An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations

Analytical Biochemistry

Volumn 484, Issue , 2015, Pages 82-90

  Kuzmič, Petr ^a   Solowiej, James ^b   Murray, Brion W ^b  

^a Biokin   (United States)

^b PFIZER INC   (United States)

Author keywords

Covalent inhibition; EGFR kinase; Enzyme kinetics; Irreversible inhibition; Mathematics; Theory

Indexed keywords

DISSOCIATION; ENZYME KINETICS; MATHEMATICAL TECHNIQUES; RATE CONSTANTS;

EGFR KINASE; ENZYME-INHIBITOR COMPLEX; EPIDERMAL GROWTH FACTOR RECEPTORS; EXPERIMENTAL CONDITIONS; INTEGRATED RATE EQUATIONS; IRREVERSIBLE INHIBITIONS; SUBSTRATE CONCENTRATIONS; THEORY;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DISSOCIATION CONSTANT; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME KINETICS; INACTIVATION RATE CONSTANT; INHIBITION CONSTANT; INHIBITION KINETICS; MATHEMATICAL MODEL; MATHEMATICS; MICHAELIS CONSTANT; NONLINEAR SYSTEM; PRIORITY JOURNAL; REACTION TIME; SUBSTRATE CONCENTRATION; ANTAGONISTS AND INHIBITORS; CHEMICAL MODEL; KINETICS; METABOLISM;

ENZYME INHIBITORS; KINETICS; MODELS, CHEMICAL; NONLINEAR DYNAMICS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84935850690     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2014.11.014     Document Type: Article

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