Testicular germ cell tumors in mice: New ways to study a genetically complex trait

Methods in Molecular Biology

Volumn 450, Issue , 2008, Pages 211-231

  Heaney, Jason D ^a   Nadeau, Joseph H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Consomic; Interaction; Modifier; Mouse; Polygene; QTL; Sensitized; Susceptibility; Testicular tumor

Indexed keywords

MUS;

EID: 84934444401     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-214-8_15     Document Type: Article

References (76)

1. Bishop, T. D., and Wing, A. (1998) Candidate regions for testicular cancer susceptibility genes. APMIS Suppl. 106, 64-72.
2. Bosl, G. J., and Motzer, R. J. (1997) Testicular germ-cell cancer. N Engl. J. Med. 337, 242-253.
3. Oosterhuis, J. W., and Looijenga, L. H. (2005) Testicular germ-cell tumours in a broader perspective. Nat. Rev. Cancer. 5, 210-222.
4. Oosterhuis, J. W., Looijenga, L. H., van, E. J., and de, J. B. (1997) Chromosomal constitution and developmental potential of human germ cell tumors and teratomas. Cancer Genet. Cytogenet. 95, 96-102.
5. Forman, D., Oliver, R. T., Brett, A. R., et al. (1992) Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysis. Br. J. Cancer. 65, 255-262.
6. Lindelof, B., and Eklund, G. (2001) Analysis of hereditary component of cancer by use of a familial index by site. Lancet. 358, 1696-1698.
7. Heimdal, K., Olsson, H., Tretli, S., Fossa, S. D., Borresen, A. L., and Bishop, D. T. (1997) A segregation analysis of testicular cancer based on Norwegian and Swedish families. Br. J. Cancer. 75, 1084-1087.
8. Stevens, L., and Little, C. C. (1954) Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl. Acad. Sci. U. S. A. 40, 1080-1087.
9. Rapley, E. A., Crockford, G. P., Teare, D., et al. (2000) Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Nat. Genet. 24, 197-200.
10. Nathanson, K. L., Kanetsky, P. A., Hawes, R., et al. (2005) The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Am. J. Hum. Genet. 11, 1034-1043.
11. Crockford, G. P., Linger, R., Hockley, S., et al. (2006) Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Hum. Mol. Genet. 15, 443-451.
12. Kunwar, P. S., Siekhaus, D. E., and Lehmann, R. (2006) In vivo migration: a germ cell perspective. Annu. Rev. Cell Dev. Biol. 22, 237-265.
13. Tam, P. P., and Snow, M. H. (1981) Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos. J. Embryol. Exp. Morphol. 64, 133-147.
14. McLaren, A. (1984) Meiosis and differentiation of mouse germ cells. Symp. Soc. Exp. Biol. 38, 7-23.
15. Stevens, L. C. (1967) The biology of teratomas. Adv. Morphog. 6, 1-31.
16. Stevens, L. C. (1967) Origin of testicular teratomas from primordial germ cells in mice. J. Natl. Cancer Inst. 38, 549-552.
17. Stevens, L. C. (1962) Testicular teratomas in fetal mice. J. Natl. Cancer Inst. 28, 247-267.
18. Stevens, L. C. (1966) Development of resistance to teratocarcinogenesis by primordial germ cells in mice. J. Natl. Cancer Inst. 37, 859-867.
19. Park, S. Y., and Jameson, J. L. (2005) Minireview: transcriptional regulation of gonadal development and differentiation. Endocrinology. 146, 1035-1042.
20. Chaillet, J. R., Vogt, T. F., Beier, D. R., and Leder, P. (1991) Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell. 66, 77-83.
21. De, F. M. (2000) Regulation of primordial germ cell development in the mouse. Int. J. Dev. Biol. 44, 575-580.
22. Lee, J., Inoue, K., Ono, R., et al. (2002) Erasing genomic imprinting memory in mouse clone embryos produced from d 11.5 primordial germ cells. Development. 129, 1807-1817.
23. Sato, S., Yoshimizu, T., Sato, E., and Matsui, Y. (2003) Erasure of methylation imprinting of Igf2r during mouse primordial germ-cell development. Mol. Reprod. Dev. 65, 41-50.
24. Stevens, L. C. (1964) Experimental production of testicular teratomas in mice. Proc. Natl. Acad. Sci. U. S. A. 52, 654-661.
