Association between aspirin therapy and clinical outcomes in patients with non-obstructive coronary artery disease: A cohort study

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Hwang, In Chang ^a,b   Jeon, Joo Yeong ^c   Kim, Younhee ^d   Kim, Hyue Mee ^a,b   Yoon, Yeonyee E ^a,e   Lee, Seung Pyo ^a,b   Kim, Hyung Kwan ^a,b   Sohn, Dae Won ^a,b   Sung, Jidong ^f,g   Kim, Yong Jin Kim ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Seoul National University   (South Korea)

^e Seoul National University Bundang Hospital   (South Korea)

^f Samsung Medical Center   (South Korea)

^g Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; CONTRAST MEDIUM; ESMOLOL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METOPROLOL; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; AGE; ANGIOCARDIOGRAPHY; ARTICLE; COHORT ANALYSIS; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY CALCIUM SCORE; CORONARY ARTERY DISEASE; DIABETES MELLITUS; FEMALE; FOLLOW UP; HEART MUSCLE REVASCULARIZATION; HIGH RISK PATIENT; HUMAN; HYPERTENSION; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIDETECTOR COMPUTED TOMOGRAPHY; OUTCOME ASSESSMENT; PATIENT IDENTIFICATION; PATIENT SELECTION; RISK REDUCTION; CASE CONTROL STUDY; COMPARATIVE STUDY; CORONARY ANGIOGRAPHY; MIDDLE AGED; PATHOLOGY; PROGNOSIS; RISK FACTOR; SURVIVAL RATE; X-RAY COMPUTED TOMOGRAPHY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CASE-CONTROL STUDIES; COHORT STUDIES; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; RISK FACTORS; SURVIVAL RATE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84934978067     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129584     Document Type: Article

References (45)

