메뉴 건너뛰기




Volumn 24, Issue 4, 2015, Pages 301-310

Cystic fibrosis from laboratory to bedside: The role of a20 in NF-κB-mediated inflammation

Author keywords

A20; Anti inflammatory effects; Cystic fibrosis; Drug repositioning; Gene connectivity mapping; Nuclear factor B

Indexed keywords

A20 PROTEIN; ANTIINFLAMMATORY AGENT; CYTOKINE; CYTOPLASM PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG; AUTACOID; DNA BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; NUCLEAR PROTEIN; SIGNAL PEPTIDE; TAX1BP1 PROTEIN, HUMAN; TNF PROTEIN, HUMAN; TNFAIP3 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; TUMOR PROTEIN;

EID: 84934441434     PISSN: 10117571     EISSN: 14230151     Source Type: Journal    
DOI: 10.1159/000381423     Document Type: Review
Times cited : (14)

References (88)
  • 2
    • 33750440785 scopus 로고    scopus 로고
    • Reduced number of CFTR molecules in erythro-cyte plasma membrane of cystic fibrosis patients
    • Lange T, Jungmann P, Haberle J, et al: Reduced number of CFTR molecules in erythro-cyte plasma membrane of cystic fibrosis patients. Mol Membr Biol 2006; 23:317-323.
    • (2006) Mol Membr Biol , vol.23 , pp. 317-323
    • Lange, T.1    Jungmann, P.2    Haberle, J.3
  • 4
    • 0032790732 scopus 로고    scopus 로고
    • Determination of the prevalence of cystic fi-brosis in the United Arab Emirates by genetic carrier screening
    • Frossard PM, Lestringant G, Girodon E, et al: Determination of the prevalence of cystic fi-brosis in the United Arab Emirates by genetic carrier screening. Clin Genet 1999; 55:496-497.
    • (1999) Clin Genet , vol.55 , pp. 496-497
    • Frossard, P.M.1    Lestringant, G.2    Girodon, E.3
  • 5
    • 0025972325 scopus 로고
    • Cystic fi-brosis presenting with recurrent vomiting and metabolic alkalosis
    • Mathew PM, Hamdan JA, Nazer H: Cystic fi-brosis presenting with recurrent vomiting and metabolic alkalosis. Eur J Pediatr 1991; 150:264-266.
    • (1991) Eur J Pediatr , vol.150 , pp. 264-266
    • Mathew, P.M.1    Hamdan, J.A.2    Nazer, H.3
  • 6
    • 0037460729 scopus 로고    scopus 로고
    • Cystic fibrosis
    • Ratjen F, Doring G: Cystic fibrosis. Lancet 2003; 361:681-689.
    • (2003) Lancet , vol.361 , pp. 681-689
    • Ratjen, F.1    Doring, G.2
  • 7
    • 33847711906 scopus 로고    scopus 로고
    • Cystic fibrosis mortality and survival in the UK: 1947-2003
    • Dodge JA, Lewis PA, Stanton M, et al: Cystic fibrosis mortality and survival in the UK: 1947-2003. Eur Respir J 2007; 29:522-526.
    • (2007) Eur Respir J , vol.29 , pp. 522-526
    • Dodge, J.A.1    Lewis, P.A.2    Stanton, M.3
  • 8
    • 0038412795 scopus 로고    scopus 로고
    • Spatial patterns of cystic fibrosis mutation spectra in European populations
    • Lao O, Andres AM, Mateu E, et al: Spatial patterns of cystic fibrosis mutation spectra in European populations. Eur J Hum Genet 2003; 11: 385-394.
    • (2003) Eur J Hum Genet , vol.11 , pp. 385-394
    • Lao, O.1    Andres, A.M.2    Mateu, E.3
  • 9
    • 50649091247 scopus 로고    scopus 로고
    • Epidemiology of cystic fibrosis
    • Hodson M, Geddes DM, Bush A (eds) Boca Raton, CRC Press
    • Walters S, Mehta A: Epidemiology of cystic fibrosis; in Hodson M, Geddes DM, Bush A (eds): Cystic Fibrosis, ed 3. Boca Raton, CRC Press, 2007, pp 21-45.
    • (2007) Cystic Fibrosis, Ed 3 , pp. 21-45
    • Walters, S.1    Mehta, A.2
  • 10
    • 84927689656 scopus 로고    scopus 로고
    • Updates on key emerging challenges in cystic fibrosis
    • Jennings MT, Riekert KA, Boyle MP: Updates on key emerging challenges in cystic fibrosis. Med Princ Pract 2014; 23:393-402.
