A pilot study on the feasibility of European harmonized human biomonitoring: Strategies towards a common approach, challenges and opportunities

Environmental Research

Volumn 141, Issue , 2015, Pages 3-14

  Casteleyn, L ^a   Dumez, B ^a   Becker, K ^b   Kolossa Gehring, M ^b   Den Hond, E ^c   Schoeters, G ^c   Castano A ^d   Koch, H M ^e   Angerer, J ^e   Esteban, M ^d   Exley, K ^f   Sepai, O ^f   Bloemen, L ^g   Horvat, M ^h   Knudsen, L E ⁱ   Joas, A ^g   Joas, R ^g   Biot, P ^j   Koppen, G ^c   Dewolf, M C ^g   Katsonouri, A ^k   Hadjipanayis, A ^l   Cerna M ^m   Krskova A ^m   Schwedler, G ^c   Fiddicke, U ^c   Nielsen, J K S ⁱ   Jensen, J F ⁱ   Rudnai, P ⁿ   Kozepesy S ⁿ   Mulcahy, M ^o   Mannion, R ^o   Gutleb, A C ^p   Fischer, M E ^q   Ligocka, D ^r   Jakubowski, M ^r   Reis, M F ^s   Namorado, S ^s   Lupsa, I R ^t   Gurzau, A E ^t   Halzlova, K ^g   Jajcaj, M ^g   Mazej, D ^h   Tratnik Snoj, J ^h   Posada, M ^d   Lopez E ^d   Berglund, M ^u   Larsson, K ^u   Lehmann, A ^v   Crettaz, P ^v   Aerts, D ^j   more..

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Federal Environment Agency (UBA)   (Germany)

^c FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e RUHR UNIVERSITY BOCHUM   (Germany)

^f PUBLIC HEALTH ENGLAND   (United Kingdom)

^g Environmental Health Sciences International ^*  (Belgium)

^h JO EF STEFAN INSTITUTE   (Slovenia)

ⁱ UNIVERSITY OF COPENHAGEN   (Denmark)

^j Federal Service of Health   (Belgium)

^k State General Laboratory   (Cyprus)

^l Larnaca Hospital   (Cyprus)

^m NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

ⁿ NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH   (Hungary)

^o HEALTH SERVICE EXECUTIVE   (Ireland)

^p LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY   (Luxembourg)

^q LABORATOIRE NATIONAL DE SANTÉ   (Luxembourg)

^r NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

^s INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^t Environmental Health Center   (Romania)

^u KAROLINSKA INSTITUTE   (Sweden)

^v Federal Office of Public Health (FOPH)   (Switzerland)

more..

Author keywords

Environmental health policy; Ethics; European harmonization; Human Biomonitoring; Study protocol

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BIOLOGICAL MARKER; CADMIUM; COTININE; MERCURY; PHTHALIC ACID;

ALKALOID; BIOMARKER; BIOMONITORING; CADMIUM; CAPACITY BUILDING; ETHICS; EUROPEAN COMMISSION; FEASIBILITY STUDY; GUIDELINE; HEALTH POLICY; HEALTH SURVEY; HUMAN ACTIVITY; INTEGRATED APPROACH; JOINT IMPLEMENTATION; MERCURY (ELEMENT); METABOLITE; PHTHALATE; STAKEHOLDER; SUSTAINABLE DEVELOPMENT;

ARTICLE; AWARENESS; BIOLOGICAL MONITORING; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL PLANNING; ENVIRONMENTAL PROTECTION; ETHICS; EUROPEAN UNION; FEASIBILITY STUDY; HAIR ANALYSIS; HEALTH SURVEY; HUMAN; HUMAN BIOMONITORING; INFORMATION PROCESSING; INTERPERSONAL COMMUNICATION; KNOWLEDGE; MEDICAL RESEARCH; MOTHER; PILOT STUDY; PRIORITY JOURNAL; PRIVACY; PROFESSIONAL STANDARD; PROGENY; REFERENCE VALUE; TRAINING; URINALYSIS; EUROPE; PUBLIC FIGURE; SCIENTIST; ANALYSIS; ENVIRONMENTAL HEALTH; INTERNATIONAL COOPERATION; PROCEDURES; PROGRAM DEVELOPMENT; STATISTICAL ANALYSIS;

