.43
, pp. 3444-3465
-
-
Holy, A.1
-
13
-
-
0019867031
-
Preparation of aliphatic analogues of S-adenosyl-L-homocysteine and related compounds
-
Holy, A. Preparation of aliphatic analogues of S-adenosyl-L-homocysteine and related compounds. Collect. Czech. Chem. Commun., 46, 3134–3144 (1981).
-
(1981)
Collect. Czech. Chem. Commun.
, vol.46
, pp. 3134-3144
-
-
Holy, A.1
-
14
-
-
0020410517
-
Preparation of enantiomeric and racemic 2, 3, 4,5-tetrahydroxypentyl derivatives of adenine, cytosine, and uracil
-
Holy, A. Preparation of enantiomeric and racemic 2,3,4,5-tetrahydroxypentyl derivatives of adenine, cytosine, and uracil. Collect. Czech. Chem. Commun., 47, 2786–2805 (1982).
-
(1982)
Collect. Czech. Chem. Commun.
, vol.47
, pp. 2786-2805
-
-
Holy, A.1
-
15
-
-
0343113665
-
Iodomethylethers from 1,3-dioxolane and 1,3-oxathiolane: Preparation of acyclic nucleoside analogs
-
Keyser, G. E., Bryant, J. D., and Barrio, J. R. Iodomethylethers from 1,3-dioxolane and 1,3-oxathiolane: Preparation of acyclic nucleoside analogs. Tetrahedron Lett., 3263–3264 (1979).
-
(1979)
Tetrahedron Lett.
, vol.326
, pp. 3-3264
-
-
Keyser, G.E.1
Bryant, J.D.2
Barrio, J.R.3
-
16
-
-
0019975382
-
Nucleic acid related compounds. 37. Convenient and high-yield syntheses of N-[(2-hydroxyethoxy)methyl] heterocycles as “acyclic nucleoside”
-
Robins, M. J. and Hatfield, P. W. Nucleic acid related compounds. 37. Convenient and high-yield syntheses of N-[(2-hydroxyethoxy)methyl] heterocycles as “acyclic nucleoside” analogues. Can. J. Chem., 60, 547–553 (1982).
-
(1982)
analogues. Can. J. Chem.
, vol.60
, pp. 547-553
-
-
Robins, M.J.1
Hatfield, P.W.2
-
17
-
-
84932172953
-
Synthesis of 9-()3-hydroxyethoxymethyl)-adenine and l-(3-hydroxyethoxymethyl)cytosine
-
Chem. Abstr., 90, 87404q (1978). Ashton, W. T., Karkas, J. D., Field, A. K., and Tolman, R. L. Activation by thymidine kinase and potent antiherpetic activity of 2T-nor-2?-deoxy-guanosine (2f-NDG). Biochem. Biophys. Res. Commun., 108, 1716–1721 1982
-
Tychinskaya, L. Y. and FlorenPev, V. L. Synthesis of 9-()3-hydroxyethoxymethyl)-adenine and l-(3-hydroxyethoxymethyl)cytosine. Bioorg. Khim., 4, 1461–1463 (1978); Chem. Abstr., 90, 87404q (1978). Ashton, W. T., Karkas, J. D., Field, A. K., and Tolman, R. L. Activation by thymidine kinase and potent antiherpetic activity of 2T-nor-2?-deoxy-guanosine (2f-NDG). Biochem. Biophys. Res. Commun., 108, 1716–1721 (1982).
-
(1978)
Bioorg. Khim.
, vol.4
, pp. 1461-1463
-
-
Tychinskaya, L.Y.1
FlorenPev, V.L.2
-
18
-
-
0021739206
-
Phosphorylation of the antiviral precursor 9-(l, 3-dihydroxy-2-propoxymethyl)guanine monophosphate by guanylate kinase isozymes
-
Boehme, R. E. Phosphorylation of the antiviral precursor 9-(l,3-dihydroxy-2-propoxymethyl)guanine monophosphate by guanylate kinase isozymes. J. Biol. Chem., 259, 12346–12349 (1984).
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 12346-12349
-
-
Boehme, R.E.1
-
19
-
-
0021211856
-
Effects of 9-(l, 3-dihydroxy-2-propoxymethyl)-guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells
-
Cheng, Y.-C., Grill, S. P., Dutschman, G. E., Frank, K. B., Chiou, J.-F., Bastow, K. F., and Nakayama, K. Effects of 9-(l,3-dihydroxy-2-propoxymethyl)-guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells. Antimicrob. Agents Chemother., 26, 283–288 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.26
, pp. 283-288
-
-
Cheng, Y.-C.1
Grill, S.P.2
Dutschman, G.E.3
Frank, K.B.4
Chiou, J.-F.5
Bastow, K.F.6
Nakayama, K.7
-
20
-
-
0021055765
-
Metabolism of 9-(l, 3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells
-
Cheng, Y.C., Grill, S. P., Dutschman, G. E., Nakayama, K., and Bastow, K. F. Metabolism of 9-(l,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells. J. Biol. Chem., 258, 12460–12464 (1983).
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 12460-12464
-
-
Cheng, Y.C.1
Grill, S.P.2
Dutschman, G.E.3
Nakayama, K.4
Bastow, K.F.5
-
21
-
-
0002391736
-
Unique spectrum of activity of 9-[(l, 3-dihydroxy-2-propoxy)methyl] guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1
-
USA
-
Cheng, Y.C., Huang, E.S., Lin, J.C., Mar, E.C., Pagano, J. S., Dutschman, G. E., and Grill, S. P. Unique spectrum of activity of 9-[(l,3-dihydroxy-2-propoxy)methyl] guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1. Proc. Natl. Acad. Sci. USA, 80, 2767–2770 (1983).
-
(1983)
Proc. Natl. Acad. Sci.
, vol.80
, pp. 2767-2770
-
-
Cheng, Y.C.1
Huang, E.S.2
Lin, J.C.3
Mar, E.C.4
Pagano, J.S.5
Dutschman, G.E.6
Grill, S.P.7
-
22
-
-
0021399785
-
Resistance of herpes simplex virus to 9-{[2-hydroxy-l-(hydroxymethyl)-ethoxy] methyljguanine: Physical mapping of drug synergism within the viral DNA polymerase locus
-
USA
-
Crumpacker, C. S., Kowalsky, P. N., Oliver, S. A., Schnipper, L. E., and Field, A. K. Resistance of herpes simplex virus to 9-{[2-hydroxy-l-(hydroxymethyl)-ethoxy] methyljguanine: Physical mapping of drug synergism within the viral DNA polymerase locus. Proc. Natl. Acad. Sci. USA, 81, 1556–1560 (1984).
-
(1984)
Proc. Natl. Acad. Sci.
, vol.81
, pp. 1556-1560
-
-
Crumpacker, C.S.1
Kowalsky, P.N.2
Oliver, S.A.3
Schnipper, L.E.4
Field, A.K.5
-
23
-
-
0021342323
-
Efficacy of 2f-nor-2'-deoxyguanosine treatment for orofacial herpes simplex virus type 1 skin infections in mice
-
Davies, M.E. M., Bondi, J. V., and Field, A. K. Efficacy of 2f-nor-2'-deoxyguanosine treatment for orofacial herpes simplex virus type 1 skin infections in mice. Antimicrob. Agents Chemother., 25, 238–241 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.25
, pp. 238-241
-
-
Davies, M.E.M.1
Bondi, J.V.2
Field, A.K.3
-
24
-
-
0021323321
-
Potent synergistic inhibition of herpes simplex virus-2 by 9-[(l, 3-dihydroxy-2-propoxy)methyl] guanine in combination with recombinant interferons
-
Eppstein, D. A. and Marsh, Y. V. Potent synergistic inhibition of herpes simplex virus-2 by 9-[(l,3-dihydroxy-2-propoxy)methyl] guanine in combination with recombinant interferons. Biochem. Biophys. Res. Commun., 120, 66–73 (1984).
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.120
, pp. 66-73
-
-
Eppstein, D.A.1
Marsh, Y.V.2
-
25
-
-
0020262167
-
9-{[2-Hydroxy-l-(hydroxymethyl)ethoxy) methyOguanine: A selective inhibitor of herpes group virus replication.
-
USA
-
Field, A. K., Davies, M. E., DeWitt, C., Perry, H. C., Liou, R., Germershausen, J., Karkas, J. D., Ashton, W. T., Johnston, D. B. R., and Tolman, R. L. 9-{[2-Hydroxy-l-(hydroxymethyl)ethoxy) methyOguanine: A selective inhibitor of herpes group virus replication. Proc. Natl. Acad. Sci. USA, 80, 4139–4143 (1983).
-
(1983)
Proc. Natl. Acad. Sci.
, vol.80
, pp. 4139-4143
-
-
Field, A.K.1
Davies, M.E.2
DeWitt, C.3
Perry, H.C.4
Liou, R.5
Germershausen, J.6
Karkas, J.D.7
Ashton, W.T.8
Johnston, D.B.R.9
Tolman, R.L.10
-
26
-
-
0021339772
-
A quantitative study of the effects of several nucleoside analogues on established herpes encephalitis in mice
-
Field, H. J., Anderson, J. R., and Efstathiou, S. A quantitative study of the effects of several nucleoside analogues on established herpes encephalitis in mice. J. Gen. Virol., 65, 707–719 (1984).
-
(1984)
J. Gen. Virol.
, vol.65
, pp. 707-719
-
-
Field, H.J.1
Anderson, J.R.2
Efstathiou, S.3
-
27
-
-
0021243237
-
Interaction of herpes simplex virus-induced DNA polym erase with 9-(1,3-dihydroxy-2-propoxym ethyUguanine triphosphate
-
Frank, K. B., Chiou, J.-F., and Cheng, Y.-C. Interaction of herpes simplex virus-induced DNA polym erase with 9-(1,3-dihydroxy-2-propoxym ethyUguanine triphosphate. J. Biol. Chem., 259, 1566–1569 (1984).
