The role of microRNAs in cell fate determination of mesenchymal stem cells: Balancing adipogenesis and osteogenesis

BMB Reports

Volumn 48, Issue 6, 2015, Pages 319-323

  Kang, Hara ^a   Hata, Akiko ^b  

^a SolarLight Ltd   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adipogenesis; Mesenchymal stem cells; MicroRNAs; Osteogenesis

Indexed keywords

MICRORNA;

ADIPOCYTE; ADIPOGENESIS; ANIMAL; BONE DEVELOPMENT; CYTOLOGY; GENETICS; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; OSTEOBLAST; PHYSIOLOGY;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; HUMANS; MESENCHYMAL STROMAL CELLS; MICRORNAS; OSTEOBLASTS; OSTEOGENESIS;

EID: 84936067349     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2015.48.6.206     Document Type: Review

References (42)

1. Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME (1992) Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102 (Pt 2), 341-351
2. Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M (2001) Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology 2, 165-171
3. Qiu W, Andersen TE, Bollerslev J, Mandrup S, Abdallah BM, Kassem M (2007) Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J Bone Miner Res 22, 1720-1731
4. Rosen ED and MacDougald OA (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7, 885-896
5. Huang W, Yang S, Shao J, Li YP (2007) Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci 12, 3068-3092
6. Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M (1996) Transcriptional control of osteoblast growth and differentiation. Physiol Rev 76, 593-629
7. Chen J and Long F (2013) beta-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice. J Bone Miner Res 28, 1160-1169
8. Rosen ED and Spiegelman BM (2000) Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16, 145-171
9. Sethi JK and Vidal-Puig AJ (2007) Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res 48, 1253-1262
10. Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233
11. Lüningschrör P, Hauser S, Kaltschmidt B, Kaltschmidt C (2013) MicroRNAs in pluripotency, reprogramming and cell fate induction. Biochim Biophys Acta 1833, 1894-1903
12. Ivey KN and Srivastava D (2010) MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell 7, 36-41
13. Oskowitz AZ, Lu J, Penfornis P et al (2008) Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression. Proc Natl Acad Sci U S A 105, 18372-18377
14. Hu R, Liu W, Li H et al (2011) A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem 286, 12328-12339
15. Kim YJ, Bae SW, Yu SS, Bae YC, Jung JS (2009) miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue. J Bone Miner Res 24, 816-825
16. Li Z, Hassan MQ, Jafferji M et al (2009) Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem 284, 15676-15684
17. Zhang J, Tu Q, Bonewald LF et al (2011) Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1. J Bone Miner Res 26, 1953-1963
18. Li Z, Hassan MQ, Volinia S et al (2008) A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci U S A 105, 13906-13911
19. Itoh T, Nozawa Y and Akao Y (2009) MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5. J Biol Chem 284, 19272-19279
20. Luzi E, Marini F, Sala SC, Tognarini I, Galli G and Brandi ML (2008) Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor. J Bone Miner Res 23, 287-295
21. Esau C, Kang X, Peralta E et al (2004) MicroRNA-143 regulates adipocyte differentiation. J Biol Chem 279, 52361-52365
22. Sun F, Wang J, Pan Q et al (2009) Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun 380, 660-665
23. Yang Z, Bian C, Zhou H et al (2011) MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1. Stem Cells Dev 20, 259-267
24. Zaragosi LE, Wdziekonski B, Brigand KL et al (2011) Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol 12, R64
25. Wu T, Zhou H, Hong Y, Li J, Jiang X and Huang H (2012) miR-30 family members negatively regulate osteoblast differentiation. J Biol Chem 287, 7503-7511
26. Wang J, Guan X, Guo F et al (2013) miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6. Cell Death Dis 4, e845
27. Li H, Li T, Wang S et al (2013) miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells. Stem Cell Res 10, 313-324
28. Komori T, Yagi H, Nomura S et al (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764
29. Yoshida CA, Yamamoto H, Fujita T et al (2004) Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev 18, 952-963
30. Huang J, Zhao L, Xing L and Chen D (2010) MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells 28, 357-364
31. Ryoo HM, Lee MH and Kim YJ (2006) Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. Gene 366, 51-57
32. Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM and Drissi H (2006) Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene 372, 62-70
33. Zhang C, Cho K, Huang Y et al (2008) Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A 105, 6936-6941
34. Zhang JF, Fu WM, He ML et al (2011) MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix. Mol Biol Cell 22, 3955-3961
35. Huang S, Wang S, Bian C et al (2012) Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression. Stem Cells Dev 21, 2531-2540
36. Westendorf JJ, Zaidi SK, Cascino JE et al (2002) Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol 22, 7982-7992
37. Chen S, Do JT, Zhang Q et al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A 103, 17266-17271
38. Li W and Ding S (2010) Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol Sci 31, 36-45
39. Ge C, Xiao G, Jiang D and Franceschi RT (2007) Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176, 709-718
40. Mei Y, Bian C, Li J et al (2013) miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation. J Cell Biochem 114, 1374-1384
41. Trohatou O, Zagoura D, Bitsika V et al (2014) Sox2 suppression by miR-21 governs human mesenchymal stem cell properties. Stem Cells Transl Med 3, 54-68
42. Boyer LA, Lee TI, Cole MF et al (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947-956