BIOLOGICAL MARKERS; DATA INTERPRETATION, STATISTICAL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; ENVIRONMENTAL MONITORING; EUROPE; FEASIBILITY STUDIES; HUMANS; INTERNATIONAL COOPERATION; PILOT PROJECTS; PROGRAM DEVELOPMENT;

EID: 84934948934     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2014.10.028     Document Type: Article

References (54)

1. Angerer J., Ewers U., Wilhelm M. Human biomonitoring: state of the art. Int. J. Hyg. Environ. Health 2007, 210(3-4):201-228. 10.1016/j.ijheh.2007.01.024.
2. Becker K., Seiwert M., Casteleyn L., Joas R., Joas A., Biot P., Aerts D., Castaño A., Esteban M., Angerer J., Koch H.M., Schoeters G., Den Hond E., Sepai O., Exley K., Knudsen L.E., Horvat M., Bloemen L., DEMOCOPHES consortium, Kolossa-Gehring M. A systematic approach for designing a HBM Pilot Study for Europe. Int. J. Hyg. Environ. Health 2014, 217(2-3):312-322. 10.1016/j.ijheh.2013.07.004.
3. Bellanger M., Pichery C., Aerts D., Berglund M., Castaño A., Cejchanová M., Crettaz P., Davidson F., Esteban M., Fischer M.E., Gurzau A.E., Halzlova K., Katsonouri A., Knudsen L.E., Kolossa-Gehring M., Koppen G., Ligocka D., Miklavčič A., Reis M.F., Rudnai P., Tratnik J.S., Weihe P., Budtz-Jørgensen E., Grandjean P., DEMO/COPHES Economic benefits of methylmercury exposure control in Europe: monetary value of neurotoxicity prevention. Environ. Health 2013, 7(12):3. 10.1186/1476-069X-12-3.
4. Blair A., Saracci R., Vineis P., Cocco P., Forastiere F., Grandjean P., Kogevinas M., Kriebel D., McMichael A., Pearce N., Porta M., Samet J., Sandler D.P., Costantini A.S., Vainio H. Epidemiology, public health, and the rhetoric of false positives. Environ. Health Perspect. 2009, 117(12):1809-1813. 10.1289/ehp.0901194.
5. Casteleyn, L., Dumez, B., Jamers, A., Van Damme, K., 2010. Ethics and data protection in human biomarker studies in environmental health. ISBN: 978-83-60818-43-5, pp. 118.
6. Casteleyn, L., Van Tongelen, B., Reis, MF., Polcher, A., Joas, R., 2007. Human biomonitoring: towards more integrated approaches in Europe (Editorial). Int. J. Hyg. Environ.-Health 210, 199-200.
7. Calafat, A., 2012. The U.S. National Health and Nutrition Examination Survey and human exposure to environmental chemicals. Int. J. Hyg. Environ. Health 215, 2, 99-101.
8. Cerná, M., Krsková, A., Cejchanová, M., Spěváčková, V., 2012. Human biomonitoring in the Czech Republic: an overview. Int. J. Hyg. Environ. Health 215 (2), 109-119.
9. Cerná, M., Spěvácková, V., Batáriová, A., Smíd, J., Cejchanová, M., Ocadlíková, D., Bavorová, H., Benes, B., Kubínová, R., 2007. Human biomonitoring system in the Czech Republic. Int. J. Hyg. Environ. Health 210(3-4), 495-499 (Epub 2007 February 12).
10. Conrad, A., Seiwert, M., Hünken, A., Quarcoo, D., Schlaud, M., Groneberg, D., 2013. The German Environmental Survey for Children (GerES IV): reference values and distributions for time-location patterns of German children. Int. J. Hyg. Environ. Health 216 (1), 25-34. doi: 10.1016/j.ijheh.2012.02.00 (Epub 2012 March 10).
11. Cyprus Presidency Conference, 'Human Biomonitoring: Linking Environment to Health and Supporting Policy', Larnaca, October 23-24, 2012. 〈〉 (accessed 08.04.14). http://www.cy2012.eu/index.php/en/news-categories/press-release-european-projects-measure-chemicals-in-people-across-europe-for-the-first-time.