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 1566-1569
-
-
Frank, K.B.1
Chiou, J.-F.2
Cheng, Y.-C.3
-
28
-
-
0021271397
-
Enhanced efficacy of the acyclic nucleoside 9-(l, 3-dihydroxy-2-propoxymethyl)guanine in combination with beta-interferon against herpes simplex virus type 2 in mice
-
Fraser-Smith, E. B., Eppstein, D. A., Marsh, Y. V., and Matthews, T. R. Enhanced efficacy of the acyclic nucleoside 9-(l,3-dihydroxy-2-propoxymethyl)guanine in combination with beta-interferon against herpes simplex virus type 2 in mice. Antimicrob. Agents Chemother., 25, 563–565 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.25
, pp. 563-565
-
-
Fraser-Smith, E.B.1
Eppstein, D.A.2
Marsh, Y.V.3
Matthews, T.R.4
-
29
-
-
0021710442
-
Enhanced efficacy of the acyclic nucleoside 9-(l, 3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice
-
Fraser-Smith, E. B., Eppstein, D. A., Marsh, Y. V., and Matthews, T. R. Enhanced efficacy of the acyclic nucleoside 9-(l,3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice. Antimicrob. Agents Chemother., 26, 937–938 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.26
, pp. 937-938
-
-
Fraser-Smith, E.B.1
Eppstein, D.A.2
Marsh, Y.V.3
Matthews, T.R.4
-
30
-
-
0021018676
-
Efficacy of the acyclic nucleoside 9-(l, 3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs
-
Fraser-Smith, E. B., Smee, D. F., and Matthews, T. R. Efficacy of the acyclic nucleoside 9-(l,3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs. Antimicrob. Agents Chemother., 24, 883–887 (1983).
-
(1983)
Antimicrob. Agents Chemother.
, vol.24
, pp. 883-887
-
-
Fraser-Smith, E.B.1
Smee, D.F.2
Matthews, T.R.3
-
31
-
-
0021842854
-
Antimyocarditic activity of the guanine derivative B1OLF-70 in a coxsackie virus B3 murine model.
-
Gauntt, C. J., Arizpe, H. M., Kung, J. T., Ogilvie, K. K., and Cheriyan, U. O. Antimyocarditic activity of the guanine derivative B1OLF-70 in a coxsackie virus B3 murine model. Antimicrob. Agents Chemother., 27, 184–191 (1985)
-
(1985)
Antimicrob. Agents Chemother.
, vol.27
, pp. 184-191
-
-
Gauntt, C.J.1
Arizpe, H.M.2
Kung, J.T.3
Ogilvie, K.K.4
Cheriyan, U.O.5
-
32
-
-
0021029814
-
A comparison of the antiviral agents 2'-nor-2t-deoxyguanosine and acyclovir: Uptake and phosphorylation in tissue culture and kinetics of in vitro inhibition of viral and cellular DNA polymerases by their respective triphosphates
-
Germershausen, J., Bostedor, R., Field, A. K., Perry, H., Liou, R., Bull, H., Tolman, R. L., and Karkas, J. D. A comparison of the antiviral agents 2'-nor-2t-deoxyguanosine and acyclovir: Uptake and phosphorylation in tissue culture and kinetics of in vitro inhibition of viral and cellular DNA polymerases by their respective triphosphates. Biochem. Biophys. Res. Commun., 116, 360–367 (1983).
-
(1983)
Biochem. Biophys. Res. Commun.
, vol.116
, pp. 360-367
-
-
Germershausen, J.1
Bostedor, R.2
Field, A.K.3
Perry, H.4
Liou, R.5
Bull, H.6
Tolman, R.L.7
Karkas, J.D.8
-
33
-
-
0021368055
-
Prolonged inhibitory effect of 9-(l, 3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus
-
Lin, J.-C., Smith, M. C., and Pagano, J. S. Prolonged inhibitory effect of 9-(l,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus. J. Virol., 50, 50–55 (1984).
-
(1984)
J.Virol.
, vol.50
, pp. 50-55
-
-
Lin, J.-C.1
Smith, M.C.2
Pagano, J.S.3
-
34
-
-
0021323109
-
Synthesis of 9-(2,3-dihydroxy-l-propoxymethyl)guanine -- A new potential antiviral agent
-
Lin, T.-S. and Liu, M.-C. Synthesis of 9-(2,3-dihydroxy-l-propoxymethyl)guanine -- A new potential antiviral agent. Tetrahedron Lett., 25, 905–906 (1984).
-
(1984)
Tetrahedron Lett.
, vol.25
, pp. 905-906
-
-
Lin, T.-S.1
Liu, M.-C.2
-
35
-
-
0020573744
-
Effect of 9-(l, 3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro
-
Mar, E.-C., Cheng, Y.-C., and Huang, E.-S. Effect of 9-(l,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro. Antimicrob. Agents Chemother., 24, 518–521 (1983).
-
(1983)
Antimicrob. Agents Chemother.
, vol.24
, pp. 518-521
-
-
Mar, E.-C.1
Cheng, Y.-C.2
Huang, E.-S.3
-
36
-
-
0020636893
-
9- [(l, 3-Dihydroxy-2-propoxy)methyl] guanine: A new potent and selective antiherpes agent
-
Martin, J. C., Dvorak, C. A., Smee, D. F., Matthews, T. R., and Verheyden, J. P. H. 9- [(l,3-Dihydroxy-2-propoxy)methyl] guanine: A new potent and selective antiherpes agent. J. Med. Chem., 26, 759–761 (1983).
-
(1983)
J. Med. Chem.
, vol.26
, pp. 759-761
-
-
Martin, J.C.1
Dvorak, C.A.2
Smee, D.F.3
Matthews, T.R.4
Verheyden, J.P.H.5
-
37
-
-
0021907992
-
Acyclic analogues of 2T-deoxynucleosides related to 9-[(l, 3-dihydroxy-2-propoxy)methyl] guanine as potential antiviral agents
-
Martin, J. C., Jeffrey, G. A., McGee, D. P. C., Tippie, M. A., Smee, D. F., Matthews, T. R., and Verheyden, J. P. H. Acyclic analogues of 2T-deoxynucleosides related to 9-[(l,3-dihydroxy-2-propoxy)methyl] guanine as potential antiviral agents. J. Med. Chem., 28, 358–362 (1985).
-
(1985)
J. Med. Chem.
, vol.28
, pp. 358-362
-
-
Martin, J.C.1
Jeffrey, G.A.2
McGee, D.P.C.3
Tippie, M.A.4
Smee, D.F.5
Matthews, T.R.6
Verheyden, J.P.H.7
-
38
-
-
0021627143
-
The relative merits and drawbacks of new nucleoside analogues with clinical potential
-
(Suppl. A)
-
Oberg, B. and Johansson, N.-G. The relative merits and drawbacks of new nucleoside analogues with clinical potential. J. Antimicrob. Chemother., 14 (Suppl. A), 5–26 (1984).
-
(1984)
J. Antimicrob. Chemother.
, vol.14
, pp. 5-26
-
-
Oberg, B.1
Johansson, N.-G.2
-
39
-
-
0020263080
-
Biologically active acyclonucleoside analogues. II. The synthesis of 9- [[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] guanine (BIOLF-62)
-
Ogilvie, K. K., Cheriyan, U. O., Radatus, B. K., Smith, K. O., Galloway, K. S., and Kennell, W. L. Biologically active acyclonucleoside analogues. II. The synthesis of 9- [[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] guanine (BIOLF-62). Can. J. Chem., 60, 3005–3010 (1982).
-
(1982)
Can. J. Chem.
, vol.60
, pp. 3005-3010
-
-
Ogilvie, K.K.1
Cheriyan, U.O.2
Radatus, B.K.3
Smith, K.O.4
Galloway, K.S.5
Kennell, W.L.6
-
40
-
-
0021205143
-
Inhibition of human cytom egalovirus replication by 9-(1,3-dihydroxy-2-propoxym ethyl) guanine alone and in combination with human interferons
-
Rasmussen, L., Chen, P. T., Mullenax, J. G., and Merigan, T. C. Inhibition of human cytom egalovirus replication by 9-(1,3-dihydroxy-2-propoxym ethyl) guanine alone and in combination with human interferons. Antimicrob. Agents Chemother., 26, 441–445 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.26
, pp. 441-445
-
-
Rasmussen, L.1
Chen, P.T.2
Mullenax, J.G.3
Merigan, T.C.4
-
41
-
-
0020611124
-
Relative activities of acyclovir and BW759 against Aujesky's disease and equine rhinopneumonitis viruses
-
Rollinson, E. A. and White, G. Relative activities of acyclovir and BW759 against Aujesky's disease and equine rhinopneumonitis viruses. Antimicrob. Agents Chemother., 24, 221–226 (1983).
-
(1983)
Antimicrob. Agents Chemother.
, vol.24
, pp. 221-226
-
-
Rollinson, E.A.1
White, G.2
-
42
-
-
0021352397
-
Inhibition of cellular a DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U
-
St. Clair, M. H., Miller, W. H., Miller, R. L., Lambe, C. U., and Furman, P. A. Inhibition of cellular a DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U. Antimicrob. Agents Chemother., 25, 191–194 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.25
, pp. 191-194
-
-
St. Clair, M.H.1
Miller, W.H.2
Miller, R.L.3
Lambe, C.U.4
Furman, P.A.5
-
43
-
-
0021861919
-
Activities of arabinosyladenine monophosphate and 9—(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase
-
Smee, D. F., Knight, S. S., Duke, A. E., Robinson, W. S., Matthews, T. R., and Marion, P. L. Activities of arabinosyladenine monophosphate and 9—(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase. Antimicrob. Agents Chemother., 27, 277–279 (1985).
-
(1985)
Antimicrob. Agents Chemother.
, vol.27
, pp. 277-279
-
-
Smee, D.F.1
Knight, S.S.2
Duke, A.E.3
Robinson, W.S.4
Matthews, T.R.5
Marion, P.L.6
-
44
-
-
0020614981
-
Anti-herpesvirus activity of the acyclic nucleoside 9-(l, 3-dihydroxy-2-propoxy-methyl)guanine
-
Smee, D. F., Martin, J. C., Verheyden, J. P. H., and Matthews, T. R. Anti-herpesvirus activity of the acyclic nucleoside 9-(l,3-dihydroxy-2-propoxy-methyl)guanine. Antimicrob. Agents Chemother., 23, 676–682 (1983).
-
(1983)
Antimicrob. Agents Chemother.
