Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy

ACS Nano

Volumn 9, Issue 6, 2015, Pages 6401-6411

  Xiang, Jian ^a   Xu, Ligeng ^a   Gong, Hua ^a   Zhu, Wenwen ^a   Wang, Chao ^a   Xu, Jun ^a   Feng, Liangzhu ^a   Cheng, Liang ^a   Peng, Rui ^a   Liu, Zhuang ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

DC vaccine; immunotherapy; sensitive tracking; UCNP

Indexed keywords

ANTIGENS; BODY FLUIDS; CELL PROLIFERATION; CELLS; CYTOLOGY; NANOPARTICLES; T-CELLS; VACCINES;

ANTIGEN DELIVERY; CYTOTOXIC T LYMPHOCYTES; DENDRITIC CELLS; IMMUNOTHERAPY; INTERFERON-GAMMA; UCNP; UPCONVERSION LUMINESCENCE; UPCONVERSION NANOPARTICLES;

IMMUNE SYSTEM;

ANTIGEN; CANCER VACCINE; CYTOKINE; NANOPARTICLE;

ANIMAL; C57BL MOUSE; CELL SURVIVAL; CELL TRACKING; CHEMISTRY; DENDRITIC CELL; FEMALE; IMMUNOLOGY; LUMINESCENCE; MOUSE; VACCINATION;

ANIMALS; ANTIGENS; CANCER VACCINES; CELL SURVIVAL; CELL TRACKING; CYTOKINES; DENDRITIC CELLS; FEMALE; LUMINESCENCE; MICE; MICE, INBRED C57BL; NANOPARTICLES; VACCINATION;

EID: 84935024404     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b02014     Document Type: Article

References (53)