12. Den Hond, E., Govarts, E., Willems, H., Smolders, R., Casteleyn, L., Kolossa-Gehring, M., Schwedler, G., Seiwert, M., Fiddicke, U., Castaño, A., Esteban, M., Angerer, J., Koch, H.M., Schindler, B.K., Sepai, O., Exley, K., Bloemen, L., Horvat, M., Knudsen, L.E., Joas, A., Joas, R., Biot, P., Aerts, D., Koppen, G., Katsonouri, A., Hadjipanayis, A., Krskova, A., Maly, M., Mørck, T.A., Rudnai, P., Kozepesy, S., Mulcahy, M., Mannion, R., Gutleb, A.C., Fischer, M.E., Ligocka, D., Jakubowski, M., Reis, M.F., Namorado, S., Gurzau, A.E., Lupsa, I.R., Halzlova, K., Jajcaj, M., Mazej, D., Snoj Tratnik, J., López, A., Lopez, E., Berglund, M., Larsson, K., Lehmann, A., Crettaz, P., Schoeters, G. 2014. First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale. Environ. Health Perspect. 123(3), 255-263 (2015).
13. ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals), 2005. Guidance for the interpretation of biomonitoring data. Doc no. 44. Brussel, Belgium.
14. Egorov, A., October 22-25, 2012. Developing an HBM survey for assessing progress towards goals set in the Parma Declaration. In: Proceedings of Human Biomonitoring (HBM) - Linking Environment to Health and Supporting Policy, Larnaca, Cyprus, p. 43.
15. Esteban M, Schindler BK, Jiménez-Guerrero JA, Koch HM, Angerer J, Rivas TC, Rosado M, Gómez S, Casteleyn L, Kolossa-Gehring M, Becker K, Bloemen L, Schoeters G, Hond ED, Sepai O, Exley K, Horvat M, Knudsen LE, Joas A, Joas R, Aerts D, Biot P, Borošová D, Davidson F, Dumitrascu I, Fisher ME, Grander M, Janasik B, Jones K, Kašparová L, Larssen T, Naray M, Nielsen F, Hohenblum P, Pinto R, Pirard C, Plateel G, Tratnik J, Wittsiepe J, Castaño A, Equas Reference Laboratories, 2015. Mercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project. Environ. Res. 141, 23--29.
16. European Commission, European environment and health strategy of 11 June 2003 [COM(2003) 338 final. (accessed 08.04.14). http://www.europa.eu/legislation_summaries/environment/general_provisions/l28133_en.htm.
17. European Commission, Communication from the Commission to the Council, the European Parliament, the European Economic and Social Committee. The European Environment & Health Action Plan 2004-2010. Brussels, 9.6.2004. COM(2004) 416 final.
18. European Union, 1976. Council Directive 76/768/EEC of 27 July 1976 relating to cosmetic products.
19. European Union, 1998. Council Directive 98/24/EC of 7 April 1998 on the protection of the health and safety of workers from the risks related to chemical agents at work.
20. Ewers U., Krause C., Schulz C., Wilhelm M. Reference values and human biological monitoring values for environmental toxins. Report on the work and recommendations of the Commission on Human Biological Monitoring of the German Federal Environmental Agency. Int. Arch. Occup. Environ. Health 1999, 72:255-260.
21. Exley, K., Cano, N., Aerts, D., Biot, P., Casteleyn, L., Kolossa-Gehring, M., Schwedler, G., Castaño, A., Angerer, J., Koch, H.M., Esteban, M., Schoeters, G., Den Hond, E., Horvat, M., Bloemen, L., Knudsen, L.E., Joas, R., Joas, A., Dewolf, M.-C., Van de Mieroop, E., Katsonouri, A., Hadjipanayis, A., Cerna M., Krskova, A., Becker, K., Fiddicke, U., Seiwert, M., Mørck, T. A., Rudnai, P., Kozepesy, S., Cullen, E., Kellegher, A., Gutleb, A.C., Fischer, M.E., Ligocka, D., Kamińska, J., Namorado, S., Fátima Reis, M., Lupsa, I.-R., Gurzau, A.E., Halzlova, K., Jajcaj, M., Mazej, D., Snoj Tratnik, J., Rivas, T.C., López, E., Berglund, M., Larsson, K., Sepai, O., 2015. Communication in a human biomonitoring study: focus group work, public engagement and lessons learnt in 17 European countries. Environ. Res. 141, 30--40.