, vol.23
, pp. 676-682
-
-
Smee, D.F.1
Martin, J.C.2
Verheyden, J.P.H.3
Matthews, T.R.4
-
45
-
-
0020614009
-
Sensitivity of equine herpesviruses 1 and 3 in vitro to a new nucleoside analog, 9-[[2-hydroxy-l-(hydroxymethyl)-ethoxy] methyl] guanine
-
Smith, K. O., Galloway, K. S., Hodges, S. L., Ogilvie, K. K., Radatus, B. K., Kalter, S. S., and Heberling, R. L. Sensitivity of equine herpesviruses 1 and 3 in vitro to a new nucleoside analog, 9-[[2-hydroxy-l-(hydroxymethyl)-ethoxy] methyl] guanine. Am. J. Vet. Res., 44, 1032–1035 (1983).
-
(1983)
Am. J. Vet. Res.
, vol.44
, pp. 1032-1035
-
-
Smith, K.O.1
Galloway, K.S.2
Hodges, S.L.3
Ogilvie, K.K.4
Radatus, B.K.5
Kalter, S.S.6
Heberling, R.L.7
-
46
-
-
0020316367
-
A new nucleoside analog, 9-[[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] - guanine, highly active in vitro against herpes simplex virus types 1 and 2
-
Smith, K. O., Galloway, K. S., Kennell, W. L., Ogilvie, K. K., and Radatus, B. K. A new nucleoside analog, 9-[[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] - guanine, highly active in vitro against herpes simplex virus types 1 and 2. Antimicrob. Agents Chemother., 22, 55–61 (1982).
-
(1982)
Antimicrob. Agents Chemother.
, vol.22
, pp. 55-61
-
-
Smith, K.O.1
Galloway, K.S.2
Kennell, W.L.3
Ogilvie, K.K.4
Radatus, B.K.5
-
47
-
-
0020366341
-
Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds
-
Smith, K. O., Galloway, K. S., Ogilvie, K. K., and Cheriyan, U. O. Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds. Antimicrob. Agents Chemother., 22, 1026–1030 (1982).
-
(1982)
Antimicrob. Agents Chemother.
, vol.22
, pp. 1026-1030
-
-
Smith, K.O.1
Galloway, K.S.2
Ogilvie, K.K.3
Cheriyan, U.O.4
-
48
-
-
0021359384
-
Experimental ocular herpetic infections in rabbits
-
Treatment with 9-([2-hydroxy-l-(hydroxymethyl)ethoxy] - methyl)guanine
-
Smith, K. O., Hodges, S. L., Kennell, W. L., Galloway, K. S., Poirier, R. H., Ogilvie, K. K., and Cheriyan, U. O. Experimental ocular herpetic infections in rabbits. Treatment with 9-([2-hydroxy-l-(hydroxymethyl)ethoxy] - methyl)guanine. Arch. Ophthalmol., 102, 778–781 (1984).
-
(1984)
Arch. Ophthalmol.
, vol.102
, pp. 778-781
-
-
Smith, K.O.1
Hodges, S.L.2
Kennell, W.L.3
Galloway, K.S.4
Poirier, R.H.5
Ogilvie, K.K.6
Cheriyan, U.O.7
-
49
-
-
0021345875
-
Effects of the nucleoside analog 2T-nor-2'-deoxyguanosine on human cytomegalovirus replication
-
Tocci, M. J., Livelli, T. J., Perry, H. C., Crumpacker, C. S., and Field, A. K. Effects of the nucleoside analog 2T-nor-2'-deoxyguanosine on human cytomegalovirus replication. Antimicrob. Agents Chemother., 25, 247–252 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.25
, pp. 247-252
-
-
Tocci, M.J.1
Livelli, T.J.2
Perry, H.C.3
Crumpacker, C.S.4
Field, A.K.5
-
50
-
-
0021161929
-
Efficacy of BW759 (9-[[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] guanine) against herpes simplex virus type 1 keratitis in rabbits
-
Trousdale, M. D., Nesburn, A. B., Willey, D. E., and Taaid, H. Efficacy of BW759 (9-[[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] guanine) against herpes simplex virus type 1 keratitis in rabbits. Curr. Eye Res., 3, 1007–1015 (1984).
-
(1984)
Curr. Eye Res.
, vol.3
, pp. 1007-1015
-
-
Trousdale, M.D.1
Nesburn, A.B.2
Willey, D.E.3
Taaid, H.4
-
51
-
-
0021061662
-
Effects of heteropolyanions and nucleoside analogs on rabies virus — In vitro study of syntheses and viral production
-
Bussereau, F. and Ermine, A. Effects of heteropolyanions and nucleoside analogs on rabies virus — In vitro study of syntheses and viral production. Ann. Virol., 134E, 487–506 (1983); Chem. Abstr., 100, 171424d (1983)
-
(1983)
Ann. Virol.
, vol.134E
, pp. 487-506
-
-
Bussereau, F.1
Ermine, A.2
-
52
-
-
0018092218
-
Distribution and metabolic transformation of 9-(S)—(2,3—dihydroxypropyl)adenine, an effective virostatic agent, in mice
-
100, 171424d (1983)
-
Cihak, A. and Holy, A. Distribution and metabolic transformation of 9-(S)—(2,3—dihydroxypropyl)adenine, an effective virostatic agent, in mice. Collect. Czech. Chem. Commun., 43, 2082–2088 (1978).
-
(1978)
Collect. Czech. Chem. Commun.
, vol.43
, pp. 2082-2088
-
-
Cihak, A.1
Holy, A.2
-
53
-
-
0021223899
-
Broad-spectrum antiviral activity of adenosine analogues
-
De Clercq, E., Bergstrom, D. E., Holy, A., and Montgomery, J. A. Broad-spectrum antiviral activity of adenosine analogues. Antiviral Res., 4, 119–133 (1984).
-
(1984)
Antiviral Res.
, vol.4
, pp. 119-133
-
-
De Clercq, E.1
Bergstrom, D.E.2
Holy, A.3
Montgomery, J.A.4
-
54
-
-
0018090383
-
(S)-9-(2,3-Dihydroxy-propyl)adenine: An aliphatic nucleoside analog with broad-spectrum antiviral activity
-
Science
-
De Clercq, E., Descamps, J., De Somer, P., and Holy, A. (S)-9-(2,3-Dihydroxy-propyl)adenine: An aliphatic nucleoside analog with broad-spectrum antiviral activity. Science, 200, 563–565 (1978).
-
(1978)
, vol.200
, pp. 563-565
-
-
De Clercq, E.1
Descamps, J.2
De Somer, P.3
Holy, A.4
-
55
-
-
0019415948
-
Inhibitory effect of a broad-spectrum antiviral agent, (S)-9-(2,3-dihydroxy-propyl)adenine, on spermatogenesis in mice
-
De Clercq, E. Leyten, R., Sobis, H., Matousek, J., Holy, A., and De Somer, P. Inhibitory effect of a broad-spectrum antiviral agent, (S)-9-(2,3-dihydroxy-propyl)adenine, on spermatogenesis in mice. Toxicol. Appl. Pharmacol., 59, 441–451 (1981).
-
(1981)
Toxicol. Appl. Pharmacol.
, vol.59
, pp. 441-451
-
-
De Clercq, E.1
Leyten, R.2
Sobis, H.3
Matousek, J.4
Holy, A.5
De Somer, P.6
-
56
-
-
0020587377
-
Transport of antiviral agent 9-(S)-(2,3-dihydroxypropyl)adenine to animal cells
-
Dragun, M., Rada, B., and Holy, A. Transport of antiviral agent 9-(S)-(2,3-dihydroxypropyl)adenine to animal cells. Acta Virol., 27, 119–129 (1983).
-
(1983)
Acta Virol.
, vol.27
, pp. 119-129
-
-
Dragun, M.1
Rada, B.2
Holy, A.3
-
57
-
-
0020419704
-
Studies on the effect of 9-(R, S)-(2,3-dihydroxypropyl)adenine on tick-borne encephalitis virus
-
Gresikova, M., Rada, B., and Holy, A. Studies on the effect of 9-(R, S)-(2,3-dihydroxypropyl)adenine on tick-borne encephalitis virus. Acta Virol., 26, 521–523 (1982).
-
(1982)
Acta Virol.
, vol.26
, pp. 521-523
-
-
Gresikova, M.1
Rada, B.2
Holy, A.3
-
58
-
-
0021509070
-
X-Ray study of the antiviral compound (S)-9-(2,3-dihydroxypropyl)adenine
-
Gurskaya, G. V., Dzhavadova, G. M., Vasiliev, D. G., Tsilevich, T. L., Zavgorodny, S. G., and Florentiev, V. L. X-Ray study of the antiviral compound (S)-9-(2,3-dihydroxypropyl)adenine. Bioorg. Khim., 10, 1414–1420 (1984).
-
(1984)
Bioorg. Khim.
, vol.10
, pp. 1414-1420
-
-
Gurskaya, G.V.1
Dzhavadova, G.M.2
Vasiliev, D.G.3
Tsilevich, T.L.4
Zavgorodny, S.G.5
Florentiev, V.L.6
-
59
-
-
0019329940
-
Quantum chemical calculation of the (S)-9-(2,3-dihydroxypropyl)adenine molecule
-
Havlas, Z., Hrebabecky, H., and Beranek, J. Quantum chemical calculation of the (S)-9-(2,3-dihydroxypropyl)adenine molecule. Nucleic Acids Res., 8, 6233–6238 (1980).
-
(1980)
Nucleic Acids Res.
, vol.8
, pp. 6233-6238
-
-
Havlas, Z.1
Hrebabecky, H.2
Beranek, J.3
-
60
-
-
0020405060
-
Novel adenosine analogs with broad-spectrum biological activity: Structure and mechanism of action
-
Holy, A. Novel adenosine analogs with broad-spectrum biological activity: Structure and mechanism of action. Nucleic Acids Symp. Ser., 11, 199–202 (1982).
-
(1982)
Nucleic Acids Symp. Ser.
, vol.11
, pp. 199-202
-
-
Holy, A.1
-
61
-
-
0019464033
-
Metabolism of 9-(S)-(2,3-dihydroxypropyl)adenine, an antiviral agent, in mice
-
Holy, A. and Cihak, A. Metabolism of 9-(S)-(2,3-dihydroxypropyl)adenine, an antiviral agent, in mice. Biochem. Pharmacol., 30, 2359–2361 (1981).