    • (2014) Med Princ Pract , vol.23 , pp. 393-402
    • Jennings, M.T.1    Riekert, K.A.2    Boyle, M.P.3
  • 11
    • 0000471085 scopus 로고
    • Cystic fibrosis of the pancreas and its relation to celiac disease
    • Anderson DH: Cystic fibrosis of the pancreas and its relation to celiac disease. Am J Dis Child 1938; 56:344.
    • (1938) Am J Dis Child , vol.56 , pp. 344
    • Anderson, D.H.1
  • 12
    • 34547164336 scopus 로고    scopus 로고
    • Patterns of GI disease in adulthood associated with mutations in the CFTR gene
    • Wilschanski M, Durie PR: Patterns of GI disease in adulthood associated with mutations in the CFTR gene. Gut 2007; 56:1153-1163.
    • (2007) Gut , vol.56 , pp. 1153-1163
    • Wilschanski, M.1    Durie, P.R.2
  • 13
    • 84959336559 scopus 로고    scopus 로고
    • Bethedsa, Cystic Fibrosis Foundation
    • Cystic Fibrosis Foundation Patient Registry: 2006 Annual Data Report to the Center Directors. Bethedsa, Cystic Fibrosis Foundation, 2007.
    • (2007) 2006 Annual Data Report to the Center Directors
  • 14
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for perciliary liquid layer depletion, not abnormal ion composition in the pathogenesis of cystic fibrosis airways disease
    • Matsui H, Grubb BR, Tarran R, et al: Evidence for perciliary liquid layer depletion, not abnormal ion composition in the pathogenesis of cystic fibrosis airways disease. Cell 1998; 95: 1005-1115.
    • (1998) Cell , vol.95 , pp. 1005-1115
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3
  • 15
    • 33845309114 scopus 로고    scopus 로고
    • A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aerugino-sa biofilms
    • Matsui H, Wagner VE, Hill DB, et al: A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aerugino-sa biofilms. Proc Natl Acad Sci USA 2006; 103: 18131-18136.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18131-18136
    • Matsui, H.1    Wagner, V.E.2    Hill, D.B.3
  • 16
    • 34047166052 scopus 로고    scopus 로고
    • Airway surface dehydration in cystic fibrosis: Pathogenesis and therapy
    • Boucher RC: Airway surface dehydration in cystic fibrosis: pathogenesis and therapy. Annu Rev Med 2007; 58:157-170.
    • (2007) Annu Rev Med , vol.58 , pp. 157-170
    • Boucher, R.C.1
  • 17
    • 0002121738 scopus 로고
    • The pathology of cystic fibrosis
    • Davis PB (ed) New York, Dekker
    • Tomashefski JF, Abramowsky CR, Dahms BB: The pathology of cystic fibrosis; in Davis PB (ed): Cystic Fibrosis. New York, Dekker, 1993, pp 435-489.
    • (1993) Cystic Fibrosis , pp. 435-489
    • Tomashefski, J.F.1    Abramowsky, C.R.2    Dahms, B.B.3
  • 18
    • 0028914085 scopus 로고
    • Early pulmonary inflammation in infants with cystic fibrosis
    • Khan TZ, Wagener JS, Bost T, et al: Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995; 151: 1075-1082.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 1075-1082
    • Khan, T.Z.1    Wagener, J.S.2    Bost, T.3
  • 19
    • 14244271277 scopus 로고    scopus 로고
    • Cy-tokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibro-sis, mild asthma and healthy volunteers
    • McGarvey LP, Dunbar K, Martin SL, et al: Cy-tokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibro-sis, mild asthma and healthy volunteers. J Cyst Fibros 2002; 1:269-275.
    • (2002) J Cyst Fibros , vol.1 , pp. 269-275
    • McGarvey, L.P.1    Dunbar, K.2    Martin, S.L.3
  • 20
    • 79960586834 scopus 로고    scopus 로고
    • Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis
    • De Boer K, Vandemheen KL, Tullis E, et al: Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis. Thorax 2011; 66:680-685.
