Meropenem therapy in extracorporeal membrane oxygenation patients: An ongoing pharmacokinetic challenge

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Honore, Patrick M ^a   Jacobs, Rita ^a   Hendrickx, Inne ^a   De Waele, Elisabeth ^a   Van Gorp, Viola ^a   Spapen, Herbert D ^a  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MEROPENEM; ANTIINFECTIVE AGENT; THIENAMYCIN DERIVATIVE;

ANTIBIOTIC THERAPY; BACTERICIDAL ACTIVITY; DOSE RESPONSE; DRUG BLOOD LEVEL; EXTRACORPOREAL OXYGENATION; HUMAN; LETTER; MINIMUM INHIBITORY CONCENTRATION; PATHOGEN LOAD; PRIORITY JOURNAL; SEPSIS; FEMALE; MALE; RENAL REPLACEMENT THERAPY;

ANTI-BACTERIAL AGENTS; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HUMANS; MALE; RENAL REPLACEMENT THERAPY; THIENAMYCINS;

EID: 84934978632     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0953-2     Document Type: Letter

References (5)

1. Gonçalves-Pereira J, Oliveira B. Antibiotics and extracorporeal circulation - one size does not fit all. Crit Care. 2014;18:695.
2. Taccone FS, Laterre PF, Dugernier T, Spapen H, Delattre I, Witebolle X, et al. Insufficient β- lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care. 2010;14:R126.
3. Roberts JA, Kirkpatrick CM, Roberts MS, Robertson TA, Dalley AJ, Lipman J. Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. J Antimicrob Chemother. 2009;64:142-50.
4. Honore PM, Jacobs R, Spapen HD. Antimicrobial dosing during extracorporeal membrane oxygenation. In: Vincent JL, editor. Annual update on intensive care and emergency care. Cham: Springer International Publishing; 2014. p. 43-53.
5. Gonçalves-Pereira J, Paiva JA. Dose modulation: a new concept of antibiotic therapy in the critically ill patient ? J Crit Care. 2013;28:341-6.