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 2359-2361
-
-
Holy, A.1
Cihak, A.2
-
62
-
-
0019852904
-
Embryotoxicity of 9-(S)-(2,3-dihydroxy-propyl)adenine
-
Jelinek, R., Holy, A., and Votruba, I. Embryotoxicity of 9-(S)-(2,3-dihydroxy-propyl)adenine. Tetratology, 24, 267–275 (1981).
-
(1981)
Tetratology
, vol.24
, pp. 267-275
-
-
Jelinek, R.1
Holy, A.2
Votruba, I.3
-
63
-
-
0018710937
-
9-(S)-(2,3-dihydroxypropyl)adenine inhibits the transformation of chick embryo fibroblasts infected with Rous sarcoma virus.
-
Evidence for inhibition of enzymatic activity of isolated cellular protein kinases by the drug
-
Kara, J., Vacha, P., and Holy, A. 9-(S)-(2,3-dihydroxypropyl)adenine inhibits the transformation of chick embryo fibroblasts infected with Rous sarcoma virus. Evidence for inhibition of enzymatic activity of isolated cellular protein kinases by the drug. FEBS Lett., 107, 187–192 (1979).
-
(1979)
FEBS Lett.
, vol.107
, pp. 187-192
-
-
Kara, J.1
Vacha, P.2
Holy, A.3
-
64
-
-
1542664520
-
Crystal structures of two forms of 9-(2,3-dihydroxypropyl)adenine
-
King, G. S. D. and Sengier, L. Crystal structures of two forms of 9-(2,3-dihydroxypropyl)adenine. J. Chem. Res. (S), 121 (1981).
-
(1981)
J. Chem. Res.(S)
, vol.121
-
-
King, G.S.D.1
Sengier, L.2
-
65
-
-
0019133057
-
Characteristics of the antiviral effect of 9-(S)-(2,3-dihydroxypropyl)adenine
-
Rada, B., Dragun, M., Votruba, I., and Holy, A. Characteristics of the antiviral effect of 9-(S)-(2,3-dihydroxypropyl)adenine. Acta Virol., 24, 433–438 (1980).
-
(1980)
Acta Virol.
, vol.24
, pp. 433-438
-
-
Rada, B.1
Dragun, M.2
Votruba, I.3
Holy, A.4
-
66
-
-
0018851340
-
Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl)adenine and 6-azauridine
-
Chemotherapy
-
Rada, B. and Holy, A. Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl)adenine and 6-azauridine. Chemotherapy, 26, 184–190 (1980).
-
(1980)
, vol.26
, pp. 184-190
-
-
Rada, B.1
Holy, A.2
-
67
-
-
85005433143
-
Insect sterility induced by a broad-spectrum antiviral agent (S)-9-(2,3-dihydroxypropyl)adenine
-
Slama, K., Holy, A., and Votruba, I. Insect sterility induced by a broad-spectrum antiviral agent (S)-9-(2,3-dihydroxypropyl)adenine. Entomol. Exp. Appl., 33, 9–14 (1983).
-
(1983)
Entomol. Exp. Appl.
, vol.33
, pp. 9-14
-
-
Slama, K.1
Holy, A.2
Votruba, I.3
-
68
-
-
0019841741
-
Inhibition of reoviruses in vitro by selected antiviral substances
-
Smee, D. F., Sidwell, R. W., Clark, S. M., Barnett, B. B., and Spendlove, R. S. Inhibition of reoviruses in vitro by selected antiviral substances. Antiviral Res., 1, 315–323 (1981).
-
(1981)
Antiviral Res.
, vol.1
, pp. 315-323
-
-
Smee, D.F.1
Sidwell, R.W.2
Clark, S.M.3
Barnett, B.B.4
Spendlove, R.S.5
-
69
-
-
0020076688
-
Inhibition of rotaviruses by selected antiviral substances: Mechanisms of viral inhibition and in vivo activity
-
Smee, D. F., Sidwell, R. W., Clark, S. M., Barnett, B. B., and Spendlove, R. S. Inhibition of rotaviruses by selected antiviral substances: Mechanisms of viral inhibition and in vivo activity. Antimicrob. Agents Chemother., 21, 66–73 (1982).
-
(1982)
Antimicrob. Agents Chemother.
, vol.21
, pp. 66-73
-
-
Smee, D.F.1
Sidwell, R.W.2
Clark, S.M.3
Barnett, B.B.4
Spendlove, R.S.5
-
70
-
-
0019785069
-
Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances
-
Smee, D. F., Sidwell, R. W., Clark, S. M., Barnett, B. B., and Spendlove, R. S. Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances. Antimicrob. Agents Chemother., 20, 533–538 (1981).
-
(1981)
Antimicrob. Agents Chemother.
, vol.20
, pp. 533-538
-
-
Smee, D.F.1
Sidwell, R.W.2
Clark, S.M.3
Barnett, B.B.4
Spendlove, R.S.5
-
71
-
-
0019145026
-
Effect of 9-(S)-(2,3-dihydroxypropyl)adenine on experimental rabies infection in laboratory mice
-
Sodja, I. and Holy, A. Effect of 9-(S)-(2,3-dihydroxypropyl)adenine on experimental rabies infection in laboratory mice. Acta Virol., 24, 317–324 (1980).
-
(1980)
Acta Virol.
, vol.24
, pp. 317-324
-
-
Sodja, I.1
Holy, A.2
-
72
-
-
0000089867
-
Inhibition of S-adenosyl-L-homocysteine hydrolase by the aliphatic nucleoside analog 9-(S)-(2,3-dihydroxypropyl)adenine
-
Votruba, I. and Holy A. Inhibition of S-adenosyl-L-homocysteine hydrolase by the aliphatic nucleoside analog 9-(S)-(2,3-dihydroxypropyl)adenine. Collect. Czech. Chem. Commun., 45, 3039–3044 (1980).
-
(1980)
Collect. Czech. Chem. Commun.
, vol.45
, pp. 3039-3044
-
-
Votruba, I.1
Holy, A.2
-
73
-
-
0020529766
-
Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl)adenine, in different cell lines
-
Votruba, I., Holy, A., and De Clercq, E. Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl)adenine, in different cell lines. Acta Virol., 27, 273–276 (1983).
-
(1983)
Acta Virol.
, vol.27
, pp. 273-276
-
-
Votruba, I.1
Holy, A.2
De Clercq, E.3
-
74
-
-
0020663387
-
Effect of several antiviral agents on human lymphocyte functions and marrow progenitor cell proliferation
-
Wingard, J. R., Hess, A. D., Stuart, R. K., Saral, R., and Burns, W. H. Effect of several antiviral agents on human lymphocyte functions and marrow progenitor cell proliferation. Antimicrob. Agents Chemother., 23, 593–597 (1983).
-
(1983)
Antimicrob. Agents Chemother.
, vol.23
, pp. 593-597
-
-
Wingard, J.R.1
Hess, A.D.2
Stuart, R.K.3
Saral, R.4
Burns, W.H.5
-
75
-
-
84948335969
-
-
Comparative efficacy of antiherpes drugs against
-
De Clercq, E., Descamps, J. Verhelst, G., Walker, R. T., Jones, A. S., Torrence, P. F., and Shugar, D. Comparative efficacy of antiherpes drugs against
-
-
-
De Clercq, E.1
Descamps, J.2
Verhelst, G.3
Walker, R.T.4
Jones, A.S.5
Torrence, P.F.6
Shugar, D.7
-
76
-
-
0018819307
-
-
different strains of herpes simplex virus
-
different strains of herpes simplex virus. J. Infect. Dis., 141, 563–574 (1980).
-
(1980)
J. Infect. Dis.
, vol.141
, pp. 563-574
-
-
-
77
-
-
0345209129
-
Erythro-9-(2-hydroxy-3-nonyl)adenine as a specific inhibitor of herpes simplex virus replication in the presence and absence of adenosine analogues
-
USA
-
North, T. W. and Cohen, S. S. Erythro-9-(2-hydroxy-3-nonyl)adenine as a specific inhibitor of herpes simplex virus replication in the presence and absence of adenosine analogues. Proc. Natl. Acad. Sci. USA, 75, 4684–4688 (1978).
-
(1978)
Proc. Natl. Acad. Sci.
, vol.75
, pp. 4684-4688
-
-
North, T.W.1
Cohen, S.S.2
-
78
-
-
0021048092
-
Effects of chirality in 9-(2-hydroxy-3-nonyl)adenine upon deoxyribonucleic acid synthesis in herpes simplex virus-infected cells
-
North, T. W., O’Connor, L., Abushanab, E., and Panzica, R. P. Effects of chirality in 9-(2-hydroxy-3-nonyl)adenine upon deoxyribonucleic acid synthesis in herpes simplex virus-infected cells. Biochem. Pharmacol., 32, 3541–3546 (1983).
-
(1983)
Biochem. Pharmacol.
, vol.32
, pp. 3541-3546
-
-
North, T.W.1
O’Connor, L.2
Abushanab, E.3
Panzica, R.P.4
-
79
-
-
0019163980
-
Erythro-9-(2-Hydroxy-3-nonyl)adenine alone and in combination with 9-/3-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice
-
Shannon, W. M., Arnett, G., Schabel, F. M., Jr., North, T. W., and Cohen, S. S. Erythro-9-(2-Hydroxy-3-nonyl)adenine alone and in combination with 9-/3-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice. Antimicrob. Agents Chemother., 18, 598–603 (1980).
-
(1980)
Antimicrob. Agents Chemother.
, vol.18
, pp. 598-603
-
-
Shannon, W.M.1
Arnett, G.2
Schabel, F.M.3
North, T.W.4
Cohen, S.S.5
-
80
-
-
0020701070
-
Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus
-
Shigeta, S., Yokota, T., Iwabuchi, T., Baba, M., Konno, K., Ogata, M., and De Clercq, E. Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus. J. Infect. Dis., 147, 576–584 (1983)
-
(1983)
J. Infect. Dis.
, vol.147
, pp. 576-584
-
-
Shigeta, S.1
Yokota, T.2
Iwabuchi, T.3
Baba, M.4
Konno, K.5
Ogata, M.6
De Clercq, E.7
-
81
-
-
0020698671
-
Search for compounds which have an inhibitory effect on rhabdovirus multiplication in vitro
-
134E
-
Bussereau, F., Chermann, J. C., De Clercq, E., and Hannoun, C. Search for compounds which have an inhibitory effect on rhabdovirus multiplication in vitro. Ann. Virol., 134E, 127–134 (1983).