    • (2011) Thorax , vol.66 , pp. 680-685
    • De Boer, K.1    Vandemheen, K.L.2    Tullis, E.3
  • 21
    • 0035991525 scopus 로고    scopus 로고
    • The role of inflammation in the pathophysiology of CF lung disease
    • Chmiel JF, Berger M, Konstan MW: The role of inflammation in the pathophysiology of CF lung disease. Clin Rev Allergy Immunol 2002; 23:5-27.
    • (2002) Clin Rev Allergy Immunol , vol.23 , pp. 5-27
    • Chmiel, J.F.1    Berger, M.2    Konstan, M.W.3
  • 23
    • 0020573198 scopus 로고
    • Frequent antibiotic therapy improves survival of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection
    • Szaff M, Hoiby N, Flensborg EW: Frequent antibiotic therapy improves survival of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection. Acta Paediatr Scand 1983; 72:651-657.
    • (1983) Acta Paediatr Scand , vol.72 , pp. 651-657
    • Szaff, M.1    Hoiby, N.2    Flensborg, E.W.3
  • 24
    • 0025230752 scopus 로고
    • Reduction of sputum Pseudomonas aerugino-sa density by antibiotics improves lung function in cystic fibrosis more than bronchodila-tors and chest physiotherapy alone
    • Regelmann WE, Elliot GR, Warwick WJ, et al: Reduction of sputum Pseudomonas aerugino-sa density by antibiotics improves lung function in cystic fibrosis more than bronchodila-tors and chest physiotherapy alone. Am Rev Respir Dis 1990; 141:914-921.
    • (1990) Am Rev Respir Dis , vol.141 , pp. 914-921
    • Regelmann, W.E.1    Elliot, G.R.2    Warwick, W.J.3
  • 25
    • 33645796654 scopus 로고    scopus 로고
    • Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa
    • Sadikot RT, Zeng H, Joo M, et al: Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J Immunol 2006; 176:4923-4930.
    • (2006) J Immunol , vol.176 , pp. 4923-4930
    • Sadikot, R.T.1    Zeng, H.2    Joo, M.3
  • 26
    • 84874594757 scopus 로고    scopus 로고
    • Tolllike receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells
    • Kelly C, Canning P, Buchanan PJ, et al: Tolllike receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2013; 304:371-378.
    • (2013) Am J Physiol Lung Cell Mol Physiol , vol.304 , pp. 371-378
    • Kelly, C.1    Canning, P.2    Buchanan, P.J.3
  • 27
    • 12444322678 scopus 로고    scopus 로고
    • TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
    • Greene CM, Carroll TP, Smith SG, et al: TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol 2005; 174:1638-1646.
    • (2005) J Immunol , vol.174 , pp. 1638-1646
    • Greene, C.M.1    Carroll, T.P.2    Smith, S.G.3
  • 28
    • 16344389339 scopus 로고    scopus 로고
    • Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fi-brosis
    • Hauber HP, Tulic MK, Tsicopoulos A, et al: Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fi-brosis. Can Respir J 2005; 12:13-18.
    • (2005) Can Respir J , vol.12 , pp. 13-18
    • Hauber, H.P.1    Tulic, M.K.2    Tsicopoulos, A.3
  • 29
    • 77950468064 scopus 로고    scopus 로고
    • TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells
    • John G, Yildirim AO, Rubin BK, et al: TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells. Am J Respir Cell Mol Biol 2010; 42:424-431.
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 424-431
    • John, G.1    Yildirim, A.O.2    Rubin, B.K.3
  • 30
    • 0037076416 scopus 로고    scopus 로고
    • CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation
    • Schroeder TH, Lee MM, Yacono PW, et al: CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proc Natl Acad Sci USA 2002; 99:6907-6912.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6907-6912
    • Schroeder, T.H.1    Lee, M.M.2    Yacono, P.W.3
  • 31
    • 46949105608 scopus 로고    scopus 로고
    • Airway epithelial cell inflammatory signalling in cystic fibrosis
    • Jacquot J, Tabary O, Le Rouzic P, et al: Airway epithelial cell inflammatory signalling in cystic fibrosis. Int J Biochem Cell Biol 2008; 40: 1703-1715.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1703-1715
    • Jacquot, J.1    Tabary, O.2    Le Rouzic, P.3
  • 32
    • 0028920643 scopus 로고
    • Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface
    • Imundo L, Barasch J, Prince A, et al: Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proc Natl Acad Sci USA 1995; 92:3019-3023.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3019-3023
    • Imundo, L.1    Barasch, J.2    Prince, A.3
  • 33
    • 40649112565 scopus 로고    scopus 로고
    • Airway epithelial control of Pseudo-monas aeruginosa infection in cystic fibrosis
    • Campodonico VL, Gadjeva M, Paradis-Bleau C, et al: Airway epithelial control of Pseudo-monas aeruginosa infection in cystic fibrosis. Trends Mol Med 2008; 14:120-133.