1. Liu, Y.-J. Dendritic Cell Subsets and Lineages, and Their Functions in Innate and Adaptive Immunity Cell 2001, 106, 259-262
2. Steinman, R. M. Dendritic Cells: Versatile Controllers of the Immune System Nat. Med. 2007, 13, 1155-1159
3. Kapsenberg, M. L. Dendritic-Cell Control of Pathogen-Driven T-Cell Polarization Nat. Rev. Immunol. 2003, 3, 984-993
4. Lu, W.; Arraes, L. C.; Ferreira, W. T.; Andrieu, J.-M. Therapeutic Dendritic-Cell Vaccine for Chronic HIV-1 Infection Nat. Med. 2004, 10, 1359-1365
5. Banchereau, J.; Palucka, A. K. Dendritic Cells as Therapeutic Vaccines against Cancer Nat. Rev. Immunol. 2005, 5, 296-306
6. Melief, C. J. Cancer Immunotherapy by Dendritic Cells Immunity 2008, 29, 372-383
7. Nestle, F. O.; Alijagic, S.; Gilliet, M.; Sun, Y.; Grabbe, S.; Dummer, R.; Burg, G.; Schadendorf, D. Vaccination of Melanoma Patients with Peptide- or Tumorlysate-Pulsed Dendritic Cells Nat. Med. 1998, 4, 328-332
8. Kugler, A.; Stuhler, G.; Walden, P.; Zöller, G.; Zobywalski, A.; Brossart, P.; Trefzer, U.; Ullrich, S.; Müller, C. A.; Becker, V. et al. Regression of Human Metastatic Renal Cell Carcinoma after Vaccination with Tumor Cell-Dendritic Cell Hybrids Nat. Med. 2000, 6, 332-336
9. Hsu, F. J.; Benike, C.; Fagnoni, F.; Liles, T. M.; Czerwinski, D.; Taidi, B.; Engleman, E. G.; Levy, R. Vaccination of Patients with B-Cell Lymphoma Using Autologous Antigen-Pulsed Dendritic Cells Nat. Med. 1996, 2, 52-58
10. Randolph, G. J.; Angeli, V.; Swartz, M. A. Dendritic-Cell Trafficking to Lymph Nodes through Lymphatic Vessels Nat. Rev. Immunol. 2005, 5, 617-628
11. Ohl, L.; Mohaupt, M.; Czeloth, N.; Hintzen, G.; Kiafard, Z.; Zwirner, J.; Blankenstein, T.; Henning, G.; Förster, R. CCR7 Governs Skin Dendritic Cell Migration under Inflammatory and Steady-State Conditions Immunity 2004, 21, 279-288
12. Acton, S. E.; Astarita, J. L.; Malhotra, D.; Lukacs-Kornek, V.; Franz, B.; Hess, P. R.; Jakus, Z.; Kuligowski, M.; Fletcher, A. L.; Elpek, K. G. et al. Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-Type Lectin Receptor CLEC-2 Immunity 2012, 37, 276-289
13. De Vries, I. J. M.; Lesterhuis, W. J.; Barentsz, J. O.; Verdijk, P.; van Krieken, J. H.; Boerman, O. C.; Oyen, W. J.; Bonenkamp, J. J.; Boezeman, J. B.; Adema, G. J. et al. Magnetic Resonance Tracking of Dendritic Cells in Melanoma Patients for Monitoring of Cellular Therapy Nat. Biotechnol. 2005, 23, 1407-1413
14. Cho, N.-H.; Cheong, T.-C.; Min, J. H.; Wu, J. H.; Lee, S. J.; Kim, D.; Yang, J.-S.; Kim, S.; Kim, Y. K.; Seong, S.-Y. A Multifunctional Core-Shell Nanoparticle for Dendritic Cell-Based Cancer Immunotherapy Nat. Nanotechnol. 2011, 6, 675-682
15. De Vries, I. J. M.; Krooshoop, D. J.; Scharenborg, N. M.; Lesterhuis, W. J.; Diepstra, J. H. S.; van Muijen, G. N.; Strijk, S. P.; Ruers, T. J.; Boerman, O. C.; Oyen, W. J. et al. Effective Migration of Antigen-Pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation State Cancer Res. 2003, 63, 12-17
16. Prince, H. M.; Wall, D. M.; Ritchie, D.; Honemann, D.; Harrrison, S.; Quach, H.; Thompson, M.; Hicks, R.; Lau, E.; Davison, J. et al. In Vivo Tracking of Dendritic Cells in Patients with Multiple Myeloma J. Immunother. 2008, 31, 166-179
17. Noh, Y.-W.; Jang, Y.-S.; Ahn, K.-J.; Lim, Y. T.; Chung, B. H. Simultaneous in Vivo Tracking of Dendritic Cells and Priming of An Antigen-Specific Immune Response Biomaterials 2011, 32, 6254-6263
18. Wang, F.; Liu, X. Recent Advances in the Chemistry of Lanthanide-Doped Upconversion Nanocrystals Chem. Soc. Rev. 2009, 38, 976-989
