-
1
-
-
78049293198
-
Pharmacokinetics and bioavailability of an integrase and novel pharmacoenhancer-containing single-tablet fixed-dose combination regimen for the treatment of HIV
-
German P, Warren D, West S, Hui J, Kearney BP. Pharmacokinetics and bioavailability of an integrase and novel pharmacoenhancer-containing single-tablet fixed-dose combination regimen for the treatment of HIV. J Acquir Immune Defic Syndr 2010; 55:323-329.
-
(2010)
J Acquir Immune Defic Syndr
, vol.55
, pp. 323-329
-
-
German, P.1
Warren, D.2
West, S.3
Hui, J.4
Kearney, B.P.5
-
2
-
-
37849002059
-
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
-
Shimura K, Kodama E, Sakagami Y, et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 2008; 82:764-774.
-
(2008)
J Virol
, vol.82
, pp. 764-774
-
-
Shimura, K.1
Kodama, E.2
Sakagami, Y.3
-
3
-
-
73549123203
-
Strand transfer inhibitors of HIV-1 integrase: Bringing IN a new era of antiretroviral therapy
-
McColl DJ, Chen X. Strand transfer inhibitors of HIV-1 integrase: bringing IN a new era of antiretroviral therapy. Antiviral Res 2010; 85:101-118.
-
(2010)
Antiviral Res
, vol.85
, pp. 101-118
-
-
McColl, D.J.1
Chen, X.2
-
4
-
-
84877843704
-
Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness
-
Abram ME, Hluhanich RM, Goodman DD, et al. Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness. Antimicrob Agents Chemother 2013; 57:2654-2663.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 2654-2663
-
-
Abram, M.E.1
Hluhanich, R.M.2
Goodman, D.D.3
-
5
-
-
77149123315
-
Pharmacokinetics and pharmacodynamics of GS-9350: A novel pharmacokinetic enhancer without anti-HIV activity
-
Mathias AA, German P, Murray BP, et al. Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther 2010; 87:322-329.
-
(2010)
Clin Pharmacol Ther
, vol.87
, pp. 322-329
-
-
Mathias, A.A.1
German, P.2
Murray, B.P.3
-
6
-
-
84862876886
-
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: A randomised, double-blind, Phase 3 trial, analysis of results after 48 weeks
-
Sax PE, DeJesus E, Mills A, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, Phase 3 trial, analysis of results after 48 weeks. Lancet 2012; 379:2439-2448.
-
(2012)
Lancet
, vol.379
, pp. 2439-2448
-
-
Sax, P.E.1
DeJesus, E.2
Mills, A.3
-
7
-
-
84876283495
-
A randomized, doubleblind comparison of co-formulated elvitegravir/cobicistat/ emtricitabine/tenofovir DF versus efavirenz/emtricitabine/ tenofovir DF for initial treatment of HIV-1 infection: Analysis of week 96 results
-
Zolopa A, Sax PE, Dejesus E, et al. A randomized, doubleblind comparison of co-formulated elvitegravir/cobicistat/ emtricitabine/tenofovir DF versus efavirenz/emtricitabine/ tenofovir DF for initial treatment of HIV-1 infection: analysis of week 96 results. J Acquir Immune Defic Syndr 2013; 63:96-100.
-
(2013)
J Acquir Immune Defic Syndr
, vol.63
, pp. 96-100
-
-
Zolopa, A.1
Sax, P.E.2
Dejesus, E.3
-
8
-
-
84894503546
-
A randomized, doubleblind comparison of single-tablet regimen elvitegravir/ cobicistat/emtricitabine/tenofovir DF versus single-tablet regimen efavirenz/emtricitabine/tenofovir DF for initial treatment of HIV-1 Infection: Analysis of week 144 results
-
Wohl DA, Cohen C, Gallant JE, et al. A randomized, doubleblind comparison of single-tablet regimen elvitegravir/ cobicistat/emtricitabine/tenofovir DF versus single-tablet regimen efavirenz/emtricitabine/tenofovir DF for initial treatment of HIV-1 Infection: analysis of week 144 results. J Acquir Immune Defic Syndr 2014; 65:e118-e121.
-
(2014)
J Acquir Immune Defic Syndr
, vol.65
, pp. e118-e121
-
-
Wohl, D.A.1
Cohen, C.2
Gallant, J.E.3
-
9
-
-
0034019566
-
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1
-
Petropoulos CJ, Parkin NT, Limoli KL, et al. A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother 2000; 44:920-928.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 920-928
-
-
Petropoulos, C.J.1
Parkin, N.T.2
Limoli, K.L.3
-
10
-
-
84859231900
-
2011 update of the drug resistance mutations in HIV-1
-
Johnson VA, Calvez V, Gunthard HF, et al. 2011 update of the drug resistance mutations in HIV-1. Top Antivir Med 2011; 19:156-164.
-
(2011)
Top Antivir Med
, vol.19
, pp. 156-164
-
-
Johnson, V.A.1
Calvez, V.2
Gunthard, H.F.3
-
11
-
-
62749200513
-
Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update
-
Bennett DE, Camacho RJ, Otelea D, et al. Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update. PLoS ONE 2009; 4:e4724.
-
(2009)
PLoS ONE
, vol.4
-
-
Bennett, D.E.1
Camacho, R.J.2
Otelea, D.3
-
12
-
-
78650263450
-
HIV-1 integrase sequence variability in antiretroviral naive patients and in triple-class experienced patients subsequently treated with raltegravir
-
Varghese V, Liu TF, Rhee SY, et al. HIV-1 integrase sequence variability in antiretroviral naive patients and in triple-class experienced patients subsequently treated with raltegravir. AIDS Res Hum Retroviruses 2010; 26:1323-1326.
