Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes

Advances in Experimental Medicine and Biology

Volumn 789, Issue , 2013, Pages 331-334

  Hapuarachchi, Tharindi ^a   Moroz, Tracy ^a   Bainbridge, Alan ^a   Price, David ^a   Cady, Ernest ^a   Baer, Esther ^a   Broad, Kevin ^a   Ezzati, Mojgan ^a   Thomas, David ^b   Golay, Xavier ^b   Robertson, Nicola J ^a   Tachtsidis, Ilias ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; FLAVINE ADENINE NUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANAEROBIC METABOLISM; BLOOD OXYGEN TENSION; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN METABOLISM; CELL FUNCTION; CELL PH; CITRIC ACID CYCLE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOPLASM; NEAR INFRARED SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; OXYGEN SATURATION; OXYGEN SUPPLY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PIGLET; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEADY STATE; TISSUE OXYGENATION;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; HYDROGEN-ION CONCENTRATION; HYPOXIA-ISCHEMIA, BRAIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CARDIOVASCULAR; OXYGEN; OXYGEN CONSUMPTION; SPECTROSCOPY, NEAR-INFRARED; SWINE;

EID: 84934442555     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-7411-1_44     Document Type: Conference Paper

References (7)

1. Robertson NJ, Cowan FM, Cox IJ, Edwards AD (2002) Brain alkaline intracellular pH after neonatal encephalopathy. Ann Neurol 52(6):732-742
2. Moroz T, Banaji M, Robertson NJ, Cooper CE, Tachtsidis I (2012) Computational modelling of the piglet brain to simulate near-infrared spectroscopy and magnetic resonance spectroscopy data collected during oxygen deprivation. J R Soc Interface 9(72):1499-1509
3. Banaji M, Tachtsidis I, Delpy D, Baigent S (2005) A physiological model of cerebral blood fow control. Math Biosci 194(2):125-173
4. Moroz T, Hapuarachchi T, Banaji M et al (2012) Modelling blood fow and metabolism in the piglet brain during hypoxic-ischaemia: simulating brain energetics (this volume)
5. Cady EB, Iwata O, Bainbridge A, Wyatt JS, Robertson NJ (2008) Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet. J Neurochem 107(4):1027-1035
6. Williamson DH, Lund P, Krebs HA (1967) The redox state of free nicotinamide-adenine dinu-cleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103(2):514-527
7. Jones E, Oliphant E, Peterson P et al (2001) SciPy: open source scientifc tools for Python. http://www.scipy.org. Accessed 20 July 2012