Mesenchymal stem cells increase T-regulatory cells and improve healing following trauma and hemorrhagic shock

Journal of Trauma and Acute Care Surgery

Volumn 79, Issue 1, 2015, Pages 48-52

  Gore, Amy V ^a   Bible, Letitia E ^a   Song, Kimberly ^a   Livingston, David H ^a   Mohr, Alicia M ^a   Sifri, Ziad C ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Cell based therapy; immunomodulation; lung Injury; MSCs; rats

Indexed keywords

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CELL THERAPY; CONTROLLED STUDY; FLOW CYTOMETRY; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; INFLAMMATORY CELL; INJECTION; LUNG; LUNG ALVEOLUS; LUNG EDEMA; LUNG INJURY; LUNG INJURY SCORE; LYMPHOCYTE SUBPOPULATION; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; SCORING SYSTEM; WOUND HEALING; WOUND HEALING IMPAIRMENT; ANIMAL; CONTUSION; EXTRACELLULAR FLUID; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY EDEMA; SHOCK, HEMORRHAGIC; SPRAGUE DAWLEY RAT;

ANIMALS; CONTUSIONS; EXTRACELLULAR FLUID; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LUNG INJURY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; T-LYMPHOCYTES, REGULATORY; WOUND HEALING;

EID: 84935057275     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000681     Document Type: Article

References (24)

1. Thornton FJ, Schaffer MR, Barbul A. Wound healing in sepsis and trauma. Shock. 1997;8(6):391-401.
2. Hierholzer CH, Billiar TR. Molecular mechanisms in the early phase of hemorrhagic shock. Langenbecks Arch Surg. 2001;386:302-308.
3. McGinn FP. Effects of haemorrhage upon surgical operations. Br J Surg. 1976;63(10):742-746.
4. Guiney DJ, Morris PJ, Donaldson GA. Wound dehiscence. A continuing problem in abdominal surgery. Arch Surg. 1966;92:47-51.
5. Angele MK, Knoferl MW, Ayala A, Albina JE, Cioffi WG, Bland KI, Chaudry IH. Trauma-hemorrhage delays wound healing potentially by increasing pro-inflammatory cytokines at the wound site. Surgery. 1999;126(2):279-285.
6. Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, Ishino K, Ishida H, Shimizu T, Kangawa K, et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med. 2006;12:459-465.
7. Walker PA, Bedi SS, Shah SK, Jimenez F, Xue J, Hamilton JA, Smith P, Thomas CP, Mays RW, Pati S, et al. Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population. J Neuroinflammation. 2012;9:228-240.
8. Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, Lanino E, Sundberg B, Bernardo ME, Remberger M, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet. 2008;371(9624):1579-1586.
9. Cook K, Sifri Z, Baranski G, Rameshwar P, Mohr A, Livingston D. The role of T regulatory cells in mesenchymal stromal cell (MSC)-mediated wound healing. Surg Infect (Larchmt). 2012;13(1):S15.
10. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8(7):523-532.
11. Hannoush EJ, Elhassan I, Sifri ZC, Mohr AM, Alzate WD, Livingston DH. Role of bone marrow and mesenchymal stem cells in healing after traumatic injury. Surgery. 2013;153(1):44-51.
12. Pasupuleti LV, Cook KM, Sifri ZC, Kotamarti S, Calderon GM, Alzate WD, Livingston DH, Mohr AM. Does selective beta-1 blockade provide bone marrow protection after trauma/hemorrhagic shock? Surgery. 2012;152(3):322-330.
13. Claridge JA, Enelow RI, Young JS. Hemorrhage and resuscitation induce inflammation and pulmonary dysfunction in mice. J Surg Res. 2000;92:206-213.
14. Parekkadan B, van Poll D, Suganuma K, Carter EA, Berthiaume F, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One. 2007;2:e941.
15. Togel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol. 2005;289:F31-F42.
16. Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O'Brien T, O'Toole D, Laffey JG. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. 2012;67:496-501.
17. Xu J, Woods CR, Mora AL, Joodi R, Brigham KL, Iyer S, Rojas M. Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol. 2007;293:L131-L141.
18. Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A. 2003;100(14):8407-8411.
19. Matthay MA, Goolaerts A, Howard J, Lee JW. Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med. 2010;38(10):S569-S573.
20. Moore FA, Moore EE. Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am. 1995;75:257-277.
21. Venet F, Chung CS, Monneret G, Huang X, Horner B, Garber M, Ayala A. Regulatory T cell populations in sepsis and trauma. J Leukoc Biol. 2008;83(3):523-535.
22. Zhang Q, Lu YQ, Jiang JK, Gu LH, Mou HZ. Early changes of CD4+CD25+Foxp3+ regulatory T cells and Th1/Th2, Tc1/Tc2 profiles in the peripheral blood of rats with controlled hemorrhagic shock and no fluid resuscitation. Chin Med J (Engl). 2012;125(12):2163-2167.
23. Cook K, Pasupuleti L, Alzate W, Mohr A, Livingston D, Sifri Z. Blocking T-regulatory cell response impairs MSC-mediated wound healing. J Surg Res. 2013;179(2):321.
24. Kavanagh H, Mahon BP. Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy. 2011;66:523-531.