19. Gai, S.; Li, C.; Yang, P.; Lin, J. Recent Progress in Rare Earth Micro/Nanocrystals: Soft Chemical Synthesis, Luminescent Properties, and Biomedical Applications Chem. Rev. 2013, 114, 2343-2389
20. Chen, G.; Qiu, H.; Prasad, P. N.; Chen, X. Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics Chem. Rev. 2014, 114, 5161-5214
21. Cheng, L.; Yang, K.; Li, Y.; Chen, J.; Wang, C.; Shao, M.; Lee, S. T.; Liu, Z. Facile Preparation of Multifunctional Upconversion Nanoprobes for Multimodal Imaging and Dual-Targeted Photothermal Therapy Angew. Chem., Int. Ed. 2011, 123, 7523-7528
22. Zhou, L.; Chen, Z.; Dong, K.; Yin, M.; Ren, J.; Qu, X. DNA-Mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near-Infrared Light Triggered Release Adv. Mater. 2014, 26, 2424-2430
23. Li, W.; Wang, J.; Ren, J.; Qu, X. Near-Infrared Upconversion Controls Photocaged Cell Adhesion J. Am. Chem. Soc. 2014, 136, 2248-2251
24. Liu, Q.; Feng, W.; Yang, T.; Yi, T.; Li, F. Upconversion Luminescence Imaging of Cells and Small Animals Nat. Protoc. 2013, 8, 2033-2044
25. Punjabi, A.; Wu, X.; Tokatli-Apollon, A.; El-Rifai, M.; Lee, H.; Zhang, Y.; Wang, C.; Liu, Z.; Chan, E. M.; Duan, C. et al. Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy ACS Nano 2014, 8, 10621-10630
26. Bhirde, A.; Xie, J.; Swierczewska, M.; Chen, X. Nanoparticles for Cell Labeling Nanoscale 2011, 3, 142-153
27. Wang, C.; Cheng, L.; Xu, H.; Liu, Z. Towards Whole-Body Imaging at the Single Cell Level Using Ultra-Sensitive Stem Cell Labeling with Oligo-Arginine Modified Upconversion Nanoparticles Biomaterials 2012, 33, 4872-4881
28. Cheng, L.; Wang, C.; Ma, X.; Wang, Q.; Cheng, Y.; Wang, H.; Li, Y.; Liu, Z. Multifunctional Upconversion Nanoparticles for Dual-Modal Imaging-Guided Stem Cell Therapy under Remote Magnetic Control Adv. Funct. Mater. 2013, 23, 272-280
29. Chen, Q.; Wang, C.; Cheng, L.; He, W.; Cheng, Z.; Liu, Z. Protein Modified Upconversion Nanoparticles for Imaging-Guided Combined Photothermal and Photodynamic Therapy Biomaterials 2014, 35, 2915-2923
30. Wang, X.; Liu, K.; Yang, G.; Cheng, L.; He, L.; Liu, Y.; Li, Y.; Guo, L.; Liu, Z. Near-Infrared Light Triggered Photodynamic Therapy in Combination with Gene Therapy Using Upconversion Nanoparticles for Effective Cancer Cell Killing Nanoscale 2014, 6, 9198-9205
31. Xu, L.; Liu, Y.; Chen, Z.; Li, W.; Liu, Y.; Wang, L.; Ma, L.; Shao, Y.; Zhao, Y.; Chen, C. Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine Adv. Mater. 2013, 25, 5928-5936
32. Lanzavecchia, A.; Sallusto, F. Regulation of T Cell Immunity by Dendritic Cells Cell 2001, 106, 263-266
33. De Vries, I. J. M.; Lesterhuis, W. J.; Scharenborg, N. M.; Engelen, L. P.; Ruiter, D. J.; Gerritsen, M.-J. P.; Croockewit, S.; Britten, C. M.; Torensma, R.; Adema, G. J. et al. Maturation of Dendritic Cells Is a Prerequisite for Inducing Immune Responses in Advanced Melanoma Patients Clin. Cancer Res. 2003, 9, 5091-5100
34. Mellman, I.; Steinman, R. M. Dendritic Cells: Specialized and Regulated Antigen Processing Machines Cell 2001, 106, 255-258
35. Brunda, M. J.; Luistro, L.; Warrier, R. R.; Wright, R. B.; Hubbard, B. R.; Murphy, M.; Wolf, S. F.; Gately, M. Antitumor and Antimetastatic Activity of Interleukin 12 against Murine Tumors J. Exp. Med. 1993, 178, 1223-1230
36. Carreno, B. M.; Becker-Hapak, M.; Huang, A.; Chan, M.; Alyasiry, A.; Lie, W.-R.; Aft, R. L.; Cornelius, L. A.; Trinkaus, K. M.; Linette, G. P. IL-12p70-Producing Patient DC Vaccine Elicits Tc1-Polarized Immunity J. Clin. Invest. 2013, 123, 3383-3394