25. Matin, A., Collin, G. B., Varnum, D. S., and Nadeau, J. H. (1998) Testicular teratocarcinogenesis in mice-a review. APMIS. 106, 174-182.
26. Rodriguez, E., Mathew, S., Reuter, V., Ilson, D. H., Bosl, G. J., and Chaganti, R. S. (1992) Cytogenetic analysis of 124 prospectively ascertained male germ cell tumors. Cancer Res. 52, 2285-2291.
27. Vos, A., Oosterhuis, J. W., de Jong, B., Buist, J., and Schraffordt, K. H. (1990) Cytogenetics of carcinoma in situ of the testis. Cancer Genet. Cytogenet. 46, 75-81.
28. Looijenga, L. H., Verkerk, A. J., Dekker, M. C., van Gurp, R. J., Gillis, A. J., and Oosterhuis, J. W. (1998) Genomic imprinting in testicular germ cell tumours. APMIS. 106, 187-195.
29. Stevens, L. C., and Hummel, K. P. (1957) A description of spontaneous congenital testicular teratomas in strain 129 mice. J. Natl. Cancer Inst. 18, 719-747.
30. Matin, A., Collin, G. B., Asada, Y., Varnum, D., and Nadeau, J. H. (1999) Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain. Nat. Genet. 23, 237-240.
31. Stevens, L. C., and Mackensen, J. A. (1961) Genetic and environmental influences on teratocarcinogenesis in mice. J. Natl. Cancer Inst. 27, 443-453.
32. Gidekel, S., Pizov, G., Bergman, Y., and Pikarsky, E. (2003) Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell. 4, 361-370.
33. Noguchi, T., and Stevens, L. C. (1982) Primordial germ cell proliferation in fetal testes in mouse strains with high and low incidences of congenital testicular teratomas. J. Natl. Cancer Inst. 69, 907-913.
34. Youngren, K. K., Coveney, D., Peng, X., et al. (2005) The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 435, 360-364.
35. Harvey, M., McArthur, M. J., Montgomery, C. A., Jr., Bradley, A., and Donehower, L. A. (1993) Genetic background alters the spectrum of tumors that develop in p53deficient mice. FASEB J. 7, 938-943.
36. Kimura, T., Suzuki, A., Fujita, Y., et al. (2003) Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development. 130, 1691-1700.
37. Di, V. D., Cito, L., Boccia, A., et al. (2005) Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors. Oncogene. 24, 1882-1894.
38. Lam, M. Y., and Nadeau, J. H. (2003) Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS. 111, 184-190.
39. Lamoreux, M. L., Wakamatsu, K., and Ito, S. (2001) Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res. 14, 23-31.
40. Parant, J. M., and Lozano, G. (2003) Disrupting TP53 in mouse models of human cancers. Hum. Mutat. 21, 321-326.
41. Moore, K. J., Swing, D. A., Copeland, N. G., and Jenkins, N. A. (1990) Interaction of the murine dilute suppressor gene (dsu) with 14 coat color mutations. Genetics. 125, 421-430.
42. Lam, M. Y., Youngren, K. K., and Nadeau, J. H. (2004) Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice. Genetics. 166, 925-933.
43. Bolivar, V. J., Cook, M. N., and Flaherty, L. (2001) Mapping of quantitative trait loci with knockout/congenic strains. Genome Res. 11, 1549-1552.
44. Simpson, E. M., Linder, C. C., Sargent, E. E., Davisson, M. T., Mobraaten, L. E., and Sharp, J. J. (1997) Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat. Genet. 16, 19-27.
45. Armstrong, N. J., Brodnicki, T. C., and Speed, T. P. (2006) Mind the gap: analysis of marker-assisted breeding strategies for inbred mouse strains. Mamm. Genome. 17, 273-287.
46. Youngren, K. K., Nadeau, J. H., and Matin, A. (2003) Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications. Hum. Mol. Genet. 12, 389-398.
47. Reusens, B., and Remade, C. (2006) Programming of the endocrine pancreas by the early nutritional environment. Int. J. Biochem. Cell Biol. 38, 913-922.
48. Wu, G., Bazer, F. W., Cudd, T. A., Meininger, C. J., and Spencer, T. E. (2004) Maternal nutrition and fetal development. J. Nutr. 134, 2169-2172.
49. Levin, B. E. (2006) Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis. Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 1107-1121.
