Effects of mutagenesis of murine hepatitis virus NSP1 and NSP14 on replication in culture

Advances in Experimental Medicine and Biology

Volumn 581, Issue , 2006, Pages 55-60

  Eckerle, Lance D ^a   Brockway, Sarah M ^a   Sperry, Steven M ^a   Lu, Xiaotao ^a   Denison, Mark R ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84934443552     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-33012-9_8     Document Type: Conference Paper

References (7)

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2. Snijder, E. J., P. J. Bredenbeek, J. C. Dobbe, V. Thiel, J. Ziebuhr, L. L. Poon, Y. Guan, M. Rozanov, W. J. Spaan, and A. E. Gorbalenya, 2003, Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol 331:991-1004.
3. Yount, B., M. R. Denison, S. R. Weiss, and R. S. Baric, 2002, Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. J Virol 76:11065-11078.
4. Sperry, S. M., L. Kazi, R. L. Graham, R. S. Baric, S. R. Weiss, and M. R. Denison, 2005, Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. J Virol 79:3391-3400.
5. Brockway, S. M., Lu, X. T., Peters, T. R., Dermody, T. S., and Denison, M. R. 2004. Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. J Virol 78:11551-11562.
6. Denison, M.R., Spaan, J.M., van der Meer, Y., Gibson, C.A., Sims, A.C., Prentice, E., and Lu, X.T, 1999, The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. J Virol 73:6862-6871.
7. Ziebuhr, J., E. J. Snijder, and A. E. Gorbalenya, 2000, Virus-encoded proteinases and proteolytic processing in the Nidovirales. J Gen Virol 81:853-879.