    • (2008) Trends Mol Med , vol.14 , pp. 120-133
    • Campodonico, V.L.1    Gadjeva, M.2    Paradis-Bleau, C.3
  • 34
    • 11044227865 scopus 로고    scopus 로고
    • Established cell lines used in cystic fibrosis research
    • Gruenert DC, Willems M, Cassiman JJ, et al: Established cell lines used in cystic fibrosis research. J Cyst Fibros 2004; 3:191-196.
    • (2004) J Cyst Fibros , vol.3 , pp. 191-196
    • Gruenert, D.C.1    Willems, M.2    Cassiman, J.J.3
  • 35
    • 1442325340 scopus 로고    scopus 로고
    • Cytokine secretion by cystic fibrosis airway epithelial cells
    • Becker MN, Sauer MS, Muhlebach MS, et al: Cytokine secretion by cystic fibrosis airway epithelial cells. Am J Respir Crit Care Med 2004; 169:645-653.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 645-653
    • Becker, M.N.1    Sauer, M.S.2    Muhlebach, M.S.3
  • 36
    • 33646469375 scopus 로고    scopus 로고
    • Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells
    • Carrabino S, Carpani D, Livraghi A, et al: Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells. J Cyst Fibros 2006; 5:113-119.
    • (2006) J Cyst Fibros , vol.5 , pp. 113-119
    • Carrabino, S.1    Carpani, D.2    Livraghi, A.3
  • 37
    • 84870511266 scopus 로고    scopus 로고
    • Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology
    • De Courcey F, Zholos AV, Atherton-Watson H, et al: Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology. Am J Physiol Cell Physiol 2012; 303:1173-1179.
    • (2012) Am J Physiol Cell Physiol , vol.303 , pp. 1173-1179
    • De Courcey, F.1    Zholos, A.V.2    Atherton-Watson, H.3
  • 38
    • 84906079483 scopus 로고    scopus 로고
    • Functional and pharmacological characterization of volume-regulated anion channels in human normal and cystic fibrosis bronchial and nasal epithelial cells
    • Stott JB, de Courcey F, Ennis M, et al: Functional and pharmacological characterization of volume-regulated anion channels in human normal and cystic fibrosis bronchial and nasal epithelial cells. Eur J Pharmacol 2014; 740:183-191.
    • (2014) Eur J Pharmacol , vol.740 , pp. 183-191
    • Stott, J.B.1    De Courcey, F.2    Ennis, M.3
  • 39
    • 84878813926 scopus 로고    scopus 로고
    • Expression of the nuclear factor-κB inhibitor A20 is altered in the cystic fibrosis epithelium
    • Kelly C, Williams MT, Mitchell K, et al: Expression of the nuclear factor-κB inhibitor A20 is altered in the cystic fibrosis epithelium. Eur Respir J 2013; 41:1315-1323.
    • (2013) Eur Respir J , vol.41 , pp. 1315-1323
    • Kelly, C.1    Williams, M.T.2    Mitchell, K.3
  • 40
    • 80051561179 scopus 로고    scopus 로고
    • A20 regulation of nuclear factor-κB: Perspectives for inflammatory lung disease
    • Kelly C, Shields MD, Elborn JS, et al: A20 regulation of nuclear factor-κB: perspectives for inflammatory lung disease. Am J Respir Cell Mol Biol 2011; 44:743-748.
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 743-748
    • Kelly, C.1    Shields, M.D.2    Elborn, J.S.3
  • 41
    • 77649225756 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
    • Shembade N, Ma A, Harhaj EW: Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 2010; 327:1135-1139.
    • (2010) Science , vol.327 , pp. 1135-1139
    • Shembade, N.1    Ma, A.2    Harhaj, E.W.3
  • 42
    • 68149139538 scopus 로고    scopus 로고
    • The ubiq-uitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
    • Vereecke L, Beyaert R, van Loo G: The ubiq-uitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. Trends Immunol 2009; 30:383-391.
