Characteristic gene expression profiles of human fibroblasts and breast cancer cells in a newly developed bilateral coculture system

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Ueno, Takayuki ^a,b   Utsumi, Jun ^c,d   Toi, Masakazu ^a   Shimizu, Kazuharu ^c  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KYORIN UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN; TRANSCRIPTOME;

AMINO ACID TRANSPORT; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER CELL; CARBOHYDRATE METABOLISM; CARBOHYDRATE TRANSPORT; CELL PROLIFERATION; CELL STRUCTURE; CHOLESTEROL SYNTHESIS; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE ONTOLOGY; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; LIPID METABOLISM; SKIN FIBROBLAST; STROMA CELL; TRANSCRIPTOMICS; UPREGULATION; BREAST TUMOR; FEMALE; FIBROBLAST; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; PROCEDURES; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DOWN-REGULATION; FEMALE; FIBROBLASTS; GENE EXPRESSION PROFILING; HUMANS; PROTEINS; TRANSCRIPTOME; UP-REGULATION;

EID: 84934965297     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/960840     Document Type: Article

References (13)

1. D. F. Quail and J. A. Joyce, "Microenvironmental regulation of tumor progression andmetastasis, " Nature Medicine, vol. 19, no. 11, pp. 1423-1437, 2013.
2. M. Buess, D. S. A. Nuyten, T. Hastie, T. Nielsen, R. Pesich, and P. O. Brown, "Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer, " Genome Biology, vol. 8, no. 9, article R191, 2007.
3. M. Buess, M. Rajski, B. M. L. Vogel-Durrer, R. Herrmann, and C. Rochlitz, "Tumor-Endothelial Interaction Links the CD44+/CD24? Phenotype with Poor Prognosis in Early-Stage Breast Cancer, " Neoplasia, vol. 11, no. 10, pp. 987-1002, 2009.
4. P. Casbas-Hernandez, J. M. Fleming, andM. A. Troester, "Gene expression analysis of in vitro cocultures to study interactions between breast epithelium and stroma, " Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 520987, 12 pages, 2011.
5. S. Liu, C. Ginestier, S. J. Ou et al., "Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks, " Cancer Research, vol. 71, no. 2, pp. 614-624, 2011.
6. R. P. C. Santos, T. T. Benvenuti, S. T. Honda et al., "Influence of the interaction between nodal fibroblast and breast cancer cells on gene expression, " Tumor Biology, vol. 32, no. 1, pp. 145-157, 2011.
7. J. T. Camp, F. Elloumi, E. Roman-Perez et al., "Interactions with fibroblasts are distinct in basal-like and luminal breast cancers, " Molecular Cancer Research, vol. 9, no. 1, pp. 3-13, 2011.
8. S. R. Khetani and S. N. Bhatia, "Microscale culture of human liver cells for drug development, " Nature Biotechnology, vol. 26, no. 1, pp. 120-126, 2008.
9. S. Iwano, M. Ichikawa, S. Takizawa, H. Hashimoto, and Y. Miyamoto, "Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-GeneHuman Immunity andMetabolic Syndrome 9k, " Toxicology in Vitro, vol. 24, no. 1, pp. 85-91, 2010.
10. T. Fiaschi, A. Marini, E. Giannoni et al., "Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay, " Cancer Research, vol. 72, no. 19, pp. 5130-5140, 2012.
11. P. B. Rozenchan, D. M. Carraro, H. Brentani et al., "Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts, " International Journal of Cancer, vol. 125, no. 12, pp. 2767-2777, 2009.
12. M. Hägg, K. Bivén, T. Ueno et al., "A novel high-through-put assay for screening of pro-apoptotic drugs, " Investigational New Drugs, vol. 20, no. 3, pp. 253-259, 2002.
13. D. Zardavas, J. Baselga, and M. Piccart, "Emerging targeted agents in metastatic breast cancer, " Nature Reviews Clinical Oncology, vol. 10, no. 4, pp. 191-210, 2013.