Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line

Advances in Experimental Medicine and Biology

Volumn 581, Issue , 2006, Pages 609-613

  Scandella, Elke ^a   Eriksson, Klara K ^a   Hertzig, Tobias ^b   Drosten, Christian ^c   Chen, Lili ^d   Gui, Chunshan ^d   Luo, Xiaomin ^d   Shen, Jianhua ^d   Shen, Xu ^d   Siddell, Stuart G ^e   Ludewig, Burkhard ^a   Jiang, Hualiang ^d   Günther, Stephan ^c   Thiel, Volker ^a  

^a CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^d China Novartis Institutes for BioMedical Research   (China)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84934443297     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-33012-9_111     Document Type: Conference Paper

References (8)

1. T. Hertzig, E. Scandella, B. Schelle, J. Ziebuhr, S. G. Siddell, B. Ludewig, and V. Thiel, Rapid identification of coronavirus replicase inhibitors using a selectable replicon RNA, J. Gen. Virol. 85, 1717-1725 (2004).
2. B. Rubin, J. J. Piala, J. C. Burke, and B. N. Craver, A new, potent and specific serotonin inhibitor (Sq 10,643) 2′-(3-dimethylaminopropylthio) cin-namanilide hydrochloride: antoserotonin activity on uterus and on gastrointestinal, vascular, and respiratory systems of animals, Arch. Int. Pharmacodyn. Ther. 152, 132-143 (1964).
3. D. M. Gallant and M. P. Bishop, Cinanserin (SQ. 10,643): a preliminary evaluation in chronic schizophrenic patients, Curr. Ther. Res. Clin. Exp. 10, 461-463 (1968).
4. T. M. Itil, N. Polvan, and J. M. Holden, Clinical and electroencephalographic effects of cinanserin in schizophrenic and manic patients, Dis. Nerv. Syst. 32, 193-200 (1971).
5. L. Chen, C. Gui, X. Luo, et al., Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro, J. Virol. 79, 7095-7103 (2005).
6. V. Thiel, J. Herold, B. Schelle, and S. G. Siddell, Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virus, J. Gen. Virol. 82, 1273-1281 (2001).
7. J. Ziebuhr, E. J. Snijder, and A. E. Gorbalenya, Virus-encoded proteinases and proteolytic processing in the Nidovirales, J. Gen. Virol. 81, 853-879 (2000).
8. K. Anand, J. Ziebuhr, P. Wadhwani, J. R. Mesters, and R. Hilgenfeld, Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs, Science 300, 1763-1767 (2003).