-
(2010)
AIDS Res Hum Retroviruses
, vol.26
, pp. 1323-1326
-
-
Varghese, V.1
Liu, T.F.2
Rhee, S.Y.3
-
13
-
-
70349682997
-
Development of HIV-1 drug resistance through 144 weeks in antiretroviral-naive subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934
-
Margot NA, Enejosa J, Cheng AK, Miller MD, McColl DJ. Development of HIV-1 drug resistance through 144 weeks in antiretroviral-naive subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934. J Acquir Immune Defic Syndr 2009; 52:209-221.
-
(2009)
J Acquir Immune Defic Syndr
, vol.52
, pp. 209-221
-
-
Margot, N.A.1
Enejosa, J.2
Cheng, A.K.3
Miller, M.D.4
McColl, D.J.5
-
14
-
-
84155164041
-
Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: Randomised, double-blind, Phase 3, non-inferiority study
-
Molina JM, Lamarca A, Andrade-Villanueva J, et al. Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: randomised, double-blind, Phase 3, non-inferiority study. Lancet Infect Dis 2012; 12:27-35.
-
(2012)
Lancet Infect Dis
, vol.12
, pp. 27-35
-
-
Molina, J.M.1
Lamarca, A.2
Andrade-Villanueva, J.3
-
15
-
-
77956646683
-
Raltegravir versus efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses
-
Lennox JL, Dejesus E, Berger DS, et al. Raltegravir versus efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses. J Acquir Immune Defic Syndr 2010; 55:39-48.
-
(2010)
J Acquir Immune Defic Syndr
, vol.55
, pp. 39-48
-
-
Lennox, J.L.1
Dejesus, E.2
Berger, D.S.3
-
16
-
-
69449101785
-
Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial
-
Lennox JL, DeJesus E, Lazzarin A, et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009; 374:796-806.
-
(2009)
Lancet
, vol.374
, pp. 796-806
-
-
Lennox, J.L.1
DeJesus, E.2
Lazzarin, A.3
-
17
-
-
81855166275
-
Raltegravir once daily or twice daily in previously untreated patients with HIV-1: A randomised, active-controlled, Phase 3 noninferiority trial
-
Eron JJ, Jr., Rockstroh JK, Reynes J, et al. Raltegravir once daily or twice daily in previously untreated patients with HIV-1: a randomised, active-controlled, Phase 3 noninferiority trial. Lancet Infect Dis 2011; 11:907-915.
-
(2011)
Lancet Infect Dis
, vol.11
, pp. 907-915
-
-
Eron, J.J.1
Rockstroh, J.K.2
Reynes, J.3
-
18
-
-
84862843404
-
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: A randomised, double-blind, Phase 3, non-inferiority trial
-
DeJesus E, Rockstroh J, Henry K, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, Phase 3, non-inferiority trial. Lancet 2012; 379:2429-2438.
-
(2012)
Lancet
, vol.379
, pp. 2429-2438
-
-
DeJesus, E.1
Rockstroh, J.2
Henry, K.3
-
19
-
-
84874411899
-
Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study
-
Raffi F, Rachlis A, Stellbrink HJ, et al. Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study. Lancet 2013; 381:735-743.
-
(2013)
Lancet
, vol.381
, pp. 735-743
-
-
Raffi, F.1
Rachlis, A.2
Stellbrink, H.J.3
-
20
-
-
84887052771
-
Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection
-
Walmsley SL, Antela A, Clumeck N, et al. Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection. N Engl J Med 2013; 369:1807-1818.
-
(2013)
N Engl J Med
, vol.369
, pp. 1807-1818
-
-
Walmsley, S.L.1
Antela, A.2
Clumeck, N.3
-
21
-
-
84903303497
-
Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label Phase 3b study
-
Clotet B, Feinberg J, van Lunzen J, et al. Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label Phase 3b study. Lancet 2014; 383:2222-2231.
-
(2014)
Lancet
, vol.383
, pp. 2222-2231
-
-
Clotet, B.1
Feinberg, J.2
Van Lunzen, J.3
-
22
-
-
50649089453
-
The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation
-
Svarovskaia ES, Feng JY, Margot NA, et al. The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation. J Acquir Immune Defic Syndr 2008; 48:428-436.
-
(2008)
J Acquir Immune Defic Syndr
, vol.48
, pp. 428-436
-
-
Svarovskaia, E.S.1
Feng, J.Y.2
Margot, N.A.3
-
23
-
-
77956150896
-
Cobicistat (GS-9350): A potent and selective inhibitor of human CYP3A as a novel pharmacoenhancer
-
Xu L, Liu H, Murray BP, et al. Cobicistat (GS-9350): a potent and selective inhibitor of human CYP3A as a novel pharmacoenhancer. ACS Med Chem Lett 2010; 1:209-213.
-
(2010)
ACS Med Chem Lett
, vol.1
, pp. 209-213
-
-
Xu, L.1
Liu, H.2
Murray, B.P.3
-
24
-
-
34447554516
-
Prevalence and determinants of transmitted antiretroviral drug resistance in HIV-1 infection
-
Booth CL, Geretti AM. Prevalence and determinants of transmitted antiretroviral drug resistance in HIV-1 infection. J Antimicrob Chemother 2007; 59:1047-1056.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 1047-1056
-
-
Booth, C.L.1
Geretti, A.M.2
-
26
-
-
84873633830
-
Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study
-
Eron JJ, Clotet B, Durant J, et al. Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study. J Infect Dis 2013; 207:740-748.
-
(2013)
J Infect Dis
, vol.207
, pp. 740-748
-
-
Eron, J.J.1
Clotet, B.2
Durant, J.3
|