Fiber-modified adenoviruses for targeted gene therapy

Methods in Molecular Biology

Volumn 434, Issue , 2008, Pages 113-132

  Wu, Hongju ^a   Curiel, David T ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Adenovirus; Adenovirus amplification; CsCl gradient purification; Fiber modification; Gene therapy; Homologous recombination; Rescuing adenoviral vectors

Indexed keywords

ADENOVIRIDAE; BACTERIA (MICROORGANISMS); HUMAN ADENOVIRUS; MIRIDAE;

EID: 84934440680     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-248-3_8     Document Type: Article

References (20)

1. Louis, N., Fender, P., Barge, A., Kitts, P., and Chroboczek, J. (1994) Cell-binding domain of adenovirus serotype 2 fiber. J Virol 68, 4104-6.
2. Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt-Jones, E. A., Krithivas, A., Hong, J. S., et al. (1997). Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275, 1320-3.
3. Santis, G., Legrand, V., Hong, S. S., Davison, E., Kirby, L, Imler, J. L., et al. (1999) Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR. J Gen Virol 80 (Pt 6), 1519-27.
4. Bai, M., Harfe, B., and Freimuth, P. (1993) Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells. J Virol 67, 5198-205.
5. Wickham, T. J., Mathias, P., Cheresh, D. A., and Nemerow, G. R. (1993) Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73, 309-19.
6. Li, E., Brown, S. L., Stupack, D. G., Puente, X. S., Cheresh, D. A., and Nemerow, G. R. (2001) Integrin alpha(v)beta1 is an adenovirus coreceptor. J Virol 75, 5405-9.
7. Curiel, D. T. (1999) Strategies to adapt adenoviral vectors for targeted delivery. Ann N Y Acad Sci 886, 158-71.
8. Silman, N. J., and Fooks, A. R. (2000) Biophysical targeting of adenovirus vectors for gene therapy. Curr Opin Mol Ther 2, 524-31.
9. Mizuguchi, H., and Hayakawa, T. (2004) Targeted adenovirus vectors. Hum Gene Ther 15, 1034-44.
10. Dmitriev, I., Kashentseva, E., Rogers, B. E., Krasnykh, V., and Curiel, D. T. (2000) Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells. J Virol 74, 6875-84.
11. Zhu, Z. B., Makhija, S. K., Lu, B., Wang, M., Rivera, A. A., Preuss, M., et al. (2004) Transport across a polarized monolayer of Caco-2 cells by transferrin receptor-mediated adenovirus transcytosis. Virology 325, 116-28.
12. Krasnykh, V. N., Mikheeva, G. V., Douglas, J. T., and Curiel, D. T. (1996) Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism. J Virol 70, 6839-46.
13. Wickham, T. J., Tzeng, E., Shears, L. L., 2nd, Roelvink, P. W., Li, Y., Lee, G. M., et al. (1997) Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins. J Virol 71, 8221-9.
14. Dmitriev, I., Krasnykh, V., Miller, C. R., Wang, M., Kashentseva, E., Mikheeva, G., et al. (1998) An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 72, 9706-13.
15. Wu, H., Seki, T., Dmitriev, I., Uil, T., Kashentseva, E., Han, T., and Curiel, D. T. (2002) Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency. Hum Gene Ther 13, 1647-53.
16. Krasnykh, V., Dmitriev, I., Mikheeva, G., Miller, C. R., Belousova, N., and Curiel., D. T. (1998) Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J Virol 72, 1844-52.
17. Belousova, N., Krendelchtchikova, V., Curiel, D. T., and Krasnykh, V. (2002) Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein. J Virol 76, 8621-31.
18. Xia, H., Anderson, B., Mao, Q., and Davidson, B. L. (2000) Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium. J Virol 74, 11359-66.
19. Wu, H., Dmitriev, I., Kashentseva, E., Seki, T., Wang, M., and Curiel, D. T. (2002) Construction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon. J Virol 76, 12775-82.
20. Quantum Adeasy™ Vector System Application Manual. (2000) Quantum Biotechnologies, Montreal, Canada.