Molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae in a hospital in Madrid: Successful establishment of an OXA-48 ST11 clone

International Journal of Antimicrobial Agents

Volumn 46, Issue 1, 2015, Pages 111-116

  Branas, Patricia ^a   Villa, Jennifer ^a   Viedma, Esther ^a,b   Mingorance, Jesús ^b,c   Orellana, M Angeles ^a,b   Chaves, Fernando ^a,b  

^a Hospital Universitario   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Klebsiella pneumoniae; Molecular epidemiology; Multidrug resistant; OXA 48; ST11

Indexed keywords

ADULT; AGED; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BIOINFORMATICS; CARBAPENEMASE PRODUCING KLEBSIELLA PNEUMONIAE; CHILD; CONTROLLED STUDY; EPIDEMIOLOGICAL DATA; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; GENE SEQUENCE; HEALTH CARE FACILITY; HUMAN; KLEBSIELLA PNEUMONIAE; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; OMPK35 GENE; OMPK36 GENE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RETROSPECTIVE STUDY; TRANSPOSON; CLASSIFICATION; CLUSTER ANALYSIS; CROSS INFECTION; ENZYMOLOGY; EPIDEMIC; GENETICS; GENOTYPE; INTERSPERSED REPEAT; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; MICROBIOLOGY; MIDDLE AGED; PRESCHOOL CHILD; SECRETION (PROCESS); SPAIN; TERTIARY CARE CENTER; VERY ELDERLY;

BETA LACTAMASE; OXACILLINASE;

ADULT; AGED; AGED, 80 AND OVER; BETA-LACTAMASES; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; CROSS INFECTION; DISEASE OUTBREAKS; FEMALE; GENOTYPE; HUMANS; INTERSPERSED REPETITIVE SEQUENCES; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; RETROSPECTIVE STUDIES; SPAIN; TERTIARY CARE CENTERS;

EID: 84934908776     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2015.02.019     Document Type: Article

References (15)

1. Nordmann P, Poirel L. The difficult-to-control spread of carbapene-mase producers among Enterobacteriaceae worldwide. Clin Microbiol Infect 2014; 20:821-30.
2. Villa J, Viedma E, Branas P., Orellana MA, Otero JR, Chaves F. Multiclonal spread of VIM-1-producing Enterobacter cloacae isolates associated with In624 and In488 integrons located in an IncHI2 plasmid. Int J Antimicrob Agents 2014; 43:451-5.
3. Villa J, Viedma E, Branãs P, Mingorance J., Chaves F. Draft whole-genome sequence of OXA-48-producing multidrug-resistant Klebsiella pneumoniae KP-ST11OXA-48. Genome Announce 2014; 2, pii e00737-14.
4. Paño-Pardo J.R., Ruiz-Carrascoso G, Navarro-SanFrancisco C, Gómez-Gil R, Mora-Rillo M, Romero-Gómez MP, et al. Infections caused by OXA-48-producing Klebsiella pneumoniae in a tertiary hospital in Spain in the setting of a prolonged, hospital-wide outbreak. J Antimicrob Chemother 2013; 68:89-96.
5. Voulgari E, Zarkotou O, Ranellou K., Karageorgopoulos DE, Vrioni G, Mamali V, et al. Outbreak of OXA-48 carbapenemase-producing Klebsiella pneumoniae in Greece involving an ST11 clone. J Antimicrob Chemother 2013; 68:84-8.
6. Dautzenberg MJ, Ossewaarde JM, de Kraker ME, van der Zee A, van Burgh S, de Greeff SC, et al. Successful control of a hospital-wide outbreak of OXA-48 producing Enterobacteriaceae in The Netherlands, 2009 to 2011. Euro Surveill 2014; 19:pii 20723.
7. Rooney PJ, O'Leary MC, Loughrey AC, McCalmont M, Smyth B., Donaghy P, et al. Nursing homes as a reservoir of extended-spectrum β-lactamase (ESBL)-producing ciprofloxacin-resistant Escherichia coli. J Antimicrob Chemother 2009; 64:635-41.
8. Damjanova I, Tóth A, Pászti J, Hajbel-Vékony G, Jakab M, Berta J, et al. Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type β-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005-the new 'MRSAs'? J Antimicrob Chemother 2008; 62:978-85.
9. Pena I, Picazo JJ, Rodríguez-Avial C, Rodríguez-Avial I. Carbapenemase-producing Enterobacteriaceae in a tertiary hospital in Madrid, Spain: high percentage of colistin resistance among VIM-1-producing Klebsiella pneumoniae ST11 isolates. Int J Antimicrob Agents 2014; 43:460-4.
10. Lauderdale TL, Shi ZY, Lin C.F., Lai JF, Tan MC, Wang JT, et al. KPC-2-producing sequence type 11 Klebsiella pneumoniae detected in Taiwan. Antimicrob Agents Chemother 2012; 56:2207-8.
11. Giske CG, Fröding I, Hasan C.M., Turlej-Rogacka A, Toleman M, Livermore D., et al. Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrob Agents Chemother 2012; 56:2735-8.
12. Potron A, Poirel L, Rondinaud E., Nordmann P. Intercontinental spread of OXA-48 β-lactamase-producing Enterobacteriaceae over a 11-year period, 2001 to 2011. Euro Surveill 2013; 18:pii 20549.
13. Poirel L, Bonnin RA, Nordmann P. Genetic features of the widespread plasmid coding for the carbapenemase OXA-48. Antimicrob Agents Chemother 2012; 56:559-62.
14. OXA-48-carrying plasmid in Enterobacteriaceae. Antimicrob Agents Chemother 2013; 57:4064-7.
15. Naparstek L, Carmeli Y, Chmelnitsky I., Banin E, Navon-Venezia S. Reduced susceptibility to chlorhexidine among extremely-drug-resistant strains of Klebsiella pneumoniae. J Hosp Infect 2012; 81:15-9.