    • (2009) Trends Immunol , vol.30 , pp. 383-391
    • Vereecke, L.1    Beyaert, R.2    Van Loo, G.3
  • 43
    • 4644313798 scopus 로고    scopus 로고
    • Inter-leukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered
    • Zaman MM, Gelrud A, Junaidi O, et al: Inter-leukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol 2004; 11:819-824.
    • (2004) Clin Diagn Lab Immunol , vol.11 , pp. 819-824
    • Zaman, M.M.1    Gelrud, A.2    Junaidi, O.3
  • 44
    • 21444461227 scopus 로고    scopus 로고
    • Cy-tokine levels in sputum of cystic fibrosis patients before and after antibiotic therapy
    • Colombo C, Costantini D, Rocchi A, et al: Cy-tokine levels in sputum of cystic fibrosis patients before and after antibiotic therapy. Pe-diatr Pulmonol 2005; 40:15-21.
    • (2005) Pe-diatr Pulmonol , vol.40 , pp. 15-21
    • Colombo, C.1    Costantini, D.2    Rocchi, A.3
  • 45
    • 4644272735 scopus 로고    scopus 로고
    • Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
    • Karp CL, Flick LM, Park KW, et al: Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol 2004; 5:388-392.
    • (2004) Nat Immunol , vol.5 , pp. 388-392
    • Karp, C.L.1    Flick, L.M.2    Park, K.W.3
  • 46
    • 0032817772 scopus 로고    scopus 로고
    • Altered respiratory epithelial cell cytokine production in cystic fibrosis
    • Bonfield TL, Konstan MW, Berger M: Altered respiratory epithelial cell cytokine production in cystic fibrosis. J Allergy Clin Immunol 1999; 104:72-78.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 72-78
    • Bonfield, T.L.1    Konstan, M.W.2    Berger, M.3
  • 47
    • 74949090299 scopus 로고    scopus 로고
    • An overview of the molecular mechanism of autophagy
    • Yang Z, Klionsky DJ: An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 2009; 335:1-32.
    • (2009) Curr Top Microbiol Immunol , vol.335 , pp. 1-32
    • Yang, Z.1    Klionsky, D.J.2
  • 48
    • 84856227062 scopus 로고    scopus 로고
    • The complex interplay between autophagy and NF-κB signaling pathways in cancer cells
    • Trocoli A, Djavaheri-Mergny M: The complex interplay between autophagy and NF-κB signaling pathways in cancer cells. Am J Cancer Res 2011; 1:629-649.
    • (2011) Am J Cancer Res , vol.1 , pp. 629-649
    • Trocoli, A.1    Djavaheri-Mergny, M.2
  • 49
    • 34447629523 scopus 로고    scopus 로고
    • Innate and adaptive immunity through autophagy
    • Schmid D, Münz C: Innate and adaptive immunity through autophagy. Immunity 2007; 27:11-21.
    • (2007) Immunity , vol.27 , pp. 11-21
    • Schmid, D.1    Münz, C.2
  • 50
    • 78650812864 scopus 로고    scopus 로고
    • Cystic fibrosis: A disorder with defective autophagy
    • Luciani A, Villella VR, Esposito S, et al: Cystic fibrosis: a disorder with defective autophagy. Autophagy 2011; 104-106.
    • (2011) Autophagy , pp. 104-106
    • Luciani, A.1    Villella, V.R.2    Esposito, S.3
  • 51
    • 84896957356 scopus 로고    scopus 로고
    • The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections
    • Junkins RD, McCormick C, Lin T-J: The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections. Autophagy 2014; 538-547.
    • (2014) Autophagy , pp. 538-547
    • Junkins, R.D.1    McCormick, C.2    Lin, T.-J.3
  • 52
    • 80655134731 scopus 로고    scopus 로고
    • Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
    • Abdulrahman BA, Khweek AA, Akhter A, et al: Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy 2011; 7:1359-1370.
    • (2011) Autophagy , vol.7 , pp. 1359-1370
    • Abdulrahman, B.A.1    Khweek, A.A.2    Akhter, A.3
  • 53
    • 0025179989 scopus 로고
    • The A20 cDNA induced by tumour necrosis factor α encodes a novel type of zinc finger protein
    • Opipari AW Jr, Boguski MS, Dixit VM: The A20 cDNA induced by tumour necrosis factor α encodes a novel type of zinc finger protein. J Biol Chem 1990; 265:14705-14708.