22. Fiddicke U., Becker K., Schwedler G., Seiwert M., Joas R., Joas A., Biot P., Aerts D., Casteleyn L., Dumez D., Castaño A., Esteban M., Angerer J., Koch H.M., Schoeters G., Den Hond E., Sepai O., Exley K., Knudsen L.E., Horvat M., Bloemen L., Katsonouri A., Hadjipanayis A., Cerna M., Krsková A., Jensen A.F., Nielsen F., Rudnai P., Közepésy S., Gutleb A.C., Fischer M.E., Ligocka D., Kamińska J., Reis F.M., Namorado S., Lupsa I.R., Gurzau A.G., Halzlová K., Mazej D., Snoj Tratnik J., Rivas T.C., Gómez S., Berglund M., Larsson K., Lehmann A., Crettaz P., Dewolf M.C., Burns D., Kellegher A., Kolossa-Gehring M. Lessons learnt on recruitment and fieldwork from a pilot European human biomonitoring survey. Environ. Res. 2015, 141:14-22.
23. Fillol C., Garnier R., Mullot J.U., Boudet C., Momas I., Salmi L.R., Vandentorren S. Prioritization of the biomarkers to be analyzed in the French biomonitoring program. Biomonitoring 2014, 1:95-104.
24. Fréry N., Vandentorren S., Etchevers A., Fillol C. Highlights of recent studies and future plans for the French human biomonitoring (HBM) programme. Int. J. Hyg. Environ. Health 2012, 215(2):127-132.
25. Gallo V., Egger M., McCormack V., Farmer P.B., Ioannidis J.P., Kirsch-Volders M., Matullo G., Phillips D.H., Schoket B., Stromberg U., Vermeulen R., Wild C., Porta M., Vineis P. STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): an extension of the STROBE Statement. PLoS Med 2011, 8(10):e1001117. 10.1371/journal.pmed.1001117.
26. Haines D.A., Murray J. Human biomonitoring of environmental chemicals - early results of the 2007-2009 Canadian Health Measures Survey for males and females. Int. J. Hyg. Environ. Health 2012, 215:2.
27. Halkoaho A., Vähäkangas K., Häggman-Laitila A., Pietilä A.M. Views of midwives about ethical aspects of participation in placental perfusion studies. Midwifery 2012, 28(1):131-137.
28. Horvat, M., Mazej, D., Snoj Tratnik, J., Kononenko, L., Lapanja, S., Kobal, A.B., Krsnik, M., Osredkar, J., 2012. A legal framework for HBM: experiences in Slovenia. Proceedings of Human Biomonitoring (HBM) - Linking Environment to Health and Supporting Policy, October 22-25, 2012, Larnaca, Cyprus, pp. 43.
29. Khoury M.J., Lam T.K., Ioannidis J.P., Hartge P., Spitz M.R., Buring J.E., Chanock S.J., Croyle R.T., Goddard K.A., Ginsburg G.S., Herceg Z., Hiatt R.A., Hoover R.N., Hunter D.J., Kramer B.S., Lauer M.S., Meyerhardt J.A., Olopade O.I., Palmer J.R., Sellers T.A., Seminara D., Ransohoff D.F., Rebbeck T.R., Tourassi G., Winn D.M., Zauber A., Schully S.D. Transforming epidemiology for 21st century medicine and public health. Cancer Epidemiol. Biomark. Prev. 2013, 22(4):508-516.
30. Kolossa-Gehring, M., Becker, K., Fiddicke, U., Schulz, C., Conrad, A., Schröter-Kermani, C., Seiwert, M., 2011. Biomonitoring as a key tool in environmental health, the German approach. (accessed 08.04.14). http://www.milieu-en-gezondheid.be/resultaten/2007-2011/studiedag%2021-12-2011/abstract%20MK.pdf.