-
(1983)
Ann. Virol.
, vol.12
, pp. 7-134
-
-
Bussereau, F.1
Chermann, J.C.2
De Clercq, E.3
Hannoun, C.4
-
82
-
-
0020378331
-
Synthesis of aliphatic nucleoside analogues with potential antiviral activity
-
Colla, L., Busson, R., De Clercq, E., and Vanderhaeghe, H. Synthesis of aliphatic nucleoside analogues with potential antiviral activity. Eur. J. Med. Chem. - Chim. Ther., 569–576 (1982).
-
(1982)
Eur. J. Med. Chem. - Chim. Ther.
, vol.56
, pp. 9-576
-
-
Colla, L.1
Busson, R.2
De Clercq, E.3
Vanderhaeghe, H.4
-
83
-
-
0018717251
-
Antiviral activity of aliphatic nucleoside analogues: Structure-function relationship.
-
De Clercq, E. and Holy, A. Antiviral activity of aliphatic nucleoside analogues: Structure-function relationship. J. Med. Chem., 22, 510–513 (1979).
-
(1979)
J. Med. Chem.
, vol.22
, pp. 510-513
-
-
De Clercq, E.1
Holy, A.2
-
84
-
-
0021997672
-
Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: A new class of broad-spectrum antiviral agents
-
De Clercq, E. and Holy, A. Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: A new class of broad-spectrum antiviral agents. J. Med. Chem., 28, 282–287 (1985).
-
(1985)
J. Med. Chem.
, vol.28
, pp. 282-287
-
-
De Clercq, E.1
Holy, A.2
-
85
-
-
0020638068
-
Altered thymidine-thymidylate kinases from strains of herpes simplex virus with modified drug sensitivities to acyclovir and (E)-5-(2-bromovinyl)-2T-deoxyuridine
-
Fyfe, J. A., McKee, S. A., and Keller, P. M. Altered thymidine-thymidylate kinases from strains of herpes simplex virus with modified drug sensitivities to acyclovir and (E)-5-(2-bromovinyl)-2T-deoxyuridine. Mol. Pharmacol., 24, 316–323 (1983).
-
(1983)
Mol. Pharmacol.
, vol.24
, pp. 316-323
-
-
Fyfe, J.A.1
McKee, S.A.2
Keller, P.M.3
-
86
-
-
0018249715
-
Synthesis of some 2,3-dihydroxypropyl derivatives of purine bases
-
Holy, A. Synthesis of some 2,3-dihydroxypropyl derivatives of purine bases. Collect. Czech. Chem. Commun., 43, 3103–3117 (1978)
-
(1978)
Collect. Czech. Chem. Commun.
, vol.43
, pp. 3103-3117
-
-
Holy, A.1
-
87
-
-
0000360117
-
Synthesis of racemic and optically active erythro- and threo-9-(2, 3, 4-trihydroxybutyl)adenines and related compounds
-
Holy, A. Synthesis of racemic and optically active erythro- and threo-9-(2,3,4-trihydroxybutyl)adenines and related compounds. Collect. Czech. Chem. Commun., 44, 593–612 (1979).
-
(1979)
Collect. Czech. Chem. Commun.
, vol.44
, pp. 593-612
-
-
Holy, A.1
-
88
-
-
0042534896
-
Stereospecific synthesis of isomeric 4-substituted 9-(2,3-dihydroxy-butyl)adenines
-
Holy, A. Stereospecific synthesis of isomeric 4-substituted 9-(2,3-dihydroxy-butyl)adenines. Collect. Czech. Chem. Commun., 47, 173–189 (1982).
-
(1982)
Collect. Czech. Chem. Commun.
, vol.47
, pp. 173-189
-
-
Holy, A.1
-
89
-
-
0001713024
-
Synthesis of eight stereoisomeric 5-(adenin-9-yl)-2, 3, 4-trihydroxy-pentanoic acids
-
Holy, A. Synthesis of eight stereoisomeric 5-(adenin-9-yl)-2,3,4-trihydroxy-pentanoic acids. Collect. Czech. Chem. Commun., 47, 2969–2988 (1982).
-
(1982)
Collect. Czech. Chem. Commun.
, vol.47
, pp. 2969-2988
-
-
Holy, A.1
-
90
-
-
0020405060
-
Novel adenosine analogs with broad-spectrum biological activity: Structure and mechanism of action
-
Holy, A. Novel adenosine analogs with broad-spectrum biological activity: Structure and mechanism of action. Nucleic Acids Symp. Ser., 11, 199–202 (1982).
-
(1982)
Nucleic Acids Symp. Ser.
, vol.11
, pp. 199-202
-
-
Holy, A.1
-
91
-
-
0007204514
-
Preparation of isomeric 3-aminopropylamino derivatives of 9-(RS)-(2,3-dihydroxypropyDadenine
-
Holy, A. Preparation of isomeric 3-aminopropylamino derivatives of 9-(RS)-(2,3-dihydroxypropyDadenine. Collect. Czech. Chem. Commun., 48, 1910–1921 (1983).
-
(1983)
Collect. Czech. Chem. Commun.
, vol.48
, pp. 1910-1921
-
-
Holy, A.1
-
92
-
-
0019950885
-
Synthesis and antiviral activity of stereoisomeric eritadenines
-
Holy, A., Votruba, I., and De Clercq, E. Synthesis and antiviral activity of stereoisomeric eritadenines. Collect. Czech. Chem. Commun., 47, 1392–1407 (1982).
-
(1982)
Collect. Czech. Chem. Commun.
, vol.47
, pp. 1392-1407
-
-
Holy, A.1
Votruba, I.2
De Clercq, E.3
-
93
-
-
37049104289
-
Purines, pyrimidines, and imidazoles. Part 56. Some aminoimidazolecarboxamidines and derived adenines
-
Kadir, K., Shaw, G., and Wright, D. Purines, pyrimidines, and imidazoles. Part 56. Some aminoimidazolecarboxamidines and derived adenines. J. Chem. Soc., Perk. Trans. 1, 2728–2731 (1980).
-
(1980)
J. Chem. Soc., Perk. Trans.
, vol.1
, pp. 2728-2731
-
-
Kadir, K.1
Shaw, G.2
Wright, D.3
-
94
-
-
0019818628
-
Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities
-
Keller, P. M., Fyfe, J. A., Beauchamp, L., Lubbers, C. M., Furman, P. A., Schaeffer, H. J., and Elion, G. B. Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities. Biochem. Pharmacol., 30, 3071–3077 (1981).
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 3071-3077
-
-
Keller, P.M.1
Fyfe, J.A.2
Beauchamp, L.3
Lubbers, C.M.4
Furman, P.A.5
Schaeffer, H.J.6
Elion, G.B.7
-
95
-
-
0019844521
-
Acyclic puromycin analogs: 9-[(2-Phenylalanylamidoethoxy)methyl] adenine and 9-(3-phenylalanylamido-propyDadenine
-
Kelley, J. L., Miller, C. A., and Schaeffer, H. J. Acyclic puromycin analogs: 9-[(2-Phenylalanylamidoethoxy)methyl] adenine and 9-(3-phenylalanylamido-propyDadenine. J. Pharm. Sci., 70, 1169–1171 (1981).
-
(1981)
J. Pharm. Sci.
, vol.70
, pp. 1169-1171
-
-
Kelley, J.L.1
Miller, C.A.2
Schaeffer, H.J.3
-
96
-
-
0020961558
-
Antiherpetic activity and mechanism of action of 9-(4-hydroxybutyl)guanine
-
Larsson, A., Alenius, S., Johansson, N.-G., and Oberg, B. Antiherpetic activity and mechanism of action of 9-(4-hydroxybutyl)guanine. Antiviral Res., 3, 77–86 (1983).
-
(1983)
Antiviral Res.
, vol.3
, pp. 77-86
-
-
Larsson, A.1
Alenius, S.2
Johansson, N.G.3
Oberg, B.4
-
97
-
-
0021019133
-
Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine
-
Larsson, A., Brannstrom, G., and Oberg, B. Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine. Antimicrob. Agents Chemother., 24, 819–822 (1983).
-
(1983)
Antimicrob. Agents Chemother.
, vol.24
, pp. 819-822
-
-
Larsson, A.1
Brannstrom, G.2
Oberg, B.3
-
98
-
-
0020586461
-
9-(3,4-Dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication
-
Larsson, A., Oberg, B., Alenius, S., Hagberg, C.-E., Johansson, N.-G., Lindborg, B., and Stening, G. 9-(3,4-Dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication. Antimicrob. Agents Chemother., 23, 664–670 (1983)
-
(1983)
Antimicrob. Agents Chemother.
, vol.23
, pp. 664-670
-
-
Larsson, A.1
Oberg, B.2
Alenius, S.3
Hagberg, C.-E.4
Johansson, N.-G.5
Lindborg, B.6
Stening, G.7
-
99
-
-
0021187886
-
Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type2thymidine kinase
-
Larsson, A. and Tao, P.-Z. Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase. Antimicrob. Agents Chemother., 25, 524–526 (1984).
-
(1984)
Antimicrob. Agents Chemother.
, vol.25
, pp. 524-526
-
-
Larsson, A.1
Tao, P.-Z.2
-
100
-
-
0021753530
-
The preparation of a crystalline guanosine trialcohol and its sodium salt
-
Lerner, L. M. The preparation of a crystalline guanosine trialcohol and its sodium salt. Carbohydr. Res., 127, 141–145 (1984).
-
(1984)
Carbohydr. Res.
, vol.127
, pp. 141-145
-
-
Lerner, L.M.1
-
101
-
-
0021339365
-
A novel method for the synthesis of 9-[[2-hydroxy-l-(aminomethyl)ethoxy] methyl] guanine — A potential antiviral agent
-
Liu, M.-C., Kuzmich, S., and Lin, T.-S. A novel method for the synthesis of 9-[[2-hydroxy-l-(aminomethyl)ethoxy] methyl] guanine — A potential antiviral agent. Tetrahedron Lett., 25, 613–616 (1984).
-
(1984)
Tetrahedron Lett.
, vol.25
, pp. 613-616
-
-
Liu, M.-C.1
Kuzmich, S.2
Lin, T.S.3
-
102
-
-
0017445237
-
Purines, pyrimidines, and imidazoles. Part 46, Some acyclic D-arabinose imidazole and purine nucleosides
-
MacKenzie, G., Shaw, G., and Robinson, D. H. Purines, pyrimidines, and imidazoles. Part 46, Some acyclic D-arabinose imidazole and purine nucleosides. J. Chem. Soc., Perk. Trans. 1, 1094–1103 (1977).