    • (1990) J Biol Chem , vol.265 , pp. 14705-14708
    • Opipari, A.W.1    Boguski, M.S.2    Dixit, V.M.3
  • 54
    • 0034805902 scopus 로고    scopus 로고
    • Dysregulated NF-kappaB activation in cystic fibrosis: Evidence for a primary inflammatory disorder
    • Blackwell TS, Stecenko AA, Christman JW: Dysregulated NF-kappaB activation in cystic fibrosis: evidence for a primary inflammatory disorder. Am J Physiol Lung Cell Mol Physiol 2001; 281:69-70.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. 69-70
    • Blackwell, T.S.1    Stecenko, A.A.2    Christman, J.W.3
  • 55
    • 84876721671 scopus 로고    scopus 로고
    • A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals
    • Da Silva CG, Studer P, Skroch M, et al: A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals. Hepatology 2013; 57: 2014-2025.
    • (2013) Hepatology , vol.57 , pp. 2014-2025
    • Da Silva, C.G.1    Studer, P.2    Skroch, M.3
  • 56
    • 79952781757 scopus 로고    scopus 로고
    • Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis
    • Mabilleau G, Chappard D, Sabokbar A: Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis. J Biol Chem 2011; 286:3242-3249.
    • (2011) J Biol Chem , vol.286 , pp. 3242-3249
    • Mabilleau, G.1    Chappard, D.2    Sabokbar, A.3
  • 57
    • 61949220270 scopus 로고    scopus 로고
    • The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling
    • Shembade N, Parvatiyar K, Harhaj NS, et al: The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. EMBO J 2009; 28:513-522.
    • (2009) EMBO J , vol.28 , pp. 513-522
    • Shembade, N.1    Parvatiyar, K.2    Harhaj, N.S.3
  • 58
    • 80051986818 scopus 로고    scopus 로고
    • The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
    • Shembade N, Pujari R, Harhaj NS, et al: The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol 2011; 12:834-843.
    • (2011) Nat Immunol , vol.12 , pp. 834-843
    • Shembade, N.1    Pujari, R.2    Harhaj, N.S.3
  • 59
    • 3943054838 scopus 로고    scopus 로고
    • De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    • Wertz IE, O'Rourke KM, Zhou H, et al: De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004; 430:694-699.
    • (2004) Nature , vol.430 , pp. 694-699
    • Wertz, I.E.1    O'Rourke, K.M.2    Zhou, H.3
  • 60
    • 84903726513 scopus 로고    scopus 로고
    • The deubiquitinase activity of A20 is dispensable for NF-κB signaling
    • De A, Dainichi T, Rathinam CV, et al: The deubiquitinase activity of A20 is dispensable for NF-κB signaling. EMBO Rep 2014; 15: 775-783.
    • (2014) EMBO Rep , vol.15 , pp. 775-783
    • De A Dainichi, T.1    Rathinam, C.V.2
  • 61
    • 0026691240 scopus 로고
    • The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity
    • Opipari AW Jr, Hu HM, Yabkowitz R, et al: The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem 1992; 267:12424-12427.
    • (1992) J Biol Chem , vol.267 , pp. 12424-12427
    • Opipari, A.W.1    Hu, H.M.2    Yabkowitz, R.3
  • 62
    • 0346656707 scopus 로고    scopus 로고
    • A genome scan in 260 inflammatory bowel disease-affected relative pairs
    • Barmada MM, Brant SR, Nicolae DL, et al: A genome scan in 260 inflammatory bowel disease-affected relative pairs. Inflamm Bowel Dis 2004; 10:513-520.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 513-520
    • Barmada, M.M.1    Brant, S.R.2    Nicolae, D.L.3
  • 63
    • 77954391573 scopus 로고    scopus 로고
    • Entero-cyte specific A20 deficiency sensitizes to tumour necrosis factor-induced toxicity and experimental colitis
    • Vereecke L, Sze M, Guire CM, et al: Entero-cyte specific A20 deficiency sensitizes to tumour necrosis factor-induced toxicity and experimental colitis. J Exp Med 2010; 207:1513-1523.
    • (2010) J Exp Med , vol.207 , pp. 1513-1523
    • Vereecke, L.1    Sze, M.2    Guire, C.M.3
  • 64
    • 33745121206 scopus 로고    scopus 로고
    • An inhibitory effect of A20 on NF-kappaB activation in airway epithelium upon influenza virus infection
    • Onose A, Hashimoto S, Hayashi S, et al: An inhibitory effect of A20 on NF-kappaB activation in airway epithelium upon influenza virus infection. Eur J Pharmacol 2006; 541:198-204.
