MLPA for prenatal diagnosis of commonly occurring aneuploidies

Methods in Molecular Biology

Volumn 444, Issue , 2008, Pages 111-122

  Schouten, Jan ^a   Galjaard, Robert Jan ^b  

^a MRC HOLLAND   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Aamniotic fluid; Aneuploidy; Gene dosage; Multiplex ligation dependent probe amplification (MLPA); Multiplex polymerase chain reaction (PCR); Trisomy

Indexed keywords

EID: 84934443760     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-66-9_8     Document Type: Article

References (5)

1. Schouten, J. P., McElgunn, C. J., Waaijer, R., Zwijnenburg, D., Diepvens, F., and Pals, G. (2002) Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res. 30, e57.
2. Slater, H. R., Bruno, D. L., Ren, H., Pertile, M., Schouten, J. P., and Choo, K. H. (2003) Rapid, high throughput prenatal detection of aneuploidy using a novel quantitative method (MLPA). J. Med . Genet. 40, 907-912.
3. Gerdes, T., Kirchhoff, M., Lind, A. M., Larsen, G. V., Schwartz, M., and Lundsteen, C. (2005) Computer-assisted prenatal aneuploidy screening for chromosome 13, 18, 21, X and Y based on multiplex ligation-dependent probe amplification (MLPA). Eur. J . Hum . Genet. 13, 171-175.
4. Nygren, A. O., Ameziane, N., Duarte, H. M., et al. (2005) Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res. 33, e128.
5. Hochstenbach, R., Meijer, J., van den Brug, J., et al. (2005) Rapid detection of chromosomal aneuploidies in uncultured amniocytes by multiplex ligation-dependent probe amplification (MLPA). Prenat. Diagnos . 25, 1032-1039.