50. Fleming, T. P., Kwong, W. Y., Porter, R., et al. (2004) The embryo and its future. Biol. Reprod. 71, 1046-1054.
51. Suomalainen, A. (1997) Mitochondrial DNA and disease. Ann. Med. 29, 235-246.
52. Luft, R. (1994) The development of mitochondrial medicine. Proc. Natl. Acad. Sci. U. S. A. 91, 8731-8738.
53. Morgan, H. D., Sutherland, H. G., Martin, D. I., and Whitelaw, E. (1999) Epigenetic inheritance at the agouti locus in the mouse. Nat. Genet. 23, 314-318.
54. Wolff, G. L., Kodell, R. L., Moore, S. R., and Cooney, C. A. (1998) Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 12, 949-957.
55. Matin, A., and Nadeau, J. H. (2001) Sensitized polygenic trait analysis. Trends Genet. 17, 727-731.
56. Tanksley, S. D. (1993) Mapping polygenes. Annu. Rev. Genet. 27, 205-233.
57. Collin, G. B., Asada, Y., Varnum, D. S., and Nadeau, J. H. (1996) DNA pooling as a quick method for finding candidate linkages in multigenic trait analysis: an example involving susceptibility to germ cell tumors. Mamm. Genome. 1, 68-70.
58. Smigielski, E. M., Sirotkin, K., Ward, M., and Sherry, S. T. (2000) dbSNP: a database of single nucleotide polymorphisms. Nucleic Acids Res. 28, 352-355.
59. Peters, L. L., Robledo, R. F., Bult, C. J., Churchill, G. A., Paigen, B. J., and Svenson, K. L. (2007) The mouse as a model for human biology: a resource guide for complex trait analysis. Nat. Rev. Genet. 8, 58-69.
60. Silver, L. M. (1995) Mouse genetics: concepts and applications, Oxford University Press, New York.
61. Khripin, Y. (2006) High-throughput genotyping with energy transfer-labeled primers. Methods Mol. Biol. 335, 215-240.
62. Stephens, M., Sloan, J. S., Robertson, P. D., Scheet, P., and Nickerson, D. A. (2006) Automating sequence-based detection and genotyping of SNPs from diploid samples. Nat. Genet. 38, 375-381.
63. Romkes, M., and Buch, S. C. (2005) Genotyping technologies: application to biotransformation enzyme genetic polymorphism screening. Methods Mol. Biol. 291, 399-414.
64. Jordan, B., Charest, A., Dowd, J. F., et al. (2002) Genome complexity reduction for SNP genotyping analysis. Proc. Natl. Acad. Sci. U. S. A. 99, 2942-2947.
65. Lindblad-Toh, K., Winchester, E., Daly, M. J., et al. (2000) Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat. Genet. 24, 381-386.
66. Zhao, Z. Z., Nyholt, D. R., Le, L., et al. (2006) KRAS variation and risk of endometriosis. Mol. Hum. Reprod. 12, 671-676.
67. Manly, K. F., and Olson, J. M. (1999) Overview of QTL mapping software and introduction to map manager QT Mamm. Genome. 10, 327-334.
68. Lander, E. S., Green, P., Abrahamson, J., et al. (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics. 1, 174-181.
69. Manly, K. F., Cudmore, R. H., Jr., and Meer, J. M. (2001) Map Manager QTX, cross-platform software for genetic mapping. Mamm. Genome. 12, 930-932.
70. Broman, K. W., Wu, H., Sen, S., and Churchill, G. A. (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics. 19, 889-890.
71. Lander, E., and Kruglyak, L. (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11, 241-247.
72. Churchill, G. A., and Doerge, R. W. (1994) Empirical threshold values for quantitative trait mapping. Genetics. 138, 963-971.
73. Muller, A. J., Teresky, A. K., and Levine, A. J. (2000) A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13. Proc. Natl. Acad. Sci. U. S. A. 97, 8421-8426.
74. Singer, J. B., Hill, A. E., Burrage, L. C., et al. (2004) Genetic dissection of complex traits with chromosome substitution strains of mice. Science. 304, 445-448.
75. Nadeau, J. H., Singer, J. B., Matin, A., and Lander, E. S. (2000) Analysing complex genetic traits with chromosome substitution strains. Nat. Genet. 24, 221-225.
76. Hill, A. E., Lander, E. S., and Nadeau, J. H. (2006) Chromosome substitution strains: a new way to study genetically complex traits. Methods Mol. Med. 128, 153-172.