Comparative Study of Analytical Techniques for Determining Protein Charge

Journal of Pharmaceutical Sciences

Volumn 104, Issue 7, 2015, Pages 2123-2131

  Filoti, Dana I ^a   Shire, Steven J ^b   Yadav, Sandeep ^b   Laue, Thomas M ^a  

^a UNIVERSITY OF NEW HAMPSHIRE   (United States)

^b GENENTECH INC   (United States)

Author keywords

colloid; electrophoresis; protein charge; protein formulation; proteins; solubility

Indexed keywords

BOVINE SERUM ALBUMIN; HUMAN SERUM ALBUMIN; HYDROGEN; SODIUM CHLORIDE; PROTEIN; SERUM ALBUMIN;

AMINO ACID COMPOSITION; CAPILLARY ELECTROPHORESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRIC CURRENT; ELECTRIC FIELD; ELECTROPHORESIS; ELECTROPHORETIC MOBILITY; EQUILIBRIUM DIALYSIS; HYDROGEN BOND; IONIC STRENGTH; LIGHT SCATTERING; MEASUREMENT; PH; PROTEIN BINDING; PROTEIN CHARGE; PROTEIN DETERMINATION; PROTEIN ELECTROPHORESIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; STATIC ELECTRICITY; STEADY STATE; STEADY STATE ELECTROPHORESIS; SURFACE AREA; TEMPERATURE; ZETA POTENTIAL; ANIMAL; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; HUMAN; OSMOLARITY; PROCEDURES;

ANIMALS; ELECTROPHORESIS; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; OSMOLAR CONCENTRATION; PROTEINS; SERUM ALBUMIN; TEMPERATURE;

EID: 84934895986     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24454     Document Type: Review

References (35)

1. Shire SJ, Shahrokh Z, Liu J,. 2004. Challenges in the development of high protein concentration formulations. J Pharm Sci 93: 1390-1402.
2. Tanford C, Swanson SA, Shore WS,. 1955. Hydrogen ion equilibria of bovine serum albumin. J Am Chem Soc 77: 6414-6421.
3. Fogh-Andersen N, Bjerrum PJ, Siggaard-Andersen O,. 1993. Ionic binding, net charge, and Donnan effect of human serum albumin as a function of pH. Clin Chem 39: 48-52.
4. Menon MK, Zydney AL,. 1998. Measurement of protein charge and ion binding using capillary electrophoresis. Anal Chem 70: 1581-1584.
5. Laue TM,. 2012. Proximity energies: A framework for understanding concentrated solutions. J Mol Recognit 25: 165-173.
6. Edsall JT, Wyman J,. 1958. Biophysical chemistry. Vol. I. New York: Academic Press, pp 241-322.
7. O'Brien RW, White LR,. Electrophoretic mobility of a spherical colloidal particle 1978. J Chem Soc Faraday Trans 2 (74): 1607-1626.
8. Tiselius A, Kabat EA,. 1939. An electrophoretic study of immune sera and purified antibody preparations. J Exp Med 69: 119-131.
9. Scatchard G, Sackmann Black E,. 1948. The effect of salts on the isoionic and isoelectric points of proteins. J Phys Colloid Chem 53: 88-100.
10. Gokarn YR, Fesinmeyer RM, Saluja A, Razinkov V, Chase SF, Laue TM, Brems DN,. 2011. Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions. Protein Sci 20: 580-587.
11. Manning GS,. 1969. Limiting laws and counterion condensation in polyelectrolyte solutions I. Colligative properties. J Chem Phys 51: 924-934.
12. Manning GS,. 2007. Counterion condensation on charged spheres, cylinders, and planes. J Phys Chem B 111: 8554-8559.
13. Durant JA, Chen C, Laue TM, Moody TP, Allison, SA,. 2002. Use of T4 lysozyme charge mutants to examine electrophoretic models. Biophys Chem 101-102: 593-609.
14. Henry DC,. 1931. The cataphoresis of suspended particles. Part I. The equation of cataphoresis. Proc Roy Soc A 133: 106-140.
15. Moody TP, Kingsbury JS, Durant JA, Wilson TJ, Chase SF, Laue TM,. 2005. Valence and anion binding of bovine ribonuclease A between pH 6 and 8. Anal Biochem 336: 243-252.
16. Moody TP, Shepard HK,. 2004. Nonequilibrium thermodynamics of membrane-confined electrophoresis. Biophys Chem 108: 51-76.
17. Laue TM, Shepard HK, Ridgeway TM, Moody TP, Wilson TJ,. 1998. Membrane-confined analytical electrophoresis. In Methods in enzymology;, Ackers GK, Johnson ML, Eds. New York: Academic Press, pp. 494-518.
18. Debye PJW, Falkenhagen H,. 1928. Dispersion der Leitfähigkeit starker Elektrolyte" as translated in The collected papers of Peter J.W. Debye. Woodbridge, Connecticut: Ox Bow Press.
19. Chase SF, Laue TM,. 2008. The determination of protein valence by capillary electrophoresis. PACE Setter, Beckman Coulter, Inc. 12: 1-12.
20. Dole VP,. 1945. A theory of moving boundary systems formed by strong electrolytes. J Am Chem Soc 67: 1119-1126.
21. Horvath J, Dolník V,. 2001. Polymer wall coatings for capillary electrophoresis. Electrophoresis 22: 644-655.
22. Custler EL,. 1997. Diffusion: Mass transfer in fluid systems. 2nd ed. New York: Cambridge University Press, pp 143.
23. Corbett JCW, Connah MT, Mattison K,. 2011. Advances in the measurement of protein mobility using laser Doppler electrophoresis-The diffusion barrier technique. Electrophoresis 32: 1787-1794.
24. Hsieh H-T, Trainoff SP,. 2011. Method and apparatus to measure particle mobility in solution. Patent US 20110210002.
25. Olsson MHM, Søndergarrd CR, Rostkowski M, Jensen JH,. 2011. PROPKA3: Consistent treatment of internal and surface residues in empirical pKa predictions. J Chem Theory Comput 7: 525-537.
26. Li H, Robertson AD, Jensen JH,. 2005. Very fast empirical prediction and rationalization of protein pKa values. Proteins 61: 704-721.
27. Shimitz KE, Lu M,. 1983. Effect of titration charge on the diffusion of bovine serum albumin. Proc Natl Acad Sci USA 80: 425-429.
28. Hoch H,. 1948. Electrophoretic studies on human serum. Biochem J 42: 181-190.
29. Jordon K,. 2014. Real-time electrophoretic mobility in membrane confined electrophoresis. M.S. thesis, University of New Hampshire, Durham, New Hampshire.
30. Sednterp. Accessed, at: http://Sednterp.unh.edu/index.php/Main-Page.
31. Wool JW,. 1996. Investigation of pd(A)20·pd(T20) in the analytical electrophoresis apparatus. Ph.D. thesis, University of New Hampshire, Durham, New Hampshire.
32. Hayes DB,. 1993. Equilibrium electrophoresis: Results from the second prototype. Ph.D. thesis, University of New Hampshire, Durham, New Hampshire.
33. Cann JR,. 1970. Interacting macromolecules. New York: Academic Press, pp 152-206.
34. Cann JR, Goad WB,. 1965. Theory of moving boundary electrophoresis of reversibly interacting systems: Reaction of proteins with small uncharged molecules such as undissociated buffer acid. J Biol Chem 240: 148-155.
35. Linde DR, Ed. 1993. CRC handbook of chemistry and physics. 74th ed. Boca Raton, Florida: CRC Press.