-
(1977)
J. Chem. Soc., Perk. Trans.
, vol.1
, pp. 1094-1103
-
-
MacKenzie, G.1
Shaw, G.2
Robinson, D.H.3
-
103
-
-
84948242614
-
Thio-sugars. Part 6. Seco-nucleosides related to 4-thio-DL-erythrofuranose and 4-thio-DL-ribofuranose
-
McCormick, J. E. and McElhinney, R. S. Thio-sugars. Part 6. Seco-nucleosides related to 4-thio-DL-erythrofuranose and 4-thio-DL-ribofuranose. J. Chem. Res. (S), 12–13 (1981).
-
(1981)
J. Chem. Res. (S)
, vol.1
, pp. 2-13
-
-
McCormick, J.E.1
McElhinney, R.S.2
-
104
-
-
84948231803
-
Thio sugars. Part 9, Antiviral nucleosides from 4-thio-DL-erythrofuranose and purines and other fused pyrimidines
-
Chem. Abstr., 100, 22947z 1983
-
McCormick, J. E. and McElhinney, R. S. Thio sugars. Part 9, Antiviral nucleosides from 4-thio-DL-erythrofuranose and purines and other fused pyrimidines. Proc. R. Ir. Acad., Sect. B, 83, 125–138 (1983); Chem. Abstr., 100, 22947z (1983).
-
(1983)
Proc. R. Ir. Acad., Sect. B
, vol.83
, pp. 125-138
-
-
McCormick, J.E.1
McElhinney, R.S.2
-
105
-
-
0021627143
-
The relative merits and drawbacks of new nucleoside analogues with clinical potential
-
(Suppl. A)
-
Oberg, B. and Johansson, N.-G. The relative merits and drawbacks of new nucleoside analogues with clinical potential. J. Antimicrob. Chemother., 14, (Suppl. A), 5–26 (1984).
-
(1984)
J. Antimicrob. Chemother.
, vol.14
, pp. 5-26
-
-
Oberg, B.1
Johansson, N.-G.2
-
106
-
-
0000039290
-
Ring open analogues of deoxynucleotides
-
Ogilvie, K. K. and Gillen, M. F. Ring open analogues of deoxynucleotides. Tetrahedron Lett., 21, 327–330 (1980).
-
(1980)
Tetrahedron Lett.
, vol.21
, pp. 327-330
-
-
Ogilvie, K.K.1
Gillen, M.F.2
-
107
-
-
0021745570
-
Synthesis of antiviral compounds
-
Preparation and rearrangement of 6-methoxyglyceropurines
-
Ogilvie, K. K. and Hanna, H. R. Synthesis of antiviral compounds. Preparation and rearrangement of 6-methoxyglyceropurines. Can. J. Chem., 62, 2702–2706 (1984).
-
(1984)
Can. J. Chem.
, vol.62
, pp. 2702-2706
-
-
Ogilvie, K.K.1
Hanna, H.R.2
-
108
-
-
0021323687
-
Synthesis of a purine acyclonucleoside series having pronounced antiviral activity
-
The glyceropurines
-
Ogilvie, K. K., Nguyen-Ba, N., Gillen, M. F., Radatus, B. K., Cheriyan, U. O., Hanna, H. R., Smith, K. O., and Galloway, K. S. Synthesis of a purine acyclonucleoside series having pronounced antiviral activity. The glyceropurines. Can. J. Chem., 62, 241–252 (1984).
-
(1984)
Can. J. Chem.
, vol.62
, pp. 241-252
-
-
Ogilvie, K.K.1
Nguyen-Ba, N.2
Gillen, M.F.3
Radatus, B.K.4
Cheriyan, U.O.5
Hanna, H.R.6
Smith, K.O.7
Galloway, K.S.8
-
109
-
-
0000730787
-
A trihydroxy acyclonucleoside series
-
Ogilvie, K. K., Nguyen-Ba, N, and Hamilton, R. G. A trihydroxy acyclonucleoside series. Can. J. Chem., 62, 1622–1627 (1984).
-
(1984)
Can. J. Chem.
, vol.62
, pp. 1622-1627
-
-
Ogilvie, K.K.1
Nguyen-Ba, N.2
Hamilton, R.G.3
-
110
-
-
0006122451
-
Synthesis of purine and pyrimidine trihydroxy-acyclonucleosides
-
Ogilvie, K. K. and Proba, Z. A. Synthesis of purine and pyrimidine trihydroxy-acyclonucleosides. Nucleosides Nucleotides, 3, 537–547 (1984).
-
(1984)
Nucleosides Nucleotides
, vol.3
, pp. 537-547
-
-
Ogilvie, K.K.1
Proba, Z.A.2
-
111
-
-
0020383954
-
Acyclic analogues of purine and imidazole nucleosides
-
Parkin, A. and Harnden, M. R. Acyclic analogues of purine and imidazole nucleosides. J. Heterocycl. Chem., 19, 33–40 (1982)
-
(1982)
J. Heterocycl. Chem.
, vol.19
, pp. 33-40
-
-
Parkin, A.1
Harnden, M.R.2
-
112
-
-
0021678923
-
Nucleic acid related compounds, 47. Synthesis and biological activities of pyrimidine and purine “acyclic”
-
Robins, M. J., Hatfield, P. W., Balzarini, J., and De Clercq, E. Nucleic acid related compounds, 47. Synthesis and biological activities of pyrimidine and purine “acyclic” nucleoside analogues. J. Med. Chem., 27, 1486–1492 (1984).
-
(1984)
nucleoside analogues. J. Med. Chem.
, vol.27
, pp. 1486-1492
-
-
Robins, M.J.1
Hatfield, P.W.2
Balzarini, J.3
De Clercq, E.4
-
113
-
-
0021672102
-
Antiherpes simplex virus activity of 9-[4-hydroxy-3-(hydroxymethyl)-l-butyl] guanine
-
Tippie, M. A., Martin, J. C., Smee, D. F., Matthews, T. R., and Verheyden, J. P. H. Antiherpes simplex virus activity of 9-[4-hydroxy-3-(hydroxymethyl)-l-butyl] guanine. Nucleosides Nucleotides, 3, 525–535 (1984).
-
(1984)
Nucleosides Nucleotides
, vol.3
, pp. 525-535
-
-
Tippie, M.A.1
Martin, J.C.2
Smee, D.F.3
Matthews, T.R.4
Verheyden, J.P.H.5
-
115
-
-
0019720660
-
The in vitro activity of acyclovir and related compounds against eytomegalovirus infections
-
Tyms, A. S., Seamans, E. M., and Naim, H. M. The in vitro activity of acyclovir and related compounds against eytomegalovirus infections. J. Antimicrob. Chemother., 8, 65–72 (1981).
-
(1981)
J. Antimicrob. Chemother.
, vol.8
, pp. 65-72
-
-
Tyms, A.S.1
Seamans, E.M.2
Naim, H.M.3
-
116
-
-
0019949992
-
Eritadenines — Novel type of potent inhibitors of S-adenosyl-L-homocysteine hydrolase
-
Votruba, I. and Holy, A. Eritadenines — Novel type of potent inhibitors of S-adenosyl-L-homocysteine hydrolase. Collect. Czech. Chem. Commun., 47, 167–172 (1982).
-
(1982)
Collect. Czech. Chem. Commun.
, vol.47
, pp. 167-172
-
-
Votruba, I.1
Holy, A.2
-
117
-
-
0021143508
-
Synthesis and biological properties of 9-(2,4-dihydroxybutyl)adenine and guanine: New analogs of 9-(2,3-dihydroxypropyl)adenine (DHPA) and 9-(2-hydroxyethoxymethyl)guanine (acyclovir)
-
Nucleosides Nucleotides
-
Zemlicka, J. Synthesis and biological properties of 9-(2,4-dihydroxybutyl)adenine and guanine: New analogs of 9-(2,3-dihydroxypropyl)adenine (DHPA) and 9-(2-hydroxyethoxymethyl)guanine (acyclovir). Nucleosides Nucleotides, 3, 245–264 (1984)
-
(1984)
, vol.3
, pp. 245-264
-
-
Zemlicka, J.1
-
118
-
-
0019719330
-
Synthesis of pyrimidine acyclonucleosides
-
Abrams, H. M., Ho, L., and Chu, S. H. Synthesis of pyrimidine acyclonucleosides. J. Heterocycl. Chem., 18, 947–951 (1981).
-
(1981)
J. Heterocycl. Chem.
, vol.18
, pp. 947-951
-
-
Abrams, H.M.1
Ho, L.2
Chu, S.H.3
-
119
-
-
0021127950
-
Synthesis and biological activity of hydroxymethyl analogs of 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine
-
Chu, S. H., Chen, Z. H., Rowe, E. C., Naguib, F. N. M., el Kouni, M. H., and Chu, M. Y. Synthesis and biological activity of hydroxymethyl analogs of 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine. Nucleosides Nucleotides, 3, 303–311 (1984).
-
(1984)
Nucleosides Nucleotides
, vol.3
, pp. 303-311
-
-
Chu, S.H.1
Chen, Z.H.2
Rowe, E.C.3
Naguib, F.N.M.4
El Kouni, M.H.5
Chu, M.Y.6
-
120
-
-
0020378331
-
Synthesis of aliphatic nucleoside analogues with potential antiviral activity
-
Colla, L., Busson, R., De Clercq, E., and Vanderhaeghe, H. Synthesis of aliphatic nucleoside analogues with potential antiviral activity. Eur. J. Med. Chem. - Chim. Ther., 17, 569–576 (1982).
-
(1982)
Eur. J. Med. Chem. - Chim. Ther.
, vol.17
, pp. 569-576
-
-
Colla, L.1
Busson, R.2
De Clercq, E.3
Vanderhaeghe, H.4
-
121
-
-
0018717251
-
Antiviral activity of aliphatic nucleoside analogues: Structure-function relationship
-
De Clercq, E. and Holy, A. Antiviral activity of aliphatic nucleoside analogues: Structure-function relationship. J. Med. Chem., 22, 510–513 (1979).