1. Shaw LJ, Hausleiter J, Achenbach S, Al-Mallah M, Berman DS, Budoff MJ, et al. Coronary computed tomographic angiography as a gatekeeper to invasive diagnostic and surgical procedures: results from the multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: an International Multicenter) registry. Journal of the American College of Cardiology. 2012; 60(20):2103-14. doi: 10. 1016/j.jacc.2012.05.062 PMID: 23083780.
2. Min JK, Dunning A, Lin FY, Achenbach S, Al-Mallah M, Budoff MJ, et al. Age- and sex-related differences in all-cause mortality risk based on coronary computed tomography angiography findings results from the International Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) of 23,854 patients without known coronary artery disease. Journal of the American College of Cardiology. 2011; 58(8):849-60. doi: 10.1016/j.jacc.2011.02. 074 PMID: 21835321.
3. Hoffmann U, Bamberg F, Chae CU, Nichols JH, Rogers IS, Seneviratne SK, et al. Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial. Journal of the American College of Cardiology. 2009; 53(18):1642-50. Epub 2009/05/02. doi: S0735-1097(09)00541-5 [pii] doi: 10.1016/j. jacc.2009.01.052 PMID: 19406338; PubMed Central PMCID: PMC2747766.
4. Choi EK, Choi SI, Rivera JJ, Nasir K, Chang SA, Chun EJ, et al. Coronary computed tomography angiography as a screening tool for the detection of occult coronary artery disease in asymptomatic individuals. Journal of the American College of Cardiology. 2008; 52(5):357-65. doi: 10.1016/j.jacc.2008.02. 086 PMID: 18652943.
5. Jespersen L, Hvelplund A, Abildstrom SZ, Pedersen F, Galatius S, Madsen JK, et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events. European heart journal. 2012; 33(6):734-44. doi: 10.1093/eurheartj/ehr331 PMID: 21911339.
6. Hulten EA, Carbonaro S, Petrillo SP, Mitchell JD, Villines TC. Prognostic value of cardiac computed tomography angiography: a systematic review and meta-analysis. Journal of the American College of Cardiology. 2011; 57(10):1237-47. doi: 10.1016/j.jacc.2010.10.011 PMID: 21145688.
7. Maddox TM, Stanislawski MA, Grunwald GK, Bradley SM, Ho PM, Tsai TT, et al. Nonobstructive coronary artery disease and risk of myocardial infarction. Jama. 2014; 312(17):1754-63. Epub 2014/11/05. doi: 10.1001/jama.2014.14681 PMID: 25369489.
8. McEvoy JW, Blaha MJ, Nasir K, Yoon YE, Choi EK, Cho IS, et al. Impact of coronary computed tomographic angiography results on patient and physician behavior in a low-risk population. Arch Intern Med. 2011; 171(14):1260-8. doi: 10.1001/archinternmed.2011.204 PMID: 21606093.
9. Cheezum MK, Hulten EA, Smith RM, Taylor AJ, Kircher J, Surry L, et al. Changes in preventive medical therapies and CV risk factors after CT angiography. JACC Cardiovascular imaging. 2013; 6(5):574-81. Epub 2013/04/16. doi: 10.1016/j.jcmg.2012.11.016 PMID: 23582355.
10. Hulten E, Bittencourt MS, Singh A, O'Leary D, Christman MP, Osmani W, et al. Coronary artery disease detected by coronary computed tomographic angiography is associated with intensification of preventive medical therapy and lower low-density lipoprotein cholesterol. Circ Cardiovasc Imaging. 2014; 7 (4):629-38. Epub 2014/06/08. doi: 10.1161/CIRCIMAGING.113.001564 PMID: 24906356.
11. Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ. 1994; 308(6921):81-106. PMID: 8298418; PubMed Central PMCID: PMC2539220.
12. Antithrombotic Trialists C. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002; 324 (7329):71-86. PMID: 11786451; PubMed Central PMCID: PMC64503.
13. Antithrombotic Trialists C, Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009; 373(9678):1849-60. doi: 10.1016/S0140-6736(09) 60503-1 PMID: 19482214; PubMed Central PMCID: PMC2715005.
14. Hwang IC, Jeon JY, Kim Y, Kim HM, Yoon YE, Lee SP, et al. Statin therapy is associated with lower allcause mortality in patients with non-obstructive coronary artery disease. Atherosclerosis. 2015; 239 (2):335-42. Epub 2015/02/16. doi: 10.1016/j.atherosclerosis.2015.01.036 PMID: 25682032.
15. Kwon S. Payment system reform for health care providers in Korea. Health Policy Plan. 2003; 18 (1):84-92. PMID: 12582111.
16. Lee CH, Kim K, Hyun MK, Jang EJ, Lee NR, Yim JJ. Use of inhaled corticosteroids and the risk of tuberculosis. Thorax. 2013; 68(12):1105-13. Epub 2013/06/12. doi: 10.1136/thoraxjnl-2012-203175 PMID: 23749841.
17. Kim L, Kim JA, Kim S. A guide for the utilization of Health Insurance Review and Assessment Service National Patient Samples. Epidemiology and health. 2014; 36:e2014008. Epub 2014/08/01. doi: 10. 4178/epih/e2014008 PMID: 25078381; PubMed Central PMCID: PMC4151963.
18. Hulten E, Bittencourt MS, Ghoshhajra B, O'Leary D, Christman MP, Blaha MJ, et al. Incremental prognostic value of coronary artery calcium score versus CT angiography among symptomatic patients without known coronary artery disease. Atherosclerosis. 2014; 233(1):190-5. Epub 2014/02/18. doi: 10.1016/j.atherosclerosis.2013.12.029 PMID: 24529143.
19. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. Journal of the American College of Cardiology. 1990; 15(4):827-32. PMID: 2407762.
20. Miller JM, Rochitte CE, Dewey M, Arbab-Zadeh A, Niinuma H, Gottlieb I, et al. Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med. 2008; 359(22):2324-36. doi: 10.1056/ NEJMoa0806576 PMID: 19038879.
21. Min JK, Shaw LJ, Devereux RB, Okin PM, Weinsaft JW, Russo DJ, et al. Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortality. Journal of the American College of Cardiology. 2007; 50(12):1161-70. doi: 10.1016/j.jacc.2007.03.067 PMID: 17868808.