37. Gustafsson, K.; Ingelsten, M.; Bergqvist, L.; Nyström, J.; Andersson, B.; Karlsson-Parra, A. Recruitment and Activation of Natural Killer Cells in Vitro by A Human Dendritic Cell Vaccine Cancer Res. 2008, 68, 5965-5971
38. Yukawa, H.; Kagami, Y.; Watanabe, M.; Oishi, K.; Miyamoto, Y.; Okamoto, Y.; Tokeshi, M.; Kaji, N.; Noguchi, H.; Ono, K. et al. Quantum Dots Labeling Using Octa-Arginine Peptides for Imaging of Adipose Tissue-Derived Stem Cells Biomaterials 2010, 31, 4094-4103
39. Kraitchman, D. L.; Tatsumi, M.; Gilson, W. D.; Ishimori, T.; Kedziorek, D.; Walczak, P.; Segars, W. P.; Chen, H. H.; Fritzges, D.; Izbudak, I. et al. Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction Circulation 2005, 112, 1451-1461
40. Baumjohann, D.; Hess, A.; Budinsky, L.; Brune, K.; Schuler, G.; Lutz, M. B. In Vivo Magnetic Resonance Imaging of Dendritic Cell Migration into the Draining Lymph Nodes of Mice Eur. J. Immunol. 2006, 36, 2544-2555
41. Bashour, K. T.; Gondarenko, A.; Chen, H.; Shen, K.; Liu, X.; Huse, M.; Hone, J. C.; Kam, L. C. CD28 and CD3 Have Complementary Roles in T-Cell Traction Forces Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 2241-2246
42. Kaech, S. M.; Wherry, E. J.; Ahmed, R. Effector and Memory T-Cell Differentiation: Implications for Vaccine Development Nat. Rev. Immunol. 2002, 2, 251-262
43. Migueles, S. A.; Laborico, A. C.; Shupert, W. L.; Sabbaghian, M. S.; Rabin, R.; Hallahan, C. W.; Van Baarle, D.; Kostense, S.; Miedema, F.; McLaughlin, M. et al. HIV-Specific CD8+ T Cell Proliferation Is Coupled to Perforin Expression and Is Maintained in Nonprogressors Nat. Immunol. 2002, 3, 1061-1068
44. Hogquist, K. A.; Jameson, S. C.; Heath, W. R.; Howard, J. L.; Bevan, M. J.; Carbone, F. R. T Cell Receptor Antagonist Peptides Induce Positive Selection Cell 1994, 76, 17-27
45. Seder, R. A.; Darrah, P. A.; Roederer, M. T-Cell Quality in Memory and Protection: Implications for Vaccine Design Nat. Rev. Immunol. 2008, 8, 247-258
46. Dranoff, G. Cytokines in Cancer Pathogenesis and Cancer Therapy Nat. Rev. Cancer 2004, 4, 11-22
47. Tao, Y.; Ju, E.; Li, Z.; Ren, J.; Qu, X. Engineered CpG-Antigen Conjugates Protected Gold Nanoclusters as Smart Self-Vaccines for Enhanced Immune Response and Cell Imaging Adv. Funct. Mater. 2014, 24, 1004-1010
48. Fung-Leung, W.-P.; Schilham, M. W.; Rahemtulla, A.; Kündig, T. M.; Vollenweider, M.; Potter, J.; van Ewijk, W.; Mak, T. W. CD8 Is Needed for Development of Cytotoxic T But Not Helper T Cells Cell 1991, 65, 443-449
49. Harari, A.; Petitpierre, S.; Vallelian, F.; Pantaleo, G. Skewed Representation of Functionally Distinct Populations of Virus-Specific CD4 T Cells in HIV-1-Infected Subjects with Progressive Disease: Changes after Antiretroviral Therapy Blood 2004, 103, 966-972
50. Brossart, P.; Wirths, S.; Stuhler, G.; Reichardt, V. L.; Kanz, L.; Brugger, W. Induction of Cytotoxic T-Lymphocyte Responses in Vivo after Vaccinations with Peptide-Pulsed Dendritic Cells Blood 2000, 96, 3102-3108
51. Li, C.; Liang, S.; Zhang, C.; Liu, Y.; Yang, M.; Zhang, J.; Zhi, X.; Pan, F.; Cui, D. Allogenic Dendritic Cell and Tumor Cell Fused Vaccine for Targeted Imaging and Enhanced Immunotherapeutic Efficacy of Gastric Cancer Biomaterials 2015, 54, 177-187
52. Celluzzi, C. M.; Mayordomo, J. I.; Storkus, W. J.; Lotze, M. T.; Falo, L. Peptide-Pulsed Dendritic Cells Induce Antigen-Specific CTL-Mediated Protective Tumor Immunity J. Exp. Med. 1996, 183, 283-287
53. Cheng, L.; Yang, K.; Shao, M.; Lu, X.; Liu, Z. In Vivo Pharmacokinetics, Long-Term Biodistribution and Toxicology Study of Functionalized Upconversion Nanoparticles in Mice Nanomedicine 2011, 6, 1327-1340