31. Kolossa-Gehring M., Becker K. German initiative to support human biomonitoring: co-operation project between the german chemical industry association and the federal ministry for the environment, nature conservation and nuclear safety. Epidemiology 2011, 22(1):S35.
32. Kuulasmaa K., Tolonen H., Koponen P., Kilpeläinen K., Avdicová M., Broda G., Calleja N., Dias C., Gösswald A., Kubinova R., Mindell J., Männistö S., Palmieri L., Tell G.S., Trichopoulou A., Verschuren W.M. An overview of the European health examination survey pilot joint action. Arch. Public Health 2012, 70(1):20. 10.1186/0778-7367-70-20.
33. Miller L. Common consent (Editorial). Nature 2009, 460(7258):933.
34. Morello-Frosch R., Green Brody J., Brown P., Gasior Altman R., Rudel R.A., Pérez C. Toxic ignorance and right-to-know in biomonitoring results communication: a survey of scientists and study participants. Environ. Health 2009, 8:6.
35. Morello-Frosch R., Varshavsky J., Liboiron M., Brown P., Brody J.G. Communicating results in post-Belmont era biomonitoring studies: Lessons from genetics and neuroimaging research. Environmental Research 2015, 136:363-372. 10.1016/j.envres.2014.10.001.
36. National Research Council of the National Academies Human Biomonitoring for environmental chemicals, Committee on Human Biomonitoring for Environmental Toxicants, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies 2006, The National Academies Press, Washington DC.
37. Pérez-Gómez B., Pastor-Barriuso R., Cervantes-Amat M., Esteban M., Ruiz-Moraga M., Aragonés N., Pollán M., Navarro C., Calvo E., Román J., López-Abente G., Castaño A. BIOAMBIENT.ES study protocol: rationale and design of a cross-sectional human biomonitoring survey in Spain. Environ. Sci. Pollut. Res. 2012, 11/2012(2):1193-1202.
38. Rappaport S.M. Biomarkers intersect with the exposome. Biomarkers 2012, 17(6):483-489. 10.3109/1354750X.2012.691553.
39. Schindler B.K., Esteban M., Koch H.M., Castaño A., Koslitz S., Cañas A., Casteleyn L., Kolossa-Gehring M., Schwedler G., Schoeters G., Den Hond E., Sepai O., Exley K., Bloemen L., Horvat M., Knudsen L.E., Joas A., Joas R., Biot P., Aerts D., Lopez A., Huetos O., Katsonouri A., Maurer-Chronakis K., Kasparova L., Vrbík K., Rudnai P., Naray M., Guignard C., Fischer M., Ligocka D., Janasik B., Reis F.M., Namorado S., Pop C., Dumitrascu I., Halzlova K., Fabianova E., Mazej D., Snoj Tratnik J., Berglund M., Jönsson B., Lehmann A., Crettaz P., Frederiksen H., Nielsen F., McGrath H., Nesbitt I., De Cremer K., Vanermen G., Koppen G., Wilhelm M., Becker K., Angerer J. The European COPHES/DEMOCOPHES project: towards transnational comparability and reliability of human biomonitoring results. Int. J. Hyg. Environ. Health 2014, 10.1016/j.ijheh.2013.12.
40. Schoeters G., Colles A., Den Hond E., Croes K., Vrijens J., Baeyens W., Nelen V., Van De Mieroop E., Covaci A., Bruckers L., Van Larebeke N., Sioen I., Morrens B., Loots I. The Flemish Environment and Health Study (FLEHS) - Second Survey (2007-2011): Establishing Reference Values for Biomarkers of Exposure in the Flemish Population. Biomarkers and Human Biomonitoring volume 1: ongoing programs and exposures 2011, 135-165. The Royal Society of Chemistry, UK. L. Knudsen, D.F. Merlo. (Eds.).