    • (2006) Eur J Pharmacol , vol.541 , pp. 198-204
    • Onose, A.1    Hashimoto, S.2    Hayashi, S.3
  • 65
    • 58649097739 scopus 로고    scopus 로고
    • Dietary (n-3) polyunsaturated fatty acids affect the kinetics of pro-and anti-inflammatory responses in mice with Pseudomonas aerugino-sa lung infection
    • Tiesset H, Pierre M, Desseyn JL, et al: Dietary (n-3) polyunsaturated fatty acids affect the kinetics of pro-and anti-inflammatory responses in mice with Pseudomonas aerugino-sa lung infection. J Nutr 2009; 139:82-89.
    • (2009) J Nutr , vol.139 , pp. 82-89
    • Tiesset, H.1    Pierre, M.2    Desseyn, J.L.3
  • 66
    • 4444257589 scopus 로고    scopus 로고
    • A20 inhibits toll-like receptor 2-and 4-mediated inter-leukin-8 synthesis in airway epithelial cells
    • Gon Y, Asai Y, Hashimoto S, et al: A20 inhibits toll-like receptor 2-and 4-mediated inter-leukin-8 synthesis in airway epithelial cells. Am J Respir Cell Mol Biol 2004; 31:330-336.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 330-336
    • Gon, Y.1    Asai, Y.2    Hashimoto, S.3
  • 67
    • 79960246157 scopus 로고    scopus 로고
    • A failure of TNFAIP3 negative regulation maintains sustained NF-kappaB activation in Sjorgen's syndrome
    • Sisto M, Lisi S, Lofrumento DD, et al: A failure of TNFAIP3 negative regulation maintains sustained NF-kappaB activation in Sjorgen's syndrome. Histochem Cell Biol 2011; 135: 615-625.
    • (2011) Histochem Cell Biol , vol.135 , pp. 615-625
    • Sisto, M.1    Lisi, S.2    Lofrumento, D.D.3
  • 68
    • 84878354615 scopus 로고    scopus 로고
    • Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis
    • Kelly C, Williams MT, Elborn JS, et al: Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis. J Cyst Fibros 2013; 12:411-415.
    • (2013) J Cyst Fibros , vol.12 , pp. 411-415
    • Kelly, C.1    Williams, M.T.2    Elborn, J.S.3
  • 69
    • 33745596809 scopus 로고    scopus 로고
    • Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells
    • Collett GP, Campbell FC: Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells. Carcinogenesis 2006; 27:1285-1291.
    • (2006) Carcinogenesis , vol.27 , pp. 1285-1291
    • Collett, G.P.1    Campbell, F.C.2
  • 70
    • 57049115018 scopus 로고    scopus 로고
    • Plant biology: Gibberellins close the lid
    • Hedden P: Plant biology: gibberellins close the lid. Nature 2008; 456:455-456.
    • (2008) Nature , vol.456 , pp. 455-456
    • Hedden, P.1
  • 71
    • 77951684080 scopus 로고    scopus 로고
    • Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action
    • Holden NS, Rider CF, Bell MJ, et al: Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. Br J Pharmacol 2010; 160:410-420.
    • (2010) Br J Pharmacol , vol.160 , pp. 410-420
    • Holden, N.S.1    Rider, C.F.2    Bell, M.J.3
  • 72
    • 0024489657 scopus 로고
    • Aloe vera and gibberel-lin. Anti-inflammatory activity in diabetes
    • Davis RH, Maro NP: Aloe vera and gibberel-lin. Anti-inflammatory activity in diabetes. J Am Podiatr Med Assoc 1989; 79:24-26.
    • (1989) J Am Podiatr Med Assoc , vol.79 , pp. 24-26
    • Davis, R.H.1    Maro, N.P.2
  • 75
    • 84934441348 scopus 로고    scopus 로고
    • Defective A20 signalling in cystic fibrosis: An anti-inflammatory action of gibberellin (abstract)
    • Reihill J, Malcomson B, Barsden R, et al: Defective A20 signalling in cystic fibrosis: an anti-inflammatory action of gibberellin (abstract). J Cyst Fibros 2014; 13:574.