22. Cheng V, Berman D, Rozanski A, Dunning A, Achenbach S, Al Khdair D, et al. Performance of the traditional age, sex, and angina typicality-based approach for estimating pretest probability of angiographically significant coronary artery disease in patients undergoing coronary computed tomography angiography: results from the multinational coronary CT angiography evaluation for clinical outcomes: an international multicenter registry (CONFIRM). Circulation. 2011; 124(22):2423-32. doi: 10.1161/ CIRCULATIONAHA.111.039255 PMID: 22025600
23. Matthys F, De Backer T, De Backer G, Stichele RV. Review of guidelines on primary prevention of cardiovascular disease with aspirin: how much evidence is needed to turn a tanker? European journal of preventive cardiology. 2014; 21(3):354-65. Epub 2013/04/24. doi: 10.1177/2047487312472077 PMID: 23610452.
24. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). European heart journal. 2012; 33(13):1635-701. doi: 10.1093/eurheartj/ehs092 PMID: 22555213.
25. Vandvik P.O. , LincoffA.M., GoreJ.M., GuttermanD.D., SonnenbergF.A., Alonso-CoelloP., et al. Primary and Secondary Prevention of Cardiovascular Disease: Antithrombotic Therapy and Prevention of Thrombosisth ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012; 141(2 Suppl):e637S-68S. Epub 2012/02/15. doi: 10.1378/chest.11-2306 PMID: 22315274; PubMed Central PMCID: PMC3278064.
26. Pearson TA, Blair SN, Daniels SR, Eckel RH, Fair JM, Fortmann SP, et al. AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation. 2002; 106(3):388-91. PMID: 12119259.
27. Seshasai SR, Wijesuriya S, Sivakumaran R, Nethercott S, Erqou S, Sattar N, et al. Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials. Arch Intern Med. 2012; 172(3):209-16. Epub 2012/01/11. doi: 10.1001/archinternmed.2011.628 PMID: 22231610.
28. Bartolucci AA, Tendera M, Howard G. Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin. The American journal of cardiology. 2011; 107(12):1796-801. Epub 2011/ 04/13. doi: 10.1016/j.amjcard.2011.02.325 PMID: 21481826.
29. Sutcliffe P, Connock M, Gurung T, Freeman K, Johnson S, Ngianga-Bakwin K, et al. Aspirin in primary prevention of cardiovascular disease and cancer: a systematic review of the balance of evidence from reviews of randomized trials. PloS one. 2013; 8(12):e81970. Epub 2013/12/18. doi: 10.1371/journal. pone.0081970 PMID: 24339983; PubMed Central PMCID: PMC3855368.
30. Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, et al. Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial. Jama. 2014; 312(23):2510-20. Epub 2014/11/18. doi: 10.1001/ jama.2014.15690 PMID: 25401325.
31. Hennekens CH, DeMets DL. Prevention: Aspirin in primary prevention needs individual judgements. Nat Rev Cardiol. 2014; 11(8):438-40. Epub 2014/06/25. doi: 10.1038/nrcardio.2014.88 PMID: 24958081.
32. Miedema MD, Duprez DA, Misialek JR, Blaha MJ, Nasir K, Silverman MG, et al. Use of coronary artery calcium testing to guide aspirin utilization for primary prevention: estimates from the multi-ethnic study of atherosclerosis. Circ Cardiovasc Qual Outcomes. 2014; 7(3):453-60. Epub 2014/05/08. doi: 10. 1161/CIRCOUTCOMES.113.000690 PMID: 24803472.
33. van Kruijsdijk RC, Visseren FL, Ridker PM, Dorresteijn JA, Buring JE, van der Graaf Y, et al. Individualised prediction of alternate-day aspirin treatment effects on the combined risk of cancer, cardiovascular disease and gastrointestinal bleeding in healthy women. Heart. 2014. Epub 2014/12/06. doi: 10.1136/ heartjnl-2014-306342 PMID: 25475110.
34. Blaha MJ, Budoff MJ, DeFilippis AP, Blankstein R, Rivera JJ, Agatston A, et al. Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study. Lancet. 2011; 378(9792):684-92. doi: 10. 1016/S0140-6736(11)60784-8 PMID: 21856482; PubMed Central PMCID: PMC3173039.
35. Emerging Risk Factors C, Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, et al. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med. 2012; 367(14):1310-20. doi: 10.1056/NEJMoa1107477 PMID: 23034020.
36. Tonelli M, Muntner P, Lloyd A, Manns B, Klarenbach S, Pannu N, et al. Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study. Lancet. 2012; 380(9844):807-14. Epub 2012 Jun 19. doi: 10.1016/S0140-6736(12)60572-8 PubMed Central PMCID: PMC22717317. PMID: 22717317
37. Hayden M, Pignone M, Phillips C, Mulrow C. Aspirin for the primary prevention of cardiovascular events: a summary of the evidence for the U.S. Preventive Services Task Force. Annals of internal medicine. 2002; 136(2):161-72. PMID: 11790072.
38. Goldstein LB, Adams R, Alberts MJ, Appel LJ, Brass LM, Bushnell CD, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2006; 113(24):e873-923. Epub 2006/06/21. doi: 10.1161/01.STR.0000223048.70103.F1 PMID: 16785347.
39. Adams RJ, Albers G, Alberts MJ, Benavente O, Furie K, Goldstein LB, et al. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke; a journal of cerebral circulation. 2008; 39(5):1647-52. Epub 2008/03/07. doi: 10.1161/ STROKEAHA.107.189063 PMID: 18322260; PubMed Central PMCID: PMC4198335.
40. Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/American stroke association. Stroke; a journal of cerebral circulation. 2011; 42(1):227-76. Epub 2010/10/23. doi: 10.1161/STR.0b013e3181f7d043 PMID: 20966421.
41. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis. 2008; 25(5):457-507. Epub 2008/05/15. doi: 10.1159/000131083 PMID: 18477843.
42. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004; 364(9431):331-7. Epub 2004/07/28. doi: 10.1016/S0140-6736(04)16721-4 PMID: 15276392.
43. Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006; 354(16):1706-17. doi: 10.1056/NEJMoa060989 PMID: 16531616.
44. Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. The New England journal of medicine. 2012; 367 (9):817-25. Epub 2012/08/31. doi: 10.1056/NEJMoa1204133 PMID: 22931315; PubMed Central PMCID: PMC4067036.
45. Pen A, Yam Y, Chen L, Dennie C, McPherson R, Chow BJ. Discordance between Framingham Risk Score and atherosclerotic plaque burden. European heart journal. 2013; 34(14):1075-82. doi: 10.1093/ eurheartj/ehs473 PMID: 23303659.