-
(1979)
J. Med. Chem.
, vol.22
, pp. 510-513
-
-
De Clercq, E.1
Holy, A.2
-
122
-
-
84915710205
-
Inhibition of herpes virus DNA polymerase by nucleotides derived from acyclonucleosides which do not suppress herpes virus replication
-
In: K. K. Gauri, editor, Antiviral Chemother.
-
Eriksson, B., Oberg, B., and Gauri, K. K. Inhibition of herpes virus DNA polymerase by nucleotides derived from acyclonucleosides which do not suppress herpes virus replication. In: K. K. Gauri, editor, Antiviral Chemother.: Des. Inhib. Viral Funct., pp. 161–170, 1981
-
(1981)
Des. Inhib. Viral Funct.
, pp. 161-170
-
-
Eriksson, B.1
Oberg, B.2
Gauri, K.K.3
-
123
-
-
34250245021
-
Analogs of pyrimidine nucleosides. 14. Synthesis and antitumorigenic activity of alkoxyalkyl derivatives of 5-fluorouracil
-
Karpeiskii, M. Y., Mikhailov, S. M., Tsieminya, A. S., Ziderman, A. A., Kravchenko, I. M., Lidak, M. Y., and Zhuk, R. A. Analogs of pyrimidine nucleosides. 14. Synthesis and antitumorigenic activity of alkoxyalkyl derivatives of 5-fluorouracil. Chem. Heterocycl. Compd. (Engl. Transl.), 16, 1176–1179 (1980).
-
(1980)
Chem. Heterocycl. Compd. (Engl. Transl.)
, vol.16
, pp. 1176-1179
-
-
Karpeiskii, M.Y.1
Mikhailov, S.M.2
Tsieminya, A.S.3
Ziderman, A.A.4
Kravchenko, I.M.5
Lidak, M.Y.6
Zhuk, R.A.7
-
124
-
-
0019462960
-
Pyrimidine acyclic nucleosides. 5-Substituted l-[(2-aminoethoxy)methyl] uracils as candidate antivirals
-
Kelley, J. L., Krochmal, M. P., and Schaeffer, H. J. Pyrimidine acyclic nucleosides. 5-Substituted l-[(2-aminoethoxy)methyl] uracils as candidate antivirals. J. Med. Chem., 24, 472–474 (1981).
-
(1981)
J. Med. Chem.
, vol.24
, pp. 472-474
-
-
Kelley, J.L.1
Krochmal, M.P.2
Schaeffer, H.J.3
-
125
-
-
0019413968
-
Pyrimidine acyclic nucleosides. I-[(2-Hydroxyethoxy)methyl] pyrimidines as candidate antivirals
-
Kelley, J. L., Kelsey, J. E., Hall, W. R., Krochmal, M. P., and Schaeffer, H. J. Pyrimidine acyclic nucleosides. I-[(2-Hydroxyethoxy)methyl] pyrimidines as candidate antivirals. J. Med. Chem., 24, 753–756 (1981).
-
(1981)
J. Med. Chem.
, vol.24
, pp. 753-756
-
-
Kelley, J.L.1
Kelsey, J.E.2
Hall, W.R.3
Krochmal, M.P.4
Schaeffer, H.J.5
-
126
-
-
84948242614
-
Thio-sugars. Part 6. Seco-nucleosides related to 4-thio-DL-erythrofuranose and 4-thio-DL-ribofuranose
-
McCormick, J. E. and McElhinney, R. S. Thio-sugars. Part 6. Seco-nucleosides related to 4-thio-DL-erythrofuranose and 4-thio-DL-ribofuranose. J. Chem. Res. (S), 12–13 (1981).
-
(1981)
J. Chem. Res. (S)
, vol.1
, pp. 2-13
-
-
McCormick, J.E.1
McElhinney, R.S.2
-
127
-
-
0019953757
-
Differential effect of nucleoside analog triphosphates on ribonucleotide reductases from uninfected and herpes simplex virus-infected Hela cells
-
Nakayama, K., Ruth, J. L., and Cheng, Y.-C. Differential effect of nucleoside analog triphosphates on ribonucleotide reductases from uninfected and herpes simplex virus-infected Hela cells. J. Virol., 43, 325–327 (1982).
-
(1982)
J.Virol.
, vol.43
, pp. 325-327
-
-
Nakayama, K.1
Ruth, J.L.2
Cheng, Y.-C.3
-
128
-
-
0020037313
-
5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase
-
Niedzwicki, J. G., Chu, S. H., el Kouni, M. H., Rowe, E. C., and Cha, S. 5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase. Biochem. Pharmacol., 31, 1857–1861 (1982).
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 1857-1861
-
-
Niedzwicki, J.G.1
Chu, S.H.2
El Kouni, M.H.3
Rowe, E.C.4
Cha, S.5
-
129
-
-
0019427592
-
Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase
-
Niedzwicki, J. G., el Kouni, M. H., Chu, S. H., and Cha, S. Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase. Biochem. Pharmacol., 30, 2097–2101 (1981).
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 2097-2101
-
-
Niedzwicki, J.G.1
El Kouni, M.H.2
Chu, S.H.3
Cha, S.4
-
130
-
-
0000039290
-
Ring open analogues of deoxynucleotides
-
Ogilvie, K. K. and Gillen, M. F. Ring open analogues of deoxynucleotides. Tetrahedron Lett., 21, 327–330 (1980.
-
(1980)
Tetrahedron Lett.
, vol.21
, pp. 327-330
-
-
Ogilvie, K.K.1
Gillen, M.F.2
-
131
-
-
0020964258
-
Synthesis of 5-substituted-l-[[2-hydroxy-l-(hydroxymethyl)ethoxy] - methyl] cytosines
-
Ogilvie, K. K., Dixit, D. M., Radatus, B. K., Smith, K. O., and Galloway, K. S. Synthesis of 5-substituted-l-[[2-hydroxy-l-(hydroxymethyl)ethoxy] - methyl] cytosines. Nucleosides Nucleotides, 2, 147–154 (1983).
-
(1983)
Nucleosides Nucleotides
, vol.2
, pp. 147-154
-
-
Ogilvie, K.K.1
Dixit, D.M.2
Radatus, B.K.3
Smith, K.O.4
Galloway, K.S.5
-
132
-
-
0006122451
-
Synthesis of purine and pyrimidine trihydroxy-acyclonucleosides
-
Nucleosides Nucleotides
-
Ogilvie, K, K. and Proba, Z. A. Synthesis of purine and pyrimidine trihydroxy-acyclonucleosides. Nucleosides Nucleotides, 3, 537–547 (1984).
-
(1984)
, vol.3
, pp. 537-547
-
-
Ogilvie, K.K.1
Proba, Z.A.2
-
133
-
-
0002137237
-
Uracil analogues of the acyclonucleoside 9-[[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] guanine (BIOLF-62)
-
Ogilvie, K. K., Hamilton, R. G., Gillen, M. F., Radatus, B. K., Smith, K. O., and Galloway, K. S. Uracil analogues of the acyclonucleoside 9-[[2-hydroxy-l-(hydroxymethyl)ethoxy] methyl] guanine (BIOLF-62). Can. J. Chem., 62, 16–21 (1984).
-
(1984)
Can. J. Chem.
, vol.62
, pp. 16-21
-
-
Ogilvie, K.K.1
Hamilton, R.G.2
Gillen, M.F.3
Radatus, B.K.4
Smith, K.O.5
Galloway, K.S.6
-
134
-
-
0000730787
-
A trihydroxy acyclonucleoside series
-
Ogilvie, K. K., Nguyen-Ba, N., and Hamilton, R. G. A trihydroxy acyclonucleoside series. Can. J. Chem., 62, 1622–1627 (1984)
-
(1984)
Can. J. Chem.
, vol.62
, pp. 1622-1627
-
-
Ogilvie, K.K.1
Nguyen-Ba, N.2
Hamilton, R.G.3
-
135
-
-
0021678923
-
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine “acyclic”
-
Robins, M. J., Hatfield, P. W., Balzarini, J., and De Clercq, E. Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine “acyclic” nucleoside analogues. J. Med. Chem., 27, 1486–1492 (1984).
-
(1984)
nucleoside analogues. J. Med. Chem.
, vol.27
, pp. 1486-1492
-
-
Robins, M.J.1
Hatfield, P.W.2
Balzarini, J.3
De Clercq, E.4
-
136
-
-
0019842463
-
Synthesis and antitumor activity of an acyclonucleoside derivative of 5-fluorouracil
-
Rosowsky, A., Kim, S.-H., and Wick, M. Synthesis and antitumor activity of an acyclonucleoside derivative of 5-fluorouracil. J. Med. Chem., 24, 1177–1181 (1981).
-
(1981)
J. Med. Chem.
, vol.24
, pp. 1177-1181
-
-
Rosowsky, A.1
Kim, S.-H.2
Wick, M.3
-
137
-
-
0021270890
-
Synthesis of some acyclic analogs of pyrimidine nucleosides
-
Chem. Abstr., 101, 111328m 1984
-
Roveri, P., Cavrini, V., and Gatti, R. Synthesis of some acyclic analogs of pyrimidine nucleosides. Farmaco, Ed. Sci., 39, 346–352 (1984); Chem. Abstr., 101, 111328m (1984).
-
(1984)
Farmaco, Ed. Sci.
, vol.39
, pp. 346-352
-
-
Roveri, P.1
Cavrini, V.2
Gatti, R.3
-
138
-
-
0019465788
-
Synthesis and biological effects of acyclic pyrimidine nucleoside analogues
-
Schroeder, A. C., Hughes, R. G., Jr., and Bloch, A. Synthesis and biological effects of acyclic pyrimidine nucleoside analogues. J. Med. Chem., 24, 1078–1083 (1981)
-
(1981)
J. Med. Chem.
, vol.24
, pp. 1078-1083
-
-
Schroeder, A.C.1
Hughes, R.G.2
Bloch, A.3
-
139
-
-
0020378331
-
Synthesis of aliphatic nucleoside analogues with potential antiviral activity
-
Colla, L., Busson, R., De Clercq, E., and Vanderhaeghe, H. Synthesis of aliphatic nucleoside analogues with potential antiviral activity. Eur. J. Med. Chem. - Chim. Ther., 17, 569–576 (1982).
-
(1982)
Eur. J. Med. Chem. - Chim. Ther.
