Individual contributions of visceral fat and total body fat to subclinical atherosclerosis: The NEO study

Atherosclerosis

Volumn 241, Issue 2, 2015, Pages 547-554

  Gast, Karin B ^a   den Heijer, Martin ^a,b   Smit, Johannes W A ^a,c,d   Widya, Ralph L ^a   Lamb, Hildo J ^a,d   de Roos, Albert ^a,d   Jukema, J Wouter ^a,d   Rosendaal, Frits R ^a,d   de Mutsert, Renée ^a,d   Rabelink, Ton J ^d   le Cessie, Saskia ^d   Hiemstra, Pieter S ^d   Kloppenburg, Margreet ^d   Huizinga, Tom W J ^d   Pijl, Hanno ^d   de Koning, Eelco J P ^d   Reitsma, Pieter H ^d   van Dijk, Ko Willems ^d   de Vries, Aiko P J ^d   Jazet, Ingrid M ^d   Dekkers, Olaf M ^d   Biermasz, Nienke R ^d   Blom, Jeanet W ^d   Rensen, Patrick C N ^d   Cobbaert, Christa M ^d   Dekker, Jacqueline M ^b   Penninx, Brenda W ^b   more..

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Cardiovascular disease; Carotid intima media thickness; Epidemiology; MRI; Obesity; Total body fat; Visceral fat

Indexed keywords

ABDOMINAL OBESITY; ABDOMINAL SUBCUTANEOUS FAT; ADULT; AGED; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BODY FAT; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; ECHOGRAPHY; FEMALE; HUMAN; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX DIFFERENCE; ABDOMINAL FAT; CARDIOVASCULAR DISEASE; IMPEDANCE; MIDDLE AGED; NETHERLANDS; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY;

ABDOMINAL FAT; ADIPOSITY; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CROSS-SECTIONAL STUDIES; ELECTRIC IMPEDANCE; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NETHERLANDS; OBESITY; SEX FACTORS; SUBCUTANEOUS FAT, ABDOMINAL;

EID: 84934969893     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.05.026     Document Type: Article

References (38)