    • (2014) J Cyst Fibros , vol.13 , pp. 574
    • Reihill, J.1    Malcomson, B.2    Barsden, R.3
  • 76
    • 70249117539 scopus 로고    scopus 로고
    • A20 attenuates allergic airway inflammation in mice
    • Kang NI, Yoon HY, Lee YR, et al: A20 attenuates allergic airway inflammation in mice. J Immunol 2009; 183:1488-1495.
    • (2009) J Immunol , vol.183 , pp. 1488-1495
    • Kang, N.I.1    Yoon, H.Y.2    Lee, Y.R.3
  • 77
    • 84871667475 scopus 로고    scopus 로고
    • An inactivated Pseudomonas aeruginosa medicament inhibits airway allergic inflammation and improves epithelial functions
    • Tan Y, Liu H, Yang H, et al: An inactivated Pseudomonas aeruginosa medicament inhibits airway allergic inflammation and improves epithelial functions. J Physiol Sci 2013; 63: 63-69.
    • (2013) J Physiol Sci , vol.63 , pp. 63-69
    • Tan, Y.1    Liu, H.2    Yang, H.3
  • 79
    • 77649234756 scopus 로고    scopus 로고
    • How to improve R&D productivity: The pharmaceutical industry's grand challenge
    • Paul SM, Mytelka DS, Dunwiddie CT, et al: How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov 2010; 9:203-214.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 203-214
    • Paul, S.M.1    Mytelka, D.S.2    Dunwiddie, C.T.3
  • 80
    • 2442482962 scopus 로고    scopus 로고
    • Key factors in the rising cost of new drug discovery and development
    • Dickson M, Gagnon JP: Key factors in the rising cost of new drug discovery and development. Nat Rev Drug Discov 2004; 3:417-429.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 417-429
    • Dickson, M.1    Gagnon, J.P.2
  • 81
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi JA, Hansen RW, Grabowski HG: The price of innovation: new estimates of drug development costs. J Health Econ 2003; 22:151-185.
    • (2003) J Health Econ , vol.22 , pp. 151-185
    • Dimasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 82
    • 84878274373 scopus 로고    scopus 로고
    • In vitro and ex vivo models of human asthma
    • Blume C, Davies DE: In vitro and ex vivo models of human asthma. Eur J Pharm Bio-pharm 2013; 84:394-400.
    • (2013) Eur J Pharm Bio-pharm , vol.84 , pp. 394-400
    • Blume, C.1    Davies, D.E.2
  • 83
    • 80051670719 scopus 로고    scopus 로고
    • Animal models of asthma: Value, limitations and opportunities for alternative approaches
    • Holmes AM, Solari R, Holgate ST: Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug Discov Today 2011; 16:659-670.
    • (2011) Drug Discov Today , vol.16 , pp. 659-670
    • Holmes, A.M.1    Solari, R.2    Holgate, S.T.3
  • 84
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn TT, Thor KB: Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 2004; 3:673-683.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 85
    • 79551622693 scopus 로고    scopus 로고
    • Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping
    • McArt DG, Zhang SD: Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping. PLoS One 2011; 6:e16382.
    • (2011) PLoS One , vol.6 , pp. e16382
    • McArt, D.G.1    Zhang, S.D.2
  • 86
    • 48949120324 scopus 로고    scopus 로고
    • A simple and robust method for connecting small-molecule drugs using gene-expression signatures
    • Zhang SD, Gant TW: A simple and robust method for connecting small-molecule drugs using gene-expression signatures. BMC Bio-informatics 2008; 9:258.
    • (2008) BMC Bio-informatics , vol.9 , pp. 258
    • Zhang, S.D.1    Gant, T.W.2
  • 87
    • 84879952062 scopus 로고    scopus 로고
    • En-tinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia
    • Ramsey JM, Kettyle LM, Sharpe DJ, et al: En-tinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia. Stem Cells 2013; 31:1434-1445.
    • (2013) Stem Cells , vol.31 , pp. 1434-1445
    • Ramsey, J.M.1    Kettyle, L.M.2    Sharpe, D.J.3
  • 88
    • 84934440619 scopus 로고    scopus 로고
    • Connectivity mapping: An advanced approach to predict A20 inducing small molecules to reduce inflammation (abstract)
    • Barsden R, Elborn JS, Schock BC, et al: Connectivity mapping: an advanced approach to predict A20 inducing small molecules to reduce inflammation (abstract). J Cyst Fibros 2014; 13:574.
    • (2014) J Cyst Fibros , vol.13 , pp. 574
    • Barsden, R.1    Elborn, J.S.2    Schock, B.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.