, vol.17
, pp. 569-576
-
-
Colla, L.1
Busson, R.2
De Clercq, E.3
Vanderhaeghe, H.4
-
140
-
-
0020422857
-
Studies on potential antiviral compounds. XXII. Synthesis and in vitro antiviral activity of l-(hydroxyalkyl)-lH-benzimidazoles
-
Garuti, L., Ferranti, A., Giovanninetti, G., Scapini, G., Franchi, L., and Landini, M. P. Studies on potential antiviral compounds. XXII. Synthesis and in vitro antiviral activity of l-(hydroxyalkyl)-lH-benzimidazoles. Arch. Pharm., 315, 1007–1013 (1982).
-
(1982)
Arch. Pharm.
, vol.315
, pp. 1007-1013
-
-
Garuti, L.1
Ferranti, A.2
Giovanninetti, G.3
Scapini, G.4
Franchi, L.5
Landini, M.P.6
-
141
-
-
0021315529
-
Acyclonucleosides: Acyclobenz-imidazole nucleoside and nucleotide analogs and conformations of the acyclic chains by means of NMR spectroscopy
-
Chem. Abstr., 101, 105903d 1984
-
Kazimierczuk, Z., Stolarski, R., and Shugar, D. Acyclonucleosides: Acyclobenz-imidazole nucleoside and nucleotide analogs and conformations of the acyclic chains by means of NMR spectroscopy. Acta Biochim. Pol., 31, 33–48 (1984); Chem. Abstr., 101, 105903d (1984).
-
(1984)
Acta Biochim. Pol.
, vol.31
, pp. 33-48
-
-
Kazimierczuk, Z.1
Stolarski, R.2
Shugar, D.3
-
142
-
-
0019867001
-
Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl] guanine as candidate antivirals
-
Kelley, J. L., Krochmal, M. P., and Schaeffer, H. J. Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl] guanine as candidate antivirals. J. Med. Chem., 24, 1528–1531 (1981).
-
(1981)
J. Med. Chem.
, vol.24
, pp. 1528-1531
-
-
Kelley, J.L.1
Krochmal, M.P.2
Schaeffer, H.J.3
-
143
-
-
0345244675
-
Synthesis of l-[(2-hydroxy-l-(hydroxymethyl)ethoxy)-methyl]-l, 2, 4-triazole-3-and 5-carboxamides
-
Tetrahedron Lett
-
Lin, T.-S. and Liu, M.-C. Synthesis of l-[(2-hydroxy-l-(hydroxymethyl)ethoxy)-methyl]-l,2,4-triazole-3-and 5-carboxamides. Tetrahedron Lett,, 25, 611–612 (1984).
-
(1984)
, vol.25
, pp. 611-612
-
-
Lin, T.-S.1
Liu, M.-C.2
-
144
-
-
0017445237
-
-
Purines, pyrimidines, and imidazoles. Part 46. Some acyclic D-arabinose imidazole and purine nucleosides
-
MacKenzie, G., Shaw, G., and Robinson, D. H. Purines, pyrimidines, and imidazoles. Part 46. Some acyclic D-arabinose imidazole and purine nucleosides. J. Chem. Soc., Perk. Trans. 1, 1094–1103 (1977)
-
(1977)
J. Chem. Soc., Perk. Trans.
, vol.1
, pp. 1094-1103
-
-
MacKenzie, G.1
Shaw, G.2
Robinson, D.H.3
-
145
-
-
84948231803
-
Thio sugars. Part 9. Antiviral nucleosides from 4-thio-DL-erythrofuranose and purines and other fused pyrimidines
-
Chem. Abstr., 100, 22947z (1983)
-
McCormick, J. E. and McElhinney, R. S. Thio sugars. Part 9. Antiviral nucleosides from 4-thio-DL-erythrofuranose and purines and other fused pyrimidines. Proc. R. Ir. Acad., Sect. B, 83, 125–138 (1983); Chem. Abstr., 100, 22947z (1983).
-
(1983)
Proc. R. Ir. Acad., Sect.B
, vol.83
, pp. 125-138
-
-
McCormick, J.E.1
McElhinney, R.S.2
-
146
-
-
0020383954
-
Acyclic analogues of purine and imidazole nucleosides
-
Parkin, A. and Harnden, M. R. Acyclic analogues of purine and imidazole nucleosides. J. Heterocycl. Chem., 19, 33–40 (1982).
-
(1982)
J. Heterocycl. Chem.
, vol.19
, pp. 33-40
-
-
Parkin, A.1
Harnden, M.R.2
-
147
-
-
0020398437
-
4-Amino-7-(rac-2,3-dihydroxypropyl)-7H-pyrrolo [2,3-d] - pyrimidin — Synthese von acyclotubercidin
-
Seela, F. and Kehne, A. 4-Amino-7-(rac-2,3-dihydroxypropyl)-7H-pyrrolo [2,3-d] - pyrimidin — Synthese von acyclotubercidin. Liebigs Ann. Chem., 1940–1945 (1982).
-
(1982)
Liebigs Ann. Chem.
, pp. 1940-1945
-
-
Seela, F.1
Kehne, A.2
-
148
-
-
84985234168
-
Synthese von acyclo-7-desazaguanosin durch regiospezifische phasentransferalkylierung von 2-amino-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin
-
Seela, F., Kehne, A., and Winkeler, H.-D. Synthese von acyclo-7-desazaguanosin durch regiospezifische phasentransferalkylierung von 2-amino-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin. Liebigs Ann. Chem., 137–146 (1983).
-
(1983)
Liebigs Ann. Chem.
, vol.13
, pp. 7-146
-
-
Seela, F.1
Kehne, A.2
Winkeler, H.-D.3
-
149
-
-
0019449894
-
Studies related to the total synthesis of pentostatin: An efficient, regiospecific glycosylation of 6,7-dihydro-imidazo [4,5-d] [1,2] diazepin-8(3H)-one and related homologs
-
Showalter, H. D. H. and Putt, S. R. Studies related to the total synthesis of pentostatin: An efficient, regiospecific glycosylation of 6,7-dihydro-imidazo [4,5-d] [1,2] diazepin-8(3H)-one and related homologs. Tetrahedron Lett., 22, 3155–3158 (1981).
-
(1981)
Tetrahedron Lett.
, vol.22
, pp. 3155-3158
-
-
Showalter, H.D.H.1
Putt, S.R.2
-
150
-
-
0020627221
-
Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+)-3, 6, 7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl] imidazo [4,5-d] [1,3] diazepin-8-ol and some selected C-5 homologues of pentostatin
-
Showalter, H. D. H., Putt, S. R., Borondy, P. E., and Shillis, J. L. Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl] imidazo [4,5-d] [1,3] diazepin-8-ol and some selected C-5 homologues of pentostatin. J. Med. Chem., 26, 1478–1482 (1983)
-
(1983)
J. Med. Chem.
, vol.26
, pp. 1478-1482
-
-
Showalter, H.D.H.1
Putt, S.R.2
Borondy, P.E.3
Shillis, J.L.4
-
151
-
-
0021030419
-
Synthese d!analogues acycliques de C-nucleosides
-
Babin, F., Dinh, T. H., and Igolen, J. Synthese d!analogues acycliques de C-nucleosides. J. Heterocycl. Chem., 20, 1169–1173 (1983).
-
(1983)
J. Heterocycl. Chem.
, vol.20
, pp. 1169-1173
-
-
Babin, F.1
Dinh, T.H.2
Igolen, J.3
-
152
-
-
0021319190
-
Antiviral activity of C-5 substituted tubercidin analogues
-
Bergstrom, D. E., Brattesani, A. J., Ogawa, M. K., Reddy, P. A., Schweickert, M. J., Balzarini, J., and De Clercq, E. Antiviral activity of C-5 substituted tubercidin analogues. J. Med. Chem., 27, 285–292 (1984).
-
(1984)
J. Med. Chem.
, vol.27
, pp. 285-292
-
-
Bergstrom, D.E.1
Brattesani, A.J.2
Ogawa, M.K.3
Reddy, P.A.4
Schweickert, M.J.5
Balzarini, J.6
De Clercq, E.7
-
153
-
-
0021366275
-
Acyclopyrimidine C-nucleosides
-
Synthesis of acyclopseudoisocytidine and its derivatives
-
Chu, C. K. Acyclopyrimidine C-nucleosides. Synthesis of acyclopseudoisocytidine and its derivatives. J. Heterocycl. Chem., 21, 9–11 (1984).
-
(1984)
J. Heterocycl. Chem.
, vol.21
, pp. 9-11
-
-
Chu, C.K.1
-
154
-
-
0021221065
-
Acyclo analogs of formycin A
-
Griengl, H. and Gunzl, F. Acyclo analogs of formycin A. J. Heterocycl. Chem., 21, 505–508 (1984).
-
(1984)
J. Heterocycl. Chem.
, vol.21
, pp. 505-508
-
-
Griengl, H.1
Gunzl, F.2
-
155
-
-
10644238191
-
Synthesis and properties of pyrimidine C-nucleoside acyclic analogs
-
Chem. Abstr., 100, 68637b 1983
-
Mel’nik, S. Y., Miniker, T. D., Yartseva, I. V., Nedorezova, T. P., Potapova, G. I., and Preobrazhenskaya, M. N. Synthesis and properties of pyrimidine C-nucleoside acyclic analogs. Bioorg. Khim., 9, 1395–1400 (1983); Chem. Abstr., 100, 68637b (1983).
-
(1983)
Bioorg. Khim.
, vol.9
, pp. 1395-1400
-
-
Mel’nik, S.Y.1
Miniker, T.D.2
Yartseva, I.V.3
Nedorezova, T.P.4
Potapova, G.I.5
Preobrazhenskaya, M.N.6
-
156
-
-
0021173156
-
Synthesis of Onucleoside isosteres of 9-(2-hydroxyethoxymethyl)guanine (acyclovir)
-
Mitchell, W. L., Hill, M. L., Newton, R. F., Ravenscroft, P., and Scopes, D. I. C. Synthesis of Onucleoside isosteres of 9-(2-hydroxyethoxymethyl)guanine (acyclovir). J. Heterocycl. Chem., 21, 697–699 (1984).
-
(1984)
J. Heterocycl. Chem.
, vol.21
, pp. 697-699
-
-
Mitchell, W.L.1
Hill, M.L.2
Newton, R.F.3
Ravenscroft, P.4
Scopes, D.I.C.5
|