1. Whitlock G., Lewington S., Sherliker P., Clarke R., Emberson J., Halsey J., et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009, 373:1083-1096.
2. Staiano A.E., Reeder B.A., Elliott S., Joffres M.R., Pahwa P., Kirkland S.A., et al. Body mass index versus waist circumference as predictors of mortality in Canadian adults. Int. J. Obes. (Lond) 2012, 36:1450-1454.
3. Gast K.B., Smit J.W., den Heijer M., Middeldorp S., Rippe R.C., le Cessie S., et al. Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study. Atherosclerosis 2013, 229:423-429.
4. Yan R.T., Yan A.T., Anderson T.J., Buithieu J., Charbonneau F., Title L., et al. The differential association between various anthropometric indices of obesity and subclinical atherosclerosis. Atherosclerosis 2009, 207:232-238.
5. Recio-Rodriguez J.I., Gomez-Marcos M.A., Patino-Alonso M.C., Agudo-Conde C., Rodriguez-Sanchez E., Garcia-Ortiz L. Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive. BMC Cardiovasc Disord. 2012, 12:3.
6. Despres J.P., Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006, 444:881-887.
7. Wajchenberg B.L., Giannella-Neto D., da Silva M.E., Santos R.F. Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome. Horm. Metab. Res. 2002, 34:616-621.
8. Nielsen S., Guo Z., Johnson C.M., Hensrud D.D., Jensen M.D. Splanchnic lipolysis in human obesity. J.Clin. Invest 2004, 113:1582-1588.
9. Wang Y., Ma X., Zhou M., Zong W., Zhang L., Hao Y., et al. Contribution of visceral fat accumulation to carotid intima-media thickness in a Chinese population. Int. J. Obes. 2012, 36:1203-1208.
10. Wildman R.P., Janssen I., Khan U.I., Thurston R., Barinas-Mitchell E., El Khoudary S.R., et al. Subcutaneous adipose tissue in relation to subclinical atherosclerosis and cardiometabolic risk factors in midlife women. Am. J. Clin. Nutr. 2011, 93:719-726.
11. Cooper J.N., Columbus M.L., Shields K.J., Asubonteng J., Meyer M.L., Sutton-Tyrrell K., et al. Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults. Metabolism 2012, 61:1589-1597.
12. Lo J., Dolan S.E., Kanter J.R., Hemphill L.C., Connelly J.M., Lees R.S., et al. Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women. J.Clin. Endocrinol. Metab. 2006, 91:1677-1682.
13. Indulekha K., Anjana R.M., Surendar J., Mohan V. Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113). Clin. Biochem. 2011, 44:281-287.
14. Lear S.A., Humphries K.H., Kohli S., Frohlich J.J., Birmingham C.L., Mancini G.B. Visceral adipose tissue, a potential risk factor for carotid atherosclerosis: results of the multicultural community health assessment trial (M-CHAT). Stroke 2007, 38:2422-2429.
15. Takami R., Takeda N., Hayashi M., Sasaki A., Kawachi S., Yoshino K., et al. Body fatness and fat distribution as predictors of metabolic abnormalities and early carotid atherosclerosis. Diabetes Care 2001, 24:1248-1252.
16. Martin A.D., Janssens V., Caboor D., Clarys J.P., Marfell-Jones M.J. Relationships between visceral, trunk and whole-body adipose tissue weights by cadaver dissection. Ann. Hum. Biol. 2003, 30:668-677.
17. Seidell J.C., Bouchard C. Visceral fat in relation to health: is it a major culprit or simply an innocent bystander?. Int. J. Obes. Relat. Metab. Disord. 1997, 21:626-631.
18. Sniderman A.D., Bhopal R., Prabhakaran D., Sarrafzadegan N., Tchernof A. Why might south Asians be so susceptible to central obesity and its atherogenic consequences? the adipose tissue overflow hypothesis. Int. J. Epidemiol. 2007, 36:220-225.
19. Kaess B.M., Pedley A., Massaro J.M., Murabito J., Hoffmann U., Fox C.S. The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk. Diabetologia 2012, 55:2622-2630.
20. de Mutsert R., den Heijer M., Rabelink T.J., Smit J.W., Romijn J.A., Jukema J.W., et al. The Netherlands epidemiology of obesity (NEO) study: study design and data collection. Eur. J. Epidemiol. 2013, 28:513-523.
21. van der Meer R.W., Rijzewijk L.J., de Jong H.W., Lamb H.J., Lubberink M., Romijn J.A., et al. Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus. Circulation 2009, 119:2069-2077.
22. Korn E.L., Graubard B.I. Epidemiologic studies utilizing surveys: accounting for the sampling design. Am. J. Public Health 1991, 81:1166-1173.
23. Lumley T. Analysis of Complex Survey Samples 2004, Available from:. http://www.jstatsoft.org/v09/i08/paper.
24. Ministerie van VWS.NdMG Hoeveel Mensen Hebben Overgewicht? 2013, Available from:. http://www.rivm.nl/dsresource?objectid=rivmp:76024%26type=org%26disposition=inline%26ns_nc=1.
25. Heitmann B.L., Erikson H., Ellsinger B.M., Mikkelsen K.L., Larsson B. Mortality associated with body fat, fat-free mass and body mass index among 60-year-old swedish men-a 22-year follow-up. The study of men born in 1913. Int. J. Obes. Relat. Metab. Disord. 2000, 24:33-37.
26. Slinker B.K., Glantz S.A. Multiple regression for physiological data analysis: the problem of multicollinearity. Am. J. Physiol. 1985, 249:R1-R12.
27. Han T.S., Kelly I.E., Walsh K., Greene R.M., Lean M.E. Relationship between volumes and areas from single transverse scans of intra-abdominal fat measured by magnetic resonance imaging. Int. J. Obes. Relat. Metab. Disord. 1997, 21:1161-1166.
28. Shen W., Chen J., Gantz M., Velasquez G., Punyanitya M., Heymsfield S.B. Asingle MRI slice does not accurately predict visceral and subcutaneous adipose tissue changes during weight loss. Obes. (Silver Spring) 2012, 20:2458-2463.
29. Tchoukalova Y.D., Votruba S.B., Tchkonia T., Giorgadze N., Kirkland J.L., Jensen M.D. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:18226-18231.
30. Nunez C., Gallagher D., Visser M., Pi-Sunyer F.X., Wang Z., Heymsfield S.B. Bioimpedance analysis: evaluation of leg-to-leg system based on pressure contact footpad electrodes. Med. Sci. Sports Exerc 1997, 29:524-531.
31. Kohli S., Sniderman A.D., Tchernof A., Lear S.A. Ethnic-specific differences in abdominal subcutaneous adipose tissue compartments. Obes. (Silver Spring) 2010, 18:2177-2183.
32. Bluher M. Adipose tissue dysfunction in obesity. Exp. Clin. Endocrinol. Diabetes 2009, 117:241-250.
33. Van Gaal L.F., Mertens I.L., De Block C.E. Mechanisms linking obesity with cardiovascular disease. Nature 2006, 444:875-880.
34. Hajjar D.P., Gotto A.M. Biological relevance of inflammation and oxidative stress in the pathogenesis of arterial diseases. Am. J. Pathol. 2013, 182:1474-1481.
35. Karastergiou K., Smith S.R., Greenberg A.S., Fried S.K. Sex differences in human adipose tissues - the biology of pear shape. Biol. Sex. Differ. 2012, 3:13.
36. Thomas E.L., Parkinson J.R., Frost G.S., Goldstone A.P., Dore C.J., McCarthy J.P., et al. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obes. (Silver Spring) 2012, 20:76-87.
37. Tchernof A., Despres J.P. Pathophysiology of human visceral obesity: an update. Physiol. Rev. 2013, 93:359-404.
38. Ten Have T.R., Joffe M.M. Areview of causal estimation of effects in mediation analyses. Stat. Methods Med. Res. 2012, 21:77-107.