41. Schulz, C., Wolf, U., Becker, K., Conrad, A., Hünken, A., Lüdecke, A., Müssig-Zufika, M., Riedel, S., Seiffert, I., Seiwert, M., Kolossa-Gehring, M., 2007. [German Environmental Survey for Children (GerES IV) in the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). First results] [Article in German]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50 (5-6) 889-894.
42. Smith, M.T., Vermeulen, R., Li, G., Zhang, L., Lan, Q., Hubbard, A.E., Forrest, M.S., McHale, C., Zhao, X., Gunn, L., Shen, M., Rappaport, S.M., Yin, S., Chanock, S., Rothman, N., 2005. Use of 'Omic' technologies to study humans exposed to benzene. Chem. Biol. Interact. 153-154, 123-127.
43. Smolders R., Koppen G., Schoeters G. Translating biomonitoring data into risk management and policy implementation options for a European Network on Human Biomonitoring. Environ. Health 2008, 7(Suppl. 1):S2. 10.1186/1476-069X-7-S1-S2.
44. Smolders R., Den Hond E., Koppen G., Govarts E., Willems H., Casteleyn L., Kolossa-Gehring M., Fiddicke U., Castaño A., Koch H.M., Angerer J., Esteban M., Sepai O., Exley K., Bloemen L., Horvat M., Knudsen L.E., Joas A., Joas R., Biot P., Aerts D., Katsonouri A., Hadjipanayis A., Cerna M., Krskova A., Schwedler G., Seiwert M., Nielsen J.K.S., Rudnai P., Közepesy S., Evans D.S., Ryan M.P., Gutleb A.C., Fischer M.E., Ligocka D., Jakubowski M., Reis M.F., Namorado S., Lupsa I.-R., Gurzau A.E., Halzlova K. Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand bio- marker differences among countries. Environ. Res. 2015, 141:85-94.
45. Snoj Tratnik J, Mazej D, Horvat M (2012). Human biomonitoring studies in Slovenia - toxic metals, arsenic and essential elements. A legal framework for HBM: experiences in Slovenia. Proceedings of "Human Biomonitoring (HBM) - Linking Environment to Health and Supporting Policy", Larnaca, Cyprus, p. 88.
46. Stokstad E. Biomonitoring. Pollution gets personal. Science. 2004, 304(5679):1892-1894.
47. Vineis P., Perera F. Molecular epidemiology and biomarkers in etiologic cancer research: the new in light of the old. Cancer Epidemiol. Biomarkers Prev. 2007, 16(10):1954-1965.
48. Vineis P., Chuang S.C., Vaissière T., Cuenin C., Ricceri F., Genair-EPIC Collaborators, Johansson M., Ueland P., Brennan P., Herceg Z. DNA methylation changes associated with cancer risk factors and blood levels of vitamin metabolites in a prospective study. Epigenetics 2011, 6(2):195-201.
49. Viso A.C., Casteleyn L., Biot P., Eilstein D. Human biomonitoring programmes and activities in the European Union. J. Epidemiol. Commun. Health 2009, 63:623-624. 10.1136/jech.2008.083709.
50. Weuve J., Yanosky J.D. Polycyclic aromatic hydrocarbons, particulate air pollution, and cognitive decline-reply. Arch. Intern. Med. 2012, 172(13):1045-1046. 10.1001/archinternmed.2012.2159.
51. WHO, Parma Declaration on Environment and Health, 2010. EUR/55934/5.1 Rev. 2 11 March 2010.
52. Wild C.P. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol. Biomark. Prev. 2005, 14(8):1847-1850.
53. Wild C.P. Future research perspectives on environment and health: the requirement for a more expansive concept of translational cancer research. Environ. Health 2011, 10(Suppl. 1):S15. (5).
54. Willett W.C. Balancing life-style and genomics research for disease prevention. Science 2002, 296(5568):695-698.